Pathology of autoimmune inflammation
Autoimmune diseases comprise a broad range of disorders such as multiple sclerosis, rheumatoid arthritis, type I diabetes, psoriasis that affect millions of people worldwide. The causative mechanisms responsible for the development of an immune response directed towards the individual’s own tissue are not fully known. Autoimmune diseases are multifactorial, complex diseases dependent on genetic and environmental factors.
The aim of the research is to identify molecular targets important for disease development in experimental models for autoimmune diseases.
The goal is to explore our findings in drug development projects and to contribute to the understanding of molecular mechanisms in autoimmune pathology.
The research is based on:
- Experimental in vivo models for Multiple Sclerosis, Rheumatoid Arthritis, Psoriatic Arthritis
- Functional genomics studies to identify novel candidate genes important for disease susceptibility
- Studies of disease pathways in congenic and transgenic mice
- In vitro cellular assays
- Protein studies
- Pharmacological studies in in vivo models
- The role for a non-receptor tyrosine kinase in T cell activation and Multiple Sclerosis
- Development of Rheumatoid Arthritis and the role for genes controlling bone formation
- Establishing experimental models for Psoriatic Arthritis