NeuroMet – University of Copenhagen

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Department of Drug Design and Pharmacology > Research > Molecular and Cellular Pharmacology > NeuroMet

NeuroMet - Neurometabolism in health and disease

Neuromet

We study the biochemical and cellular mechanisms underlying energy and amino acid metabolism in the mammalian brain, as well as metabolic brain disorders.

The research in NeuroMet is focused on energy and amino acid metabolism in the mammalian brain. Primary mouse cell culture systems of neurons and astrocytes from cerebral cortex or cerebellum are extensively employed. In addition, genetically modified animals, organotypical hippocampal cultures, acutely isolated brain tissue, isolated mitochondria and cell lines are applied as model systems. An array of 3H, 15N and 13C isotopes is utilized in the mapping of metabolic pathways and their regulation. HPLC and mass spectrometry are key analytical tools combined with biochemical assays, protein biochemistry, molecular biology and fluorescence-based assays and imaging techniques.