Our main target classes are G protein-coupled receptors, ligand-gated ion channels and transporters of which the majority are related to central nervous system (CNS) disorders including chronic pain states, cognitive dysfunction and emotional disturbances.
Our main focus is to develop and use pharmacological tool compounds to delineate mechanisms of drug action, and investigate the mechanisms underlying CNS disorders and their potential treatment.
Our approach is highly interdisciplinary and builds on integration molecular, ex vivo and in vivo pharmacology with medicinal chemistry, as well as computational chemistry and clinical pharmacology with collaborators in academia, pharmaceutical companies and hospitals, both in Denmark and abroad.
- We study the structure, function and pharmacology of receptors and transporters at the molecular level and develop novel pharmacological tool compounds. In addition, we use animal models for ex/in vivo studies.
- We study mechanisms underlying chronic pain states, cognitive dysfunction, emotional disturbances, as well as the mechanism of action and efficacy of compounds used in the treatment of these conditions.