Cluster for Metabolism and Inflammation

 

Our mission is to:
Establish a leading interdisciplinary research environment that will contribute to the development of effective therapeutics for metabolic and inflammatory disorders by:

  • Studies of the biochemical basis for the disorders
  • Identification and validation of new targets and therapeutic approaches
  • Development of tool compounds that can enable studies of new target and serve as leads for drug discovery

  

 

 

 

 

2022

  • Petersen, M.J.; Liang, C.; Kjaerulff, L.; Ndi, C.; Semple, S.; Buirchell, B.; Coriani, S.; Møller, B.L.; Staerk, D. Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycaemic drug leads. Phytochemistry 2022, 196, 113072. https://doi.org/10.1016/j.phytochem.2021.113072

2021

  • Liang, C.; Kjaerulff, L.; Hansen, P.R.; Kongstad, K.T.; Staerk, D. Dual high-resolution α-glucosidase and PTP1B profiling combined with HPLC-PDA-HRMS-SPE-NMR analysis for the identification of potentially antidiabetic chromene meroterpenoids in Rhododendron capitatum. Nat. Prod. 2021, 84, 2454-2467. https://doi.org/10.1021/acs.jnatprod.1c00454

2020

  • Beidokhti, M.N.; Eid, H.M.; Villavicencio, M.L.S.; Jäger, A.K.; Lobbens, E.S.; Rasoavaivo, P.; McNair, L.M.; Haddad, P.S.; Staerk, D. Assessment of antidiabetic potential of Psidium guajava using assays for a-glucosidase, a-amylase, muscle glucose uptake, liver glucose production, and triglyceride accumulation if adipocytes. Journal of Ethnopharmacology 2020,257, 112877. https://doi.org/10.1016/j.jep.2020.112877
  • Pedersen, H.A.; Semple, S.J.; Buirchell, B.; Møller, B.L.; Staerk, D. PTP1B-inhibiting branched-chain fatty acid dimers from Eremophila oppositifolia angustifolia identified by high-resolution PTP1B inhibition profiling and HPLC-PDA-HRMS-SPE-NMR analysis. Journal of Natural Products 2020, 83, 1598-1610. https://doi.org/10.1021/acs.jnatprod.0c00070
  • Zhu, J.; Pedersen, M.D.; Ahmed, L.S.; Abdolalizadeh, B.; Grell, A.S.; Berg, J.O.; Thulstrup, P.W., Franzyk, H.; Edvinsson, L.; Sams, A.; Sheykhzade, M.; Hansen, P.R. Fluorescent analogues of human α-calcitonin gene-related peptide with potent vasodilator activity. International Journal of Molecular Sciences 2020, 21,1343. https://doi.org/10.3390/ijms21041343 
  • Aldana, B.I.; Zhang, Y.; Jensen, P.; Chandrasekaran, A.; Christensen, S.K.; Nielsen, T.T.; Nielsen, J.E.; Hyttel, P.; Larsen, M.R.; Waagepetersen, H.S.; Freude, K,K. Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia. Molecular Brain 2020, 13, 125. https://doi.org/10.1186/s13041-020-00658-6
  • Ulven, E.R.; Quon, T.; Sergeev, E,; Barki, N.; Brvar, M.; Hudson, B.D., Dutta, P.; Hansen, A.H., Bielefeldt, L.Ø.; Tobin, A.B,; McKenzie, C.J,; Milligan, G.; Ulven, T. Structure-activity relationship studies of tetrahydroquinolone free fatty acid receptor 3 modulators. Journal of Medicinal Chemistry 2020, 63, 3577-3595. https://doi.org/10.1021/acs.jmedchem.9b02036 

2019

  • Arildsen L, Andersen JV, Waagepetersen HS, Nissen JBD, Sheykhzade M. Hypermetabolism and impaired endothelium-dependent vasodilation in mesenteric arteries of type 2 diabetes mellitus db/db mice. Diab Vasc Dis Res. 2019 Nov;16(6):539-548. doi: 10.1177/1479164119865885. Epub 2019 Jul 31. PMID: 31364402.

 

 

 

portrait of Trond Ulven

Cluster Leader

Trond Ulven
Professor
tu@sund.ku.dk

portrait of Blanca Garcia

Communications Representative

Blanca Irene Aldana Garcia
Assistant professor
blanca.aldana@sund.ku.dk