Employees – University of Copenhagen

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Department of Drug Design and Pharmacology > Employees

Hans Bräuner-Osborne

Hans Bräuner-Osborne

Professor


  1. 2017
  2. Published

    Applying label-free dynamic mass redistribution assay for studying endogenous FPR1 receptor signalling in human neutrophils. / Christensen, Hanna B; Gloriam, David E; Pedersen, Daniel Sejer; Cowland, Jack B; Borregaard, Niels; Bräuner-Osborne, Hans.

    In: Journal of Pharmacological and Toxicological Methods, Vol. 88, No. Pt 1, 15.07.2017, p. 72-78.

    Publication: Research - peer-reviewJournal article

  3. Published

    Robust GLP-1 secretion by basic L-amino acids does not require the GPRC6A receptor. / Clemmensen, Christoffer; Jørgensen, Christinna V; Smajilovic, Sanela; Bräuner-Osborne, Hans.

    In: Diabetes, Obesity and Metabolism, Vol. 19, No. 4, 2017, p. 599-603.

    Publication: Research - peer-reviewJournal article

  4. Published

    Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method. / Frandsen, Ida Osborn; Boesgaard, Michael W; Fidom, Kimberley; Hauser, Alexander S; Isberg, Vignir; Bräuner-Osborne, Hans; Wellendorph, Petrine; Gloriam, David E.

    In: Scientific Reports, Vol. 7, No. 1, 4829, 06.07.2017.

    Publication: Research - peer-reviewJournal article

  5. Published

    Structural insight to mutation effects uncover a common allosteric site in class C GPCRs. / Harpsøe, Kasper; Boesgaard, Michael W; Munk, Christian; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Bioinformatics (Oxford, England), Vol. 33, No. 8, btw784, 2017, p. 1116-1120.

    Publication: Research - peer-reviewJournal article

  6. Published
  7. Published

    The GPRC6A Receptor displays Constitutive Internalization and Sorting to the Slow Recycling Pathway. / Jacobsen, Stine Engesgaard; Ammendrup-Johnsen, Ina; Jansen, Anna Mai; Gether, Ulrik; Madsen, Kenneth Lindegaard; Bräuner-Osborne, Hans.

    In: The Journal of biological chemistry, Vol. 292, No. 17, 2017, p. 6910-6926.

    Publication: Research - peer-reviewJournal article

  8. Published

    Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist. / Jensen, Anders A; McCorvy, John D; Petersen, Sebastian Leth; Bundgaard, Christoffer; Liebscher, Gudrun; Kenakin, Terry P; Bräuner-Osborne, Hans; Kehler, Jan; Kristensen, Jesper L.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 361, No. 3, 2017, p. 441-453.

    Publication: Research - peer-reviewJournal article

  9. Published
  10. Published

    Identification of AICP as a GluN2C-Selective N-Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site. / Jessen, Maja; Frederiksen, Kristen; Yi, Feng; Clausen, Rasmus P; Hansen, Kasper B; Bräuner-Osborne, Hans; Kilburn, John Paul; Damholt, Anders.

    In: Molecular Pharmacology, Vol. 92, No. 2, 08.2017, p. 151-161.

    Publication: Research - peer-reviewJournal article

  11. E-pub ahead of print

    Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1). / Jørgensen, Lars; Al-Khawaja, Anas; Kickinger, Stefanie; Vogensen, Stine B; Skovgaard-Petersen, Jonas; Rosenthal, Emil; Borkar, Nrupa; Löffler, Rebekka; Madsen, Karsten K; Bräuner-Osborne, Hans; Schousboe, Arne; Ecker, Gerhard F; Wellendorph, Petrine; Clausen, Rasmus P.

    In: Journal of medicinal chemistry, 19.10.2017.

    Publication: Research - peer-reviewJournal article

  12. Published

    Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function. / Jørgensen, Stine; Have, Christian Theil; Underwood, Christina Rye; Johansen, Lars Dan; Wellendorph, Petrine; Gjesing, Anette Prior; Jørgensen, Christinna V; Quan, Shi; Rui, Gao; Inoue, Asuka; Linneberg, Allan; Grarup, Niels; Jun, Wang; Pedersen, Oluf; Hansen, Torben; Bräuner-Osborne, Hans.

    In: The Journal of biological chemistry, Vol. 292, No. 4, 27.01.2017, p. 1524-1534.

    Publication: Research - peer-reviewJournal article

  13. Published

    Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors. / Roszko, Kelly L; Bi, Ruiye; Gorvin, Caroline M; Bräuner-Osborne, Hans; Xiong, Xiao-Feng; Inoue, Asuka; Thakker, Rajesh V; Strømgaard, Kristian; Gardella, Thomas; Mannstadt, Michael.

    In: JCI Insight, Vol. 2, No. 3, e91079, 09.02.2017.

    Publication: Research - peer-reviewJournal article

  14. Published

    The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site. / Shehata, Mohamed A.; Jensen, Anne Cathrine Nøhr; Jespers, Willem; Floryan, Leonard; Isberg, Vignir; Andersen, Kirsten Bayer; Åqvist, Johan; Gutiérrez-de-Terán, Hugo; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 7, 1128, 25.04.2017.

    Publication: Research - peer-reviewJournal article

  15. Published
  16. 2016
  17. Published

    Receptors : Structure, Function, and Pharmacology. / Bräuner-Osborne, Hans.

    Textbook of Drug Design and Discovery. ed. / Kristian Strømgaard; Povl Krogsgaard-Larsen; Ulf Madsen. 5th. ed. C R C Press LLC, 2016. p. 193-212.

    Publication: Education - peer-reviewBook chapter

  18. Published

    Radiosynthesis and characterisation of a potent and selective GPR139 agonist radioligand. / Kuhne, Sebastiaan; Nøhr, Anne Cathrine; Marek, AleŠ; Elbert, TomáŠ; Klein, Anders Bue; Bräuner-Osborne, Hans; Wellendorph, Petrine; Pedersen, Daniel Sejer.

    In: RSC Advances, Vol. 6, No. 2, 2016, p. 947-952.

    Publication: Research - peer-reviewJournal article

  19. Published

    Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139. / Shehata, Mohamed A; Jensen, Anne Cathrine Nøhr; Lissa, Delphine; Bisig, Christoph; Isberg, Vignir; Andersen, Kirsten B; Harpsøe, Kasper; Björkling, Fredrik; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 6, 36681, 10.11.2016, p. 1-13.

    Publication: Research - peer-reviewJournal article

  20. Published
  21. 2015
  22. Published

    L-amino acid sensing G protein-coupled receptors and their role in food intake sensing. / Brauner-Osborne, H.

    In: Chemical Senses, Vol. 40, No. 3, 03.2015, p. 231-231.

    Publication: Research - peer-reviewConference abstract in journal

  23. Published

    Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists. / Hansen, Martin; Jacobsen, Stine Engesgaard; Plunkett, Shane; Liebscher, Gudrun Eckhard; McCorvy, John D; Bräuner-Osborne, Hans; Kristensen, Jesper Langgaard.

    In: Bioorganic & Medicinal Chemistry, Vol. 23, No. 14, 2015, p. 3933-3937.

    Publication: Research - peer-reviewJournal article

  24. Published

    Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors - A Structural Perspective of Ligands and Mutants. / Harpsøe, Kasper; Isberg, Vignir; Tehan, Benjamin G; Weiss, Dahlia; Arsova, Angela; Marshall, Fiona H; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 5, 13869, 11.09.2015, p. 1-11.

    Publication: Research - peer-reviewJournal article

  25. Published

    Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold. / Johansson, Henrik; Boesgaard, Michael Worch; Nørskov-Lauritsen, Lenea; Larsen, Inna; Kuhne, Sebastiaan; Gloriam, David E; Bräuner-Osborne, Hans; Sejer Pedersen, Daniel.

    In: Journal of Medicinal Chemistry, Vol. 58, No. 22, 25.11.2015, p. 8938-51.

    Publication: Research - peer-reviewJournal article

  26. Published

    N-glycosylation and disulfide bonding affects GPRC6A receptor expression, function, and dimerization. / Nørskov-Lauritsen, Lenea; Jørgensen, Stine; Bräuner-Osborne, Hans.

    In: FEBS letters, Vol. 589, 21.01.2015, p. 588–597.

    Publication: Research - peer-reviewJournal article

  27. Published

    Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors. / Nørskov-Lauritsen, Lenea; Bräuner-Osborne, Hans.

    In: European journal of pharmacology, Vol. 763, 2015, p. 233-240.

    Publication: Research - peer-reviewJournal article

  28. Published

    Functional Consequences of Glucagon-like Peptide-1 Receptor Cross-talk and Trafficking. / Roed, Sarah Noerklit; Nøhr, Anne Cathrine; Wismann, Pernille; Iversen, Helle; Bräuner-Osborne, Hans; Knudsen, Sanne Moeller; Waldhoer, Maria.

    In: The Journal of biological chemistry, Vol. 290, No. 2, 09.01.2015, p. 1233-1243.

    Publication: Research - peer-reviewJournal article

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