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Department of Drug Design and Pharmacology > Employees

Hans Bräuner-Osborne

Hans Bräuner-Osborne

Professor


  1. 2017
  2. Published

    Applying label-free dynamic mass redistribution assay for studying endogenous FPR1 receptor signalling in human neutrophils. / Christensen, Hanna B; Gloriam, David E; Pedersen, Daniel Sejer; Cowland, Jack B; Borregaard, Niels; Bräuner-Osborne, Hans.

    In: Journal of Pharmacological and Toxicological Methods, Vol. 88, No. Pt 1, 15.07.2017, p. 72-78.

    Publication: Research - peer-reviewJournal article

  3. Published

    Robust GLP-1 secretion by basic L-amino acids does not require the GPRC6A receptor. / Clemmensen, Christoffer; Jørgensen, Christinna V; Smajilovic, Sanela; Bräuner-Osborne, Hans.

    In: Diabetes, Obesity and Metabolism, Vol. 19, No. 4, 2017, p. 599-603.

    Publication: Research - peer-reviewJournal article

  4. Published

    Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method. / Frandsen, Ida Osborn; Boesgaard, Michael W; Fidom, Kimberley; Hauser, Alexander S; Isberg, Vignir; Bräuner-Osborne, Hans; Wellendorph, Petrine; Gloriam, David E.

    In: Scientific Reports, Vol. 7, No. 1, 4829, 06.07.2017.

    Publication: Research - peer-reviewJournal article

  5. Published

    Structural insight to mutation effects uncover a common allosteric site in class C GPCRs. / Harpsøe, Kasper; Boesgaard, Michael W; Munk, Christian; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Bioinformatics (Oxford, England), Vol. 33, No. 8, btw784, 2017, p. 1116-1120.

    Publication: Research - peer-reviewJournal article

  6. Published
  7. Published

    The GPRC6A Receptor displays Constitutive Internalization and Sorting to the Slow Recycling Pathway. / Jacobsen, Stine Engesgaard; Ammendrup-Johnsen, Ina; Jansen, Anna Mai; Gether, Ulrik; Madsen, Kenneth Lindegaard; Bräuner-Osborne, Hans.

    In: The Journal of biological chemistry, Vol. 292, No. 17, 2017, p. 6910-6926.

    Publication: Research - peer-reviewJournal article

  8. Published

    Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist. / Jensen, Anders A; McCorvy, John D; Petersen, Sebastian Leth; Bundgaard, Christoffer; Liebscher, Gudrun; Kenakin, Terry P; Bräuner-Osborne, Hans; Kehler, Jan; Kristensen, Jesper L.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 361, No. 3, 2017, p. 441-453.

    Publication: Research - peer-reviewJournal article

  9. Published
  10. Published

    Identification of AICP as a GluN2C-Selective N-Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site. / Jessen, Maja; Frederiksen, Kristen; Yi, Feng; Clausen, Rasmus P; Hansen, Kasper B; Bräuner-Osborne, Hans; Kilburn, John Paul; Damholt, Anders.

    In: Molecular Pharmacology, Vol. 92, No. 2, 08.2017, p. 151-161.

    Publication: Research - peer-reviewJournal article

  11. Published

    Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors. / Roszko, Kelly L; Bi, Ruiye; Gorvin, Caroline M; Bräuner-Osborne, Hans; Xiong, Xiao-Feng; Inoue, Asuka; Thakker, Rajesh V; Strømgaard, Kristian; Gardella, Thomas; Mannstadt, Michael.

    In: JCI Insight, Vol. 2, No. 3, e91079, 09.02.2017.

    Publication: Research - peer-reviewJournal article

  12. Published

    The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site. / Shehata, Mohamed A.; Jensen, Anne Cathrine Nøhr; Jespers, Willem; Floryan, Leonard; Isberg, Vignir; Andersen, Kirsten Bayer; Åqvist, Johan; Gutiérrez-de-Terán, Hugo; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 7, 1128, 25.04.2017.

    Publication: Research - peer-reviewJournal article

  13. Published
  14. 2016
  15. Published

    Receptors : Structure, Function, and Pharmacology. / Bräuner-Osborne, Hans.

    Textbook of Drug Design and Discovery. ed. / Kristian Strømgaard; Povl Krogsgaard-Larsen; Ulf Madsen. 5th. ed. C R C Press LLC, 2016. p. 193-212.

    Publication: Education - peer-reviewBook chapter

  16. Published

    Radiosynthesis and characterisation of a potent and selective GPR139 agonist radioligand. / Kuhne, Sebastiaan; Nøhr, Anne Cathrine; Marek, AleŠ; Elbert, TomáŠ; Klein, Anders Bue; Bräuner-Osborne, Hans; Wellendorph, Petrine; Pedersen, Daniel Sejer.

    In: RSC Advances, Vol. 6, No. 2, 2016, p. 947-952.

    Publication: Research - peer-reviewJournal article

  17. Published

    Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139. / Shehata, Mohamed A; Jensen, Anne Cathrine Nøhr; Lissa, Delphine; Bisig, Christoph; Isberg, Vignir; Andersen, Kirsten B; Harpsøe, Kasper; Björkling, Fredrik; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 6, 36681, 10.11.2016, p. 1-13.

    Publication: Research - peer-reviewJournal article

  18. Published
  19. 2015
  20. Published

    L-amino acid sensing G protein-coupled receptors and their role in food intake sensing. / Brauner-Osborne, H.

    In: Chemical Senses, Vol. 40, No. 3, 03.2015, p. 231-231.

    Publication: Research - peer-reviewConference abstract in journal

  21. Published

    Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists. / Hansen, Martin; Jacobsen, Stine Engesgaard; Plunkett, Shane; Liebscher, Gudrun Eckhard; McCorvy, John D; Bräuner-Osborne, Hans; Kristensen, Jesper Langgaard.

    In: Bioorganic & Medicinal Chemistry, Vol. 23, No. 14, 2015, p. 3933-3937.

    Publication: Research - peer-reviewJournal article

  22. Published

    Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors - A Structural Perspective of Ligands and Mutants. / Harpsøe, Kasper; Isberg, Vignir; Tehan, Benjamin G; Weiss, Dahlia; Arsova, Angela; Marshall, Fiona H; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 5, 13869, 11.09.2015, p. 1-11.

    Publication: Research - peer-reviewJournal article

  23. Published

    Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold. / Johansson, Henrik; Boesgaard, Michael Worch; Nørskov-Lauritsen, Lenea; Larsen, Inna; Kuhne, Sebastiaan; Gloriam, David E; Bräuner-Osborne, Hans; Sejer Pedersen, Daniel.

    In: Journal of Medicinal Chemistry, Vol. 58, No. 22, 25.11.2015, p. 8938-51.

    Publication: Research - peer-reviewJournal article

  24. Published

    N-glycosylation and disulfide bonding affects GPRC6A receptor expression, function, and dimerization. / Nørskov-Lauritsen, Lenea; Jørgensen, Stine; Bräuner-Osborne, Hans.

    In: FEBS letters, Vol. 589, 21.01.2015, p. 588–597.

    Publication: Research - peer-reviewJournal article

  25. Published

    Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors. / Nørskov-Lauritsen, Lenea; Bräuner-Osborne, Hans.

    In: European journal of pharmacology, Vol. 763, 2015, p. 233-240.

    Publication: Research - peer-reviewJournal article

  26. Published

    Functional Consequences of Glucagon-like Peptide-1 Receptor Cross-talk and Trafficking. / Roed, Sarah Noerklit; Nøhr, Anne Cathrine; Wismann, Pernille; Iversen, Helle; Bräuner-Osborne, Hans; Knudsen, Sanne Moeller; Waldhoer, Maria.

    In: The Journal of biological chemistry, Vol. 290, No. 2, 09.01.2015, p. 1233-1243.

    Publication: Research - peer-reviewJournal article

  27. Published

    Identification of the first surrogate agonists for the G protein-coupled receptor GPR132. / Shehata, Mohamed A.; Christensen, Hanna Belcik; Isberg, Vignir; Pedersen, Daniel Sejer; Bender, Andreas; Bräuner-Osborne, Hans; Gloriam, David E.

    In: RSC Advances, Vol. 5, 2015, p. 48551-48557.

    Publication: Research - peer-reviewJournal article

  28. Published
  29. 2014
  30. Published

    Pharmacological Identification of a Guanidine-Containing β-Alanine Analogue with Low Micromolar Potency and Selectivity for the Betaine/GABA Transporter 1 (BGT1). / Al-Khawaja, Anas Mohammad Ali; Petersen, Jette Gellert; Damgaard, Maria; Jensen, Mette Høgh; Vogensen, Stine Byskov; Lie, Maria Elena Klibo; Kragholm, Bolette; Bräuner-Osborne, Hans; Clausen, Rasmus Prætorius; Frølund, Bente; Wellendorph, Petrine.

    In: Neurochemical Research, Vol. 39, No. 10, 23.05.2014, p. 1988-1996.

    Publication: Research - peer-reviewJournal article

  31. Published

    Introduction to special issue in honor of Professor Povl Krogsgaard-Larsen. / Bräuner-Osborne, Hans; Schousboe, Arne.

    In: Neurochemical research, Vol. 39, No. 10, 10.2014, p. 1845-6.

    Publication: ResearchJournal article

  32. Published

    The G protein-coupled receptor, class C, group 6, subtype A (GPRC6A) receptor : from cloning to physiological function. / Clemmensen, C; Smajilovic, S; Wellendorph, P; Bräuner-Osborne, Hans.

    In: British journal of pharmacology, Vol. 171, No. 5, 2014, p. 1129-1141.

    Publication: Research - peer-reviewJournal article

  33. Published

    Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. / Hansen, Martin; Phonekeo, Karina; Paine, James S; Leth-Petersen, Sebastian; Begtrup, Mikael; Bräuner-Osborne, Hans; Kristensen, Jesper Langgaard.

    In: A C S Chemical Neuroscience, Vol. 5, No. 3, 07.01.2014, p. 243-249.

    Publication: Research - peer-reviewJournal article

  34. Published

    mGluR5 : Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery. / Mølck, Christina; Harpsøe, Kasper; Gloriam, David E; Mathiesen, Jesper M; Nielsen, Søren M; Bräuner-Osborne, Hans.

    In: Neurochemical research, Vol. 39, No. 10, 10.2014, p. 1862-1875.

    Publication: Research - peer-reviewJournal article

  35. Published

    G protein-coupled receptor signaling analysis using homogenous time-resolved Förster resonance energy transfer (HTRF®) technology. / Nørskov-Lauritsen, Lenea; Thomsen, Alex Rojas Bie; Bräuner-Osborne, Hans.

    In: International Journal of Molecular Sciences (Online), Vol. 15, No. 2, 2014, p. 2554-2572.

    Publication: Research - peer-reviewJournal article

  36. Published

    Real-time trafficking and signaling of the glucagon-like peptide-1 receptor. / Roed, Sarah Noerklit; Wismann, Pernille; Underwood, Christina Rye; Kulahin, Nikolaj; Iversen, Helle; Cappelen, Karen Arevad; Schäffer, Lauge; Lehtonen, Janne; Hecksher-Soerensen, Jacob; Secher, Anna; Mathiesen, Jesper Mosolff; Bräuner-Osborne, Hans; Whistler, Jennifer L; Knudsen, Sanne Moeller; Waldhoer, Maria.

    In: Molecular and cellular endocrinology, Vol. 382, No. 2, 02.2014, p. 938-949.

    Publication: Research - peer-reviewJournal article

  37. Published

    Promiscuous Seven Transmembrane Receptors Sensing L-α-amino Acids. / Smajilovic, Sanela; Wellendorph, Petrine; Bräuner-Osborne, Hans.

    In: Current pharmaceutical design, Vol. 20, 2014, p. 2693-702.

    Publication: Research - peer-reviewJournal article

  38. Published

    Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139. / Ísberg, Vignir; Andersen, Kirsten Bayer; Bisig, Christoph; Dietz, Gunnar Ph; Bräuner-Osborne, Hans; Gloriam, David Erik.

    In: Journal of chemical information and modeling, Vol. 54, No. 6, 14.05.2014, p. 1553-1557.

    Publication: Research - peer-reviewJournal article

  39. 2013
  40. Published

    Synthesis and pharmacological characterization of certain baclofen analogues. / Attia, M.I.; Herdeis, C.; Bräuner-Osborne, Hans.

    In: Digest Journal of Nanomaterials and Biostructures, Vol. 8, No. 1, 01.01.2013, p. 139-149.

    Publication: Research - peer-reviewJournal article

  41. Published

    GABA-B-agonistic activity of certain baclofen homologues. / Attia, Mohamed; Herdeis, Claus; Bräuner-Osborne, Hans.

    In: Molecules, Vol. 18, No. 9, 22.08.2013, p. 10266-10284.

    Publication: Research - peer-reviewJournal article

  42. Published

    Enhanced voluntary wheel running in GPRC6A receptor knockout mice. / Clemmensen, Christoffer; Pehmøller, Christian; Klein, Anders B; Ratner, Cecilia; Wojtaszewski, Jørgen; Bräuner-Osborne, Hans.

    In: Physiology & Behavior, Vol. 118, 2013, p. 144-151.

    Publication: Research - peer-reviewJournal article

  43. Published

    Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice. / Clemmensen, Christoffer; Smajilovic, Sanela; Madsen, Andreas N; Klein, Anders B; Holst, Birgitte; Bräuner-Osborne, Hans.

    In: Journal of Endocrinology, Vol. 217, No. 2, 2013, p. 151-60.

    Publication: Research - peer-reviewJournal article

  44. Published

    Oral L-Arginine Stimulates GLP-1 Secretion to Improve Glucose Tolerance in Male Mice. / Clemmensen, Christoffer; Smajilovic, Sanela; Smith, Eric P; Woods, Stephen C; Bräuner-Osborne, Hans; Seeley, Randy J; D'Alessio, David A.; Ryan, Karen K.

    In: Endocrinology, Vol. 154, No. 11, 11.2013, p. 3978-83.

    Publication: ResearchJournal article

  45. Published

    The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors. / Hoestgaard-Jensen, K; O'Connor, R M; Dalby, Nils Ole; Simonsen, C; Finger, B C; Golubeva, A; Hammer, H; Bergmann, M L; Kristiansen, U; Krogsgaard-Larsen, P; Bräuner-Osborne, H; Ebert, B; Frølund, B; Cryan, J F; Jensen, A A.

    In: British journal of pharmacology, Vol. 170, No. 4, 10.2013, p. 919-32.

    Publication: Research - peer-reviewJournal article

  46. Published

    Delineation of the GPRC6A Receptor Signaling Pathways Using a Mammalian Cell Line Stably Expressing the Receptor. / Jacobsen, Stine Engesgaard; Nørskov-Lauritsen, Lenea; Thomsen, Alex Rojas Bie; Smajilovic, Sanela; Wellendorph, Petrine; Larsson, Niklas H P; Lehmann, Anders; Bhatia, Vikram Kjøller; Bräuner-Osborne, Hans.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 347, No. 2, 11.2013, p. 298-309.

    Publication: Research - peer-reviewJournal article

  47. Published

    3-Substituted 2-phenyl-indoles : Privileged structures for medicinal chemistry. / Johansson, Karl Henrik; Jørgensen, T.B.; Gloriam, D.E.; Bräuner-Osborne, Hans; Pedersen, D.S.

    In: R S C Advances, Vol. 3, No. 3, 21.01.2013, p. 945-960.

    Publication: Research - peer-reviewJournal article

  48. Published

    Synthesis of the calcilytic ligand NPS2143. / Johansson, Karl Henrik; Cailly, Thomas Bastien Gaëtan; Thomsen, Alex Rojas Bie; Bräuner-Osborne, Hans; Pedersen, Daniel Sejer.

    In: Beilstein Journal of Organic Chemistry, Vol. 9, 2013, p. 1383-1387.

    Publication: Research - peer-reviewJournal article

  49. Published

    Discovery of a subtype-selective of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile. / Kragholm, Bolette; Kvist, Trine; Madsen, Karsten Kirkegaard; Jørgensen, Lars; Vogensen, Stine Byskov; Schousboe, Arne; Clausen, Rasmus Prætorius; Jensen, Anders A.; Bräuner-Osborne, Hans.

    In: Biochemical Pharmacology, Vol. 86, 2013, p. 521-528.

    Publication: Research - peer-reviewJournal article

  50. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. / Kvist, Trine; Steffensen, Thomas Bielefeldt; Greenwood, Jeremy R; Mehrzad Tabrizi, Fatemeh; Hansen, Kasper Bø; Gajhede, Michael; Pickering, Darryl S; Traynelis, Stephen F; Kastrup, Jette Sandholm; Bräuner-Osborne, Hans.

    In: The Journal of biological chemistry, Vol. 288, 2013, p. 33124-35.

    Publication: Research - peer-reviewJournal article

  51. Published

    Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors. / Kvist, Trine; Greenwood, Jeremy R; Hansen, Kasper B; Traynelis, Stephen F; Bräuner-Osborne, Hans.

    In: Neuropharmacology, Vol. 75, 22.08.2013, p. 324-336.

    Publication: Research - peer-reviewJournal article

  52. Published
  53. Published

    Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo. / Quinn, S.J.; Thomsen, A.R.B.; Pang, J.L.; Kantham, L.; Brown, E.M.; Bräuner-Osborne, Hans; Pollak, M.; Goltzman, D.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 304, No. 3, 01.02.2013, p. E310-320.

    Publication: Research - peer-reviewJournal article

  54. Published
  55. 2012
  56. Published

    α4βδ GABA receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). / Absalom, N.; Karim, N.; Eghorn, L.F.; Villumsen, I.S.; Bay, T.; Bräuner-Osborne, H.; Frølund, B.; Clausen, R.P.; Olsen, J.V.; Knudsen, G.M.; Chebib, M.; Wellendorph, P.

    In: Proceedings of the National Academy of Sciences USA (PNAS), Vol. 109, No. 33, 14.08.2012, p. 13404-13409.

    Publication: Research - peer-reviewJournal article

  57. Published

    L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances. / Clemmensen, Christoffer; Madsen, Andreas Nygaard; Smajilovic, Sanela; Holst, Birgitte; Bräuner-Osborne, Hans.

    In: Amino Acids, Vol. 43, No. 3, 2012, p. 1265-1275.

    Publication: Research - peer-reviewJournal article

  58. Published

    Molecular pharmacology of human NMDA receptors. / Hedegaard, Maiken; Hansen, Kasper Bø; Andersen, Karen Toftegaard; Bräuner-Osborne, Hans; Traynelis, Stephen F.

    In: Neurochemistry International, Vol. 61, No. 4, 09.2012, p. 601-609.

    Publication: Research - peer-reviewJournal article

  59. Published

    Structure-activity relationships for negative allosteric mGluR5 modulators. / Kaae, Birgitte H; Harpsøe, Kasper; Kvist, Trine; Mathiesen, Jesper M; Mølck, Christina; Gloriam, David E; Jimenez, Hermogenes N; Uberti, Michelle A; Nielsen, Søren M; Nielsen, Birgitte; Bräuner-Osborne, Hans; Sauerberg, Per; Clausen, Rasmus Prætorius; Madsen, Ulf.

    In: ChemMedChem, Vol. 7, No. 3, 2012, p. 440-451.

    Publication: Research - peer-reviewJournal article

  60. Published
  61. Published

    (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent gamma-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction. / Pan, Yue; Gerasimov, Madina R; Kvist, Trine; Wellendorph, Petrine; Madsen, Karsten Kirkegaard; Pera, Elena; Lee, Hyunbeom; Schousboe, Arne; Chebib, Mary; Bräuner-Osborne, Hans; Craft, Cheryl M; Brodie, Jonathan D; Schiffer, Wynne K; Dewey, Stephen L; Miller, Stephen R; Silverman, Richard B.

    In: Journal of Medicinal Chemistry, Vol. 55, No. 1, 01.01.2012, p. 357-366.

    Publication: Research - peer-reviewJournal article

  62. Published

    Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors. / Rossol, Manuela; Pierer, Matthias; Raulien, Nora; Quandt, Dagmar; Meusch, Undine; Rothe, Kathrin; Schubert, Kristin; Schöneberg, Torsten; Schaefer, Michael; Krügel, Ute; Smajilovic, Sanela; Bräuner-Osborne, Hans; Baerwald, Christoph; Wagner, Ulf.

    In: Nature Communications, Vol. 3, 2012, p. 1329.

    Publication: Research - peer-reviewJournal article

  63. Published

    Biased agonism of the calcium-sensing receptor. / Thomsen, Alex Rojas Bie; Hvidtfeldt, Maja; Bräuner-Osborne, Hans.

    In: Cell Calcium, Vol. 51, No. 2, 02.2012, p. 107-116.

    Publication: Research - peer-reviewJournal article

  64. Published

    Novel strategies in drug discovery of the calcium-sensing receptor based on biased signaling. / Thomsen, Alex Rojas Bie; Smajilovic, Sanela; Bräuner-Osborne, Hans.

    In: Current Drug Targets, Vol. 13, No. 10, 01.09.2012, p. 1324-35.

    Publication: Research - peer-reviewJournal article

  65. Published

    Strontium is a biased agonist of the calcium-sensing receptor in rat medullary thyroid carcinoma 6-23 cells. / Thomsen, Alex Rojas Bie; Worm, Jesper; Jacobsen, Stine Engesgaard; Stahlhut, Martin; Latta, Markus; Bräuner-Osborne, Hans.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 343, No. 3, 12.2012, p. 638-49.

    Publication: Research - peer-reviewJournal article

  66. 2011
  67. Published

    Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor. / Gloriam, David E.; Wellendorph, Petrine; Johansen, Lars Dan; Thomsen, Alex Rojas Bie; Phonekeo, Karina; Pedersen, Daniel Sejer; Bräuner-Osborne, Hans.

    In: Chemistry & Biology, Vol. 18, No. 11, 23.11.2011, p. 1489-1498.

    Publication: Research - peer-reviewJournal article

  68. Published

    Kemogenomik : Receptoren set fra lægemiddelstoffets synspunkt. / Johansson, Henrik; Jørgensen, Tanja Bøgeløv; Gloriam, David E; Wellendorph, Petrine; Johansen, Lars Dan; Pedersen, Daniel Sejer; Bräuner-Osborne, Hans.

    In: Dansk Kemi, Vol. 92, No. 11, 2011, p. 22-26.

    Publication: ResearchJournal article

  69. Published

    The use of Xenopus oocytes in drug screening. / Kvist, Trine; Hansen, Kasper Bø; Bräuner-Osborne, Hans.

    In: Expert Opinion on Drug Discovery, Vol. 6, No. 2, 2011, p. 141-153.

    Publication: Research - peer-reviewReview

  70. Published

    Binding Mode of a Novel MPEP-Derived Metabotropic Glutamate Receptor Subtype 5 (mGluR5) NAM, 1,3-Bis(pyridin-2-ylethynyl)Benzene. / Molck, C.; Harpsoe, K.; Gloriam, D. E.; Kaae, B. H.; Jimenez, H. N.; Uberti, M. A.; Topiol, S.; Clausen, Rasmus Prætorius; Madsen, U.; Nielsen, S. M.; Mathiesen, J. M.; Brauner-Osborne, H.

    In: Current Neuropharmacology, Vol. 9, 09.2011, p. 43-43.

    Publication: ResearchConference abstract in journal

  71. Published

    A highly selective agonist for the metabotropic glutamate receptor mGluR2. / Nielsen, Simon Dalsgaard; Fulco, Marica; Serpi, Michaela; Nielsen, Birgitte; Hansen, Maria Brinck ; Hansen, Kasper Lind; Thomsen, Christian; Brodbeck, Robb; Bräuner-Osborne, Hans; Pellicciari, Roberto; Norrby, Per-Ola; Greenwood, Jeremy R; Clausen, Rasmus Prætorius.

    In: MedChemComm, Vol. 2, No. 11, 23.09.2011, p. 1120-1124.

    Publication: Research - peer-reviewJournal article

  72. Published

    Transmembrane a-helix 2 and 7 are important for small molecule-mediated activation of the GLP-1 receptor. / Underwood, Christina Rye; Knudsen, Sanne Møller; Wulff, Birgitte Schjellerup; Bräuner-Osborne, Hans; Lau, Jesper; Knudsen, Lotte Bjerre; Peters, Günther H.J.; Reedtz-Runge, Steffen.

    In: Pharmacology, Vol. 88, No. 5-6, 2011, p. 340-348.

    Publication: Research - peer-reviewJournal article

  73. 2010
  74. Published

    Biologiens låsesmed. / Bräuner-Osborne, Hans.

    In: Universitetsavisen, Vol. 2010, No. 9, 02.12.2010, p. 22-23.

    Publication: CommunicationJournal article

  75. Published

    Receptors : Structure, function, and pharmacology. / Bräuner-Osborne, Hans.

    Textbook of drug design and discovery. ed. / Povl Krogsgaard-Larsen; Kristian Strømgaard; Ulf Madsen. 4. ed. Boca Raton : C R C Press LLC, 2010. p. 189-205.

    Publication: EducationBook chapter

  76. Published

    Novel 3-carboxy- and 3-phosphonopyrazoline amino acids as potent and selective NMDA receptor antagonists : Design, synthesis, and pharmacological characterization. / Conti, Paola; Pinto, Andrea; Tamborini, Lucia; Madsen, Ulf; Nielsen, Birgitte; Bräuner-Osborne, Hans; Hansen, Kasper Bø; Landucci, Elisa; Pellegrini-Giampietro, Domenico E; De Sarro, Giovambattista; Donato Di Paola, Eugenio; De Micheli, Carlo.

    In: ChemMedChem, Vol. 5, No. 9, 2010, p. 1465-1475.

    Publication: Research - peer-reviewJournal article

  77. Published

    Kemogenomik : receptoren set fra lægemiddelstoffets synspunkt. / Gloriam, David Erik Immanuel; Wellendorph, Petrine; Johansen, Lars Dan; Pedersen, Daniel Sejer; Bräuner-Osborne, Hans.

    In: Lægemiddelforskning, Vol. 2010, 12.2010, p. 28-30.

    Publication: CommunicationJournal article

  78. Published

    Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists. / Hansen, Kasper Bø; Mullasseril, Praseeda; Dawit, Sara; Kurtkaya, Natalie L; Yuan, Hongjie; Vance, Katie M; Orr, Anna G; Kvist, Trine; Ogden, Kevin K; Le, Phuong; Vellano, Kimberly M; Lewis, Iestyn; Kurtkaya, Serdar; Du, Yuhong; Qui, Min; Murphy, T J; Snyder, James P; Bräuner-Osborne, Hans; Traynelis, Stephen F.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 333, No. 3, 2010, p. 650-662.

    Publication: Research - peer-reviewJournal article

  79. Published

    Quinazolin-4-one derivatives : A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. / Mosley, Cara A; Acker, Timothy M; Hansen, Kasper Bø; Mullasseril, Praseeda; Andersen, Karen T; Le, Phuong; Vellano, Kimberly M; Bräuner-Osborne, Hans; Liotta, Dennis C; Traynelis, Stephen F.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 15, 2010, p. 5476-5490.

    Publication: Research - peer-reviewJournal article

  80. Published
  81. Published

    Homology modelling of the GABA transporter and analysis of tiagabine binding. / Skovstrup, Søren; Taboureau, Olivier; Bräuner-Osborne, Hans; Jørgensen, Flemming Steen.

    In: ChemMedChem, Vol. 5, No. 7, 2010, p. 986-1000.

    Publication: Research - peer-reviewJournal article

  82. Published

    A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. / Stanley, Nathan J; Hutchinson, Mark R; Kvist, Trine; Nielsen, Birgitte; Mathiesen, Jesper M; Bräuner-Osborne, Hans; Avery, Thomas D; Tiekink, Edward R T; Pedersen, Daniel Sejer; Irvine, Rodney J; Abell, Andrew D; Taylor, Dennis K.

    In: Bioorganic & Medicinal Chemistry, Vol. 18, No. 16, 2010, p. 6089-6098.

    Publication: Research - peer-reviewJournal article

  83. Published

    1,2,3-triazolyl amino acids as AMPA receptor ligands. / Stanley, Nathan J.; Pedersen, Daniel Sejer; Nielsen, Birgitte; Kvist, Trine; Mathiesen, Jesper M; Bräuner-Osborne, Hans; Taylor, Dennis K; Abell, Andrew D.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 20, No. 24, 15.12.2010, p. 7512-7515.

    Publication: Research - peer-reviewJournal article

  84. Published

    Novel radioiodinated γ-hydroxybutyric acid analogues for radiolabeling and photolinking of high-affinity γ-hydroxybutyric acid binding sites. / Wellendorph, Petrine; Høg, Signe; Sabbatini, Paola; Pedersen, Martin Holst Friborg; Martiny, Lars; Knudsen, Gitte Moos; Frølund, Bente Flensborg; Clausen, Rasmus Prætorius; Bräuner-Osborne, Hans.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 335, No. 2, 2010, p. 458-464.

    Publication: Research - peer-reviewJournal article

  85. Published

    The emerging role of promiscuous 7TM receptors as chemosensors for food intake. / Wellendorph, Petrine; Johansen, Lars Dan; Bräuner-Osborne, Hans.

    Incretins and insulin secretion. ed. / Gerald Litwack. Vol. 84 Amsterdam : ELSEVIER EDITORA LTDA, 2010. p. 151-184 (Vitamins & hormones, Vol. 84).

    Publication: ResearchBook chapter

  86. 2009
  87. Published

    Receptorer i historisk og nutidig belysning. / Bräuner-Osborne, Hans.

    In: Carlsbergfondet. Aarsskrift, 2009, p. 30-35.

    Publication: CommunicationJournal article

  88. Published
  89. Published

    Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor. / Faure, Helene; Gorojankina, Tatiana; Rice, Nadejda; Dauban, Philippe; Dodd, Robert H; Bräuner-Osborne, Hans; Rognan, Didier; Ruat, Martial.

    In: Cell Calcium, Vol. 46, No. 5-6, 2009, p. 323-332.

    Publication: Research - peer-reviewJournal article

  90. Published

    The GABAB1a isoform mediates heterosynaptic depression at hippocampal mossy fiber synapses. / Guetg, Nicole; Seddik, Riad; Vigot, Réjan; Turecek, Rostislav; Gassmann, Martin; Vogt, Kaspar E; Bräuner-Osborne, Hans; Shigemoto, Ryuichi; Kretz, Oliver; Frotscher, Michael; Kulik, Ákos; Bettler, Bernhard.

    In: Journal of Neuroscience, Vol. 29, No. 5, 2009, p. 1414-1423.

    Publication: Research - peer-reviewJournal article

  91. Published

    FLIPR assays of intracellular calcium in GPCR drug discovery. / Hansen, Kasper Bø; Bräuner-Osborne, Hans.

    G protein-coupled receptors in drug discovery. ed. / Wayne R Leifert. Vol. 552 United States : Humana Press, 2009. p. 269-278 (Methods in molecular biology, Vol. 552).

    Publication: ResearchBook chapter

  92. Published

    Xenopus oocyte electrophysiology in GPCR drug discovery. / Hansen, Kasper Bø; Bräuner-Osborne, Hans.

    G protein-coupled receptors in drug discovery. ed. / Wayne R Leifert. Vol. 552 United States : Humana Press, 2009. p. 343-357 (Methods in molecular biology, Vol. 552).

    Publication: ResearchBook chapter

  93. Published

    The four human ¿-aminobutyric acid (GABA) transporters : pharmacological characterization and validation of a highly efficient screening assay. / Kvist, Trine; Christiansen, Bolette; Jensen, Anders Asbjørn; Bräuner-Osborne, Hans.

    In: Combinatorial Chemistry & High Throughput Screening, Vol. 12, No. 3, 2009, p. 241-249.

    Publication: Research - peer-reviewJournal article

  94. Published

    (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action. / Lehmann, Anders; Antonsson, Madeleine; Holmberg, Ann Aurell; Blackshaw, L. Ashley; Brändén, Lena; Bräuner-Osborne, Hans; Christiansen, Bolette; Dent, John; Elebring, Thomas; Jacobson, Britt-Marie; Jensen, Jörgen; Mattsson, Jan P.; Nilsson, Karolina; Oja, Simo S.; Page, Amanda J.; Saransaari, Pirjo; von Unge, Sverker.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 331, No. 2, 2009, p. 504-512.

    Publication: Research - peer-reviewJournal article

  95. Published

    Molecular basis for amino acid sensing by family C G-protein-coupled receptors. / Wellendorph, Petrine; Bräuner-Osborne, Hans.

    In: British Journal of Pharmacology, Vol. 156, No. 6, 2009, p. 869-884.

    Publication: Research - peer-reviewJournal article

  96. Published

    Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. / Wellendorph, Petrine; Johansen, Lars Dan; Bräuner-Osborne, Hans.

    In: Molecular Pharmacology, Vol. 76, No. 3, 2009, p. 453-465.

    Publication: Research - peer-reviewJournal article

  97. Published

    No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions. / Wellendorph, Petrine; Johansen, Lars Dan; Jensen, Anders Asbjørn; Casanova, Emilio; Gassmann, Martin; Deprez, Pierre; Clément-Lacroix, Philippe; Bettler, Bernhard; Bräuner-Osborne, Hans.

    In: Journal of Molecular Endocrinology, Vol. 42, No. 3, 2009, p. 215-223.

    Publication: Research - peer-reviewJournal article

  98. Published

    Phenylacetic acids and the structurally related non-steroidal anti-inflammatory drug diclofenac bind to specific gamma-hydroxybutyric acid sites in rat brain. / Wellendorph, Petrine; Høg, Signe; Skonberg, Christian; Bräuner-Osborne, Hans.

    In: Fundamental and Clinical Pharmacology, Vol. 23, No. 2, 2009, p. 207-213.

    Publication: Research - peer-reviewJournal article

  99. 2008
  100. Published

    Ny human GABA-transportør : et muligt mål for behandling af epilepsi. / Christiansen, Bolette; Kvist, Trine; Jensen, Anders Asbjørn; Bräuner-Osborne, Hans.

    In: Lægemiddelforskning, 2008, p. 25-27.

    Publication: CommunicationJournal article

  101. Published

    The human GABA transporter GAT-2 : From cloning to high throughput screening. / Christiansen, Bolette; Kvist, Trine; Jensen, Anders Asbjørn; Bräuner-Osborne, Hans.

    Innovative drug development for headache disorders. ed. / Jes Olesen; Nabih Ramadan. Vol. 16 Oxford, Storbritannien : Oxford University Press, 2008. p. 3-15 (Frontiers in headache research series, Vol. 16).

    Publication: ResearchBook chapter

  102. Published

    The human γ-aminobutyric acid transporter GAT-2: from cloning to high throughput screening. / Christiansen, Bolette; Kvist, Trine; Jensen, Anders A.; Bräuner-Osborne, Hans.

    Innovative Drug Development for Headache Disorders. Frontiers in Headache Research. ed. / J Olesen; N Ramadan. Vol. 16 Oxford, UK : Oxford University Press, 2008. p. 3-15 .

    Publication: Research - peer-reviewBook chapter

  103. Published

    N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands. / Clausen, Rasmus Prætorius; Christensen, Caspar; Hansen, Kasper Bø; Greenwood, Jeremy R; Jørgensen, Lars; Micale, Nicola; Madsen, Jens Christian; Nielsen, Birgitte; Egebjerg, Jan; Bräuner-Osborne, Hans; Traynelis, Stephen F; Kristensen, Jesper Langgaard.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 14, 2008, p. 4179-87.

    Publication: Research - peer-reviewJournal article

  104. Published

    Pharmacological characterization of ligands at recombinant NMDA receptor subtypes by electrophysiological recordings and intracellular calcium measurements. / Hansen, Kasper Bø; Bräuner-Osborne, Hans; Egebjerg, Jan.

    In: Combinatorial Chemistry & High Throughput Screening, Vol. 11, No. 4, 2008, p. 304-315.

    Publication: Research - peer-reviewJournal article

  105. Published
  106. Published

    3B but which 3B? And that's just one of the questions : the heterogeneity of human 5-HT3 receptors. / Jensen, Anders A.; Davies, Paul A.; Bräuner-Osborne, Hans; Krzywkowski, Karen.

    In: TIPS - Trends in Pharmacological Sciences, Vol. 29, No. 9, 2008, p. 437-444.

    Publication: Research - peer-reviewJournal article

  107. Published

    Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling. / Krzywkowski, Karen Margrethe; Davies, Paul A.; Irving, Andrew J.; Bräuner-Osborne, Hans; Jensen, Anders Asbjørn.

    In: Pharmacogenetics and Genomics (Print Edition), Vol. 18, No. 12, 2008, p. 1027-1040.

    Publication: Research - peer-reviewJournal article

  108. Published

    En genetisk variation i en serotonin–receptor – et muligt link til depression? / Krzywkowski, Karen Margrethe; Feinberg-Zadek, Paula; Davies, Paul A.; Jensen, Anders A.; Bräuner-Osborne, Hans.

    In: Dansk Kemi 83, Vol. 89, No. 6/7, 2008.

    Publication: CommunicationJournal article

  109. Published

    High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor. / Krzywkowski, Karen Margrethe; Davies, Paul A.; Feinberg-Zadek, Paula L.; Bräuner-Osborne, Hans; Jensen, Anders Asbjørn.

    In: Proceedings of the National Academy of Science of the United States of America, Vol. 105, No. 2, 2008, p. 722-727.

    Publication: Research - peer-reviewJournal article

  110. Published

    Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid. / Pinto, Andrea; Conti, Paola; De Amici, Marco; Tamborini, Lucia; Madsen, Ulf; Nielsen, Birgitte; Christesen, Thomas; Bräuner-Osborne, Hans; De Micheli, Carlo.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 7, 2008, p. 2311-2315.

    Publication: Research - peer-reviewJournal article

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