Jesper M. Mathiesen

Jesper M. Mathiesen

Associate Professor

  • Molecular and Cellular Pharmacology

    Jagtvej 162, 2100 København Ø

    Phone: +45 35 33 42 44

  1. 2020
  2. Published

    Delineation of molecular determinants for FR900359 inhibition of Gq/11 unlocks inhibition of Gαs

    Boesgaard, M. W., Harpsøe, Kasper, Malmberg, M., Underwood, C. R., Inoue, A., Mathiesen, Jesper M., König, G. M., Kostenis, E., Gloriam, David E. & Bräuner-Osborne, Hans, 2020, In : The Journal of Biological Chemistry. 295, p. 13850-13861

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells

    Møller, Thor C., Pedersen, M. F., van Senten, Jeffrey Roy, Seiersen, S. D., Mathiesen, Jesper M., Bouvier, M. & Bräuner-Osborne, Hans, 2020, In : Scientific Reports. 10, 1, 13 p., 17395.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Structures of metabotropic GABAB receptor

    Papasergi-Scott, M. M., Robertson, M. J., Seven, A. B., Panova, O., Mathiesen, Jesper M. & Skiniotis, G., 2020, In : Nature. 584, 7820, p. 310-314 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2019
  6. Published

    Probing the Existence of a Metastable Binding Site at the β2-Adrenergic Receptor with Homobivalent Bitopic Ligands

    Gaiser, B. I., Danielsen, M., Marcher, Emil, Røpke Jørgensen, K., Wróbel, T. M., Frykman, M., Johansson, H., Bräuner-Osborne, Hans, Gloriam, David E., Mathiesen, Jesper M. & Sejer Pedersen, D., 12 Sep 2019, In : Journal of Medicinal Chemistry. 62, 17, p. 7806-7839 34 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Structural Insights into the Process of GPCR-G Protein Complex Formation

    Liu, X., Xu, X., Hilger, D., Aschauer, P., Tiemann, J. K. S., Du, Y., Liu, H., Hirata, K., Sun, X., Guixa-Gonzalez, R., Mathiesen, Jesper M., Hildebrand, P. W. & Kobilka, B. K., 16 May 2019, In : Cell. 177, 5, p. P1243-1251

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Structural insights into the activation of metabotropic glutamate receptors

    Koehl, A., Hu, H., Feng, D., Sun, B., Zhang, Y., Robertson, M. J., Chu, M., Kobilka, T. S., Laeremans, T., Steyaert, J., Tarrasch, J., Dutta, S., Fonseca, R., Weis, W. I., Mathiesen, Jesper M., Skiniotis, G. & Kobilka, B. K., 7 Feb 2019, In : Nature. 566, 7742, p. 79-84

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2018
  10. Published

    Gs protein peptidomimetics as allosteric modulators of the β2-adrenergic receptor

    Boyhus, L. E., Danielsen, M., Bengtson, N. S., Kunze, M. B. A., Kubiak, X., Sminia, T. J., Løper, J. H., Tran, P. T., Lindorff-Larsen, Kresten, Rasmussen, Søren Gøgsig Faarup, Mathiesen, Jesper M. & Pedersen, D. S., 2018, In : RSC Advances. 8, 4, p. 2219-2228 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2016
  12. Published

    Allosteric modulators of group III metabotropic glutamate receptors as novel therapeutics

    Mathiesen, Jesper M. & Teresa Ramirez, M., 19 Apr 2016, Allosteric Receptor Modulation in Drug Targeting. CRC Press, p. 207-234 28 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  13. 2015
  14. Published

    A cAMP Biosensor-Based High-Throughput Screening Assay for Identification of Gs-Coupled GPCR Ligands and Phosphodiesterase Inhibitors

    Vedel, L., Bräuner-Osborne, Hans & Mathiesen, Jesper M., 2015, In : Journal of Biomolecular Screening. 20, p. 849-857 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2014
  16. Published

    mGluR5: Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery

    Mølck, C., Harpsøe, Kasper, Gloriam, David E., Mathiesen, Jesper M., Nielsen, S. M. & Bräuner-Osborne, Hans, Oct 2014, In : Neurochemical Research. 39, 10, p. 1862-1875 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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