The common theme of our research is design and synthesis of novel tool compounds for investigating the cellular and molecular function of biological targets. Our overall goal is to identify novel therapeutic principles.
Peptides and Proteins
We develop pharmacological probes and drug leads by engineering proteins, peptides and natural products. We characterize drug target functions through state-of-the-art structural biology, biophysics, functional assaying, and computational biology.
Molecular and Cellular Pharmacology
We focus on a range of biological systems, particularly those that regulate brain function, as well as elements and processes implicated in many neurological disorders.