Employees – University of Copenhagen

Trine Meldgaard Lund

Trine Meldgaard Lund

Associate Professor

Primary fields of research

Population PKPD modelling

Current research

Pharmacometrics

We optimise pharmacotherapy and clinical trial designs by characterising pharmacokinetic-pharmacodynamic relationships using mathematical models that identify sources of variability in drug response.

Examples of projects in our group:

•Fixed dose combinations in drug development - Design of Trials for Identifying Optimal Combination Ratios using Advanced Computer Modelling Tools
•Model-based dose finding in clinical drug development
•The development of fixed-dose combinations (FDCs) through improved methodology – regulatory perspective
•Linking rescue medication with pain intensity using PKPD modelling in clinical pain trials
•PK meta-model on morphine and active metabolite based on 22 clinical studies
•PKPD modelling on synergistic effects of gabapentin and morphine
•Modelling on effect of high-dose target-controlled naloxone infusion on pain and hyperalgesia in patients following groin-hernia-repair
•Differences in metabolic activity of CYP enzymes in obese and lean children

 

Teaching

Pharmacokinetics and Pharmacodynamics on the following courses:

Basic pharmacology, Principles of Pharmacology, Organ-related pharmacology

Elective course in Pharmacokinetics and -dynamics and post graduate MIND courses and PhD course

 

ID: 1303792