Computational Drug Design
G protein-coupled receptors (GPCRs) constitute one of the largest human protein families. They are cell-surface receptors widely abundant in physiological systems and mediate the effect of ca 30% of marketed drugs. The Gloriam group studies receptor structures and functions of a number of GPCRs and applies computational methods to identify ligands.
- Orphan Receptor Characterisation
We identify orphan receptor ligands and probes to characterise new physiological signal systems and therapeutic targets.
- GPCRdb Database, Tools and Visualisation
GPCRdb features reference data, web tools and visualisation diagrams enabling science in the wider GPCR community.
- Ligand identification and optimisation
Computational drug design guides chemical synthesis and rationalise pharmacological activities.
|Gloriam group joins new network for Structural Biology....>>||2017.03|
|Open Access publication video featuring David Gloriam...>>||2017.03|
|PhD Scholarship to Christian Munk (GPCRdb lead dev) ...>>||2016.11|
|Bronze in GPCR crystal refinement competition ...>>||2016.11|