Employees – University of Copenhagen

Forward this page to a friend Resize Print Bookmark and Share

Department of Drug Design and Pharmacology > Employees

Rasmus Prætorius Clausen

Rasmus Prætorius Clausen

Associate Professor

  • neuromedicinal chemistry
  • epigenetic medicinal chemistry
  • biostructure based SAR studies
  • peptide and protein based ligands
  • organic synthesis

Selected publications

  1. Published

    Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C

    Leurs, U., Lohse, B., Rand, K. D., Ming, S., Riise, E. S., Cole, P. A., Kristensen, J. L. & Clausen, R. P. 11 Jul 2014 In : A C S Chemical Biology. 9, 9, p. 2131-2138 8 p.

    Publication: Research - peer-reviewJournal article

  2. Published

    Posttranslational Modifications of the Histone 3 Tail and Their Impact on the Activity of Histone Lysine Demethylases In Vitro

    Lohse, B., Helgstrand, C., Andersson, J. L., Leurs, U., Cloos, P. A. C., Kristensen, J. L. & Clausen, R. P. 2 Jul 2013 In : P L o S One. 8, 7, p. e67653

    Publication: Research - peer-reviewJournal article

  3. Published

    Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors

    Lohse, B., Nielsen, A. L., Kristensen, J. B. L., Helgstrand, C., Cloos, P. A. C., Olsen, L., Gajhede, M., Clausen, R. P. & Kristensen, J. L. 19 Sep 2011 In : Angewandte Chemie (International Edition). 50, 39, p. 9100-9103

    Publication: Research - peer-reviewJournal article

  4. Published

    Development of 2 '-substituted (2S,1 ' R,2 ' S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-D-aspartic acid receptor agonists

    Risgaard, R., Nielsen, S. D., Hansen, K. B., Jensen, C. M., Nielsen, B., Traynelis, S. F. & Clausen, R. P. 23 May 2013 In : Journal of Medicinal Chemistry. 56, 10, p. 4071-4081

    Publication: Research - peer-reviewJournal article

  5. Published

    Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors

    Hansen, K. B., Tajima, N., Risgaard, R., Perszyk, R. E., Jørgensen, L., Vance, K. M., Ogden, K. K., Clausen, R. P., Furukawa, H. & Traynelis, S. F. Jul 2013 In : Molecular Pharmacology. 84, 1, p. 114-127

    Publication: Research - peer-reviewJournal article

  6. Published

    α4βδ GABA receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)

    Absalom, N., Karim, N., Eghorn, L. F., Villumsen, I. S., Bay, T., Bräuner-Osborne, H., Frølund, B., Clausen, R. P., Olsen, J. V., Knudsen, G. M., Chebib, M. & Wellendorph, P. 14 Aug 2012 In : Proceedings of the National Academy of Sciences USA (PNAS). 109, 33, p. 13404-13409 6 p.

    Publication: Research - peer-reviewJournal article

  7. Published

    Tweaking subtype-selectivity and agonist efficacy at (S)-2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) receptors in a small series of BnTetAMPA analogues

    Wang, S-Y., Larsen, Y., Navarrete, C. V., Jensen, A. A., Nielsen, B., Al-Musaed, A., Frydenvang, K., Kastrup, J. S., Pickering, D. S. & Clausen, R. P. 2016 In : Journal of Medicinal Chemistry. 59, 5, p. 2244-2254 11 p.

    Publication: Research - peer-reviewJournal article

  8. Published

    New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites

    Vogensen, S. B., Marek, A., Bay, T., Wellendorph, P., Kehler, J., Bundgaard, C., Frølund, B., Pedersen, M. H. F. & Clausen, R. P. 2013 In : Journal of Medicinal Chemistry. 56, 20, p. 8201–8205

    Publication: Research - peer-reviewJournal article

ID: 1302218