Employees – University of Copenhagen

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Department of Drug Design and Pharmacology > Employees

Pablo Antonio Martin Gago

Pablo Antonio Martin Gago

Assistant professor

  • Medicinal Chemistry Research

    Jagtvej 162, 2100 København Ø

    Phone: +45 35 33 59 42


2017–present. Assistant Professor. Center for Biopharmaceuticals and Department of Drug Design and Pharmacology. University of Copenhagen. Denmark.

2013–2017. Max-Planck Postdoctoral Research Associate. Chemical Biology Department. MPI of Molecular Physiology, Dortmund, Germany.



2008-2013. Ph.D. in Organic Chemistry (Summa Cum Laude). Institute for Research in Biomedicine (IRB Barcelona), Spain.

2012. FPU-Research stay. California Institute of Technology, Pasadena (CA), USA.

2008-2009. M.Sc. in Organic Chemistry. Faculty of Chemistry. University of Barcelona, Spain.



13. Martín-Gago, P., Fansa, E., Winzker, M., Murarka S., Schultz-Fademrecht C., Baumann M., Janning, P., Wittinghofer, A., Waldmann H. “Covalent Protein Labeling at Glutamic Acids.” Cell Chemical Biology. 2017, 24, 1.
Most read article May 2017.

12. Martín-Gago, P.,* Fansa, E.,* Klein, C.,* Murarka S.,* Janning, P., Schürmann, P., Schultz-Fademrecht C., Baumann M., Wittinghofer, A., Bastiaens P. I. H, Waldmann H. “A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity Prevents Efficient Inhibitor Release by Arl2.” Angew. Chem. Int. Ed., 2017, 56, 2423.
* Denotes co-first authors

11. Martín-Gago P., Fansa E., Wittinghofer A., Waldmann H. “Structure-based development of PDEδ inhibitors.” Invited review. Bio. Chem. 2017, 398, 535.

10. Murarka S.,* Martín-Gago P.,* Schultz-Fademrecht C., Al Saabi, A, Baumann M., Fansa E., Ismail I., Nussbaumer P., Wittinghofer A., Waldmann H. “Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site.” Chem. Eur. J., 2016, 23, 6083.
* Denotes co-first authors

9. Martín-Gago P.,* Rol A.,* Todorovski T., Aragón E., Martin-Malpartida P., Verdaguer X., Vallès-Miret M., Fernández-Carneado J., Ponsati B., Macias M. J., Riera A. “Peptide aromatic interactions modulated by fluorinated residues: Synthesis, structure and biological activity of Somatostatin analogs containing 3-(3′,5′difluorophenyl)-alanine.” Sci. Rep. 2016, 6, 27285.
* Denotes co-first authors

8. Björn P.,* Murarka S.,* Vogel H. A.,* Martín-Gago, P.*, Kovacevic M., Truxius D., Fansa, E., Ismail S., Zimmermann G., Heinelt K., Schultz-Fademrecht C., Al Saabi A., Baumann M., Nussbaumer P., Wittinghofer, A., Waldmann H., Bastiaens P. I. H. “Identification of pyrazolopyridazinones as PDEδ inhibitors.” Nat. Commun., 2016, 7, 11360.
* Denotes co-first authors

7. Choi, J., Martín-Gago, P., Fu, G. C. “Stereoconvergent Arylations and Alkenylations of Unactivated Alkyl Electrophiles: Catalytic enantioselective synthesis of secondary sulfonamides and sulfones.” J. Am. Chem. Soc., 2014, 136, 12161-12165.
-Highlighted as spotlight in JACS, 2014, 136, 12515. “Negishi coupling goes asymmetric on sulfonamides and sulfones.”
- Also as ChemInform, 03/2015, 46 (12).

6. Cristobal-Lecina E., Etayo P., Doran S., Reves M., Martín-Gago P., Grabulosa A., Costantino A R., Vidal-Ferran A., Riera A., Verdaguer X. “MaxPHOS ligand: PH/NH tautomerism and rhodium- catalyzed asymmetric hydrogenations.” Adv. Synth. Catal., 2014356, 795-804.
- Also as ChemInform, 08/2014, 45 (35).

5. Martín-Gago P., Ramón R., Aragón E., Fernández-Carneado J., Martin-Malpartida P., Verdaguer X., López-Ruiz P., Colás B., Cortes M., Ponsati B., Macias M., Riera A. “A tetradecapeptide somatostatin dicarba-analog: Synthesis, structural impact and biological activity.” Bioorg. Med. Chem. Lett., 201424, 103-107.

4. Martín-Gago P., Aragón E., Gomez-Caminals M., Fernández-Carneado J., Ramón R., Martin-Malpartida P., Verdaguer X., López-Ruiz P., Colás B., Cortes M., Ponsati B., Macias M., Riera A. “Insights into structure-activity relationships of somatostatin analogs containing mesitylalanine.” Molecules2013, 18, 14564-14584.

3. Martín-Gago, P., Gomez-Caminals, M., Ramón, R., Verdaguer, X., Martin-Malpartida, P., Aragón, E., Fernández-Carneado, J., Ponsati, B., López-Ruiz, P., Cortes, M. A., Colás, B., Macias, M., Riera, A. “Fine-tuning the π–π aromatic interactions in peptides: Somatostatin analogues containing mesityl alanine.” Angew. Chem. Int. Ed., 2012, 51, 1820-1825.
- Featured as Back Cover in Angew. Chem. Int. Ed. 8/2012.

2. Ortiz D., Martín-Gago P., Riera A., Song K., Salpin J-Y, Spezia R., “Gas-phase collision induced dissociation mechanisms of peptides: Theoretical and experimental study of N-formylalanylamide fragmentation.” Int. J. Mass Spectrom., 2012335, 33-44.

1. Ramón, R., Martín-Gago, P., Verdaguer, X., Macias, M. J., Martin-Malpartida, P.,Fernández-Carneado J., Ponsati, B., López-Ruiz, P., Cortes M. A., Colas, B., Riera, A. “SSTR1- and SSTR3-selective somatostatin analogs.” ChemBioChem, 201112, 625-632.



Waldmann H., Martín-Gago, P., Murarka S., Bastiaens P. I. H.,Klein, C., Wittinghofer, A., Fansa, E. “Benzene disulfonamide for the treatment of cancer.” Patent Application No. EP17151296.5, Unpublished (filing date January 12, 2017).

Waldmann H., Murarka S., Martín-Gago, P., Zimmermann G., Bastiaens P. I. H.,Björn P., Wittinghofer, A., Fansa, E., Ismail S. “Preparation of pyridazinone derivatives for use as antitumor agents.” PCT Int. Appl. (2015), WO 2015189433 A1 Dec 17, 2015.


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