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Department of Drug Design and Pharmacology > Employees

Hans Bräuner-Osborne

Hans Bräuner-Osborne

Professor


  1. 2017
  2. Published

    Applying label-free dynamic mass redistribution assay for studying endogenous FPR1 receptor signalling in human neutrophils. / Christensen, Hanna B; Gloriam, David E; Pedersen, Daniel Sejer; Cowland, Jack B; Borregaard, Niels; Bräuner-Osborne, Hans.

    In: Journal of Pharmacological and Toxicological Methods, Vol. 88, No. Pt 1, 15.07.2017, p. 72-78.

    Research output: Research - peer-reviewJournal article

  3. Published

    Robust GLP-1 secretion by basic L-amino acids does not require the GPRC6A receptor. / Clemmensen, Christoffer; Jørgensen, Christinna V; Smajilovic, Sanela; Bräuner-Osborne, Hans.

    In: Diabetes, Obesity and Metabolism, Vol. 19, No. 4, 2017, p. 599-603.

    Research output: Research - peer-reviewJournal article

  4. Published

    Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method. / Frandsen, Ida Osborn; Boesgaard, Michael W; Fidom, Kimberley; Hauser, Alexander S; Isberg, Vignir; Bräuner-Osborne, Hans; Wellendorph, Petrine; Gloriam, David E.

    In: Scientific Reports, Vol. 7, No. 1, 4829, 06.07.2017.

    Research output: Research - peer-reviewJournal article

  5. Published

    Structural insight to mutation effects uncover a common allosteric site in class C GPCRs. / Harpsøe, Kasper; Boesgaard, Michael W; Munk, Christian; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Bioinformatics (Oxford, England), Vol. 33, No. 8, btw784, 2017, p. 1116-1120.

    Research output: Research - peer-reviewJournal article

  6. Published
  7. Published

    The GPRC6A Receptor displays Constitutive Internalization and Sorting to the Slow Recycling Pathway. / Jacobsen, Stine Engesgaard; Ammendrup-Johnsen, Ina; Jansen, Anna Mai; Gether, Ulrik; Madsen, Kenneth Lindegaard; Bräuner-Osborne, Hans.

    In: The Journal of biological chemistry, Vol. 292, No. 17, 2017, p. 6910-6926.

    Research output: Research - peer-reviewJournal article

  8. Published

    Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist. / Jensen, Anders A; McCorvy, John D; Petersen, Sebastian Leth; Bundgaard, Christoffer; Liebscher, Gudrun; Kenakin, Terry P; Bräuner-Osborne, Hans; Kehler, Jan; Kristensen, Jesper L.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 361, No. 3, 2017, p. 441-453.

    Research output: Research - peer-reviewJournal article

  9. Published

    The orphan G protein-coupled receptor GPR139 is activated by the peptides : Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. / Jensen, Anne Cathrine Nøhr; Shehata, Mohamed A; Hauser, Alexander S; Isberg, Vignir; Mokrosinski, Jacek; Farooqi, I Sadaf; Pedersen, Daniel Sejer; Gloriam, David E; Bräuner-Osborne, Hans.

    In: Neurochemistry international, Vol. 102, 01.01.2017, p. 105-113.

    Research output: Research - peer-reviewJournal article

  10. Published

    Identification of AICP as a GluN2C-Selective N-Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site. / Jessen, Maja; Frederiksen, Kristen; Yi, Feng; Clausen, Rasmus P; Hansen, Kasper B; Bräuner-Osborne, Hans; Kilburn, John Paul; Damholt, Anders.

    In: Molecular Pharmacology, Vol. 92, No. 2, 08.2017, p. 151-161.

    Research output: Research - peer-reviewJournal article

  11. Published

    Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function. / Jorgensen, Stine; Have, Christian Theil; Underwood, Christina Rye; Johansen, Lars Dan; Wellendorph, Petrine; Gjesing, Anette Prior; Jorgensen, Christinna V.; Quan, Shi; Rui, Gao; Inoue, Asuka; Linneberg, Allan; Grarup, Niels; Jun, Wang; Pedersen, Oluf; Hansen, Torben; Bräuner-Osborne, Hans.

    In: The Journal of biological chemistry, Vol. 292, No. 4, 2017, p. 1524-1534.

    Research output: Research - peer-reviewJournal article

  12. E-pub ahead of print

    Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1). / Jørgensen, Lars; Al-Khawaja, Anas; Kickinger, Stefanie; Vogensen, Stine B; Skovgaard-Petersen, Jonas; Rosenthal, Emil; Borkar, Nrupa; Löffler, Rebekka; Madsen, Karsten K; Bräuner-Osborne, Hans; Schousboe, Arne; Ecker, Gerhard F; Wellendorph, Petrine; Clausen, Rasmus P.

    In: Journal of medicinal chemistry, 19.10.2017.

    Research output: Research - peer-reviewJournal article

  13. Published

    Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors. / Roszko, Kelly L; Bi, Ruiye; Gorvin, Caroline M; Bräuner-Osborne, Hans; Xiong, Xiao-Feng; Inoue, Asuka; Thakker, Rajesh V; Strømgaard, Kristian; Gardella, Thomas; Mannstadt, Michael.

    In: JCI Insight, Vol. 2, No. 3, e91079, 09.02.2017.

    Research output: Research - peer-reviewJournal article

  14. Published

    The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site. / Shehata, Mohamed A.; Jensen, Anne Cathrine Nøhr; Jespers, Willem; Floryan, Leonard; Isberg, Vignir; Andersen, Kirsten Bayer; Åqvist, Johan; Gutiérrez-de-Terán, Hugo; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 7, 1128, 25.04.2017.

    Research output: Research - peer-reviewJournal article

  15. Published

    Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein. / Zhang, Hang; Xiong, Xiao-feng; Boesgaard, Michael W; Underwood, Christina R; Bräuner-Osborne, Hans; Strømgaard, Kristian.

    In: ChemMedChem, Vol. 12, No. 11, 07.06.2017, p. 830-834.

    Research output: Research - peer-reviewJournal article

  16. 2016
  17. Published

    Receptors : Structure, Function, and Pharmacology. / Bräuner-Osborne, Hans.

    Textbook of Drug Design and Discovery. ed. / Kristian Strømgaard; Povl Krogsgaard-Larsen; Ulf Madsen. 5th. ed. C R C Press LLC, 2016. p. 193-212.

    Research output: Education - peer-reviewBook chapter

  18. Published

    Radiosynthesis and characterisation of a potent and selective GPR139 agonist radioligand. / Kuhne, Sebastiaan; Nøhr, Anne Cathrine; Marek, AleŠ; Elbert, TomáŠ; Klein, Anders Bue; Bräuner-Osborne, Hans; Wellendorph, Petrine; Pedersen, Daniel Sejer.

    In: RSC Advances, Vol. 6, No. 2, 2016, p. 947-952.

    Research output: Research - peer-reviewJournal article

  19. Published

    Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139. / Shehata, Mohamed A; Jensen, Anne Cathrine Nøhr; Lissa, Delphine; Bisig, Christoph; Isberg, Vignir; Andersen, Kirsten B; Harpsøe, Kasper; Björkling, Fredrik; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 6, 36681, 10.11.2016, p. 1-13.

    Research output: Research - peer-reviewJournal article

  20. Published

    Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors. / Xiong, Xiaofeng; Zhang, Hang; Underwood, Christina R.; Harpsøe, Kasper; Gardella, Thomas J.; Wöldike, Mie F.; Mannstadt, Michael; Gloriam, David E.; Bräuner-osborne, Hans; Strømgaard, Kristian.

    In: Nature Chemistry, Vol. 8, No. 11, 11.2016, p. 1035-1041.

    Research output: Research - peer-reviewJournal article

  21. 2015
  22. Published

    L-amino acid sensing G protein-coupled receptors and their role in food intake sensing. / Brauner-Osborne, H.

    In: Chemical Senses, Vol. 40, No. 3, 03.2015, p. 231-231.

    Research output: Research - peer-reviewConference abstract in journal

  23. Published

    Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists. / Hansen, Martin; Jacobsen, Stine Engesgaard; Plunkett, Shane; Liebscher, Gudrun Eckhard; McCorvy, John D; Bräuner-Osborne, Hans; Kristensen, Jesper Langgaard.

    In: Bioorganic & Medicinal Chemistry, Vol. 23, No. 14, 2015, p. 3933-3937.

    Research output: Research - peer-reviewJournal article

  24. Published

    Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors - A Structural Perspective of Ligands and Mutants. / Harpsøe, Kasper; Isberg, Vignir; Tehan, Benjamin G; Weiss, Dahlia; Arsova, Angela; Marshall, Fiona H; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 5, 13869, 11.09.2015, p. 1-11.

    Research output: Research - peer-reviewJournal article

  25. Published

    Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold. / Johansson, Henrik; Boesgaard, Michael Worch; Nørskov-Lauritsen, Lenea; Larsen, Inna; Kuhne, Sebastiaan; Gloriam, David E; Bräuner-Osborne, Hans; Sejer Pedersen, Daniel.

    In: Journal of Medicinal Chemistry, Vol. 58, No. 22, 25.11.2015, p. 8938-51.

    Research output: Research - peer-reviewJournal article

  26. Published

    N-glycosylation and disulfide bonding affects GPRC6A receptor expression, function, and dimerization. / Nørskov-Lauritsen, Lenea; Jørgensen, Stine; Bräuner-Osborne, Hans.

    In: FEBS letters, Vol. 589, 21.01.2015, p. 588–597.

    Research output: Research - peer-reviewJournal article

  27. Published

    Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors. / Nørskov-Lauritsen, Lenea; Bräuner-Osborne, Hans.

    In: European journal of pharmacology, Vol. 763, 2015, p. 233-240.

    Research output: Research - peer-reviewJournal article

  28. Published

    Functional Consequences of Glucagon-like Peptide-1 Receptor Cross-talk and Trafficking. / Roed, Sarah Noerklit; Nøhr, Anne Cathrine; Wismann, Pernille; Iversen, Helle; Bräuner-Osborne, Hans; Knudsen, Sanne Moeller; Waldhoer, Maria.

    In: The Journal of biological chemistry, Vol. 290, No. 2, 09.01.2015, p. 1233-1243.

    Research output: Research - peer-reviewJournal article

  29. Published

    Identification of the first surrogate agonists for the G protein-coupled receptor GPR132. / Shehata, Mohamed A.; Christensen, Hanna Belcik; Isberg, Vignir; Pedersen, Daniel Sejer; Bender, Andreas; Bräuner-Osborne, Hans; Gloriam, David E.

    In: RSC Advances, Vol. 5, 2015, p. 48551-48557.

    Research output: Research - peer-reviewJournal article

  30. Published
  31. 2014
  32. Published

    Pharmacological Identification of a Guanidine-Containing β-Alanine Analogue with Low Micromolar Potency and Selectivity for the Betaine/GABA Transporter 1 (BGT1). / Al-Khawaja, Anas Mohammad Ali; Petersen, Jette Gellert; Damgaard, Maria; Jensen, Mette Høgh; Vogensen, Stine Byskov; Lie, Maria Elena Klibo; Kragholm, Bolette; Bräuner-Osborne, Hans; Clausen, Rasmus Prætorius; Frølund, Bente; Wellendorph, Petrine.

    In: Neurochemical Research, Vol. 39, No. 10, 23.05.2014, p. 1988-1996.

    Research output: Research - peer-reviewJournal article

  33. Published

    Introduction to special issue in honor of Professor Povl Krogsgaard-Larsen. / Bräuner-Osborne, Hans; Schousboe, Arne.

    In: Neurochemical research, Vol. 39, No. 10, 10.2014, p. 1845-6.

    Research output: ResearchJournal article

  34. Published

    The G protein-coupled receptor, class C, group 6, subtype A (GPRC6A) receptor : from cloning to physiological function. / Clemmensen, C; Smajilovic, S; Wellendorph, P; Bräuner-Osborne, Hans.

    In: British journal of pharmacology, Vol. 171, No. 5, 2014, p. 1129-1141.

    Research output: Research - peer-reviewJournal article

  35. Published

    Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. / Hansen, Martin; Phonekeo, Karina; Paine, James S; Leth-Petersen, Sebastian; Begtrup, Mikael; Bräuner-Osborne, Hans; Kristensen, Jesper Langgaard.

    In: A C S Chemical Neuroscience, Vol. 5, No. 3, 07.01.2014, p. 243-249.

    Research output: Research - peer-reviewJournal article

  36. Published

    mGluR5 : Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery. / Mølck, Christina; Harpsøe, Kasper; Gloriam, David E; Mathiesen, Jesper M; Nielsen, Søren M; Bräuner-Osborne, Hans.

    In: Neurochemical research, Vol. 39, No. 10, 10.2014, p. 1862-1875.

    Research output: Research - peer-reviewJournal article

  37. Published

    G protein-coupled receptor signaling analysis using homogenous time-resolved Förster resonance energy transfer (HTRF®) technology. / Nørskov-Lauritsen, Lenea; Thomsen, Alex Rojas Bie; Bräuner-Osborne, Hans.

    In: International Journal of Molecular Sciences (Online), Vol. 15, No. 2, 2014, p. 2554-2572.

    Research output: Research - peer-reviewJournal article

  38. Published

    Real-time trafficking and signaling of the glucagon-like peptide-1 receptor. / Roed, Sarah Noerklit; Wismann, Pernille; Underwood, Christina Rye; Kulahin, Nikolaj; Iversen, Helle; Cappelen, Karen Arevad; Schäffer, Lauge; Lehtonen, Janne; Hecksher-Soerensen, Jacob; Secher, Anna; Mathiesen, Jesper Mosolff; Bräuner-Osborne, Hans; Whistler, Jennifer L; Knudsen, Sanne Moeller; Waldhoer, Maria.

    In: Molecular and cellular endocrinology, Vol. 382, No. 2, 02.2014, p. 938-949.

    Research output: Research - peer-reviewJournal article

  39. Published

    Promiscuous Seven Transmembrane Receptors Sensing L-α-amino Acids. / Smajilovic, Sanela; Wellendorph, Petrine; Bräuner-Osborne, Hans.

    In: Current pharmaceutical design, Vol. 20, 2014, p. 2693-702.

    Research output: Research - peer-reviewJournal article

  40. Published

    Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139. / Ísberg, Vignir; Andersen, Kirsten Bayer; Bisig, Christoph; Dietz, Gunnar Ph; Bräuner-Osborne, Hans; Gloriam, David Erik.

    In: Journal of chemical information and modeling, Vol. 54, No. 6, 14.05.2014, p. 1553-1557.

    Research output: Research - peer-reviewJournal article

  41. 2013
  42. Published

    Synthesis and pharmacological characterization of certain baclofen analogues. / Attia, M.I.; Herdeis, C.; Bräuner-Osborne, Hans.

    In: Digest Journal of Nanomaterials and Biostructures, Vol. 8, No. 1, 01.01.2013, p. 139-149.

    Research output: Research - peer-reviewJournal article

  43. Published

    GABA-B-agonistic activity of certain baclofen homologues. / Attia, Mohamed; Herdeis, Claus; Bräuner-Osborne, Hans.

    In: Molecules, Vol. 18, No. 9, 22.08.2013, p. 10266-10284.

    Research output: Research - peer-reviewJournal article

  44. Published

    Enhanced voluntary wheel running in GPRC6A receptor knockout mice. / Clemmensen, Christoffer; Pehmøller, Christian; Klein, Anders B; Ratner, Cecilia; Wojtaszewski, Jørgen; Bräuner-Osborne, Hans.

    In: Physiology & Behavior, Vol. 118, 2013, p. 144-151.

    Research output: Research - peer-reviewJournal article

  45. Published

    Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice. / Clemmensen, Christoffer; Smajilovic, Sanela; Madsen, Andreas N; Klein, Anders B; Holst, Birgitte; Bräuner-Osborne, Hans.

    In: Journal of Endocrinology, Vol. 217, No. 2, 2013, p. 151-60.

    Research output: Research - peer-reviewJournal article

  46. Published

    Oral L-Arginine Stimulates GLP-1 Secretion to Improve Glucose Tolerance in Male Mice. / Clemmensen, Christoffer; Smajilovic, Sanela; Smith, Eric P; Woods, Stephen C; Bräuner-Osborne, Hans; Seeley, Randy J; D'Alessio, David A.; Ryan, Karen K.

    In: Endocrinology, Vol. 154, No. 11, 11.2013, p. 3978-83.

    Research output: ResearchJournal article

  47. Published

    The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors. / Hoestgaard-Jensen, K; O'Connor, R M; Dalby, Nils Ole; Simonsen, C; Finger, B C; Golubeva, A; Hammer, H; Bergmann, M L; Kristiansen, U; Krogsgaard-Larsen, P; Bräuner-Osborne, H; Ebert, B; Frølund, B; Cryan, J F; Jensen, A A.

    In: British journal of pharmacology, Vol. 170, No. 4, 10.2013, p. 919-32.

    Research output: Research - peer-reviewJournal article

  48. Published

    Delineation of the GPRC6A Receptor Signaling Pathways Using a Mammalian Cell Line Stably Expressing the Receptor. / Jacobsen, Stine Engesgaard; Nørskov-Lauritsen, Lenea; Thomsen, Alex Rojas Bie; Smajilovic, Sanela; Wellendorph, Petrine; Larsson, Niklas H P; Lehmann, Anders; Bhatia, Vikram Kjøller; Bräuner-Osborne, Hans.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 347, No. 2, 11.2013, p. 298-309.

    Research output: Research - peer-reviewJournal article

  49. Published

    3-Substituted 2-phenyl-indoles : Privileged structures for medicinal chemistry. / Johansson, Karl Henrik; Jørgensen, T.B.; Gloriam, D.E.; Bräuner-Osborne, Hans; Pedersen, D.S.

    In: R S C Advances, Vol. 3, No. 3, 21.01.2013, p. 945-960.

    Research output: Research - peer-reviewJournal article

  50. Published

    Synthesis of the calcilytic ligand NPS2143. / Johansson, Karl Henrik; Cailly, Thomas Bastien Gaëtan; Thomsen, Alex Rojas Bie; Bräuner-Osborne, Hans; Pedersen, Daniel Sejer.

    In: Beilstein Journal of Organic Chemistry, Vol. 9, 2013, p. 1383-1387.

    Research output: Research - peer-reviewJournal article

  51. Published

    Discovery of a subtype-selective of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile. / Kragholm, Bolette; Kvist, Trine; Madsen, Karsten Kirkegaard; Jørgensen, Lars; Vogensen, Stine Byskov; Schousboe, Arne; Clausen, Rasmus Prætorius; Jensen, Anders A.; Bräuner-Osborne, Hans.

    In: Biochemical Pharmacology, Vol. 86, 2013, p. 521-528.

    Research output: Research - peer-reviewJournal article

  52. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. / Kvist, Trine; Steffensen, Thomas Bielefeldt; Greenwood, Jeremy R; Mehrzad Tabrizi, Fatemeh; Hansen, Kasper Bø; Gajhede, Michael; Pickering, Darryl S; Traynelis, Stephen F; Kastrup, Jette Sandholm; Bräuner-Osborne, Hans.

    In: The Journal of biological chemistry, Vol. 288, 2013, p. 33124-35.

    Research output: Research - peer-reviewJournal article

  53. Published

    Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors. / Kvist, Trine; Greenwood, Jeremy R; Hansen, Kasper B; Traynelis, Stephen F; Bräuner-Osborne, Hans.

    In: Neuropharmacology, Vol. 75, 22.08.2013, p. 324-336.

    Research output: Research - peer-reviewJournal article

  54. Published

    cAMP biosensors applied in molecular pharmacological studies of G protein-coupled receptors. / Mathiesen, Jesper Mosolff; Vedel, Line; Bräuner-Osborne, Hans.

    In: Methods in Enzymology, Vol. 522, 2013, p. 191-207.

    Research output: ResearchJournal article

  55. Published

    Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo. / Quinn, S.J.; Thomsen, A.R.B.; Pang, J.L.; Kantham, L.; Brown, E.M.; Bräuner-Osborne, Hans; Pollak, M.; Goltzman, D.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 304, No. 3, 01.02.2013, p. E310-320.

    Research output: Research - peer-reviewJournal article

  56. Published
  57. 2012
  58. Published

    α4βδ GABA receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). / Absalom, N.; Karim, N.; Eghorn, L.F.; Villumsen, I.S.; Bay, T.; Bräuner-Osborne, H.; Frølund, B.; Clausen, R.P.; Olsen, J.V.; Knudsen, G.M.; Chebib, M.; Wellendorph, P.

    In: Proceedings of the National Academy of Sciences USA (PNAS), Vol. 109, No. 33, 14.08.2012, p. 13404-13409.

    Research output: Research - peer-reviewJournal article

  59. Published

    L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances. / Clemmensen, Christoffer; Madsen, Andreas Nygaard; Smajilovic, Sanela; Holst, Birgitte; Bräuner-Osborne, Hans.

    In: Amino Acids, Vol. 43, No. 3, 2012, p. 1265-1275.

    Research output: Research - peer-reviewJournal article

  60. Published

    Molecular pharmacology of human NMDA receptors. / Hedegaard, Maiken; Hansen, Kasper Bø; Andersen, Karen Toftegaard; Bräuner-Osborne, Hans; Traynelis, Stephen F.

    In: Neurochemistry International, Vol. 61, No. 4, 09.2012, p. 601-609.

    Research output: Research - peer-reviewJournal article

  61. Published

    Structure-activity relationships for negative allosteric mGluR5 modulators. / Kaae, Birgitte H; Harpsøe, Kasper; Kvist, Trine; Mathiesen, Jesper M; Mølck, Christina; Gloriam, David E; Jimenez, Hermogenes N; Uberti, Michelle A; Nielsen, Søren M; Nielsen, Birgitte; Bräuner-Osborne, Hans; Sauerberg, Per; Clausen, Rasmus Prætorius; Madsen, Ulf.

    In: ChemMedChem, Vol. 7, No. 3, 2012, p. 440-451.

    Research output: Research - peer-reviewJournal article

  62. Published
  63. Published

    (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent gamma-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction. / Pan, Yue; Gerasimov, Madina R; Kvist, Trine; Wellendorph, Petrine; Madsen, Karsten Kirkegaard; Pera, Elena; Lee, Hyunbeom; Schousboe, Arne; Chebib, Mary; Bräuner-Osborne, Hans; Craft, Cheryl M; Brodie, Jonathan D; Schiffer, Wynne K; Dewey, Stephen L; Miller, Stephen R; Silverman, Richard B.

    In: Journal of Medicinal Chemistry, Vol. 55, No. 1, 01.01.2012, p. 357-366.

    Research output: Research - peer-reviewJournal article

  64. Published

    Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors. / Rossol, Manuela; Pierer, Matthias; Raulien, Nora; Quandt, Dagmar; Meusch, Undine; Rothe, Kathrin; Schubert, Kristin; Schöneberg, Torsten; Schaefer, Michael; Krügel, Ute; Smajilovic, Sanela; Bräuner-Osborne, Hans; Baerwald, Christoph; Wagner, Ulf.

    In: Nature Communications, Vol. 3, 2012, p. 1329.

    Research output: Research - peer-reviewJournal article

  65. Published

    Biased agonism of the calcium-sensing receptor. / Thomsen, Alex Rojas Bie; Hvidtfeldt, Maja; Bräuner-Osborne, Hans.

    In: Cell Calcium, Vol. 51, No. 2, 02.2012, p. 107-116.

    Research output: Research - peer-reviewJournal article

  66. Published

    Novel strategies in drug discovery of the calcium-sensing receptor based on biased signaling. / Thomsen, Alex Rojas Bie; Smajilovic, Sanela; Bräuner-Osborne, Hans.

    In: Current Drug Targets, Vol. 13, No. 10, 01.09.2012, p. 1324-35.

    Research output: Research - peer-reviewJournal article

  67. Published

    Strontium is a biased agonist of the calcium-sensing receptor in rat medullary thyroid carcinoma 6-23 cells. / Thomsen, Alex Rojas Bie; Worm, Jesper; Jacobsen, Stine Engesgaard; Stahlhut, Martin; Latta, Markus; Bräuner-Osborne, Hans.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 343, No. 3, 12.2012, p. 638-49.

    Research output: Research - peer-reviewJournal article

  68. 2011
  69. Published

    Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor. / Gloriam, David E.; Wellendorph, Petrine; Johansen, Lars Dan; Thomsen, Alex Rojas Bie; Phonekeo, Karina; Pedersen, Daniel Sejer; Bräuner-Osborne, Hans.

    In: Chemistry & Biology, Vol. 18, No. 11, 23.11.2011, p. 1489-1498.

    Research output: Research - peer-reviewJournal article

  70. Published

    Kemogenomik : Receptoren set fra lægemiddelstoffets synspunkt. / Johansson, Henrik; Jørgensen, Tanja Bøgeløv; Gloriam, David E; Wellendorph, Petrine; Johansen, Lars Dan; Pedersen, Daniel Sejer; Bräuner-Osborne, Hans.

    In: Dansk Kemi, Vol. 92, No. 11, 2011, p. 22-26.

    Research output: ResearchJournal article

  71. Published

    The use of Xenopus oocytes in drug screening. / Kvist, Trine; Hansen, Kasper Bø; Bräuner-Osborne, Hans.

    In: Expert Opinion on Drug Discovery, Vol. 6, No. 2, 2011, p. 141-153.

    Research output: Research - peer-reviewReview

  72. Published

    Binding Mode of a Novel MPEP-Derived Metabotropic Glutamate Receptor Subtype 5 (mGluR5) NAM, 1,3-Bis(pyridin-2-ylethynyl)Benzene. / Molck, C.; Harpsoe, K.; Gloriam, D. E.; Kaae, B. H.; Jimenez, H. N.; Uberti, M. A.; Topiol, S.; Clausen, Rasmus Prætorius; Madsen, U.; Nielsen, S. M.; Mathiesen, J. M.; Brauner-Osborne, H.

    In: Current Neuropharmacology, Vol. 9, 09.2011, p. 43-43.

    Research output: ResearchConference abstract in journal

  73. Published

    A highly selective agonist for the metabotropic glutamate receptor mGluR2. / Nielsen, Simon Dalsgaard; Fulco, Marica; Serpi, Michaela; Nielsen, Birgitte; Hansen, Maria Brinck ; Hansen, Kasper Lind; Thomsen, Christian; Brodbeck, Robb; Bräuner-Osborne, Hans; Pellicciari, Roberto; Norrby, Per-Ola; Greenwood, Jeremy R; Clausen, Rasmus Prætorius.

    In: MedChemComm, Vol. 2, No. 11, 23.09.2011, p. 1120-1124.

    Research output: Research - peer-reviewJournal article

  74. Published

    Transmembrane a-helix 2 and 7 are important for small molecule-mediated activation of the GLP-1 receptor. / Underwood, Christina Rye; Knudsen, Sanne Møller; Wulff, Birgitte Schjellerup; Bräuner-Osborne, Hans; Lau, Jesper; Knudsen, Lotte Bjerre; Peters, Günther H.J.; Reedtz-Runge, Steffen.

    In: Pharmacology, Vol. 88, No. 5-6, 2011, p. 340-348.

    Research output: Research - peer-reviewJournal article

  75. 2010
  76. Published

    Biologiens låsesmed. / Bräuner-Osborne, Hans.

    In: Universitetsavisen, Vol. 2010, No. 9, 02.12.2010, p. 22-23.

    Research output: CommunicationJournal article

  77. Published

    Receptors : Structure, function, and pharmacology. / Bräuner-Osborne, Hans.

    Textbook of drug design and discovery. ed. / Povl Krogsgaard-Larsen; Kristian Strømgaard; Ulf Madsen. 4. ed. Boca Raton : C R C Press LLC, 2010. p. 189-205.

    Research output: EducationBook chapter

  78. Published

    Novel 3-carboxy- and 3-phosphonopyrazoline amino acids as potent and selective NMDA receptor antagonists : Design, synthesis, and pharmacological characterization. / Conti, Paola; Pinto, Andrea; Tamborini, Lucia; Madsen, Ulf; Nielsen, Birgitte; Bräuner-Osborne, Hans; Hansen, Kasper Bø; Landucci, Elisa; Pellegrini-Giampietro, Domenico E; De Sarro, Giovambattista; Donato Di Paola, Eugenio; De Micheli, Carlo.

    In: ChemMedChem, Vol. 5, No. 9, 2010, p. 1465-1475.

    Research output: Research - peer-reviewJournal article

  79. Published

    Kemogenomik : receptoren set fra lægemiddelstoffets synspunkt. / Gloriam, David Erik Immanuel; Wellendorph, Petrine; Johansen, Lars Dan; Pedersen, Daniel Sejer; Bräuner-Osborne, Hans.

    In: Lægemiddelforskning, Vol. 2010, 12.2010, p. 28-30.

    Research output: CommunicationJournal article

  80. Published

    Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists. / Hansen, Kasper Bø; Mullasseril, Praseeda; Dawit, Sara; Kurtkaya, Natalie L; Yuan, Hongjie; Vance, Katie M; Orr, Anna G; Kvist, Trine; Ogden, Kevin K; Le, Phuong; Vellano, Kimberly M; Lewis, Iestyn; Kurtkaya, Serdar; Du, Yuhong; Qui, Min; Murphy, T J; Snyder, James P; Bräuner-Osborne, Hans; Traynelis, Stephen F.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 333, No. 3, 2010, p. 650-662.

    Research output: Research - peer-reviewJournal article

  81. Published

    Quinazolin-4-one derivatives : A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. / Mosley, Cara A; Acker, Timothy M; Hansen, Kasper Bø; Mullasseril, Praseeda; Andersen, Karen T; Le, Phuong; Vellano, Kimberly M; Bräuner-Osborne, Hans; Liotta, Dennis C; Traynelis, Stephen F.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 15, 2010, p. 5476-5490.

    Research output: Research - peer-reviewJournal article

  82. Published

    Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites. / Sabbatini, Paola; Wellendorph, Petrine; Høg, Signe; Pedersen, Martin Holst Friborg; Bräuner-Osborne, Hans; Martiny, Lars; Frølund, Bente Flensborg; Clausen, Rasmus Prætorius.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 17, 2010, p. 6506-6510.

    Research output: Research - peer-reviewJournal article

  83. Published

    Homology modelling of the GABA transporter and analysis of tiagabine binding. / Skovstrup, Søren; Taboureau, Olivier; Bräuner-Osborne, Hans; Jørgensen, Flemming Steen.

    In: ChemMedChem, Vol. 5, No. 7, 2010, p. 986-1000.

    Research output: Research - peer-reviewJournal article

  84. Published

    A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. / Stanley, Nathan J; Hutchinson, Mark R; Kvist, Trine; Nielsen, Birgitte; Mathiesen, Jesper M; Bräuner-Osborne, Hans; Avery, Thomas D; Tiekink, Edward R T; Pedersen, Daniel Sejer; Irvine, Rodney J; Abell, Andrew D; Taylor, Dennis K.

    In: Bioorganic & Medicinal Chemistry, Vol. 18, No. 16, 2010, p. 6089-6098.

    Research output: Research - peer-reviewJournal article

  85. Published

    1,2,3-triazolyl amino acids as AMPA receptor ligands. / Stanley, Nathan J.; Pedersen, Daniel Sejer; Nielsen, Birgitte; Kvist, Trine; Mathiesen, Jesper M; Bräuner-Osborne, Hans; Taylor, Dennis K; Abell, Andrew D.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 20, No. 24, 15.12.2010, p. 7512-7515.

    Research output: Research - peer-reviewJournal article

  86. Published

    Novel radioiodinated γ-hydroxybutyric acid analogues for radiolabeling and photolinking of high-affinity γ-hydroxybutyric acid binding sites. / Wellendorph, Petrine; Høg, Signe; Sabbatini, Paola; Pedersen, Martin Holst Friborg; Martiny, Lars; Knudsen, Gitte Moos; Frølund, Bente Flensborg; Clausen, Rasmus Prætorius; Bräuner-Osborne, Hans.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 335, No. 2, 2010, p. 458-464.

    Research output: Research - peer-reviewJournal article

  87. Published

    The emerging role of promiscuous 7TM receptors as chemosensors for food intake. / Wellendorph, Petrine; Johansen, Lars Dan; Bräuner-Osborne, Hans.

    Incretins and insulin secretion. ed. / Gerald Litwack. Vol. 84 Amsterdam : ELSEVIER EDITORA LTDA, 2010. p. 151-184.

    Research output: ResearchBook chapter

  88. 2009
  89. Published

    Receptorer i historisk og nutidig belysning. / Bräuner-Osborne, Hans.

    In: Carlsbergfondet. Aarsskrift, 2009, p. 30-35.

    Research output: CommunicationJournal article

  90. Published
  91. Published

    Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor. / Faure, Helene; Gorojankina, Tatiana; Rice, Nadejda; Dauban, Philippe; Dodd, Robert H; Bräuner-Osborne, Hans; Rognan, Didier; Ruat, Martial.

    In: Cell Calcium, Vol. 46, No. 5-6, 2009, p. 323-332.

    Research output: Research - peer-reviewJournal article

  92. Published

    The GABAB1a isoform mediates heterosynaptic depression at hippocampal mossy fiber synapses. / Guetg, Nicole; Seddik, Riad; Vigot, Réjan; Turecek, Rostislav; Gassmann, Martin; Vogt, Kaspar E; Bräuner-Osborne, Hans; Shigemoto, Ryuichi; Kretz, Oliver; Frotscher, Michael; Kulik, Ákos; Bettler, Bernhard.

    In: Journal of Neuroscience, Vol. 29, No. 5, 2009, p. 1414-1423.

    Research output: Research - peer-reviewJournal article

  93. Published

    FLIPR assays of intracellular calcium in GPCR drug discovery. / Hansen, Kasper Bø; Bräuner-Osborne, Hans.

    G protein-coupled receptors in drug discovery. ed. / Wayne R Leifert. Vol. 552 United States : Humana Press, 2009. p. 269-278.

    Research output: ResearchBook chapter

  94. Published

    Xenopus oocyte electrophysiology in GPCR drug discovery. / Hansen, Kasper Bø; Bräuner-Osborne, Hans.

    G protein-coupled receptors in drug discovery. ed. / Wayne R Leifert. Vol. 552 United States : Humana Press, 2009. p. 343-357.

    Research output: ResearchBook chapter

  95. Published

    The four human ¿-aminobutyric acid (GABA) transporters : pharmacological characterization and validation of a highly efficient screening assay. / Kvist, Trine; Christiansen, Bolette; Jensen, Anders Asbjørn; Bräuner-Osborne, Hans.

    In: Combinatorial Chemistry & High Throughput Screening, Vol. 12, No. 3, 2009, p. 241-249.

    Research output: Research - peer-reviewJournal article

  96. Published

    (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action. / Lehmann, Anders; Antonsson, Madeleine; Holmberg, Ann Aurell; Blackshaw, L. Ashley; Brändén, Lena; Bräuner-Osborne, Hans; Christiansen, Bolette; Dent, John; Elebring, Thomas; Jacobson, Britt-Marie; Jensen, Jörgen; Mattsson, Jan P.; Nilsson, Karolina; Oja, Simo S.; Page, Amanda J.; Saransaari, Pirjo; von Unge, Sverker.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 331, No. 2, 2009, p. 504-512.

    Research output: Research - peer-reviewJournal article

  97. Published

    Molecular basis for amino acid sensing by family C G-protein-coupled receptors. / Wellendorph, Petrine; Bräuner-Osborne, Hans.

    In: British Journal of Pharmacology, Vol. 156, No. 6, 2009, p. 869-884.

    Research output: Research - peer-reviewJournal article

  98. Published

    Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. / Wellendorph, Petrine; Johansen, Lars Dan; Bräuner-Osborne, Hans.

    In: Molecular Pharmacology, Vol. 76, No. 3, 2009, p. 453-465.

    Research output: Research - peer-reviewJournal article

  99. Published

    No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions. / Wellendorph, Petrine; Johansen, Lars Dan; Jensen, Anders Asbjørn; Casanova, Emilio; Gassmann, Martin; Deprez, Pierre; Clément-Lacroix, Philippe; Bettler, Bernhard; Bräuner-Osborne, Hans.

    In: Journal of Molecular Endocrinology, Vol. 42, No. 3, 2009, p. 215-223.

    Research output: Research - peer-reviewJournal article

  100. Published

    Phenylacetic acids and the structurally related non-steroidal anti-inflammatory drug diclofenac bind to specific gamma-hydroxybutyric acid sites in rat brain. / Wellendorph, Petrine; Høg, Signe; Skonberg, Christian; Bräuner-Osborne, Hans.

    In: Fundamental and Clinical Pharmacology, Vol. 23, No. 2, 2009, p. 207-213.

    Research output: Research - peer-reviewJournal article

  101. 2008
  102. Published

    Ny human GABA-transportør : et muligt mål for behandling af epilepsi. / Christiansen, Bolette; Kvist, Trine; Jensen, Anders Asbjørn; Bräuner-Osborne, Hans.

    In: Lægemiddelforskning, 2008, p. 25-27.

    Research output: CommunicationJournal article

  103. Published

    The human GABA transporter GAT-2 : From cloning to high throughput screening. / Christiansen, Bolette; Kvist, Trine; Jensen, Anders Asbjørn; Bräuner-Osborne, Hans.

    Innovative drug development for headache disorders. ed. / Jes Olesen; Nabih Ramadan. Vol. 16 Oxford, Storbritannien : Oxford University Press, 2008. p. 3-15.

    Research output: ResearchBook chapter

  104. Published

    The human γ-aminobutyric acid transporter GAT-2: from cloning to high throughput screening. / Christiansen, Bolette; Kvist, Trine; Jensen, Anders A.; Bräuner-Osborne, Hans.

    Innovative Drug Development for Headache Disorders. Frontiers in Headache Research. ed. / J Olesen; N Ramadan. Vol. 16 Oxford, UK : Oxford University Press, 2008. p. 3-15 .

    Research output: Research - peer-reviewBook chapter

  105. Published

    N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands. / Clausen, Rasmus Prætorius; Christensen, Caspar; Hansen, Kasper Bø; Greenwood, Jeremy R; Jørgensen, Lars; Micale, Nicola; Madsen, Jens Christian; Nielsen, Birgitte; Egebjerg, Jan; Bräuner-Osborne, Hans; Traynelis, Stephen F; Kristensen, Jesper Langgaard.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 14, 2008, p. 4179-87.

    Research output: Research - peer-reviewJournal article

  106. Published

    Pharmacological characterization of ligands at recombinant NMDA receptor subtypes by electrophysiological recordings and intracellular calcium measurements. / Hansen, Kasper Bø; Bräuner-Osborne, Hans; Egebjerg, Jan.

    In: Combinatorial Chemistry & High Throughput Screening, Vol. 11, No. 4, 2008, p. 304-315.

    Research output: Research - peer-reviewJournal article

  107. Published
  108. Published

    3B but which 3B? And that's just one of the questions : the heterogeneity of human 5-HT3 receptors. / Jensen, Anders A.; Davies, Paul A.; Bräuner-Osborne, Hans; Krzywkowski, Karen.

    In: TIPS - Trends in Pharmacological Sciences, Vol. 29, No. 9, 2008, p. 437-444.

    Research output: Research - peer-reviewJournal article

  109. Published

    Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling. / Krzywkowski, Karen Margrethe; Davies, Paul A.; Irving, Andrew J.; Bräuner-Osborne, Hans; Jensen, Anders Asbjørn.

    In: Pharmacogenetics and Genomics (Print Edition), Vol. 18, No. 12, 2008, p. 1027-1040.

    Research output: Research - peer-reviewJournal article

  110. Published

    En genetisk variation i en serotonin–receptor – et muligt link til depression? / Krzywkowski, Karen Margrethe; Feinberg-Zadek, Paula; Davies, Paul A.; Jensen, Anders A.; Bräuner-Osborne, Hans.

    In: Dansk Kemi 83, Vol. 89, No. 6/7, 2008.

    Research output: CommunicationJournal article

  111. Published

    High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor. / Krzywkowski, Karen Margrethe; Davies, Paul A.; Feinberg-Zadek, Paula L.; Bräuner-Osborne, Hans; Jensen, Anders Asbjørn.

    In: Proceedings of the National Academy of Science of the United States of America, Vol. 105, No. 2, 2008, p. 722-727.

    Research output: Research - peer-reviewJournal article

  112. Published

    Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid. / Pinto, Andrea; Conti, Paola; De Amici, Marco; Tamborini, Lucia; Madsen, Ulf; Nielsen, Birgitte; Christesen, Thomas; Bräuner-Osborne, Hans; De Micheli, Carlo.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 7, 2008, p. 2311-2315.

    Research output: Research - peer-reviewJournal article

  113. Published

    Regulation of GABAB receptors by extracellular proteins and phosphorylation. / Tiao, J Y; Bradaia, A; Jensen, Anders A.; Biermann, B; Bräuner-Osborne, Hans; Müller, M; Kaupmann, K; Gassmann, M; Bettler, B.

    In: Neuropharmacology, No. 4, 2008, p. 626.

    Research output: ResearchConference abstract in journal

  114. Published

    Characterization of GPRC6A : a 7TM receptor activated by L-alpha-amino acids and positively modulated by divalent cations. / Wellendorph, Petrine; Hansen, Kasper Bø; Christiansen, Bolette; Burhenne, Nicole; Balsgaard, Anders; Greenwood, Jeremy R; Walter, Bettina; Schmale, Hartwig; Egebjerg, Jan; Bräuner-Osborne, Hans.

    In: Fundamental and Clinical Pharmacology, No. Suppl. 2, 2008, p. 19.

    Research output: ResearchConference abstract in journal

  115. 2007
  116. Published

    GABA/benzodiazepinreceptorer. / Bräuner-Osborne, Hans.

    Basal og klinisk farmakologi. ed. / Jens P. Kampmann; Kim Brøsen; Ulf Simonsen. 3. ed. København : FADL's Forlag, 2007. p. 209-212.

    Research output: EducationBook chapter

  117. Published

    Molekylær farmakologiske subtyper. / Bräuner-Osborne, Hans.

    In: Lundbeckfondens årsskrift 2006-2007, Vol. 2006-2007, 2007, p. 30-32.

    Research output: CommunicationJournal article

  118. Published

    Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. / Bräuner-Osborne, Hans; Wellendorph, Petrine; Jensen, Anders Asbjørn.

    In: Current Drug Targets, Vol. 8, No. 1, 2007, p. 169-184.

    Research output: Research - peer-reviewJournal article

  119. Published

    Pharmacological characterization of mouse GPRC6A, an L-alpha-amino-acid receptor modulated by divalent cations. / Christiansen, B; Hansen, K B; Wellendorph, P; Bräuner-Osborne, Hans.

    In: British Journal of Pharmacology, Vol. 150, No. 6, 2007, p. 798-807.

    Research output: Research - peer-reviewJournal article

  120. Published

    Cloning and characterization of a functional human ¿-aminobutyric acid (GABA) transporter, human GAT-2. / Christiansen, Bolette; Meinild, Anne-Kristine; Jensen, Anders A.; Bräuner-Osborne, Hans.

    In: Journal of Biological Chemistry, Vol. 282, No. 27, 2007, p. 19331-19341.

    Research output: Research - peer-reviewJournal article

  121. Published

    Synthesis and pharmacological characterization at glutamate receptors of erythro- and threo-tricholomic acid and homologues thereof. / Conti, Paolo; De Amici, Marco; Roda, Gabriella; Pinto, Andrea; Tamborini, Lucia; Madsen, Ulf; Nielsen, Birgitte; Bräuner-Osborne, Hans; De Micheli, Carlo.

    In: Tetrahedron, Vol. 63, No. 10, 2007, p. 2249-2256.

    Research output: Research - peer-reviewJournal article

  122. Published

    Synthesis of conformationally constrained glutamic acid homologues and investigation of their pharmacological profiles. / Conti, Paolo; Pinto, Andrea; Tamborini, Lucia; Grazioso, Giovanni; De Sarro, Giovambattista; Bräuner-Osborne, Hans; Szabo, Geza; Hársing, László Gábor; De Micheli, Carlo.

    In: ChemMedChem, Vol. 2, No. 11, 2007, p. 1639-1647.

    Research output: Research - peer-reviewJournal article

  123. Published

    Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA. / Jensen, Anders A.; Christesen, Thomas; Bølcho, Ulrik; Greenwood, Jeremy R; Postorino, Giovanna; Vogensen, Stine B; Johansen, Tommy N; Egebjerg, Jan; Bräuner-Osborne, Hans; Clausen, Rasmus P.

    In: Journal of Medicinal Chemistry, Vol. 50, No. 17, 2007, p. 4177-4185.

    Research output: Research - peer-reviewJournal article

  124. Published

    Allosteric modulation of the calcium-sensing receptor. / Jensen, Anders Asbjørn; Bräuner-Osborne, Hans.

    In: Current Neuropharmacology, Vol. 5, No. 3, 2007, p. 180-186.

    Research output: Research - peer-reviewJournal article

  125. Published

    Novel 5-substituted 1-pyrazolol analogues of ibotenic acid : synthesis and pharmacology at glutamate receptors. / Jørgensen, Charlotte Grube; Bräuner-Osborne, Hans; Nielsen, Birgitte; Kehler, Jan; Clausen, Rasmus Prætorius; Krogsgaard-Larsen, Povl; Madsen, Ulf.

    In: Bioorganic & Medicinal Chemistry, Vol. 15, No. 10, 2007, p. 3524-3538.

    Research output: Research - peer-reviewJournal article

  126. Published

    Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid. / Jørgensen, Charlotte Grube; Clausen, Rasmus Prætorius; Hansen, Kasper Bø; Bräuner-Osborne, Hans; Nielsen, Birgitte; Metzler, Bjørn; Kehler, Jan; Krogsgaard-Larsen, Povl; Madsen, Ulf.

    In: Organic & Biomolecular Chemistry, Vol. 5, No. 3, 2007, p. 463-471.

    Research output: Research - peer-reviewJournal article

  127. Published

    En genetisk variation i en serotonin-receptor : et muligt link til depression? / Krzywkowski, Karen Margrethe; Davies, Paul A.; Feinberg-Zadek, Paula L.; Jensen, Anders Asbjørn; Bräuner-Osborne, Hans.

    In: Lægemiddelforskning, 2007, p. 30-31.

    Research output: CommunicationJournal article

  128. Published

    Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression. / Krzywkowski, Karen Margrethe; Jensen, Anders Asbjørn; Connolly, Christopher N.; Bräuner-Osborne, Hans.

    In: Pharmacogenetics and Genomics (Print Edition), Vol. 17, No. 4, 2007, p. 255-266.

    Research output: Research - peer-reviewJournal article

  129. Published

    The rat GPRC6A : cloning and characterization. / Wellendorph, Petrine; Burhenne, Nicole; Christiansen, Bolette; Walter, Bettina; Schmale, Hartwig; Bräuner-Osborne, Hans.

    In: Gene, Vol. 396, No. 2, 15.07.2007, p. 257-267.

    Research output: Research - peer-reviewJournal article

  130. 2006
  131. Published
  132. Published

    Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24. / Christiansen, Bolette; Wellendorph, Petrine; Bräuner-Osborne, Hans.

    In: European Journal of Pharmacology, Vol. 536, No. 1-2, 24.04.2006, p. 98-101.

    Research output: Research - peer-reviewJournal article

  133. Published

    Known regulators of nitric oxide synthase and arginase are agonists at the human G-protein-coupled receptor GPRC6A. / Christiansen, Bolette; Wellendorph, Petrine; Bräuner-Osborne, Hans.

    In: British Journal of Pharmacology, Vol. 147, No. 8, 04.2006, p. 855-63.

    Research output: Research - peer-reviewJournal article

  134. Published

    Functional characterisation of homomeric ionotropic glutamate receptors GluR1-GluR6 in a fluorescence-based high throughput screening assay. / Strange, Mette; Bräuner-Osborne, Hans; Jensen, Anders A.

    In: Combinatorial Chemistry & High Throughput Screening, Vol. 9, No. 2, 2006, p. 147-58.

    Research output: Research - peer-reviewJournal article

  135. Published

    Differential compartmentalization and distinct functions of GABAB receptor variants. / Vigot, Réjan; Barbieri, Samuel; Bräuner-Osborne, Hans; Turecek, Rostislav; Shigemoto, Ryuichi; Zhang, Yan-Ping; Luján, Rafael; Jacobson, Laura H; Biermann, Barbara; Fritschy, Jean-Marc; Vacher, Claire-Marie; Müller, Matthias; Sansig, Gilles; Guetg, Nicole; Cryan, John F; Kaupmann, Klemens; Gassmann, Martin; Oertner, Thomas G; Bettler, Bernhard.

    In: Neuron, Vol. 50, No. 4, 18.05.2006, p. 589-601.

    Research output: Research - peer-reviewJournal article

  136. 2005
  137. Published

    Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3. / Alaux, Sebastien; Kusk, Mie; Sagot, Emanuelle; Bolte, Jean; Jensen, Anders A.; Bräuner-Osborne, Hans; Gefflaut, Thierry; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 48, No. 25, 2005, p. 7980-92.

    Research output: Research - peer-reviewJournal article

  138. Published

    Azetidinic amino acids : stereocontrolled synthesis and pharmacological characterization as ligands for glutamate receptors and transporters. / Bräuner-Osborne, Hans; Bunch, Lennart; Chopin, Nathalie; Couty, François; Evano, Gwilherm; Jensen, Anders A.; Kusk, Mie Lindskov; Nielsen, Birgitte; Rabasso, Nicolas.

    In: Organic & Biomolecular Chemistry, Vol. 3, No. 21, 2005, p. 3926-36.

    Research output: Research - peer-reviewJournal article

  139. Published

    Synthesis of novel N1-substituted bicyclic pyrazole amino acids and evaluation of their interaction with glutamate receptors. / Conti, Paola; Grazioso, Giovanni; di Ventimiglia, Samuele Joppolo; Pinto, Andrea; Roda, Gabriella; Madsen, Ulf; Bräuner-Osborne, Hans; Nielsen, Birgitte; Costagli, Chiara; Galli, Alessandro.

    In: Chemistry & Biodiversity, Vol. 2, No. 6, 06.2005, p. 748-57.

    Research output: Research - peer-reviewJournal article

  140. Published

    Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids. / Conti, Paola; De Amici, Marco; Grazioso, Giovanni; Roda, Gabriella; Pinto, Andrea; Hansen, Kasper Bø; Nielsen, Birgitte; Madsen, Ulf; Bräuner-Osborne, Hans; Egebjerg, Jan; Vestri, Valentina; Pellegrini-Giampietro, Domenico E; Sibille, Pauline; Acher, Francine C; De Micheli, Carlo.

    In: Journal of Medicinal Chemistry, Vol. 48, No. 20, 06.10.2005, p. 6315-25.

    Research output: Research - peer-reviewJournal article

  141. Published

    Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology. / Frølund, Bente; Greenwood, Jeremy R; Holm, Mai Marie; Egebjerg, Jan; Madsen, Ulf; Nielsen, Birgitte; Bräuner-Osborne, Hans; Stensbøl, Tine B; Krogsgaard-Larsen, Povl.

    In: Bioorganic & Medicinal Chemistry, Vol. 13, No. 18, 15.09.2005, p. 5391-8.

    Research output: Research - peer-reviewJournal article

  142. Published

    Tweaking agonist efficacy at N-methyl-D-aspartate receptors by site-directed mutagenesis. / Hansen, Kasper B; Clausen, Rasmus P; Bjerrum, Esben J; Bechmann, Christian; Greenwood, Jeremy R; Christensen, Caspar; Kristensen, Jesper L; Egebjerg, Jan; Bräuner-Osborne, Hans.

    In: Molecular Pharmacology, Vol. 68, No. 6, 12.2005, p. 1510-23.

    Research output: Research - peer-reviewJournal article

  143. Published
  144. Published

    Rigid nonproteinogenic cyclic amino acids as ligands for glutamate receptors: trans-tris(homoglutamic) acids. / Meyer, Udo; Bisel, Philippe; Bräuner-Osborne, Hans; Madsen, Ulf; Höfner, Georg; Wanner, Klaus Th; Frahm, August Wilhelm.

    In: Chirality, Vol. 17, No. 2, 02.2005, p. 99-107.

    Research output: Research - peer-reviewJournal article

  145. Published

    Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. / Wellendorph, Petrine; Hansen, Kasper B; Balsgaard, Anders; Greenwood, Jeremy R; Egebjerg, Jan; Bräuner-Osborne, Hans.

    In: Molecular Pharmacology, Vol. 67, No. 3, 03.2005, p. 589-97.

    Research output: Research - peer-reviewJournal article

  146. Published

    Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain. / Wellendorph, Petrine; Høg, Signe; Greenwood, Jeremy R; de Lichtenberg, Anne; Nielsen, Birgitte; Frølund, Bente; Brehm, Lotte; Clausen, Rasmus P; Bräuner-Osborne, Hans.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 315, No. 1, 10.2005, p. 346-51.

    Research output: Research - peer-reviewJournal article

  147. 2004
  148. Published

    Synthesis, theoretical and structural analyses, and enantiopharmacology of 3-carboxy homologs of AMPA. / Brehm, Lotte; Greenwood, Jeremy R; Sløk, Frank A; Holm, Mai Marie; Nielsen, Birgitte; Geneser, Ulla; Stensbøl, Tine B; Bräuner-Osborne, Hans; Begtrup, Mikael; Egebjerg, Jan; Krogsgaard-Larsen, Povl.

    In: Chirality, Vol. 16, No. 7, 08.2004, p. 452-66.

    Research output: Research - peer-reviewJournal article

  149. Published

    The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid. / Clausen, Rasmus P; Hansen, Kasper B; Calí, Patrizia; Nielsen, Birgitte; Greenwood, Jeremy R; Begtrup, Mikael; Egebjerg, Jan; Bräuner-Osborne, Hans.

    In: European Journal of Pharmacology, Vol. 499, No. 1-2, 19.09.2004, p. 35-44.

    Research output: Research - peer-reviewJournal article

  150. Published

    Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists. / Conti, Paola; De Amici, Marco; Grazioso, Giovanni; Roda, Gabriella; Barberis Negra, Federico F; Nielsen, Birgitte; Stensbøl, Tine B; Madsen, Ulf; Bräuner-Osborne, Hans; Frydenvang, Karla Andrea; De Sarro, Giovambattista; Toma, Lucio; De Micheli, Carlo.

    In: Journal of Medicinal Chemistry, Vol. 47, No. 27, 30.12.2004, p. 6740-8.

    Research output: Research - peer-reviewJournal article

  151. Published

    Ibotenic acid and thioibotenic acid : a remarkable difference in activity at group III metabotropic glutamate receptors. / Hermit, Mette B; Greenwood, Jeremy R; Nielsen, Birgitte; Bunch, Lennart; Jørgensen, Charlotte G; Vestergaard, Henrik T; Stensbøl, Tine B; Sanchez, Connie; Krogsgaard-Larsen, Povl; Madsen, Ulf; Bräuner-Osborne, Hans.

    In: European Journal of Pharmacology, Vol. 486, No. 3, 23.02.2004, p. 241-50.

    Research output: Research - peer-reviewJournal article

  152. Published

    Mutation-induced quisqualic acid and ibotenic acid affinity at the metabotropic glutamate receptor subtype 4: ligand selectivity results from a synergy of several amino acid residues. / Hermit, Mette B; Greenwood, Jeremy R; Bräuner-Osborne, Hans.

    In: Journal of Biological Chemistry, Vol. 279, No. 33, 13.08.2004, p. 34811-7.

    Research output: Research - peer-reviewJournal article

  153. Published

    Carbamoylcholine homologs : synthesis and pharmacology at nicotinic acetylcholine receptors. / Jensen, Anders A.; Mikkelsen, Ivan Bisgaard; Frølund, Bente; Frydenvang, Karla; Brehm, Lotte; Jaroszewski, Jerzy W; Bräuner-Osborne, Hans; Falch, Erik; Krogsgaard-Larsen, Povl.

    In: European Journal of Pharmacology, Vol. 497, No. 2, 2004, p. 125-37.

    Research output: Research - peer-reviewJournal article

  154. Published

    Fluorescensbaseret farmakologi. / Jensen, Anders A.; Strange, Mette; Bräuner-Osborne, Hans.

    In: Dansk Kemi 83, 2004, p. 29.

    Research output: CommunicationJournal article

  155. Published

    Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. / Jensen, Anders A.; Bräuner-Osborne, Hans.

    In: Biochemical Pharmacology, Vol. 67, No. 11, 2004, p. 2115-27.

    Research output: Research - peer-reviewJournal article

  156. Published

    Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. / Wellendorph, Petrine; Bräuner-Osborne, Hans.

    In: Gene, Vol. 335, 23.06.2004, p. 37-46.

    Research output: Research - peer-reviewJournal article

  157. 2003
  158. Published

    Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). / Bjerrum, Esben J; Kristensen, Anders S; Pickering, Darryl S; Greenwood, Jeremy R; Nielsen, Birgitte; Liljefors, Tommy; Schousboe, Arne; Bräuner-Osborne, Hans; Madsen, Ulf; Pickering, Darryl.

    In: Journal of Medicinal Chemistry, Vol. 46, No. 11, 2003, p. 2246-9.

    Research output: Research - peer-reviewJournal article

  159. Published

    (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology. / Brehm, Lotte; Greenwood, Jeremy R; Hansen, Kasper B; Nielsen, Birgitte; Egebjerg, Jan; Stensbøl, Tine B; Bräuner-Osborne, Hans; Sløk, Frank A; Kronborg, Tine T A; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 46, No. 8, 10.04.2003, p. 1350-8.

    Research output: Research - peer-reviewJournal article

  160. Published
  161. Published

    Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids. / Conti, Paola; De Amici, Marco; Joppolo Di Ventimiglia, Samuele; Stensbøl, Tine B; Madsen, Ulf; Bräuner-Osborne, Hans; Russo, Emilio; De Sarro, Giovambattista; Bruno, Giuseppe; De Micheli, Carlo.

    In: Journal of Medicinal Chemistry, Vol. 46, No. 14, 03.07.2003, p. 3102-8.

    Research output: Research - peer-reviewJournal article

  162. Published

    Carbamoylcholine homologs : novel and potent agonists at neuronal nicotinic acetylcholine receptors. / Jensen, Anders A.; Frølund, Bente; Bräuner-Osborne, Hans; Falch, Erik; Krogsgaard-Larsen, Povl.

    In: Molecular Pharmacology, Vol. 64, No. 4, 2003, p. 865-75.

    Research output: Research - peer-reviewJournal article

  163. Published

    Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA-B1-deficient mice. / Kaupmann, Klemens; Cryan, John F; Wellendorph, Petrine; Mombereau, Cedric; Sansig, Gilles; Klebs, Klaus; Schmutz, Markus; Froestl, Wolfgang; van der Putten, Herman; Mosbacher, Johannes; Bräuner-Osborne, Hans; Waldmeier, Peter; Bettler, Bernhard.

    In: European Journal of Neuroscience, Vol. 18, No. 10, 11.2003, p. 2722-30.

    Research output: Research - peer-reviewJournal article

  164. Published

    Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. / Mathiesen, Jesper Mosolff; Svendsen, Nannette; Bräuner-Osborne, Hans; Thomsen, Christian; Ramirez, M Teresa.

    In: British Journal of Pharmacology, Vol. 138, No. 6, 03.2003, p. 1026-30.

    Research output: Research - peer-reviewJournal article

  165. Published

    Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity. / Runge, S; Wulff, B S; Madsen, K; Bräuner-Osborne, Hans; Knudsen, L B.

    In: British Journal of Pharmacology, Vol. 138, No. 5, 03.2003, p. 787-94.

    Research output: Research - peer-reviewJournal article

  166. Published

    Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus. / Runge, Steffen; Gram, Christian; Bräuner-Osborne, Hans; Madsen, Kjeld; Knudsen, Lotte B; Wulff, Birgitte S.

    In: Journal of Biological Chemistry, Vol. 278, No. 30, 25.07.2003, p. 28005-10.

    Research output: Research - peer-reviewJournal article

  167. Published

    Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues. / Valgeirsson, Jon; Christensen, Jeppe K; Kristensen, Anders S; Pickering, Darryl S; Nielsen, Birgitte; Fischer, Christina; Bräuner-Osborne, Hans; Nielsen, Elsebet Ø; Krogsgaard-Larsen, Povl; Madsen, Ulf.

    In: Bioorganic & Medicinal Chemistry, Vol. 11, No. 20, 2003, p. 4341-9.

    Research output: Research - peer-reviewJournal article

  168. 2002
  169. Published

    Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid. / Clausen, Rasmus P; Bräuner-Osborne, Hans; Greenwood, Jeremy R; Hermit, Mette B; Stensbøl, Tine B; Nielsen, Birgitte; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 45, No. 19, 12.09.2002, p. 4240-5.

    Research output: Research - peer-reviewJournal article

  170. Published

    Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid. / Conti, P; De Amici, M; Bräuner-Osborne, Hans; Madsen, U; Toma, L; De Micheli, C.

    In: Farmaco, Vol. 57, No. 11, 11.2002, p. 889-95.

    Research output: Research - peer-reviewJournal article

  171. Published

    Glutamate receptor ligands : synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs. / Guldbrandt, Mette; Johansen, Tommy N; Frydenvang, Karla Andrea; Bräuner-Osborne, Hans; Stensbøl, Tine B; Nielsen, Birgitte; Karla, Rolf; Santi, Flavio; Krogsgaard-Larsen, Povl; Madsen, Ulf.

    In: Chirality, Vol. 14, No. 4, 2002, p. 351-63.

    Research output: Research - peer-reviewJournal article

  172. Published

    Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET). / Jensen, Anders A.; Hansen, Jakob L; Sheikh, Søren P; Bräuner-Osborne, Hans.

    In: European Journal of Biochemistry, Vol. 269, No. 20, 2002, p. 5076-87.

    Research output: Research - peer-reviewJournal article

  173. Published

    The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors. / Jensen, Anders A.; Mosbacher, Johannes; Elg, Susanne; Lingenhoehl, Kurt; Lohmann, Tania; Johansen, Tommy N; Abrahamsen, Bjarke; Mattsson, Jan; Lehmann, Anders; Bettler, Bernhard; Bräuner-Osborne, Hans.

    In: Molecular Pharmacology, Vol. 61, No. 6, 2002, p. 1377-84.

    Research output: Research - peer-reviewJournal article

  174. Published

    The dance of the clams : twists and turns in the family C GPCR homodimer. / Jensen, Anders A.; Greenwood, Jeremy R; Bräuner-Osborne, Hans.

    In: Trends in Pharmacological Sciences, Vol. 23, No. 11, 2002, p. 491-3.

    Research output: Research - peer-reviewJournal article

  175. Published

    2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid : resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors. / Johansen, Tommy N; Janin, Yves L; Nielsen, Birgitte; Frydenvang, Karla Andrea; Bräuner-Osborne, Hans; Stensbøl, Tine B; Vogensen, Stine B; Madsen, Ulf; Krogsgaard-Larsen, Povl.

    In: Bioorganic & Medicinal Chemistry, Vol. 10, No. 7, 2002, p. 2259-66.

    Research output: Research - peer-reviewJournal article

  176. Published

    Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids. / Kromann, Hasse; Sløk, Frank A; Stensbøl, Tine B; Bräuner-Osborne, Hans; Madsen, Ulf; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 45, No. 4, 14.02.2002, p. 988-91.

    Research output: Research - peer-reviewJournal article

  177. Published

    Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology. / Stensbøl, Tine B; Uhlmann, Peter; Morel, Sandrine; Eriksen, Birgitte L; Felding, Jakob; Kromann, Hasse; Hermit, Mette B; Greenwood, Jeremy R; Braüner-Osborne, Hans; Madsen, Ulf; Junager, Finn; Krogsgaard-Larsen, Povl; Begtrup, Mikael; Vedsø, Per; Bräuner-Osborne, Hans.

    In: Journal of Medicinal Chemistry, Vol. 45, No. 1, 03.01.2002, p. 19-31.

    Research output: Research - peer-reviewJournal article

  178. 2001
  179. Published

    Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. / Bräuner-Osborne, H; Jensen, A A; Sheppard, P O; Brodin, Birger; Krogsgaard-Larsen, P; O'Hara, P.

    In: Biochimica et Biophysica Acta, Vol. 1518, No. 3, 2001, p. 237-48.

    Research output: Research - peer-reviewJournal article

  180. Published

    Synthesis and receptor binding affinity of new selective GluR5 ligands. / Bunch, L; Johansen, T H; Bräuner-Osborne, Hans; Stensbøl, T B; Johansen, T N; Krogsgaard-Larsen, P; Madsen, U.

    In: Bioorganic & Medicinal Chemistry, Vol. 9, No. 4, 04.2001, p. 875-9.

    Research output: Research - peer-reviewJournal article

  181. Published

    Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR1 : noncompetitive antagonism originating from the amino-terminal domain of a family C G-protein-coupled receptor. / Jensen, Anders A.; Sheppard, P O; Jensen, L B; O'Hara, P J; Bräuner-Osborne, H.

    In: Journal of Biological Chemistry, Vol. 276, No. 13, 2001, p. 10110-8.

    Research output: Research - peer-reviewJournal article

  182. Published

    Pharmacological characterization of homobaclofen on wild type and mutant GABA(B)1b receptors coexpressed with the GABA(B)2 receptor. / Jensen, Anders A.; Madsen, Bo E.; Krogsgaard-Larsen, P; Bräuner-Osborne, H.

    In: European Journal of Pharmacology, Vol. 417, No. 3, 2001, p. 177-80.

    Research output: Research - peer-reviewJournal article

  183. Published
  184. Published

    Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. / Madsen, U; Bräuner-Osborne, H; Frydenvang, Karla Andrea; Hvene, L; Johansen, T N; Nielsen, B; Sánchez, C; Stensbøl, T B; Bischoff, F; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 44, No. 7, 2001, p. 1051-9.

    Research output: Research - peer-reviewJournal article

  185. Published

    Structural and stereochemical requirements for activation and blocade of excitatory amino acid receptors. / Sløk, Frank A; Bräuner-Osborne, Hans; Stensbøl, Tine B; Johansen, Tommy Nørskov; Ebert, Bjarke; Mortensen, Martin; Nielsen, Birgitte; Madsen, Ulf; Brehm, Lotte; Falch, Erik; Krogsgaard-Larsen, Povl.

    Medicinal Chemistry into the Millenium. ed. / Malcolm M Campbell; Ian S Blagbrough. UK : The Royal Society of Chemistry, 2001. p. 52-64.

    Research output: Research - peer-reviewBook chapter

  186. 2000
  187. Published

    A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2. / Bräuner-Osborne, Hans; Hermit, M B; Nielsen, B; Krogsgaard-Larsen, P; Johansen, T N.

    In: European Journal of Pharmacology, Vol. 406, No. 1, 06.10.2000, p. 41-4.

    Research output: Research - peer-reviewJournal article

  188. Published

    Ligands for glutamate receptors: design and therapeutic prospects. / Bräuner-Osborne, Hans; Egebjerg, J; Nielsen, E O; Madsen, U; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 43, No. 14, 13.07.2000, p. 2609-45.

    Research output: Research - peer-reviewJournal article

  189. Published
  190. Published

    Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor. / Jensen, Anders A.; Spalding, T A; Burstein, E S; Sheppard, P O; O'Hara, P J; Brann, M R; Krogsgaard-Larsen, P; Bräuner-Osborne, H.

    In: Journal of Biological Chemistry, Vol. 275, No. 38, 2000, p. 29547-55.

    Research output: Research - peer-reviewJournal article

  191. Published

    The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity. / Jensen, Anders A.; Sheppard, P O; O'Hara, P J; Krogsgaard-Larsen, P; Bräuner-Osborne, H.

    In: European Journal of Pharmacology, Vol. 397, No. 2-3, 2000, p. 247-53.

    Research output: Research - peer-reviewJournal article

  192. Published

    Øget forståelse af vigtig receptor i hjernen. / Jensen, Anders A.; Bräuner-Osborne, Hans.

    In: Lægemiddelforskning, 2000, p. 28-29.

    Research output: CommunicationJournal article

  193. Published

    Ionotropic excitatory amino acid receptor ligands. Synthesis and pharmacology of a new amino acid AMPA antagonist. / Madsen, U; Sløk, F A; Stensbøl, T B; Bräuner-Osborne, Hans; Lützhøft, H H; Poulsen, M V; Eriksen, L; Krogsgaard-Larsen, P.

    In: European Journal of Medicinal Chemistry, Vol. 35, No. 1, 01.2000, p. 69-76.

    Research output: Research - peer-reviewJournal article

  194. 1999
  195. Published

    Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor. / Bräuner-Osborne, H; Jensen, Anders A.; Krogsgaard-Larsen, P.

    In: NeuroReport, Vol. 10, No. 18, 1999, p. 3923-5.

    Research output: Research - peer-reviewJournal article

  196. Published

    The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain. / Bräuner-Osborne, H; Jensen, Anders A.; Sheppard, P O; O'Hara, P; Krogsgaard-Larsen, P.

    In: Journal of Biological Chemistry, Vol. 274, No. 26, 1999, p. 18382-6.

    Research output: Research - peer-reviewJournal article

  197. Published

    Functional pharmacology of cloned heterodimeric GABA-B receptors expressed in mammalian cells. / Bräuner-Osborne, Hans; Krogsgaard-Larsen, P.

    In: British Journal of Pharmacology, Vol. 128, No. 7, 12.1999, p. 1370-4.

    Research output: Research - peer-reviewJournal article

  198. Published

    Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists. / Conti, P; De Amici, M; De Sarro, G; Rizzo, M; Stensbøl, T B; Bräuner-Osborne, Hans; Madsen, U; Toma, L; De Micheli, C.

    In: Journal of Medicinal Chemistry, Vol. 42, No. 20, 07.10.1999, p. 4099-107.

    Research output: Research - peer-reviewJournal article

  199. Published

    Synthesis and muscarinic receptor pharmacology of a series of 4,5,6,7-tetrahydroisothiazolo[4,5-c]pyridine bioisosteres of arecoline. / Pedersen, H; Bräuner-Osborne, H; Ball, R G; Frydenvang, Karla Andrea; Meier, E; Bøgesø, K P; Krogsgaard-Larsen, P.

    In: Bioorganic & Medicinal Chemistry, Vol. 7, No. 5, 1999, p. 795-809.

    Research output: Research - peer-reviewJournal article

  200. Published

    Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74. / Rosenkilde, M M; Kledal, T N; Bräuner-Osborne, Hans; Schwartz, T W.

    In: Journal of Biological Chemistry, Vol. 274, No. 2, 08.01.1999, p. 956-961.

    Research output: Research - peer-reviewJournal article

  201. Published

    3-pyrazolone analogues of the 3-isoxazolol metabotropic excitatory amino acid receptor agonist homo-AMPA. Synthesis and pharmacological testing. / Zimmermann, D.; Janin, Y.L.; Brehm, L.; Bräuner-Osborne, Hans; Ebert, B.; Johansen, T.N.; Madsen, U.; Krogsgaard-Larsen, P.

    In: European Journal of Medicinal Chemistry, Vol. 34, No. 11, 01.11.1999, p. 967-976.

    Research output: Research - peer-reviewJournal article

  202. 1998
  203. Published

    Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors. / Bräuner-Osborne, Hans; Nielsen, B; Krogsgaard-Larsen, P.

    In: European Journal of Pharmacology, Vol. 350, No. 2-3, 05.06.1998, p. 311-6.

    Research output: Research - peer-reviewJournal article

  204. Published

    Pharmacology of (S)-homoquisqualic acid and (S)-2-amino-5-phosphonopentanoic acid [(S)-AP5] at cloned metabotropic glutamate receptors. / Bräuner-Osborne, Hans; Krogsgaard-Larsen, P.

    In: British Journal of Pharmacology, Vol. 123, No. 2, 01.1998, p. 269-74.

    Research output: Research - peer-reviewJournal article

  205. Published

    Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity. / Conti, P; De Amici, M; De Sarro, G; Stensbøl, T B; Bräuner-Osborne, Hans; Madsen, U; De Micheli, C.

    In: Journal of Medicinal Chemistry, Vol. 41, No. 20, 24.09.1998, p. 3759-62.

    Research output: Research - peer-reviewJournal article

  206. Published

    Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid. / Johansen, T N; Ebert, B; Bräuner-Osborne, Hans; Didriksen, M; Christensen, I T; Søby, K K; Madsen, U; Krogsgaard-Larsen, P; Brehm, L.

    In: Journal of Medicinal Chemistry, Vol. 41, No. 6, 12.03.1998, p. 930-9.

    Research output: Research - peer-reviewJournal article

  207. Published

    Synthesis and pharmacology of N-alkylated derivatives of the excitotoxin ibotenic acid. / Madsen, U; Dumpis, M A; Bräuner-Osborne, Hans; Piotrovsky, L B.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 8, No. 12, 16.06.1998, p. 1563-8.

    Research output: Research - peer-reviewJournal article

  208. 1997
  209. Published

    (S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors. / Ahmadian, H; Nielsen, B; Bräuner-Osborne, Hans; Johansen, T N; Stensbøl, T B; Sløk, F A; Sekiyama, N; Nakanishi, S; Krogsgaard-Larsen, P; Madsen, U.

    In: Journal of Medicinal Chemistry, Vol. 40, No. 22, 24.10.1997, p. 3700-5.

    Research output: Research - peer-reviewJournal article

  210. Published

    Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors. / Bräuner-Osborne, Hans; Nielsen, B; Stensbøl, T B; Johansen, T N; Skjaerbaek, N; Krogsgaard-Larsen, P.

    In: European Journal of Pharmacology, Vol. 335, No. 2-3, 24.09.1997, p. R1-3.

    Research output: Research - peer-reviewJournal article

  211. Published

    New analogues of ACPD with selective activity for group II metabotropic glutamate receptors. / Bräuner-Osborne, Hans; Madsen, U; Mikiciuk-Olasik, E; Curry, K.

    In: European Journal of Pharmacology, Vol. 332, No. 3, 13.08.1997, p. 327-31.

    Research output: Research - peer-reviewJournal article

  212. Interactions of muscarinic receptors with the heterotrimeric G proteins Gq and G12: transduction of proliferative signals. / Burstein, E S; Bräuner-Osborne, Hans; Spalding, T A; Conklin, B R; Brann, M R.

    In: Journal of Neurochemistry, Vol. 68, No. 2, 02.1997, p. 525-33.

    Research output: Research - peer-reviewJournal article

  213. 1996
  214. Published

    A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid. / Bräuner-Osborne, Hans; Sløk, F A; Skjaerbaek, N; Ebert, B; Sekiyama, N; Nakanishi, S; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 39, No. 16, 02.08.1996, p. 3188-94.

    Research output: Research - peer-reviewJournal article

  215. Published

    Functional partial agonism at cloned human muscarinic acetylcholine receptors. / Bräuner-Osborne, Hans; Ebert, B; Brann, M R; Falch, E; Krogsgaard-Larsen, P.

    In: European Journal of Pharmacology, Vol. 313, No. 1-2, 10.10.1996, p. 145-50.

    Research output: Research - peer-reviewJournal article

  216. Pharmacology of muscarinic acetylcholine receptor subtypes (m1-m5): high throughput assays in mammalian cells. / Bräuner-Osborne, Hans; Brann, M R.

    In: European Journal of Pharmacology, Vol. 295, No. 1, 04.01.1996, p. 93-102.

    Research output: Research - peer-reviewJournal article

  217. Structure of a G-protein-coupling domain of a muscarinic receptor predicted by random saturation mutagenesis. / Hill-Eubanks, D; Burstein, E S; Spalding, T A; Bräuner-Osborne, Hans; Brann, M R.

    In: Journal of Biological Chemistry, Vol. 271, No. 6, 09.02.1996, p. 3058-65.

    Research output: Research - peer-reviewJournal article

  218. Published

    Design of excitatory amino acid receptor agonists, partial agonists and antagonists : Ibotenic acid as a key lead structure. / Krogsgaard-Larsen, P.; Ebert, B.; Lund, Trine Meldgaard; Bräuner-Osborne, H.; Sloøk, F. A.; Johansen, T. N.; Brehm, L.; Madsen, U.

    In: European Journal of Medicinal Chemistry, Vol. 31, No. 7-8, 10.09.1996, p. 515-537.

    Research output: Research - peer-reviewJournal article

  219. 1995
  220. Published

    Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors. / Bräuner-Osborne, Hans; Ebert, B; Brann, M R; Falch, E; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 38, No. 12, 09.06.1995, p. 2188-95.

    Research output: Research - peer-reviewJournal article

  221. Constitutive activation of muscarinic receptors by the G-protein Gq. / Burstein, E S; Spalding, T A; Bräuner-Osborne, Hans; Brann, M R.

    In: F E B S Letters, Vol. 363, No. 3, 24.04.1995, p. 261-3.

    Research output: Research - peer-reviewJournal article

  222. High throughput assays of cloned adrenergic, muscarinic, neurokinin, and neurotrophin receptors in living mammalian cells. / Messier, T L; Dorman, C M; Bräuner-Osborne, Hans; Eubanks, D; Brann, M R.

    In: Basic & Clinical Pharmacology & Toxicology, Vol. 76, No. 5, 05.1995, p. 308-11.

    Research output: Research - peer-reviewJournal article

  223. Pharmacology of a constitutively active muscarinic receptor generated by random mutagenesis. / Spalding, T A; Burstein, E S; Bräuner-Osborne, Hans; Hill-Eubanks, D; Brann, M R.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 275, No. 3, 12.1995, p. 1274-9.

    Research output: Research - peer-reviewJournal article

  224. 1993
  225. Published

    Muscarinic acetylcholine receptor subtypes: localization and structure/function. / Brann, M R; Ellis, J; Jørgensen, H; Hill-Eubanks, D; Jones, S V; Bräuner-Osborne, Hans.

    In: Progress in Brain Research, Vol. 98, 1993, p. 121-7.

    Research output: Research - peer-reviewJournal article

  226. Studies of the pharmacology, localization, and structure of muscarinic acetylcholine receptors. / Brann, M R; Jørgensen, H B; Burstein, E S; Spalding, T A; Ellis, J; Jones, S V; Hill-Eubanks, D; Bräuner-Osborne, Hans.

    In: Annuals of the New York Academy of Sciences, Vol. 707, 20.12.1993, p. 225-36.

    Research output: Research - peer-reviewJournal article

ID: 1302910