Retrovirus Assembly – University of Copenhagen

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Department of Drug Design and Pharmacology > Research > Molecular and Cellular Pharmacology > Retrovirus Assembly

Retrovirus assembly

HIV project

We have earlier indicated that the sequence PLASL binds to the HIV pre-protein Gag. This sequence is also a part of of the HIV protein p6. P6 has importance for the infectious pathway, especially controlling budding by controlling membrane traffic. Secondly, p6 binds to the HIV protein Vpr, which controls the entry. Many other cellular proteins have been shown to interfere with p6. We have set out to find the sequences of other proteins that bind to p6 using phage display. In another project, the assembly of murine retrovirus proteins in cells before budding is investigated.