BUNCH RESEARCH GROUP

BUnch research group

Organic chemistry and medicinal chemistry. Design and synthesis of neuroactive ligands, SAR studies, target-oriented synthesis, new synthetic methodology to access sp3-rich molecules, new planarheterocycles, new techniques in medicinal chemistry


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SELECTED, RECENT PUBLICATIONS

Journal of Medicinal Chemistry, 2017, 60, 9885-9904: Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist./ Gynther, Mikko; Proietti Silvestri, Ilaria; Hansen, Jacob C; Hansen, Kasper B; Malm, Tarja; Ishchenko, Yevheniia; Larsen, Younes; Han, Liwei; Kayser, Silke; Auriola, Seppo; Petsalo, Aleksanteri; Nielsen, Birgitte; Pickering, Darryl S; Bunch, Lennart.

ACS Chemical Neuroscience 2017, 8, 2477-2495: Revisiting the Quinoxalinedione scaffold in the Construction of New Ligands for the Ionotropic Glutamate Receptors. / Demmer, Charles Sylvain; Rombach, David; Liu, Na; Nielsen, Birgitte; Pickering, Darryl S; Bunch, Lennart.


Journal of Medicinal Chemistry 2017, 60, 441-457: Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. / Krogsgaard-Larsen, Niels; Delgar, Claudia; Koch, Karina; Brown, Patricia M G E; Møller, Charlotte; Han, Liwei; Huynh, Tri Hien Viet; Hansen, Stinne Wessel; Nielsen, Birgitte; Bowie, Derek; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen; Frydenvang, Karla Andrea; Bunch, Lennart..

Journal of Medicinal Chemistry 2016, 59, 8771-8786: Beta-Sulfonamido Functionalized Aspartate Analogs as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype-Selectivity Profiles Arising from Subtle Structural Differences. / Hansen, Jacob Christian; Bjørn-Yoshimoto, Walden Emil; Bisballe, Niels; Nielsen, Birgitte; Jensen, Anders A.; Bunch, Lennart.

Journal of Medicinal Chemistry 2016, 59, 8757-8770: Identification of a New Class of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors Followed by a Structure-Activity-Relationship Study. / Hansen, Stinne Wessel; Erichsen, Mette Norman; Fu, Bingru; Bjørn-Yoshimoto, Walden Emil; Abrahamsen, Bjarke; Hansen, Jacob Christian; Jensen, Anders A.; Bunch, Lennart.

Journal of Medicinal Chemistry 2016, 59, 914-924: New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III. / Huynh, Tri H. V.; Erichsen, Mette N.; Tora, Amelie S.; Goudet, Cyril; Sagot, Emmanuelle; Assaf, Zeinab; Thomsen, Christian; Brodbeck, Robb; Stensbol, Tine B.; Bjorn-Yoshimoto, Walden E.; Nielsen, Birgitte; Pin, Jean-Philippe; Gefflaut, Thierry; Bunch, Lennart.

MedChemComm 2016, 7, 2136-2144: Synthesis and Pharmacological Characterization of the Selective GluK1 Radioligand (S)-2-Amino-3-(6-[3H]-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)propanoic acid ([3H]-NF608). / Alcaide, Anna; Marconi, Laura; Marek, Ales; Haym, Isabell; Nielsen, Birgitte; Møllerud, Stine; Jensen, Mikael; Conti, Paola; Pickering, Darryl S; Bunch, Lennart.