Chemistry and Medicinal Chemistry
The common theme of our research is organic chemistry and design of bioactive molecules. Our chemical compounds are used as tools for investigating the cellular and molecular function of biological targets or to identify new therapeutic principles. We work with various aspects of medicinal chemistry such as small molecules, fragment-based drug discovery, peptides and peptidomimetics, synthetic methodologies, and radiochemistry. We mainly focus on CNS targets, but are interested in other areas as well.
- We apply fragment-based drug discovery on proteins involved in CNS diseases. We screen fragments and optimize hits by chemical synthesis in order to identify novel chemical probes and therapeutic principles.
- Organic chemistry and medicinal chemistry. Design and synthesis of neuroactive ligands, SAR studies, new synthetic methodology to access sp3-rich molecules, new planar heterocycles, new techniques in medchem.
- With special focus on ligand gated ion channels, we design and synthesize ligands for selective targeting specific receptor subtypes with the aim to study localization and function.
We focus on the development of radiopharmaceutical materials for diagnosis and therapy. A special interest in my group is neurochemistry and pretargeted imaging.
- We are developing new chemical probes and imaging agents to elucidate the underlying mechanisms responsible for the function and regulation of different pharmacological targets.
- Modulation of neurotransmitter systems in the central nervous system, and epigenetic mechanisms. Medicinal chemistry, small molecule organic synthesis, and peptide chemistry.
- Our aim is to delineate the structure and function of G protein-coupled receptors (GPCRs). To this end, we design small molecule and peptide ligands as pharmacological tool compounds.