Employees – University of Copenhagen

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Department of Drug Design and Pharmacology > Employees

Kasper Skytte Harpsøe

Kasper Skytte Harpsøe

Academic staff

Primary fields of research

Cheminformatics, computational chemistry and molecular modeling in drug design in general, specifically protein-ligand interactions. 

Allosteric modulation of ligand-gated ion channels (Cys-loop receptors and glutamate receptors) and GPCRs.

Selected publications

  1. Published

    Structural insight to mutation effects uncover a common allosteric site in class C GPCRs

    Harpsøe, K., Boesgaard, M. W., Munk, C., Bräuner-Osborne, H. & Gloriam, D. E. 2017 In : Bioinformatics (Oxford, England). 33, 8, p. 1116-1120 5 p., btw784

    Publication: Research - peer-reviewJournal article

  2. Published

    Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors

    Xiong, X., Zhang, H., Underwood, C. R., Harpsøe, K., Gardella, T. J., Wöldike, M. F., Mannstadt, M., Gloriam, D. E., Bräuner-osborne, H. & Strømgaard, K. Nov 2016 In : Nature Chemistry. 8, 11, p. 1035-1041 7 p.

    Publication: Research - peer-reviewJournal article

  3. Published

    GPCRdb: an information system for G protein-coupled receptors

    Isberg, V., Mordalski, S., Munk, C., Rataj, K., Harpsøe, K., Hauser, A. S., Vroling, B., Bojarski, A. J., Vriend, G. & Gloriam, D. E. 4 Jan 2016 In : Nucleic acids research. 44, D1, p. D356-64

    Publication: Research - peer-reviewJournal article

  4. Published

    Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors - A Structural Perspective of Ligands and Mutants

    Harpsøe, K., Isberg, V., Tehan, B. G., Weiss, D., Arsova, A., Marshall, F. H., Bräuner-Osborne, H. & Gloriam, D. E. 11 Sep 2015 In : Scientific Reports. 5, p. 1-11 11 p., 13869

    Publication: Research - peer-reviewJournal article

  5. Published

    Revision of the Classical Dopamine D2 Agonist Pharmacophore Based on an Integrated Medicinal Chemistry, Homology Modelling and Computational Docking Approach

    Krogsgaard-Larsen, N., Harpsøe, K., Kehler, J., Christoffersen, C. T., Brøsen, P. & Balle, T. 24 Jul 2014 In : Neurochemical research. 39, 10, p. 1997-2007 12 p.

    Publication: Research - peer-reviewJournal article

  6. Published

    mGluR5: Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery

    Mølck, C., Harpsøe, K., Gloriam, D. E., Mathiesen, J. M., Nielsen, S. M. & Bräuner-Osborne, H. Oct 2014 In : Neurochemical research. 39, 10, p. 1862-1875 14 p.

    Publication: Research - peer-reviewJournal article

  7. Published

    A robust force field based method for calculating conformational energies of charged drug-like molecules

    Pøhlsgaard, J., Harpsøe, K., Jørgensen, F. S. & Olsen, L. 2012 In : Journal of Chemical Information and Modeling. 52, 2, p. 409-419

    Publication: Research - peer-reviewJournal article

  8. Published

    Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors

    Harpsøe, K., Ahring, P. K., Christensen, J. K., Jensen, M. L., Peters, D. & Balle, T. 27 Jul 2011 In : Journal of Neuroscience. 31, 30, p. 10759-10766

    Publication: Research - peer-reviewJournal article

ID: 1428429