G Protein-Coupled Receptors -
GPCR Computational Drug Design Group
GPCRs constitute one of the largest human protein families. They are cell-surface receptors widely abundant in physiological systems and mediate the effect of ca 30% of marketed drugs. The Gloriam group studies receptor structures and functions of a number of GPCRs and applies computational methods to identify ligands:
- Virtual Screening
- Focused Compound Libraries
- Bioinformatics & Chemoinformatics
- Structure-based drug design
- Web database / tool development
The group has a particular focus on the least characterised so called orphan receptors for which the endogenous ligands and functions are unknown. We also head GPCRdb, a community hub on the web for GPCR data, analysis tools and visualisation. Read more on the project pages below:
- Orphan receptors have unknown physiological ligands and functions. Elucidating these can unravel new physiological signal systems and therapeutic targets.
- GPCRdb features reference data, web tools and visualisation diagrams enabling science in the wider GPCR community.
- Modern drug design is highly interdisciplinary. Computational drug design guides chemical synthesis and rationalised pharmacological activities.