Employees – University of Copenhagen

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Department of Drug Design and Pharmacology > Employees

Hans Bräuner-Osborne

Hans Bräuner-Osborne

Professor


  1. 2017
  2. E-pub ahead of print

    Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1). / Jørgensen, Lars; Al-Khawaja, Anas; Kickinger, Stefanie; Vogensen, Stine B; Skovgaard-Petersen, Jonas; Rosenthal, Emil; Borkar, Nrupa; Löffler, Rebekka; Madsen, Karsten K; Bräuner-Osborne, Hans; Schousboe, Arne; Ecker, Gerhard F; Wellendorph, Petrine; Clausen, Rasmus P.

    In: Journal of medicinal chemistry, 19.10.2017.

    Research output: Research - peer-reviewJournal article

  3. Published

    Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors. / Roszko, Kelly L; Bi, Ruiye; Gorvin, Caroline M; Bräuner-Osborne, Hans; Xiong, Xiao-Feng; Inoue, Asuka; Thakker, Rajesh V; Strømgaard, Kristian; Gardella, Thomas; Mannstadt, Michael.

    In: JCI Insight, Vol. 2, No. 3, e91079, 09.02.2017.

    Research output: Research - peer-reviewJournal article

  4. Published

    The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site. / Shehata, Mohamed A.; Jensen, Anne Cathrine Nøhr; Jespers, Willem; Floryan, Leonard; Isberg, Vignir; Andersen, Kirsten Bayer; Åqvist, Johan; Gutiérrez-de-Terán, Hugo; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 7, 1128, 25.04.2017.

    Research output: Research - peer-reviewJournal article

  5. Published

    Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein. / Zhang, Hang; Xiong, Xiao-feng; Boesgaard, Michael W; Underwood, Christina R; Bräuner-Osborne, Hans; Strømgaard, Kristian.

    In: ChemMedChem, Vol. 12, No. 11, 07.06.2017, p. 830-834.

    Research output: Research - peer-reviewJournal article

  6. 2016
  7. Published

    Receptors : Structure, Function, and Pharmacology. / Bräuner-Osborne, Hans.

    Textbook of Drug Design and Discovery. ed. / Kristian Strømgaard; Povl Krogsgaard-Larsen; Ulf Madsen. 5th. ed. C R C Press LLC, 2016. p. 193-212.

    Research output: Education - peer-reviewBook chapter

  8. Published

    Radiosynthesis and characterisation of a potent and selective GPR139 agonist radioligand. / Kuhne, Sebastiaan; Nøhr, Anne Cathrine; Marek, AleŠ; Elbert, TomáŠ; Klein, Anders Bue; Bräuner-Osborne, Hans; Wellendorph, Petrine; Pedersen, Daniel Sejer.

    In: RSC Advances, Vol. 6, No. 2, 2016, p. 947-952.

    Research output: Research - peer-reviewJournal article

  9. Published

    Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139. / Shehata, Mohamed A; Jensen, Anne Cathrine Nøhr; Lissa, Delphine; Bisig, Christoph; Isberg, Vignir; Andersen, Kirsten B; Harpsøe, Kasper; Björkling, Fredrik; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 6, 36681, 10.11.2016, p. 1-13.

    Research output: Research - peer-reviewJournal article

  10. Published

    Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors. / Xiong, Xiaofeng; Zhang, Hang; Underwood, Christina R.; Harpsøe, Kasper; Gardella, Thomas J.; Wöldike, Mie F.; Mannstadt, Michael; Gloriam, David E.; Bräuner-osborne, Hans; Strømgaard, Kristian.

    In: Nature Chemistry, Vol. 8, No. 11, 11.2016, p. 1035-1041.

    Research output: Research - peer-reviewJournal article

  11. 2015
  12. Published

    L-amino acid sensing G protein-coupled receptors and their role in food intake sensing. / Brauner-Osborne, H.

    In: Chemical Senses, Vol. 40, No. 3, 03.2015, p. 231-231.

    Research output: Research - peer-reviewConference abstract in journal

  13. Published

    Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists. / Hansen, Martin; Jacobsen, Stine Engesgaard; Plunkett, Shane; Liebscher, Gudrun Eckhard; McCorvy, John D; Bräuner-Osborne, Hans; Kristensen, Jesper Langgaard.

    In: Bioorganic & Medicinal Chemistry, Vol. 23, No. 14, 2015, p. 3933-3937.

    Research output: Research - peer-reviewJournal article

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