Department of Drug Design and Pharmacology > Employees
Ciarán Martin Fitzpatrick
Jagtvej 160, 2100 København Ø
ADHD is characterized by inattention, hyperactivity and impulsivity, and involves disturbances in dopamine (DA) and noradrenaline (NA) neurotransmission, particularly in frontal cortex and basal ganglia circuitry.
DA- and NA-enhancing drugs are used clinically to treat ADHD symptoms, but the relative role of the different brain DA and NA pathways in mediating the therapeutic effect are not known.
This project will study the role of DA and NA transmission in controlling visual attention. This will be done by using pharmacological, chemogenetic, and optogenetic techniques to understand this relationship in the five-choice serial reaction time (5-CSRT) task in mice. 5-CSRTT data will be analysed using the Theory of Visual Attention model to directly compare mouse attentional performance to human performing similar continuous performance tasks.
This study expects to gain new knowledge into how DA and NA are involved in controlling attention and impulsivity. This information will further our understanding of the molecular and cellular basis of visual attention, and promote the development of improved treatment options for patients with ADHD