We determine three-dimensional structures of human biological macro-molecules that are potential targets for new drugs, and study the relationship between their structure and function.
Our research forms the basis for design of new drug molecules that are uniquely adapted to the three-dimensional structure of individual receptors, enzymes, transport molecules and other proteins implicated in diseases.
Our research contributes to the fundamental scientific understanding of biological processes at the atomic level. We also contribute with our expertise and facilities to a number of Danish and international research partnerships.
The Section for Biostructural Research operates as one large research group. Our integration of methods and expertise creates critical mass and helps us stay internationally competitive. We focus on seven core projects.
- BRAINSTRUC is a Lundbeck Foundation initiative that aims to understand the molecular basis of selected brain functions and diseases.
- We use and develop computer-based methods to predict the binding and subsequent metabolism of drugs in the body by the Cytochrome P450 enzyme family.
- We investigate molecules that transport other small molecules across biological membranes and are considered important targets for future drugs.
- We perform Computational Drug Design for G protein-coupled receptors - a major drug target family, and develop the GPCRDB database and web tools.
- We study the interactions between potential drugs and certain proteins that are essential for epigenetic control of gene expression and promising targets for cancer treatment.
- We work to provide a rational basis for design of drugs to treat diseases and disorders within the brain – one of the largest and fastest growing areas of unmet medical need.
- We apply our expertise in solution small angle X-ray scattering to the structural analysis of protein fibrillation, which is associated with many neurodegenerative diseases.