Employees – University of Copenhagen

David E. Gloriam

David E. Gloriam

Associate Professor


  1. 2018
  2. Published

    Pharmacogenomics of GPCR Drug Targets. / Hauser, Alexander Sebastian; Chavali, Sreenivas; Masuho, Ikuo; Jahn, Leonie; Martemyanov, Kirill; Gloriam, David E.; Babu, Madan.

    In: Cell, 01.2018, p. 41-54 e19.

    Research output: Contribution to journalJournal article

  3. Published

    Structural Mapping of Adenosine Receptor Mutations : Ligand Binding and Signaling Mechanisms. / Jespers, Willem; Schiedel, Anke C; Heitman, Laura H; Cooke, Robert M; Kleene, Lisa; van Westen, Gerard J P; Gloriam, David E; Müller, Christa E; Sotelo, Eddy; Gutiérrez-de-Terán, Hugo.

    In: Trends in Pharmacological Sciences, Vol. 39, No. 1, 01.2018, p. 75-89.

    Research output: Contribution to journalReview

  4. Published

    5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. / Peng, Yao; Mccorvy, John D.; Harpsøe, Kasper; Lansu, Katherine; Yuan, Shuguang; Popov, Petr; Qu, Lu; Pu, Mengchen; Che, Tao; Nikolajsen, Louise F.; Huang, Xi-ping; Wu, Yiran; Shen, Ling; Bjørn-Yoshimoto, Walden E.; Ding, Kang; Wacker, Daniel; Han, Gye Won; Cheng, Jianjun; Katritch, Vsevolod; Jensen, Anders A.; Hanson, Michael A.; Zhao, Suwen; Gloriam, David E.; Roth, Bryan L.; Stevens, Raymond C.; Liu, Zhi-jie.

    In: Cell, Vol. 172, No. 4, 08.02.2018.

    Research output: Contribution to journalJournal article

  5. 2017
  6. Published

    Applying label-free dynamic mass redistribution assay for studying endogenous FPR1 receptor signalling in human neutrophils. / Christensen, Hanna B; Gloriam, David E; Pedersen, Daniel Sejer; Cowland, Jack B; Borregaard, Niels; Bräuner-Osborne, Hans.

    In: Journal of Pharmacological and Toxicological Methods, Vol. 88, No. Pt 1, 15.07.2017, p. 72-78.

    Research output: Contribution to journalJournal article

  7. Published

    Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. / Di Giglio, Maria Giulia; Muttenthaler, Markus; Harpsøe, Kasper; Liutkeviciute, Zita; Keov, Peter; Eder, Thomas; Rattei, Thomas; Arrowsmith, Sarah; Wray, Susan; Marek, Ales; Elbert, Tomas; Alewood, Paul F; Gloriam, David E; Gruber, Christian W.

    In: Scientific reports, Vol. 7, 41002, 01.02.2017.

    Research output: Contribution to journalJournal article

  8. Published

    Selectivity determinants of GPCR-G-protein binding. / Flock, Tilman; Hauser, Alexander S; Lund, Nadia; Gloriam, David E; Balaji, Santhanam; Babu, M Madan.

    In: Nature, Vol. 545, No. 7654, 18.05.2017, p. 317-322.

    Research output: Contribution to journalJournal article

  9. Published

    Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method. / Frandsen, Ida Osborn; Boesgaard, Michael W; Fidom, Kimberley; Hauser, Alexander S; Isberg, Vignir; Bräuner-Osborne, Hans; Wellendorph, Petrine; Gloriam, David E.

    In: Scientific Reports, Vol. 7, No. 1, 4829, 06.07.2017.

    Research output: Contribution to journalJournal article

  10. Published

    Structural insight to mutation effects uncover a common allosteric site in class C GPCRs. / Harpsøe, Kasper; Boesgaard, Michael W; Munk, Christian; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Bioinformatics (Oxford, England), Vol. 33, No. 8, btw784, 2017, p. 1116-1120.

    Research output: Contribution to journalJournal article

  11. Published

    Trends in GPCR drug discovery: new agents, targets and indications. / Hauser, Alexander Sebastian; Gloriam, David E.; Attwood, Misty M.; Rask-Andersen, Mathias ; Schiöth, Helgi B. .

    In: Nature Reviews. Drug Discovery, Vol. 16, 178, 27.10.2017, p. 829-842.

    Research output: Contribution to journalJournal article

  12. Published

    The orphan G protein-coupled receptor GPR139 is activated by the peptides : Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. / Jensen, Anne Cathrine Nøhr; Shehata, Mohamed A; Hauser, Alexander S; Isberg, Vignir; Mokrosinski, Jacek; Farooqi, I Sadaf; Pedersen, Daniel Sejer; Gloriam, David E; Bräuner-Osborne, Hans.

    In: Neurochemistry international, Vol. 102, 01.01.2017, p. 105-113.

    Research output: Contribution to journalJournal article

  13. Published

    Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs. / Krall, Jacob; Jensen, Claus Hatt; Bavo, Francesco; Falk-Petersen, Christina Birkedahl; Haugaard, Anne Stæhr; Vogensen, Stine Byskov; Tian, Yongsong; Nittegaard-Nielsen, Mia; Sigurdardóttir, Sara Björk; Kehler, Jan; Kongstad, Kenneth Thermann; Gloriam, David E.; Clausen, Rasmus Prætorius; Harpsøe, Kasper; Wellendorph, Petrine; Frølund, Bente.

    In: Journal of Medicinal Chemistry, Vol. 60, No. 21, 2017, p. 9022-9039.

    Research output: Contribution to journalJournal article

  14. Published
  15. Published

    The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site. / Shehata, Mohamed A.; Jensen, Anne Cathrine Nøhr; Jespers, Willem; Floryan, Leonard; Isberg, Vignir; Andersen, Kirsten Bayer; Åqvist, Johan; Gutiérrez-de-Terán, Hugo; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 7, 1128, 25.04.2017.

    Research output: Contribution to journalJournal article

  16. 2016
  17. Published

    GPCRdb : an information system for G protein-coupled receptors. / Isberg, Vignir; Mordalski, Stefan; Munk, Christian; Rataj, Krzysztof; Harpsøe, Kasper; Hauser, Alexander S; Vroling, Bas; Bojarski, Andrzej J; Vriend, Gert; Gloriam, David E.

    In: Nucleic acids research, Vol. 44, No. D1, 04.01.2016, p. D356-64.

    Research output: Contribution to journalJournal article

  18. GPCRdb: The G protein-coupled receptor database - an introduction. / Munk, C; Isberg, V; Mordalski, S; Harpsøe, K; Rataj, K; Hauser, A S; Kolb, P; Bojarski, A J; Vriend, G; Gloriam, D E.

    In: British journal of pharmacology, Vol. 173, No. 14, 07.2016, p. 2195-207.

    Research output: Contribution to journalJournal article

  19. Published

    Integrating structural and mutagenesis data to elucidate GPCR ligand binding. / Munk, Christian; Harpsøe, Kasper; Hauser, Alexander S; Isberg, Vignir; Gloriam, David E.

    In: Current Opinion in Pharmacology, Vol. 30, 10.2016, p. 51-58.

    Research output: Contribution to journalJournal article

  20. Published

    Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139. / Shehata, Mohamed A; Jensen, Anne Cathrine Nøhr; Lissa, Delphine; Bisig, Christoph; Isberg, Vignir; Andersen, Kirsten B; Harpsøe, Kasper; Björkling, Fredrik; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 6, 36681, 10.11.2016, p. 1-13.

    Research output: Contribution to journalJournal article

  21. Published

    Editorial overview : New technologies: GPCR drug design and function-exploiting the current (of) structures. / Tautermann, Christofer S; Gloriam, David E.

    In: Current Opinion in Pharmacology, Vol. 30, 02.08.2016, p. 7-10.

    Research output: Contribution to journalComment/debate

  22. Published

    Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors. / Xiong, Xiaofeng; Zhang, Hang; Underwood, Christina R.; Harpsøe, Kasper; Gardella, Thomas J.; Wöldike, Mie F.; Mannstadt, Michael; Gloriam, David E.; Bräuner-osborne, Hans; Strømgaard, Kristian.

    In: Nature Chemistry, Vol. 8, No. 11, 11.2016, p. 1035-1041.

    Research output: Contribution to journalJournal article

  23. 2015
  24. Published

    Identification and characterization of small molecular NPR-B receptor antagonists. / Andresen, Henriette; Moltzau, Lise; Fagerheim, Steffen; Gloriam, David; Bach, Trond; Levy, Finn.

    In: BMC Pharmacology & Toxicology, Vol. 16, No. Suppl 1, 01.01.2015, p. A70.

    Research output: Contribution to journalJournal article

  25. Published

    Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat. / Babbitt, Patricia C.; Bagos, Pantelis G.; Bairoch, Amos; Bateman, Alex; Chatonnet, Arnaud; Chen, Mark Jinan; Craik, David J.; Finn, Robert D.; Gloriam, David; Haft, Daniel H.; Henrissat, Bernard; Holliday, Gemma L.; Isberg, Vignir; Kaas, Quentin; Landsman, David; Lenfant, Nicolas; Manning, Gerard; Nagano, Nozomi; Srinivasan, Narayanaswamy; O’Donovan, Claire; Pruitt, Kim D.; Sowdhamini, Ramanathan; Rawlings, Neil D.; Saier, Milton H.; Sharman, Joanna L.; Spedding, Michael; Tsirigos, Konstantinos D.; Vastermark, Ake; Vriend, Gerrit.

    In: Database, Vol. 2015, 18.05.2015, p. 1-5.

    Research output: Contribution to journalJournal article

  26. Published

    A new crystal structure fragment-based pharmacophore method for G protein-coupled receptors. / Fidom, Kimberley; Isberg, Vignir; Hauser, Alexander Sebastian; Mordalski, Stefan; Lehto, Thomas; Bojarski, Andrzej J; Gloriam, David E.

    In: Methods, Vol. 71, 01.2015, p. 104-112.

    Research output: Contribution to journalJournal article

  27. Published

    Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors - A Structural Perspective of Ligands and Mutants. / Harpsøe, Kasper; Isberg, Vignir; Tehan, Benjamin G; Weiss, Dahlia; Arsova, Angela; Marshall, Fiona H; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 5, 13869, 11.09.2015, p. 1-11.

    Research output: Contribution to journalJournal article

  28. Published

    Generic GPCR residue numbers - aligning topology maps while minding the gaps. / Isberg, Vignir; de Graaf, Chris; Bortolato, Andrea; Cherezov, Vadim; Katritch, Vsevolod; Marshall, Fiona H; Mordalski, Stefan; Pin, Jean-Philippe; Stevens, Raymond C; Vriend, Gerrit; Gloriam, David E.

    In: Trends in Pharmacological Sciences, Vol. 36, No. 1, 01.01.2015, p. 22-31.

    Research output: Contribution to journalJournal article

  29. Published

    Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold. / Johansson, Henrik; Boesgaard, Michael Worch; Nørskov-Lauritsen, Lenea; Larsen, Inna; Kuhne, Sebastiaan; Gloriam, David E; Bräuner-Osborne, Hans; Sejer Pedersen, Daniel.

    In: Journal of Medicinal Chemistry, Vol. 58, No. 22, 25.11.2015, p. 8938-51.

    Research output: Contribution to journalJournal article

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ID: 5953796