Molecular and Cellular Pharmacology
We focus on a range of biological systems, particularly those that regulate brain function, as well as elements and processes implicated in many neurological disorders.
Our research is aimed at developing novel drug design strategies to treat disorders such as epilepsy and stroke. The research includes in vitro and in vivo pharmacological studies to better understand cognitive functions and treat conditions such as pain and depression.
- We study the physiological and pharmaco-logical roles of bioactive lipids, especially in signaling between the gut and the brain and in regulation of energy metabolism.
- We use and develop research tools to help elucidate mechanisms in epigenetics, cancer and Venomics and develop drugs, biomarkers and crystallisation facilitators.
- We focus on the pharmacology of GABA transporters, their role in neurotransmission and the targeting of this system in the treatment of epilepsy.
- We study the pharmacology of ionotropic glutamate receptors, which are important for the function of the central nervous system and are potential drug targets.
- We study the biochemical and cellular mechanisms underlying energy and amino acid metabolism in the mammalian brain, as well as metabolic brain disorders.
- The signalling taking place inside cells are often affected in disease. We aim to develop novel ways of manipulating these signals to treat disease.
- We work to shed light on the molecular causes of autoimmunity, and to help develop new drugs for diseases such as multiple sclerosis and rheumatoid/psoriatic arthritis.
- We investigate a number of proteins involved in the infection pathway of HIV and other retroviruses, focusing particularly on the HIV protein p6 and its binding partners.
- We focus on the regulation of vascular tone in health and disease. We aim to improve current diagnosis and treatment of patients suffering from ischemic heart diseases.