Employees – University of Copenhagen

Forward this page to a friend Resize Print Bookmark and Share

Department of Drug Design and Pharmacology > Employees

Hans Bräuner-Osborne

Hans Bräuner-Osborne

Professor


  1. 2017
  2. Published

    Applying label-free dynamic mass redistribution assay for studying endogenous FPR1 receptor signalling in human neutrophils. / Christensen, Hanna B; Gloriam, David E; Pedersen, Daniel Sejer; Cowland, Jack B; Borregaard, Niels; Bräuner-Osborne, Hans.

    In: Journal of Pharmacological and Toxicological Methods, Vol. 88, No. Pt 1, 15.07.2017, p. 72-78.

    Publication: Research - peer-reviewJournal article

  3. Published

    Robust GLP-1 secretion by basic L-amino acids does not require the GPRC6A receptor. / Clemmensen, Christoffer; Jørgensen, Christinna V; Smajilovic, Sanela; Bräuner-Osborne, Hans.

    In: Diabetes, Obesity and Metabolism, Vol. 19, No. 4, 2017, p. 599-603.

    Publication: Research - peer-reviewJournal article

  4. Published

    Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method. / Frandsen, Ida Osborn; Boesgaard, Michael W; Fidom, Kimberley; Hauser, Alexander S; Isberg, Vignir; Bräuner-Osborne, Hans; Wellendorph, Petrine; Gloriam, David E.

    In: Scientific Reports, Vol. 7, No. 1, 4829, 06.07.2017.

    Publication: Research - peer-reviewJournal article

  5. Published

    Structural insight to mutation effects uncover a common allosteric site in class C GPCRs. / Harpsøe, Kasper; Boesgaard, Michael W; Munk, Christian; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Bioinformatics (Oxford, England), Vol. 33, No. 8, btw784, 2017, p. 1116-1120.

    Publication: Research - peer-reviewJournal article

  6. Published
  7. Published

    The GPRC6A Receptor displays Constitutive Internalization and Sorting to the Slow Recycling Pathway. / Jacobsen, Stine Engesgaard; Ammendrup-Johnsen, Ina; Jansen, Anna Mai; Gether, Ulrik; Madsen, Kenneth Lindegaard; Bräuner-Osborne, Hans.

    In: The Journal of biological chemistry, Vol. 292, No. 17, 2017, p. 6910-6926.

    Publication: Research - peer-reviewJournal article

  8. Published

    Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist. / Jensen, Anders A; McCorvy, John D; Petersen, Sebastian Leth; Bundgaard, Christoffer; Liebscher, Gudrun; Kenakin, Terry P; Bräuner-Osborne, Hans; Kehler, Jan; Kristensen, Jesper L.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 361, No. 3, 2017, p. 441-453.

    Publication: Research - peer-reviewJournal article

  9. Published
  10. Published

    Identification of AICP as a GluN2C-Selective N-Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site. / Jessen, Maja; Frederiksen, Kristen; Yi, Feng; Clausen, Rasmus P; Hansen, Kasper B; Bräuner-Osborne, Hans; Kilburn, John Paul; Damholt, Anders.

    In: Molecular Pharmacology, Vol. 92, No. 2, 08.2017, p. 151-161.

    Publication: Research - peer-reviewJournal article

  11. E-pub ahead of print

    Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1). / Jørgensen, Lars; Al-Khawaja, Anas; Kickinger, Stefanie; Vogensen, Stine B; Skovgaard-Petersen, Jonas; Rosenthal, Emil; Borkar, Nrupa; Löffler, Rebekka; Madsen, Karsten K; Bräuner-Osborne, Hans; Schousboe, Arne; Ecker, Gerhard F; Wellendorph, Petrine; Clausen, Rasmus P.

    In: Journal of medicinal chemistry, 19.10.2017.

    Publication: Research - peer-reviewJournal article

  12. Published

    Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function. / Jørgensen, Stine; Have, Christian Theil; Underwood, Christina Rye; Johansen, Lars Dan; Wellendorph, Petrine; Gjesing, Anette Prior; Jørgensen, Christinna V; Quan, Shi; Rui, Gao; Inoue, Asuka; Linneberg, Allan; Grarup, Niels; Jun, Wang; Pedersen, Oluf; Hansen, Torben; Bräuner-Osborne, Hans.

    In: The Journal of biological chemistry, Vol. 292, No. 4, 27.01.2017, p. 1524-1534.

    Publication: Research - peer-reviewJournal article

  13. Published

    Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors. / Roszko, Kelly L; Bi, Ruiye; Gorvin, Caroline M; Bräuner-Osborne, Hans; Xiong, Xiao-Feng; Inoue, Asuka; Thakker, Rajesh V; Strømgaard, Kristian; Gardella, Thomas; Mannstadt, Michael.

    In: JCI Insight, Vol. 2, No. 3, e91079, 09.02.2017.

    Publication: Research - peer-reviewJournal article

  14. Published

    The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site. / Shehata, Mohamed A.; Jensen, Anne Cathrine Nøhr; Jespers, Willem; Floryan, Leonard; Isberg, Vignir; Andersen, Kirsten Bayer; Åqvist, Johan; Gutiérrez-de-Terán, Hugo; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 7, 1128, 25.04.2017.

    Publication: Research - peer-reviewJournal article

  15. Published
  16. 2016
  17. Published

    Receptors : Structure, Function, and Pharmacology. / Bräuner-Osborne, Hans.

    Textbook of Drug Design and Discovery. ed. / Kristian Strømgaard; Povl Krogsgaard-Larsen; Ulf Madsen. 5th. ed. C R C Press LLC, 2016. p. 193-212.

    Publication: Education - peer-reviewBook chapter

  18. Published

    Radiosynthesis and characterisation of a potent and selective GPR139 agonist radioligand. / Kuhne, Sebastiaan; Nøhr, Anne Cathrine; Marek, AleŠ; Elbert, TomáŠ; Klein, Anders Bue; Bräuner-Osborne, Hans; Wellendorph, Petrine; Pedersen, Daniel Sejer.

    In: RSC Advances, Vol. 6, No. 2, 2016, p. 947-952.

    Publication: Research - peer-reviewJournal article

  19. Published

    Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139. / Shehata, Mohamed A; Jensen, Anne Cathrine Nøhr; Lissa, Delphine; Bisig, Christoph; Isberg, Vignir; Andersen, Kirsten B; Harpsøe, Kasper; Björkling, Fredrik; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 6, 36681, 10.11.2016, p. 1-13.

    Publication: Research - peer-reviewJournal article

  20. Published
  21. 2015
  22. Published

    L-amino acid sensing G protein-coupled receptors and their role in food intake sensing. / Brauner-Osborne, H.

    In: Chemical Senses, Vol. 40, No. 3, 03.2015, p. 231-231.

    Publication: Research - peer-reviewConference abstract in journal

  23. Published

    Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists. / Hansen, Martin; Jacobsen, Stine Engesgaard; Plunkett, Shane; Liebscher, Gudrun Eckhard; McCorvy, John D; Bräuner-Osborne, Hans; Kristensen, Jesper Langgaard.

    In: Bioorganic & Medicinal Chemistry, Vol. 23, No. 14, 2015, p. 3933-3937.

    Publication: Research - peer-reviewJournal article

  24. Published

    Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors - A Structural Perspective of Ligands and Mutants. / Harpsøe, Kasper; Isberg, Vignir; Tehan, Benjamin G; Weiss, Dahlia; Arsova, Angela; Marshall, Fiona H; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 5, 13869, 11.09.2015, p. 1-11.

    Publication: Research - peer-reviewJournal article

  25. Published

    Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold. / Johansson, Henrik; Boesgaard, Michael Worch; Nørskov-Lauritsen, Lenea; Larsen, Inna; Kuhne, Sebastiaan; Gloriam, David E; Bräuner-Osborne, Hans; Sejer Pedersen, Daniel.

    In: Journal of Medicinal Chemistry, Vol. 58, No. 22, 25.11.2015, p. 8938-51.

    Publication: Research - peer-reviewJournal article

  26. Published

    N-glycosylation and disulfide bonding affects GPRC6A receptor expression, function, and dimerization. / Nørskov-Lauritsen, Lenea; Jørgensen, Stine; Bräuner-Osborne, Hans.

    In: FEBS letters, Vol. 589, 21.01.2015, p. 588–597.

    Publication: Research - peer-reviewJournal article

  27. Published

    Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors. / Nørskov-Lauritsen, Lenea; Bräuner-Osborne, Hans.

    In: European journal of pharmacology, Vol. 763, 2015, p. 233-240.

    Publication: Research - peer-reviewJournal article

  28. Published

    Functional Consequences of Glucagon-like Peptide-1 Receptor Cross-talk and Trafficking. / Roed, Sarah Noerklit; Nøhr, Anne Cathrine; Wismann, Pernille; Iversen, Helle; Bräuner-Osborne, Hans; Knudsen, Sanne Moeller; Waldhoer, Maria.

    In: The Journal of biological chemistry, Vol. 290, No. 2, 09.01.2015, p. 1233-1243.

    Publication: Research - peer-reviewJournal article

  29. Published

    Identification of the first surrogate agonists for the G protein-coupled receptor GPR132. / Shehata, Mohamed A.; Christensen, Hanna Belcik; Isberg, Vignir; Pedersen, Daniel Sejer; Bender, Andreas; Bräuner-Osborne, Hans; Gloriam, David E.

    In: RSC Advances, Vol. 5, 2015, p. 48551-48557.

    Publication: Research - peer-reviewJournal article

  30. Published
  31. 2014
  32. Published

    Pharmacological Identification of a Guanidine-Containing β-Alanine Analogue with Low Micromolar Potency and Selectivity for the Betaine/GABA Transporter 1 (BGT1). / Al-Khawaja, Anas Mohammad Ali; Petersen, Jette Gellert; Damgaard, Maria; Jensen, Mette Høgh; Vogensen, Stine Byskov; Lie, Maria Elena Klibo; Kragholm, Bolette; Bräuner-Osborne, Hans; Clausen, Rasmus Prætorius; Frølund, Bente; Wellendorph, Petrine.

    In: Neurochemical Research, Vol. 39, No. 10, 23.05.2014, p. 1988-1996.

    Publication: Research - peer-reviewJournal article

  33. Published

    Introduction to special issue in honor of Professor Povl Krogsgaard-Larsen. / Bräuner-Osborne, Hans; Schousboe, Arne.

    In: Neurochemical research, Vol. 39, No. 10, 10.2014, p. 1845-6.

    Publication: ResearchJournal article

  34. Published

    The G protein-coupled receptor, class C, group 6, subtype A (GPRC6A) receptor : from cloning to physiological function. / Clemmensen, C; Smajilovic, S; Wellendorph, P; Bräuner-Osborne, Hans.

    In: British journal of pharmacology, Vol. 171, No. 5, 2014, p. 1129-1141.

    Publication: Research - peer-reviewJournal article

  35. Published

    Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. / Hansen, Martin; Phonekeo, Karina; Paine, James S; Leth-Petersen, Sebastian; Begtrup, Mikael; Bräuner-Osborne, Hans; Kristensen, Jesper Langgaard.

    In: A C S Chemical Neuroscience, Vol. 5, No. 3, 07.01.2014, p. 243-249.

    Publication: Research - peer-reviewJournal article

  36. Published

    mGluR5 : Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery. / Mølck, Christina; Harpsøe, Kasper; Gloriam, David E; Mathiesen, Jesper M; Nielsen, Søren M; Bräuner-Osborne, Hans.

    In: Neurochemical research, Vol. 39, No. 10, 10.2014, p. 1862-1875.

    Publication: Research - peer-reviewJournal article

  37. Published

    G protein-coupled receptor signaling analysis using homogenous time-resolved Förster resonance energy transfer (HTRF®) technology. / Nørskov-Lauritsen, Lenea; Thomsen, Alex Rojas Bie; Bräuner-Osborne, Hans.

    In: International Journal of Molecular Sciences (Online), Vol. 15, No. 2, 2014, p. 2554-2572.

    Publication: Research - peer-reviewJournal article

  38. Published

    Real-time trafficking and signaling of the glucagon-like peptide-1 receptor. / Roed, Sarah Noerklit; Wismann, Pernille; Underwood, Christina Rye; Kulahin, Nikolaj; Iversen, Helle; Cappelen, Karen Arevad; Schäffer, Lauge; Lehtonen, Janne; Hecksher-Soerensen, Jacob; Secher, Anna; Mathiesen, Jesper Mosolff; Bräuner-Osborne, Hans; Whistler, Jennifer L; Knudsen, Sanne Moeller; Waldhoer, Maria.

    In: Molecular and cellular endocrinology, Vol. 382, No. 2, 02.2014, p. 938-949.

    Publication: Research - peer-reviewJournal article

  39. Published

    Promiscuous Seven Transmembrane Receptors Sensing L-α-amino Acids. / Smajilovic, Sanela; Wellendorph, Petrine; Bräuner-Osborne, Hans.

    In: Current pharmaceutical design, Vol. 20, 2014, p. 2693-702.

    Publication: Research - peer-reviewJournal article

  40. Published

    Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139. / Ísberg, Vignir; Andersen, Kirsten Bayer; Bisig, Christoph; Dietz, Gunnar Ph; Bräuner-Osborne, Hans; Gloriam, David Erik.

    In: Journal of chemical information and modeling, Vol. 54, No. 6, 14.05.2014, p. 1553-1557.

    Publication: Research - peer-reviewJournal article

  41. 2013
  42. Published

    Synthesis and pharmacological characterization of certain baclofen analogues. / Attia, M.I.; Herdeis, C.; Bräuner-Osborne, Hans.

    In: Digest Journal of Nanomaterials and Biostructures, Vol. 8, No. 1, 01.01.2013, p. 139-149.

    Publication: Research - peer-reviewJournal article

  43. Published

    GABA-B-agonistic activity of certain baclofen homologues. / Attia, Mohamed; Herdeis, Claus; Bräuner-Osborne, Hans.

    In: Molecules, Vol. 18, No. 9, 22.08.2013, p. 10266-10284.

    Publication: Research - peer-reviewJournal article

  44. Published

    Enhanced voluntary wheel running in GPRC6A receptor knockout mice. / Clemmensen, Christoffer; Pehmøller, Christian; Klein, Anders B; Ratner, Cecilia; Wojtaszewski, Jørgen; Bräuner-Osborne, Hans.

    In: Physiology & Behavior, Vol. 118, 2013, p. 144-151.

    Publication: Research - peer-reviewJournal article

  45. Published

    Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice. / Clemmensen, Christoffer; Smajilovic, Sanela; Madsen, Andreas N; Klein, Anders B; Holst, Birgitte; Bräuner-Osborne, Hans.

    In: Journal of Endocrinology, Vol. 217, No. 2, 2013, p. 151-60.

    Publication: Research - peer-reviewJournal article

  46. Published

    Oral L-Arginine Stimulates GLP-1 Secretion to Improve Glucose Tolerance in Male Mice. / Clemmensen, Christoffer; Smajilovic, Sanela; Smith, Eric P; Woods, Stephen C; Bräuner-Osborne, Hans; Seeley, Randy J; D'Alessio, David A.; Ryan, Karen K.

    In: Endocrinology, Vol. 154, No. 11, 11.2013, p. 3978-83.

    Publication: ResearchJournal article

  47. Published

    The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors. / Hoestgaard-Jensen, K; O'Connor, R M; Dalby, Nils Ole; Simonsen, C; Finger, B C; Golubeva, A; Hammer, H; Bergmann, M L; Kristiansen, U; Krogsgaard-Larsen, P; Bräuner-Osborne, H; Ebert, B; Frølund, B; Cryan, J F; Jensen, A A.

    In: British journal of pharmacology, Vol. 170, No. 4, 10.2013, p. 919-32.

    Publication: Research - peer-reviewJournal article

  48. Published

    Delineation of the GPRC6A Receptor Signaling Pathways Using a Mammalian Cell Line Stably Expressing the Receptor. / Jacobsen, Stine Engesgaard; Nørskov-Lauritsen, Lenea; Thomsen, Alex Rojas Bie; Smajilovic, Sanela; Wellendorph, Petrine; Larsson, Niklas H P; Lehmann, Anders; Bhatia, Vikram Kjøller; Bräuner-Osborne, Hans.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 347, No. 2, 11.2013, p. 298-309.

    Publication: Research - peer-reviewJournal article

  49. Published

    3-Substituted 2-phenyl-indoles : Privileged structures for medicinal chemistry. / Johansson, Karl Henrik; Jørgensen, T.B.; Gloriam, D.E.; Bräuner-Osborne, Hans; Pedersen, D.S.

    In: R S C Advances, Vol. 3, No. 3, 21.01.2013, p. 945-960.

    Publication: Research - peer-reviewJournal article

  50. Published

    Synthesis of the calcilytic ligand NPS2143. / Johansson, Karl Henrik; Cailly, Thomas Bastien Gaëtan; Thomsen, Alex Rojas Bie; Bräuner-Osborne, Hans; Pedersen, Daniel Sejer.

    In: Beilstein Journal of Organic Chemistry, Vol. 9, 2013, p. 1383-1387.

    Publication: Research - peer-reviewJournal article

  51. Published

    Discovery of a subtype-selective of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile. / Kragholm, Bolette; Kvist, Trine; Madsen, Karsten Kirkegaard; Jørgensen, Lars; Vogensen, Stine Byskov; Schousboe, Arne; Clausen, Rasmus Prætorius; Jensen, Anders A.; Bräuner-Osborne, Hans.

    In: Biochemical Pharmacology, Vol. 86, 2013, p. 521-528.

    Publication: Research - peer-reviewJournal article

  52. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. / Kvist, Trine; Steffensen, Thomas Bielefeldt; Greenwood, Jeremy R; Mehrzad Tabrizi, Fatemeh; Hansen, Kasper Bø; Gajhede, Michael; Pickering, Darryl S; Traynelis, Stephen F; Kastrup, Jette Sandholm; Bräuner-Osborne, Hans.

    In: The Journal of biological chemistry, Vol. 288, 2013, p. 33124-35.

    Publication: Research - peer-reviewJournal article

  53. Published

    Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors. / Kvist, Trine; Greenwood, Jeremy R; Hansen, Kasper B; Traynelis, Stephen F; Bräuner-Osborne, Hans.

    In: Neuropharmacology, Vol. 75, 22.08.2013, p. 324-336.

    Publication: Research - peer-reviewJournal article

  54. Published
  55. Published

    Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo. / Quinn, S.J.; Thomsen, A.R.B.; Pang, J.L.; Kantham, L.; Brown, E.M.; Bräuner-Osborne, Hans; Pollak, M.; Goltzman, D.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 304, No. 3, 01.02.2013, p. E310-320.

    Publication: Research - peer-reviewJournal article

Previous 1 2 3 4 5 Next

ID: 1302910