GHB-ACTION

The project investigates brain mechanisms involving g-hydroxybutyric acid (GHB). We recently discovered that GHB binds to the protein Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIa), a central brain enzyme.

The aim of the project is to understand molecular interactions of our developed GHB related compounds at CaMKIIa, and to utilize this for developing new and better medicines for brain diseases such as cerebral ischemia and narcolepsy.

 

 

 

 

 

 

 

 

The project is funded through a Lundbeck Foundation thematic grant (2019-2024)

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