Employees – University of Copenhagen

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Department of Drug Design and Pharmacology > Employees

Fredrik Björkling

Fredrik Björkling

Professor

Professional appointments

2013-                    Professor, Department of Drug Design and Pharmacology, The Faculty of Health and Medical Sciences, University of Copenhagen.

2012-2013           Deputy Head of Department of Drug Design and Pharmacology, The Faculty of Health and Medical Sciences, University of Copenhagen.

2011-2012           Head of Department, Molecular Drug Research, The Faculty of Health and Medical Sciences, University of Copenhagen.

2008- Head of Department, Medicinal Chemistry The Faculty of Pharmaceutical Sciences, Copenhagen University.
2008-   Director (consultant), Medicinal Chemistry, TopoTarget A/S
2005-2008 Director, Medicinal Chemistry, TopoTarget A/S
2001-2005 Director, Medicinal Chemistry Research, LEO Pharma.
1993-2001 Head of Chemical Research, Leo Pharmaceutical Products.
1990-1993 Manager, Department for Drug Design, NovoNordisk A/S.
1987-1990 Department head, Dept. for Natural Products NovoNordisk A/S.
1986-1987 Research chemist, Dept. of Enzymatic synthesis, NovoNordisk A/S.
1985-1986 Research associate, Organic chemistry, The Royal Institute of Technology (RIT), Stockholm, Sweden.
1981 Visiting research associate, UC Davis, Davis, CA, USA.
1980-1985 Research assistant, Organic chemistry, RIT


Education

2011 Professor, 1991 Docent, Assoc. professor
1985 Ph.D., Stereoselective and enzyme catalysed synthesis
1980-1985 Graduate student, Department of Organic Chemistry , RIT.
1980 Master of chemical engineering
1978-1980 RIT, Chemical Engineering.
1977-1978 Stockholm University, Chemistry.
1976 RIT, Civil Engineering
1975-1976 Umeå University, Mathematics.
1975-1976 Military service, Ing 3, Boden.
1972-1975 High school, natural science.

Referee

Referee for international journals in organic and medicinal chemistry. e.g. J. Med Chem., Eurpean J. Medicinal Chem. and Tetrahedron Letters

Supervisor

External supervisor for M.Sc. and Ph.D. students from RIT (1990-1993), The Danish University of Pharmaceutical Sciences (several 1994-), Danish Technical University DTU (1998-) and Royal Veterinary and Agricultural University (1999-2003).

Examiner

External examiner for several PhD thesis at Danish Technical University, The Danish University of Pharmaceutical Sciences and at Lund University, Lund, Sweden. I have been on the evaluation comity for professorship at RDSP.

Membership

Member of the Danish Research Agency for Technology and Production (2005-2010), the Danish research funding body. Member of Skolkovo Foundation, Moscow , Russia,  expert panel. Reviewer for Qatar research foundation. Elected member of The Danish Academy of Technical Sciences, ATV.

List of Invited Lectures

I have lectured at a several international symposia within my expertise. I have also lectured at Universities in Denmark and Sweden as part of advanced courses in enzyme catalyzed organic synthesis, medicinal chemistry or just as invited speaker. Universities: Royal Institute of Technology, Stockholm, Sweden; Lund University, Lund, Sweden; Denmark Institute of Technology, Copenhagen, Denmark; The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark. Chairman for the Medicinal Chemistry day as part of Master of Industrial Drug Development MIND and chairman during ISMC 2004 in Copenhagen.

Language

Swedish mother tongue, Danish fluent, English fluent, German basic.

Publications

PhD Thesis (Stereoselective synthesis) 1985.

77.   Munk Jensen M, Erichsen KD, Johnbeck CB, Bjorkling F, Madsen J, Bzorek M, Jensen PB, Hojgaard L, Sehested M, Kjaer A: [18F]FLT and [18F]FDG PET for Non-invasive Treatment Monitoring of the Nicotinamide Phosphoribosyltransferase Inhibitor APO866 in Human Xenografts. PloS one (2013), 8(1):e53410.

76.   Munk Jensen, M., Dumong Erichsen, K., Johnbeck, C.B., Björkling, F., Madsen, J., Buhl Jensen, P., Højgaard, L.,        Sehested, M., Kjær, A. [18F]FDG and [18F]FLT positron emission tomography imaging following treatment with belinostat in human ovary cancer xenografts in mice. BMC Cancer (2013), 13, 168.

75.   Kelly, J.M., Taylor, M.C., Horn, D., Loza, E., Kalvinsh, I., Björkling, F. Inhibitors of human histone deacetylase   with potent activity against the African trypanosome Trypanosoma brucei. Bioorg. Med. Chem. Lett. (2012), 22(5), 1886–1890.

74.   Munk Jensen M, Erichsen KD, Bjorkling F, Madsen J, Jensen PB, Sehested M, Hojgaard L, Kjaer A: [18F]FLT PET for Non-Invasive Assessment of Tumor Sensitivity to Chemotherapy: Studies with Experimental Chemotherapy TP202377 in Human Cancer Xenografts in Mice. PloS one (2012), 7(11):e50618.

73.    Wan, P., Li, Q., Larsen, J.E.P., Eklund, A.C., Parlesak, A., Rigina, O., Nielsen, S.J., Bjorkling, F., Jonsdottir, S.O. Prediction of drug efficacy for cancer treatment based on comparative analysis of chemosensitivity and gene expression data. Bioorg. Med. Chem. (2012), 20(1), 167-176.

72.    Olesen, U.H., Petersen, J.G., Garten, A., Kiess, W., Yoshino, J., Imai, S-I., Christensen, M.K., Fristrup, P., Thougaard, A.V., Björkling, F., Jensen, P.B., Nielsen, S.J. Sehested, M. Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase. BMC Cancer (2010), 10, 677

71.    Munk Jensen, M., Dumong Erichsen, K., Björkling, F., Madsen, J., Buhl Jensen, P., Højgaard, L., Sehested, M., Kjær, A. Early Detection of Response to Experimental Chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in Human Ovary Cancer Xenografts in Mice. PLoS ONE (2010), 5(9), e12965

70.    Christensen, M.K., Erichsen,K.D., Trojel-Hansen, C., Tjørnelund, J., Nielsen, S.J., Frydenvang, K.,  Johansen,  T.N., Nielsen, B., Sehested, M., Buhl Jensen, P., Ikaunieks, M., Zaichenko, A., Loza, E., Kalvinsh, I., Björkling, F. Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones. J. Med. Chem. (2010), 53(19), 7140-7145.  

69. Martin, E., Vinding Thougaard, A., Grauslund, M., Jensen, P.B., Björkling, F., Hasinoff, B.B., Tjørnelund, J., Sehested, M., Jensen, L.H. Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy. Toxicology  (2009),  255(1-2),  72-79. 
68.    Andrianov, V., Gailite, V., Lola, D., Loza, E., Semenikhina, V., Kalvinsh, I., Finn, P., Dumong Petersen, K.,           Ritchie, J.W.A.,  Khan, N., Tumber, A., Collins, L.S., Vadlamudi, S.M., Björkling*, F., Sehested, M. Novel Amide Derivatives as Inhibitors of Histone Deacetylase: Design, Synthesis and SAR. European J. Med. Chem. (2009) 44,  1067-1085.
67.  Høllund Jensen, L., Björkling, F. Chapter 23 - Anticancer Agents 4th edition of Textbook of Drug Design and Discovery. (2008) In press.
66.    Kouskoumvekaki, I., Hansen, N.T., Björkling, F., Vadlamudi, S.M., Jonsdottir, S.O. Prediction of pH-dependent              solubility of histone deacetylase (HDAC) inhibitors. SAR and QSAR in Environmental Research (2008), 19, 167-177.
65.    Høgh Olesen, U., Knak Christensen, M., Björkling, F., Jäättelä M., Buhl Jensen, P.,  Sehested, M., Jensby Nielsen, S.         Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem. Biophys. Res. Commun. (2008) 367, 799-804.
64.    Fyffe, S.A., Alphey, M.S., Buetow, L., Smith, T.K., Ferguson, M.A.J., Sorensen, M.D., Björkling, F., Hunter, W.N.           Reevaluation of the PPAR-ß/¿ ligand binding domain model reveals why it exhibits the activated form.  Molecular          Cell  (2006),  21(1) 1-2.
63.    Fyffe, S.A., Alphey, M.S., Buetow, L., Smith, T.K., Ferguson, M.A.J., Sorensen, M.D., Björkling, F., Hunter, W.N.            Recombinant Human PPAR-ß/¿  Ligand-binding Domain Locked in an Activated Conformation by Endogenous           Fatty Acids.    J. of Molecular Biol.  (2006),  356,  1005-1013
62 .   Andersen, J., Madsen, U., Björkling, F., Liang, X. Rapid synthesis of aryl azides from aryl halides under mild                    conditions. Synlett (2005), 14,  2209-2213.
61.  Binderup, E., Björkling, F., Hjarnaa, P.V., Latini, S., Baltzer, B., Carlsen, M., Binderup, L. EB1627; a soluble pro-drug of the potent anticancer cyanoguanidine CHS828. Bioorganic and Medicinal Chemistry Letters (2005), 15, 2491-2494.
60.  Gullbo J, Lovborg H, Dhar S, Lukinius A, Oberg F, Nilsson K, Björkling F, Binderup L, Nygren P, Larsson R. Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguanidine CHS 828 Anticancer Drugs (2004), 15(1), 45-54.
59. Jensen, B.F., Sørensen, M.D., Kissmeyer, A-M., Björkling, F., Sonne, K.,Engelsen S.B., Nørgaard, L. Prediction of In Vitro Metabolic Stability of Calcitriol Analogs by QSAR. J. Comput. Aided Mol. Design (2003), 17 (12), 849-859.
58.  Sørensen, M.D., Blæhr, L-K-A., Christensen, M.K., Høyer, T., Latini, S., Hjarnaa, P. J. V, Björkling, F. Cyclic Phosphinamides and Phosphonamides, Novel Series of Potent Matrix-Metalloproteinase Inhibitors with Antitumor Activity. Bioorg. Med. Chem. (2003), 11, 5461-5484.
57. Ottosen, E.R., Sørensen, M.D., Björkling, F., Skak-Nielsen, T., Fjording, M.S., Aaes, H., Binderup, L. Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high anti-inflammatory activity. J. Med. Chem. (2003), 46, 5651-5662.
56.  Jørgensen, A.T., Sørensen, M.D., Björkling, F., Liljefors, T. Binding of a-hydroxy-ß-amino acid inhibitors to methionine aminopeptidase The performance of two types of scoring functions. J. Comput. Aided Mol. Design (2003), 17, 383-397.
55.  Blæhr, L.K.A., Björkling, F., Calverley, M., Binderup, E., Begtrup, M. Synthesis of novel hapten derivatives of 1a,25-dihydroxyvitamin D3 and its 20-epi analogue. J. Org. Chem. (2003), 68, 1367-1375.
54.  Duvold, T., Jørgensen, A., Andersen, N.R., Henriksen, A.S., Dahl Sørensen, M., Björkling, F. 17S,20S-Methanofusidic Acid, a New Potent Semi-synthetic Fusidane Antibiotic. Bioorg. Med. Chem. Lett. (2002), 12, 3569-3572.
53.  Bonasera, T.A., Grue-Sørensen, G., Ortu, G., Binderup, E., Bergström, M., Björkling, F., Långström, B. The synthesis of (26,27-11C)Dihydroxyvitamin D3, a tracer for positron emission tomography (PET). Bioorganic and Medicinal Chemistry, (2001), 9, 3123-3128.
52.  Duvold, T., Sørensen, M.D., Björkling, F., Henriksen, A.S., Rastrup-Andersen, N. Synthesis and conformational analysis of Fusidic acid side chain derivatives. J. Med. Chem.  (2001), 44, 3125-3131.
51.  Blæhr, L.K.A., Björkling, F., Binderup, E., Calverley, M.J., Kaastrup, P. Polyclonal antibodies to EB1089 (Seocalcitol), an analog of 1¿,25-dihydroxyvitamin D3 with potential in anti-cancer treatment. Steroids (2001), 66, 539-548.
50.  Weiskopf, A.S., Vouros, P., Cunniff, J., Binderup, E., Björkling, F., Binderup, L., White, M-C., Posner, G.H.  Examination of structurally selective derivatization of vitamin D3 analogues by electrospray mass spectrometry.    J. Mass Spectrom.  (2001),  36(1),  71-78.
49. Ekelund, S., Liminga, G., Björkling, F., Ottosen, E., Schou, C., Binderup, L., Larsson, R. Early stimulation of acidification rate by novel cytotoxic pyridyl cyanoguanidines in human tumor cells: comparison with m-Iodobenzylguanidine.    Biochem. Pharmacol.  (2000),  60(6),  839-849.
48.  Laghmich, A., Ladriere, L., Dannacher, H., Björkling, F., Malaisse, W. J.  New esters of succinic acid and mixed molecules formed by such esters and a meglitinide analog: study of their insulinotropic potential.    Pharmacol. Res.  (2000),  41(5),  543-554.
47.  Malaisse, W.J., Ladriere, L., Verbruggen, I., Grue-Sorenson, G., Björkling, F., Willem, R. Metabolism of [1,3-13C]glycerol-1,2,3-tris(methylsuccinate) and glycerol-1,2,3-tris(methyl[2,3-13C]succinate) in rat hepatocytes.    Metab., Clin. Exp.  (2000),  49(2),  178-185.
46.  Ladriere, L., Björkling, F., Malaisse, W.J.  Stimulation of insulin release in hereditarily diabetic rats by mixed molecules formed of nateglinide and a succinic acid ester.   Int. J. Mol. Med.  (2000),  5(1),  63-65.
45.  Berglund, P., Vallikivi, I., Fransson, L., Dannacher, H., Holmquist, M., Martinelle, M., Björkling, F., Parve, O., Hult, K.  Switched enantiopreference of Humicola lipase for 2-phenoxyalkanoic acid ester homologs can be rationalized by different substrate binding modes.    Tetrahedron: Asymmetry  (1999),  10(21),  4191-4202
44.  Ladriere, L., Björkling, F., Malaisse, W. Assessment of the nutritional value of glycerol-1,2,3-tris(methylsuccinte) in fed and starved rats. Molecular Genetics and Metabolism. (1999), 67, 254-260.
43.  Ladriere, L., Grue-Sørensen, G., Björkling, F., Malaisse, W. Metabolism of glycerol-1,2,3-trimethylsuccinate in rat hepatocytes. Mol. Cell. Biochem., (1999), 198(1&2), 135-139.
42.  Ladriere, L., Verbruggen, I., Grue-Sørensen, G., Björkling, F., Willem, R., Malaisse, W. Metabolism of (1,3-13C)glycerol-1,2,3-tris(methyl(2,3-13C)succinate) in hepatocytes from Goto-Kakizaki rats. Int. J. of Mol. Med. (1999), 3, 285-289.
41.  Ladriere, L., Mercan, D., Björkling, F., Malaisse, W. Improved viability and metabolic behavior of  hepatocytes after liver storage in the presence of a succinic acid ester. Transplantation (1998), 66, 183-185.
40.  Quack, M., Clarin, A., Binderup, E., Björkling F., Mørk Hansen, C., Carlberg, C.  Structural variants of the vitamin D analogue EB 1089 reduce its ligand sensitivity and promoter selectivity. J. Cell. Biochem. (1998), 71, 340-350.
39.  Mathiasen, I.S., Grue-Sørensen, G., Mørk Hansen, C., Binderup L., Björkling, F. Studies on the Interaction between the Vitamin D Receptor and the Radiolabelled 20-epi Vitamin D Analogue GS 1500.  Biochem. Biophys. Res. Commun., (1998), 250, 283-286.
38.  Ladrière, L., Laghmich, A., Malaisse-Lagae, F., Dannacher, H., Björkling, F., Malaisse, W.J.  Comparison between the insulinotropic potential of ten new esters of succinic acid. Eur. J. Pharmacol., (1998), 344, 87-93.
37.  Laghmich, A., Ladrière, L., Malaisse-Lagae, F., Dannacher, H., Björkling, F., Malaisse, W.J. Stimulation of Biosynthetic Activity by Novel Succinate Esters in Rat Pancreatic Islets.  Biochem. Pharmacol., (1998), 55, 909-913.
36.  García-Martínez, J.A., Villanueva-Peñacarrillo,M.L., Valverde, I., Björkling, F., Malaisse, W.J. Stimulation of Insulin Release and Potentiation of the Insulinotropic Action of Antidiabetic Agents by 1,2,3-Tri(methylsuccinyl)glycerol Ester in Anaesthetized Rats. Pharmacol. Res., (1997), 36(5), 369-372.
35.  Schou, C., Ottosen, E.R., Petersen, H.J., Björkling, F., Latini, S., Hjarnaa, P.V., Bramm, E., Binderup, L. Novel Cyanoguanidines with Potent Oral Antitumour Activity. Bioorg. Med. Chem. Lett. (1997), 7(24), 3095-3100.
34.  Malaisse, W.J., Ladrière, L., Laghmich, A., Louchami, K., Jijakli, H., Viñambres, C., Villanueva-Peñacarrillo, M.L., Valverde, I., Björkling, F.  Insulinotropic Action of 1,2,3-Tri(methylsuccinyl)-glycerol Ester.  Biochem. Mol. Med., (1997), 62, 76-84.
33. Malaisse, W.J., Grue-Sørensen, G., and  Björkling, F.  Metabolism of Glycerol-1,2,3-trimethylsuccinate in Rat Pancreatic Islets. Biochem. Biophys. Res. Commun. (1997), 236, 26-28.
32.  Garcia-Matinez, T-M., Villanueva-Penacarrillo, M.L., Valverde, I., Björkling, F., Malaisse, W.J. Potentiation of the insulinotropic and hypoglycemic action of gliquidone by succinic acid esters. European J. Pharmaccol. (1997), 325, 65-68.
31.  Garcia-Matinez, J.A., Zhang, T-M., Villanueva-Penacarrillo, M.L., Valverde, I., Björkling, F., Malaisse, W.J.  In vivo stimulation of insulin release by the monoethyl, monopropyl, monoisopropyl, monoallyl and diallyl esters of succinic acid. Res. Commun. Mol. Pathol. Pharmacol. (1997), 95, 209-216.
30.  Tværmose-Nielsen, O., Rachlin, S., Dannacher, H.; Björkling, F., Kirstein, D., Bramm, E., Kærgaard, Nielsen, C.,  Mortensen, J.T., Binderup, L. Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist.  Bioorg. Med. Chem. (1997), 5, 415-427. 
29. Björkling, F., Malaisse-Lagae, F., Malaisse, W.J. Pharmacol. Res. Insuliotropic action of novel succinic acid esters. (1996), 33, 273-275.  
28.  Zang, T.-M., Björkling, F., Malaisse, W.J. In vivo stimulation of insulin secretion by novel esters of succinic acid. Hormon. Metab. Res. (1995), 27, 251-252.
27. Malaisse, W.J., Blaehr, L., Björkling, F. Insulinotropic action of new succinic acid esters.  Med. Sci. Res.(1995), 23, 9-10.
26.  Malaisse, W.J., Zhang, T-M., Leclercq-Meyer, V., Sener, A., Björkling, F. Insulinotropic action of the D-glucosyl and 3-O-methyl  D-glucosyl monomethyl esters of succinic acid .  Diabetes Research (1994), 25, 93-105. 
25. Björkling, F., Dahl, A., Patkar, S., Zundel, M. Inhibition of lipases by phosphonates. Bioorganic Medicinal Chemistry (1994), 2, 697-705.
24.  Patkar, S., Björkling, F. Lipase inhibitors. In "Lipases, Structure, Biochemistry and applications" (1994) Ch.10 pg. 207-224, Edrs, Woolley, P.; Petersen, S.B., Ed. Cambridge University Press, Cambridge, England.
23.  Patkar, S.A., Björkling, F., Zundel, M., Schulein, M., Svendsen, A., Heldt-Hansen, H.P., Gormsen, E. Purification of two lipases from Candida antarctica and their inhibition by various inhibitors. Indian J. of Chemistry (1993), 32B, 76-80.
22. Thiel, F., Björkling, F. "Specificity of Candida antarctica lipase B in the presence of lipase A in a double enantioselective transesterification" Biotech. Letters (1993), 15, 605-608.
21.  Björkling, F., Godtfredsen, S-E., Kirk, O., Patkar, S.A., Andresen, O. Lipase catalysed organic synthesis. in S. Servi (ed) Microbial Reagents in Organic Synthesis (1992) 249-260. Kluwer Academic Publ.
20.  Kirk, O., Björkling, F., Godtfredsen, S-E., Ostenfeldt-Larsen, T. Fatty acid specificity in lipase catalyzed synthesis of glucoside esters. Biocatalysis  (1992), 6, 127-134.
19.  Björkling, F., Frykman, H., Godtfredsen, S-E., Kirk, O. Lipase catalyzed synthesis of peroxycarboxylic acids and lipase mediated oxidations. Tetrahedron (1992) 48, 4587-4592.
18.  Björkling, F., Godtfredsen, S-E., Kirk, O. The future impact of industrial lipases. Trends Biotech. (1991) 360-363.
17.  Brzozowski, A.M., Derewenda, U., Derewenda, Z.S., Dodson, G., Lawson, D., Turkenburg, J., Björkling, F., Huge-Jensen, B., Patkar, S., Thim, L., A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex. Nature (1991) 351, 491-497.
16.  Kirk, O., Barfoed, M., Björkling, F. Application of a neural network in the optimization of an enzymatic synthesis. Tehrahedron Computer Methodol. (1990) 3, 239-243.
15.  Björkling, F., Godtfredsen, S-E., Kirk, O. Lipase mediated formation of peroxycarboxylic acids used in catalytic epoxidation of alkenes. J. Chem. Soc. Chem. Commun. (1990) 1301-1303.
14.  Adelhorst, K., Björkling, F., Godtfredsen, S-E., Kirk, O. Enzyme catalysed preparation of 6-O-acylglucopyranosides. Synthesis (1990) 112-115.
13. Björkling, F., Godtfredsen, S-E., Kirk, O. A highly selective enzyme-catalysed eterification of simple glucosides. J. Chem. Soc. Chem. Commun. (1989) 934-935. 
12.  Baeckström, P., Bergström, G., Björkling, F., Hui-zhu, H., Högberg, H-E., Jacobsson, U., Guo-Qiang, L., Löfqvist, J., Norin, T.; Wassgren, A-B. Structures, absolut configurations, and synthesis of volatile signals from three sympatric ant-lion species, Euroleon nostras, Grocus bore and Myrmeleon formicarius (neuroptera:myrmeleontidae). J. Chem. Ecol. (1989) 15, 61-80.
11.  Björkling, F., Godtfredsen, S-E. New enzyme catalyzed synthesis of monoacyl galactoglycerides. Tetrahedron (1988) 44, 2957-2962.
10.  Björkling, F., Boutelje, J., Hjalmarsson, M., Hult, K., Norin, T. Highly enantioselective route to (R)-prolin derivatives via enzyme catalysed hydrolysis of cis-N-benzyl-2,5-bismethoxycarbonylpyrrolidine in an aqueous dimethyl sulphoxide medium. J. Chem. Soc. Chem. Commun. (1987) 1041-1042. 
9.  Björkling, F., Boutelje, J., Hult, K., Kraulis, P., Norin, T., Szmulik, P. Computer graphics as a tool for the prediction of the stereochemistry of enzyme catalyzed reactions. a-chymotrypsin catalyzed hydrolysis of substituted propanedioic acid diesters. Biocatalysis (1987) 1, 87-98.
8.  Björkling, F., Norin, T., Unelius, R., Miller, R.B. A stereospecific synthesis of all four isomers of 9,11-teradeadienyl acetat using a general method applicable to 1,3-dienes. J. Org. Chem. (1987) 52, 292-294.
7.  Björkling, F., Boutelje, J., Gatenbeck, S., Hult, K., Norin, T., Szmulik, P. The effect of dimethyl sulfoxide on the enantioselevtivity in the pig liver esterase catalysed hydrolysis of dialkylated propanedioic acid dimethyl esters. Bioorganic. Chem. (1986) 14, 176-181.
6. Björkling, F., Boutelje, J., Gatenbeck, S., Hult, K., Norin, T. Enzyme catalysed hydrolysis of dialkylated propanedioic acid diesters, synthesis of optically pure (S)-a-methylphenylalanine, (S)-a-methyltyrosine and (S)-a-methyl-3,4-dihydroxyphenylalanine. Tetrahedron. Lett. (1985) 26, 4957-4958.
5.  Björkling, F., Boutelje, J., Gatenbeck, S., Hult, K., Norin, T., Szmulik, P. Enzyme catalysed hydrolysis of dialkylated propanedioic acid diesters, chain length dependent reversal of enantioselectivity. Tetrahedron (1985) 41, 1347-1352.
4. Björkling, F., Boutelje, J., Gatenbeck, S., Hult, K., Norin, T. Enzyme catalysed hydrolysis of the diesters of cis- and trans-cyclohexanedicarboxylic acids. Appl. Microbiol. Biotechnol. (1985) 21, 16-19.  
3. Björkling, F., Norin, T., Unelius, R. Synthesis of 8Z,10Z-Dodecadienyl acetat using a general method applicable to Z,Z-1,3-dienes. Synth. Commun. (1985), 15, 463-472.
2. Baeckström, P., Björkling, F., Högberg, H-E., Norin, T. Cross-coupling of Vinyl Cuprates and Allylic Halides and Synthesis of the Comstock Mealybug Pheromone via Photooxidation of 2,6-Dimethyl-2,5-heptadiene. Acta Chem. Scand. (1984) 38, 779-782.
1. Baeckström, P., Björkling, F., Högberg, H-E., Norin, T. New Three-Step Syntheses of Racemic and Optically Active Ipsdienol from Myrcene. Acta Chem. Scand. (1983) 37, 1-5.

Patents

18-22. Björkling et. al. 5 patent applications submitted and under review 2007-2009.
17. Christensen, M.K., Bjoerkling, F., Ikaunieks, M., Zaichenko, A., Gailite, V., Loza, E., Kalvinsh, I., Madre, M. Prodrugs of diphenyl ox-indol-2-one compounds for the treatment of cancers. Publ (2008) Pat no. WO2008071387
16.    Bjoerkling, F.; Dannacher, H,W.   Preparation of novel pyridyl cyanoguanidine compounds for treating                            hyperproliferative and neoplastic diseases.    PCT Int. Appl.  (2006),  WO  2006066584  A1  20060629 
15. Ottosen, E,R; Bjorkling, F; Dannacher, H,W.  Preparation of aminobenzophenones for use in the treatment of inflammatory diseases. PCT Int. Appl. (2004), WO 2004056762.
14. Bjoerkling, F. Preparation of pyridylcyanoguanidines as antiproliferatives. PCT Int. Appl. (2002), WO  2002094813.
13. Binderup, E,T; Bjoerkling, F. Quaternary proforms of tertiary amine containing compounds. PCT Int. Appl.  (2002), WO 2002042276.
12. Ottosen, E,R; Bjorkling, F. Preparation of novel aminobenzophenones as anti-acne agents. PCT Int. Appl.  (2001), WO 2001005744.
11. Carswell, S; Dobrzanski, P; Binderup, L; Bjorkling, F; Miller, M,S. Vitamin D analogs and their neuronal effects.    PCT Int. Appl.  (1998), WO 9852574.
10. Malaisse, W,J; Bjorkling, F. Pharmaceutical formulations containing polyol succinates. PCT Int. Appl. (1997),                   WO9747584.
9.      Bjoerkling, F; Patkar, S,A. Phosphonate derivatives as lipase inhibitors and their use as pharmaceuticals. PCT Int. Appl.  (1992), WO9205788.
8.      Godtfredsen, S,E Kirk, O; Bjoerkling, F; Christensen, L.B.,  A PROCESS FOR PREPARING PEROXYCARBOXYLIC ACIDS (1990) WO9106574
7.      Godtfredsen, S,E Kirk, O; Bjoerkling, F; A process for preparing percarboxylic acids using an enzyme catalyst; (1991) WO9104333
6.     Godtfredsen, S,E. Bjoerkling, F; ENZYME-CATALYZED PROCESS FOR PREPARING N-ACYL AMINO ACIDS AND N- ACYL AMINO ACID AMIDES (1990) CA19902057041
5.      Kirk, O; Bjoerkling, F; Godtfredsen, S,E. ESTERS OF GLYCOSIDES AND A PROCESS FOR ENZYMATIC PREPARATION THEREOF (1990) NO19900000807
4. Kirk, O; Bjoerkling, F; Godtfredsen, S,E. A PROCESS FOR PRODUCING GLYCOSIDE ESTERS AND COMPOSITIONS COMPRISING GLYCOSIDE ESTERS PCT Int. Appl. (1990), WO9009451.
3. Barfoed, M; Bjoerkling, F. Hexose fatty acid esters as foaming agents in cleaning and personal care compositions. PCT Int. Appl. (1988), WO8810147.
2. Godtfredsen, S,E; Bjoerkling, F. Enzymatic method for preparation of epoxy-substituted aldose or ketose sugars. Eur. Pat. Appl. (1988), EP 268461, US4859589 (1989). 
1. Hult, K; Boutelje, J; Gatenbeck, S; Norin, T; Bjoerkling, F. Enzymic manufacture of optically active malonic acid monoesters from the corresponding diesters. Swed. (1986), SE8502051. 

 

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