News


September 1, 2019
Petrine Wellendorph and Hans Bräuner-Osborne have each received grants of 10 mio DKK from the Lundbeck Foundation to study gamma-hydroxybutyric acid (GHB) and G protein-coupled receptor pharmacogenomics, respectively. You can read more about the latter project here.


September 1, 2019
SUND-KU researchers and Ceremedy founders Birgitte Kornum (IN), Petrine Wellendorph (ILF) and Bente Frølund (ILF) have received a 3.5 mio DKK pre-seed grant from the Novo Nordisk Foundation to continue and extend their efforts in CNS drug discovery. This is the second pre-seed grant for the purpose. The research will be carried out partly at SUND, partly through contract-based research.


July 5, 2019
Maria Elena Klibo Lie received a grant of 395,000 DKK from the Hørslev Foundation for a project entitled "Functional investigations into the GABA/betaine transporter (BGT1) as a novel drug target for ischemic stroke".


May 31, 2019
Petrine Wellendorph received a grant of 478,000 DKK from the Simon Fougner Hartmanns familiefond to purchase a iBright imaging system.


October 1, 2018
Petrine Wellendorph, Bente Frølund, Birgitte Kornum and Casper Tind Hansen have received a pre-seed grant from the Novo Nordisk Foundation to found the biotech company Ceremedy ApS. The company focus on drug discovery in CNS disorders based on analogs of the neuroactive substance gamma-hydroxybutyric acid (GHB). The group has also received a proof-of-concept grant from the Technology Transfer Office at University of Copenhagen.


May 1, 2018
Petrine Wellendorph and Hans Bräuner-Osborne have each received grants of 2.6 million DKK from the Danish Council for Independent Research | Medical Sciences for projects entitled "Dissecting mGlu5 receptor internalization pathways using genetic and pharmacological tools" and "Investigations into the mechanism-of-action of GHB analogues via a novel site", respectively.


January 29, 2018
Thor C. Møller has received a 2-year Marie Skłodowska-Curie Individual Fellowship of 212,000 € for a project entitled "Dissecting mGlu5 receptor internalization pathways using genetic and pharmacological tools" to be performed in the Hans Bräuner-Osborne group.



January 26, 2018
Anders Bue Klein and Petrine Wellendorph have received grants of 70,000 and 25,000 DKK from The A. P. Møller Foundation for the Advancement of Medical Sciences for studies of the GHB receptor and BGT1 transporter, respectively.

December 8, 2017
Petrine Wellendorph and Hans Bräuner-Osborne received grants of 1.1 and 1.4 mio. DKK from the Novo Nordisk Foundation for projects entitled "Pharmacological characterization of GHB analogues at a novel target" and "Molecular pharmacology of the orphan GPR15 receptor", respectively.


December 3, 2017
Anders A. Jensen has received a grant of 144,000 DKK from the Independent Research Fund Denmark | Medical Sciences for a scholar student project entitled "Probing the molecular basis for the selective modulation of 5-HT1B/1D receptors by the endogenous peptide 5-HT-moduline".


December 3, 2017
Anders A. Jensen has received a grant of 200,000 DKK from the Augustinus Foundation for a project entitled "Purchase of a compound library for screenings at neurotransmitter receptors and transporters in the search for interesting pharmacological tools".


November 24, 2017
Hans Bräuner-Osborne has received grants of 30,000 € and 60,000 DKK from the journal Basic & Clinical Pharmacology & Toxicology and the Carlsberg Foundation, respectively, to organize a conference entitled "GPCR Pharmacology - the next generation" in the Fall of 2018. The conference will be co-organized by Assoc. Prof. David Gloriam, Prof. Mette M. Rosenkilde and Prof. Ulrik Gether.


November 24, 2017
Anders A. Jensen received a grant of 1,000,000 DKK from the Carlsberg Foundation for a project entitled ”Studies of ligand-gated ion channel signaling using the QPatch 16, an automated patch-clamp system”.


November 24, 2017
Hans Bräuner-Osborne received a grant of 160,000 DKK from the Carlsberg Foundation to co-finance purchase of another Envision plate reader necessary to conduct a large ongoing orphan receptor screen.


November 2, 2017
Petrine Wellendorph has received a grant of 200,000 DKK from the Augustinus Foundation for a project entitled "New medicine to treat brain injuries".


September 5, 2017
Hans Bräuner-Osborne received a grant of 400,000 DKK from the Novo Nordisk Foundation for a project entitled "Dissecting GLP-1 receptor internalization pathways using genetic and pharmacological tools".


July 11, 2017
Hans Bräuner-Osborne received a grant of 100,000 DKK from Toyota Fonden to co-finance purchase of another Envision plate reader necessary to conduct a large ongoing orphan receptor screen.


June 14, 2017
The Bräuner-Osborne group is part of a group of basic and clinical researchers at the University of Copenhagen and the Capital Region of Copenhagen Hospitals who have just been awarded a "Clinical-Academic-Group (CAG)" grant for a translational project entitled "Precision Diagnostics in Cardiology". You can read more about the new funding initiative and project here [in Danish].


June 12, 2017
The Bräuner-Osborne and Strømgaard groups have published a collaborative article in ChemMedChem, which made it to the front page of the current issue. The cover image illustrates how one of the natural product analogs synthesized in the article is envisioned to bind to the target Gq protein. You can read the full article here [paywalled].

 


March 28, 2017
Christina Falk-Petersen and Patrick Gentry have received PhD scholarship and postdoc fellowship grants of 1,575,000 DKK and 2,100,000 DKK from the Lundbeck Foundation for projects entitled "Molecular pharmacology studies on the involvement of ß1-containing GABAA receptors in neurotransmission" and "Development of novel tool molecules for the study of orphan G protein-coupled receptor biology", respectively.


February 23, 2017
Anders A. Jensen has received a grant of 350,000 DKK from the Augustinus Foundation for to purchase a state-of-the-art scintillation counter to be used in pharmacological experiments with radiolabeled ligands.


September 22, 2016
Hans Bräuner-Osborne has received a grant of 100,000 DKK from the Augustinus Foundation for a project entitled "Pharmacological characterization of metabotropic glutamate receptors".


July 1, 2016
Petrine Wellendorph has received a grant of 760,000 DKK from the Lundbeck Foundation for a six month visiting professorship for Dr. Delia Belelli for a project entitled "GABAA receptors containing the α4 subunit: a common relevant target for neurosteroids and GHB?".


June 30, 2016
Anders A. Jensen has received a grant of 200,000 DKK from the Augustinus Foundation for a project entitled "Studies of 'orphan' Cys-loop receptors in fish".


June 22, 2016
Anders A. Jensen has received a grant of 2.6 mio. DKK from the Danish Council for Independent Research | Medical Sciences for a project entitled "Functional Properties of the Recombinant and the Native Zinc-Activated Channel".             


April 25, 2016
Anders A. Jensen has received two grants of 100,000 DKK and 200,000 DKK from the Augustinus Foundation for projects entitled "Identifikation af Allosteriske Modulatorer af Oxytocin Receptoren" and "Molekylær opbygning og signalering af α1α3βγ GABAA receptorer", respectively.


April 25, 2016
Anders A. Jensen has received a grant of 1,050,000 DKK from the Lundbeck Foundation for a PhD scholarship project entitled "Allosteric Modulation of alpha6* Nicotinic Acetylcholine Receptors".


March 31, 2016
Simon R. Foster received a grant of 100,000 DKK from the Augustinus Foundation to co-finance purchase of another Envision plate reader necessary to conduct his large upcoming orphan receptor screen.


March 18, 2016

Today the Molecular Pharmacology Group celebrated the completion of our move back to campus after almost 6 years 'outposting' at Symbion. We have moved into state-of-the-art facilities in the new Pharma Science Building. Really nice that all our laboratories are now connected on one floor. Great to be back on campus!


February 9, 2016
Kristian Strømgaard (PI), Hans Bräuner-Osborne (co-PI) and David Gloriam (contributor) have received a Large Biomedical Project grant of 10,000,000 DKK from the Lundbeck Foundation for a project entitled "Novel principles for targeting intracellular receptor signaling pathways in the brain".


November 27, 2015
Petrine Wellendorph has received a grant of 150,000 DKK from the Carlsberg Foundation to purchase a MACS cell separator, which will enable us to isolate primary cells fast and reproducibly.


October 16, 2015
Ulrike Leurs has received a 1 year post doc of 700,000 DKK from the Lundbeck Foundation for a project entitled "Proteomics-based Identification and Characterization of a Family of GHB-Binding Proteins in the Mammalian Brain".


September 16, 2015
Hans Bräuner-Osborne received a grant of 100,000 DKK for running costs from the Augustinus Foundation for a project entitled "Development of highly potent antagonists to investigate the role of the GPRC6A receptor in regulation of metabolism".


September 15, 2015
Anders Bue Klein has received a grant of 80.000 DKK from the Aase and Ejner Danielsens Foundation for running costs for a project entitled "Investigations of gene expression in neurons after stimulation with GHB and the GHB analog HOCPCA".


September 7, 2015
Petrine Wellendorph and Hans Bräuner-Osborne have each received grants of ~440.000 DKK from the Research and Innovation Committee at the Department of Drug Design and Pharmacology for hiring Dr. Line Vedel and Dr. Ulrike Leurs as post docs for projects entitled "Pharmacological characterization of allosteric modulator selectivity hotspots in metabotropic glutamate receptors" and "Prying into GHB binding proteins by proteomics", respectively.


June 10, 2015
Hans Bräuner-Osborne has received a 3 year grant of 2.7 million DKK from the Danish Council for Independent Research | Medical Sciences for a PhD scholarship to Mie Fabricius Wöldike for a project entitled "Holistic delineation of biased µ-opioid receptor signaling".


May 12, 2015
Hans Bräuner-Osborne and Petrine Wellendorph has obtained a grant of up to 290,000 € for a PhD scholarship on biased signaling of the calcium-sensing receptor. The project is part of the Marie Skłodowska-Curie European Training Network program "CaSR Biomedicine" coordinated by Dr. Enikö Kallay, Medical University Wienna with a total budget of up to 3,66 million €. 


March 26, 2015
Simon R. Foster has received 700,000 DKK for a 3rd year of his post doc  from the Lundbeck Foundation for the project entitled "Novel strategies to elucidate orphan GPCR biology".


February 17, 2015
Simon R. Foster has received a 2 year post doc grant of 1.9 million DKK from the Danish Council for Independent Research | Medical Sciences for a project entitled "Novel strategies to elucidate orphan GPCR biology".


January 27, 2015
David Gloriam has received a prestigious Lundbeckfond Fellowship of 10 million DKK from the Lundbeck Foundation for a project entitled "Orphan receptor ligands and signals: Keys to physiological functions and drug discovery". Hans Bräuner-Osborne is co-PI and will mentor two molecular pharmacological post docs as part of the project.


December 31, 2014
Christina Rye Underwood has received a post doc fellowship of 2.1 million DKK from the Lundbeck Foundation for a project entitled "Development and characterization of G protein inhibitors". The project will be conducted in the Bräuner-Osborne group in collaboration with prof. Roger Sunahara, University of California at San Diego, USA.


December 16, 2014
David Gloriam has received a prestigeous Starting Grant of of 11.4 million DKK each from the European Research Council for a project entitled "Determination of orphan receptor physiological agonists and signals". Hans Bräuner-Osborne is co-PI and will mentor two molecular pharmacological post docs as part of the project.


December 13, 2014
Stine Jørgensen and Hans Bräuner-Osborne have received grants of 50,000 DKK each from The A. P. Møller Foundation for the Advancement of Medical Sciences for studies of the GPRC6A receptor. Rikke Søgaard and Petrine Wellendorph received 50,000 and 80,000 DKK for studies of the GHB receptor and transporter, respectively.


November 7, 2014

Maja Jessen and Maria Amat Foraster have each received an Industrial PhD fellowship from  Innovation Fund Denmark for projects entitled "Mechanism of action studies of clinical active NMDA compounds on both hetero- and triheteromeric NMDA receptors expressed in vitro" and "Modulating NMDA receptors in the thalamocortical system – a novel approach to treatment of depression", with Hans Bräuner-Osborne and Anders A. Jensen as principal supervisors, respectively. Both scholarships have H. Lundbeck A/S as industrial partner.


October 29, 2014
Professor Markus Seibel, ANZAC Research Institute, Sydney, Australia (PI), Hans Bräuner-Osborne (co-PI) et al. have received a grant of 615,000 AUD from the National Health and Medical Research Council (NHMRC), Australia for a project entitled 'How Does Osteocalcin Reverse Glucocorticoid- Induced Dysmetabolism?'. PhD student Christinna V. Jørgensen will be the Danish researcher working on the project together with Australian colleagues.


October 10, 2014
Angela Arsova (Hans Bräuner-Osborne group), Birgit Isabel Gaiser (Daniel Sejer Pedersen group) and Louise Thiesen (Petrine Wellendorph group) have each received a PhD scholarship from the Faculty of Health and Medical Science for projects entitled "ß-arrestin mediated internalization and biased signaling of metabotropic glutamate receptors", "Targeting Meta-Stable Binding Sites with Bitopic Ligands – A New Concept in GPCR Medicinal Chemistry" and "Pharmacological Characterization of Membrane Transporters for γ-Hydroxybutyric Acid ( GHB)", respectively.


August 28, 2014
Hans Bräuner-Osborne has received a grant of 500,000 DKK from the Novo Nordisk Foundation to cover researcher salary and running costs for a project entitled "In vitro characterization of single nucleotide polymorphisms (SNPs) in the GPRC6A receptor and correlation with metabolic phenotypes in humans".


June 27, 2014

Josefine Nørgaard and Hans Bräuner-Osborne received a grant of 150.000 DKK from the Sawmill owner Jeppe Juhl and wife Ovita Juhl's Memorial Foundation to hire pharmacist student Josefine Nørgaard as a scholarship student for a project entitled "Development of novel signaling molecules to investigate brain function".


June 23, 2014

Anders A. Jensen and Hans Bräuner-Osborne each received a grant of 1 million DKK from the Department of Drug Design and Pharmacology to co-finance two 2/3 PhD scholarships. In addition, Hans Bräuner-Osborne received a grant of 100.000 AUD from the ANZAC Institute, Australia to co-finance 1/3 PhD scholarship.


June 11, 2014
Hans Bräuner-Osborne received a grant of 130.000 DKK from the Danish Council for Independent Research | Medical Sciences to hire pharmacist student Isabella Kok Helgogaard as a scholarship student for a project entitled "Characterization of single nucleotide polymorphisms (SNPs) in the human GPRC6A receptor".


May 26, 2014
Anders Bue Klein received a grant of 100.000 DKK for running costs from the Desirée & Niels Ydes Foundation for a project entitled "Neuroprotective mechanisms of y-hydroxybutyric acid (GHB) receptors: Therapeutic potential in neurodegenerative disorders". The project will run as a collaboration with professor Bernhard Bettler, University of Basel, Switzerland.


May 8, 2014
Christoffer Clemmensen co-authors a landmark study in Nature from his scientific visit to the prof. Randy J. Seeley group at University of Cincinnati conducted during his PhD studies in our group. The article is entitled "FXR is a molecular target for the effects of vertical sleeve gastrectomy".
Read popular scientific commentary at Videnskab.dk [in Danish].


March 28, 2014
Mohamed A. Shehata received a PhD scholarship from the Faculty of Health and Medical Science for a project entitled "Discovery of Orphan Receptor Inhibitors -Keys to Novel Physiological Functions and Therapies" to be performed in the David Gloriam group.


January 21, 2014
Hans Bräuner-Osborne received a grant of 375.000 DKK for running costs from the Lundbeck Foundation for a project entitled "In vitro pharmaco- logical characterization of the GPR139 receptor".


January 10, 2014
Hans Bräuner-Osborne received grant of 130.000 DKK from the Danish Council for Independent Research | Medical Sciences to hire pharmacist student Anne Mette Kærn as a scholarship student for a project entitled "Pharmacological characterization of potent and selective agonists at the G protein-coupled receptors GPR32".


December 19, 2013
Petrine Wellendorph has received a prestigeous Fellowship of 10 million DKK from the Lundbeck Foundation for the project "Molecular and Functional Analysis of Brain GHB Receptors".


December 13, 2013
Anders Bue Klein, Trine Kvist, Stine Jørgensen and Hans Bräuner-Osborne have received grants of 70,000 DKK, 77,000 DKK, 80,000 DKK and 50,000 DKK from The A. P. Møller Foundation for the Advancement of Medical Sciences for studies of the GHB (ABK,TK), GPRC6A (SJ) or GPR32 receptor (HBO), respectively.


December 12, 2013
Master student Louise Thiesen has received a Novo Scholarship for project entitled "Molecular pharmacology of monocarboxylate transporters – Targets for gamma-hydroxybutyric acid (GHB) analogues?".


December 4, 2013
Petrine Wellendorph and Hans Bräuner-Osborne have each received a grant of 200,000 DKK from the Carlsberg Foundation to purchase a molecular imager for autoradiography measurements and Viaflo 384-well pipettor, respectively.


October 11, 2013
Anne Cathrine Nøhr received a PhD scholarship from the Faculty of Health and Medical Science for a project entitled "In vitro pharmacological characterization of the GPR139 receptor" to be performed in the Hans Bräuner-Osborne group.


October 10, 2013
Anders A. Jensen has received a grant of 100.000 DKK from the Aase and Ejner Danielsens Foundation for running costs for a project entitled "Identification, development and characterization of compounds with actitivity at Group II metabotropic glutamate (mGlu) receptors and the possible mGlu2/5-HT2A complex, and their potential in schizophrenia".


September 27, 2013
Anders Bue Klein and Trine Kvist each received post doc grants of 3.0 million DKK from the Danish Council for Independent Research | Medical Sciences for projects entitled "On the neurophysiological role of GHB: Identification of molecular mechanisms and studies on the neuroprotective effects of GHB (γ-hydroxybutyrate) and GHB analogues" and "Molecular and cellular pharmacology of triheteromeric GluN3-containing NMDA receptors", respectively.


September 20, 2013
Anders Bue Klein received a grant of 50.000 DKK from Dagmar Marshalls Fond for equipment to be used in a project entitled "Characterization of GHB bindingsites in the brain".


August 19, 2013
Daniel S. Pedersen has received a grant of 80.000 DKK from the Lundbeck Foundation to hire a scholarship student for the project "ß-Arrestin-1 derived peptide ligands as intracellular modulators of the ß2 adrenergic receptor – Investigating the function and signalling for G protein-coupled receptors".


July 24, 2013
The pharmacological tool compound PU02, discovered by the Anders A. Jensen group has become commerically available from Tocris Biosciences. PU02 is a potent and selective negative allosteric modulator at 5-HT3 receptors.


June 21, 2013
Anders Bue Klein and Hans Bräuner-Osborne received grants of 380,000 DKK and 595,000 DKK, respectively, for a 6 month post doc each and running costs from the Hørslev Foundation for projects entitled "In vitro and in vivo characterization of the GPR139 receptor" and "Characterization of the molecular mechanism of action of GHB".


June 13, 2013
David Gloriam received grant of 2.0 million DKK from the Danish Council for Independent Research | Medical Sciences to hire a post doc for a project entitled "Discovery of Orphan and Chemokine Receptor Ligands - Keys to Novel Physiological Functions and Therapies".


June 7, 2013
Anders A. Jensen received a grant of 100,000 DKK for running costs from the Augustinus Foundation for a project entitled "Identification, development and characterization of ligands with activity at group II metabotropic glutamate (mGlu) receptors and the potential mGlu2/5-HT2A complex and their potential in schizophrenia".


June 5, 2013
Petrine Wellendorph received a prestigeous Sapere Aude DFF-Starting Grant of 6.8 million DKK from the Danish Council for Independent Research for a project entitled "Molecular and Functional Analysis of Brain GHB Receptors". [subsequently declined due to award of overlapping Lundbeckfond Fellowship]


May 14, 2013
Daniel S. Pedersen has received a grant of 1.2 million DKK from the Lundbeck Foundation to hire a post doc for the project "New Synthetic Organic Methodologies Based on Endoperoxide Chemistry – Synthesis of Potential Tumor Selective Chemotherapeutics".


May 1, 2013
Lotte-Emilie Boyhus received a PhD scholarship from the Faculty of Health and Medical Science for a project entitled "Peptidomimetics for the Study of G Protein-Coupled Receptors - Elucidating GPCR Function and Signalling for the beta2 Adrenergic Receptor" with Daniel S. Pedersen and Jesper L. Kristensen [MedChem group] as supervisors.


April 8, 2013
Hans Bräuner-Osborne received a grant of 300.000 DKK for running costs from the Lundbeck Foundation for a project entitled "Cross-talk between GPRC6A and calcium-sensing receptors - effects on receptor pharmacology, signaling and trafficking".


March 23, 2013
Henrik Johansson received a research scholarship of 50.000 SEK from the Stiftelsen Markussens Studiefond. The grant was awarded at a ceremony at Teleborg Castle in Sweden.


February 21, 2013
Stine Engesgaard Jacobsen received a PhD scholarship from the Faculty of Health and Medical Science for a project entitled "Cross-talk between GPRC6A and calcium-sensing receptors - effects on receptor pharmacology, signaling and trafficking" with Hans Bräuner-Osborne and Ulrik Gether [Dept. of Neuroscience and Pharmacology] as supervisors.


February 7, 2013

Alex Rojas Bie Thomsen who recently graduated as PhD from our group received a prestigenous DFF - Postdoc grant of 1 million DKK from The Danish Council for Independent Research. The grant will give a great boost to his post doc project entitled "Development of a cell free approach for determining the G protein or β-arrestin bias of ligands at 7 transmembrane receptors", which he is currently undertaking in the laboratory of Nobel Laureate Robert J. Lefkowitz, Duke University.


February 6, 2013
Anders Bue Klein has received a grant of 146.000 DKK from the Aase and Ejner Danielsens Foundation to purchase a state-of-the-art Stratagene MX3005P qPCR machine.


December 21, 2012
Anders Bue Klein, Petrine Wellendorph and Hans Bräuner-Osborne have received grants of 37,000 DKK, 50,000 DKK and 75,000 DKK from The A. P. Møller Foundation for the Advancement of Medical Sciences for studies of the GHB (ABK,PW) and mGluR5 receptor (HBO), respectively.


December 15, 2012
Hans Bräuner-Osborne has received a grant of 420,000 DKK from the Carlsberg Foundation to purchase the soon-to-be-released Corning Epic BT label-free microplate reader, which will be used in our deorphanization projects to identify novel GPCR ligands.


December 7, 2012
High school student Viktor Hesselberg-Thomsen from Helsingør Gymnasium won the 'Årets Forskerspire 2012' prize [Research Talent of the Year] in the category of Bio- and Health Sciences. The prize was awarded by the Minister for Science, Innovation and Higher Education Morten Østergaard. Viktor's project proposal is to develop an 'elixir of love' by targeting the oxytocin receptor with an allosteric ligand. He was supervised by PhD students Lenea Nørskov-Lauritsen, Christoffer Clemmensen and professor Hans Bräuner-Osborne.


November 23, 2012

Petrine Wellendorph received a grant of 1.3 million DKK from the Lundbeck Foundation to hire a PhD student for a project entitled "GABA transporters subtypes and their functional relevance in strokes".


November 22, 2012
Hans Bräuner-Osborne received grant of 130.000 DKK from the Danish Council for Independent Research | Medical Sciences to hire a scholarship student for a project entitled "Molecular mechanisms of novel positive allosteric modulators at the metabotropic glutamate receptor subtype 5".


September 26, 2012
Anders A. Jensen and Hans Bräuner-Osborne received grants of 3.8 and 3.1 million DKK from the Danish Council for Independent Research | Medical Sciences for projects entitled "Novel tools for the dissection of excitatory amino acid transporter function and expression" and "Molecular and cellular pharmacology of the GPRC6A G protein-coupled receptor", respectively. In addition Anders A. Jensen received a 3-year ph.d. scholarship grant from the Department of Drug Design and Pharmacology for a project entitled "Allosteric modulation of 5-HT3 serotonin receptors".


September 25, 2012
Daniel Sejer Pedersen received a 2-year post doc grant from the Lundbeck Foundation to hire a PhD student for a project entitled "Bio-Molecular Recognition with Beta-Peptidic Foldamers".


August 23, 2012

Today, Ph.D. students Laura Friis Egholm and Christoffer Clemmensen received a Poster Prize and Young Investigator Award, respectively. Laura received her prize at the annual Drug Research Academy Summer Conference and Christoffer received his award for an oral presentation at the 19th International Symposium on Regulatory Peptides.


July 2, 2012

Today the Petrine Wellendorph group, Hans Bräuner-Osborne and collaborators at the department and University of Sydney published an article in the high-ranking journal Proceedings of the National Academy of Sciences USA (PNAS). In the article we show that α4βδ GABAA receptors are high-affinity targets for γ-hydroxybutyric acid (GHB) a.k.a. known as the drug of abuse Fantasy.


May 16, 2012

Group member Jesper M. Mathiesen co-authors a landmark article in today's issue of Nature together with the Brian Kobilka group at Stanford University, USA. In the article, the X-ray 3D structure of the µ-opioid receptor is revealed, which is an important drug target. Interestingly, it is also demonstrated that the receptor is a dimer in the crystal, which correlate with previous pharmacological and biochemical data.


February 9, 2012
Hans Bräuner-Osborne received the Elite Researcher Prize of 1.2 million DKK from the Danish Ministry of Research, Innovation and Higher Education. The prize is given to an outstanding Danish researcher for an excellent contribution to Danish science.


January 23, 2012
David Gloriam and Hans Bräuner-Osborne have each received 200,000 DKK from the Lead Discovery initiative at the Department of Molecular Drug Research to purchase privileged structure and endogenous peptide libraries for our GPCR deorphanization projects.


December 19, 2011

Petrine Wellendorph, Anders A. Jensen and Hans Bräuner-Osborne have received grants of 50,000 DKK, 45,000 DKK and 40,000 DKK from The A. P. Møller Foundation for the Advancement of Medical Sciences for the projects "Identification of compounds with specific action on GABA transporters in the brain", "Development of glutamate transporter ligands and use of these in studies of transporter physiology" and "Development of novel selective serotonin 5-HT2A receptor ligands", respectively.


December 7, 2011
Sanela Smajilovic and Jesper Mosolff Mathiesen have each received a 2-year post doc grant from the Carlsberg Foundation. Furthermore, Petrine Wellendorph got a grant to hire Anders Bue Klein as post doc for 1 year.


December 1, 2011
Anders A. Jensen received the annual Researcher of the Year prize of 20,000 DKK from the Faculty of Pharmaceutical Sciences. The prize was given based on his high level research within molecular pharmacology and medicinal chemistry.


November 23, 2011
David Gloriam has received a grant of 300,000 DKK from the Novo Nordisk Foundation for a project entitled "Chemogenomic Identification Of Pharmacological Tool Compounds for Orphan Receptors".


October 10, 2011
Hans Bräuner-Osborne has received a grant of 60,000 DKK from Brødrene Hartmanns Fond to cover running costs for the project entitled "Characterization of binding mechanisms for mGluR5 selective allosteric modulators".


September 29, 2011
In todays issue 477 of Nature group member Jesper M. Mathiesen co-authors landmark article entitled "Crystal structure of the ß2 adrenergic receptor–Gs protein complex". During his post doc Jesper M. Mathiesen has been visiting scientist for 1 year in the professor Brian K. Kobilka group at Stanford where he performed experiments published in the article, which for the first time shows the 3D structure of a G protein-coupled receptor and its G protein.


September 2, 2011
David Gloriam has received a grant of 200,000 SEK from Stiftelsen Olle Engkvist Byggmästare to purchase a library of privileged structures for the project entitled "Chemogenomic identification of pharmacological tool compounds for orphan receptors".


September 1, 2011
Hans Bräuner-Osborne has received a grant of 500,000 DKK from Novo Nordisk Foundation to cover post doc salary and running costs for the project entitled "Delineation of the molecular mechanism(s) of metabolic disturbances in GPRC6A knockout mice".


April 13, 2011
Anders A. Jensen has received a grant of 1,100,000 DKK from the Lundbeck Foundation to hire a PhD student for a project entitled "Human alpha6 nicotinic acetylcholine receptors: Molecular pharmacology and therapeutic perspectives".


March 25, 2011
Anders A. Jensen has received a highly prestigeous Hallas Møller stipend from the Novo Nordisk Foundation of 11 million DKK for a 5-year period to study GABAA receptors using molecular pharmacological and genetic tools.


February 7, 2011
Anders A. Jensen has received a grant of 100,000 DKK from Aase og Ejner Danielsens Fond to cover running costs for the project entitled "Development and characterization of alpha6 nicotinic acetyl choline receptor ligands and evaluation of their therapeutic potential as anti-parkinsons disease drugs".


January 27, 2011
Vikram Kjøller Bhatia has received a prestigenous DFF - Postdoc grant of approximately 1 million DKK from The Danish Council for Independent Research. The grant will give a great boost to his post doc project entitled "Molecular and cellular pharmacology of the GPRC6A G protein-coupled receptor".


December 21, 2010
Hans Bräuner-Osborne has received a grant of 50,000 DKK from The A. P. Møller Foundation for the Advancement of Medical Sciences for the project "Characterization of binding mechanisms for mGluR5 selective allosteric modulators".


December 13, 2010
David E. Gloriam has received a 3-year post doc grant of approximately 1,2 million DKK from the Carlsberg Foundation and 1 million DKK from the Lundbeck Foundation for a project entitled "Chemogenomic identification of pharmacological tool compounds for orphan receptors".


December 6, 2010
Anders A. Jensen has received a grant of 200,000 DKK from the Novo Nordisk Foundation for a project entitled "Molecular pharmacology of human alpha6 nicotinic acethylcholine receptors".


September 30, 2010
Hans Bräuner-Osborne has received a grant of 1,525,000 DKK from the Lundbeck Foundation to hire a PhD student for a project entitled "Elucidation of the physiological ligand and function of GPR139 - a G protein-coupled receptor linked to neurological disease".


July 5, 2010.
Kirsten Bayer Andersen and Morten Grupe have each received an Industrial PhD scholarship to work on collaborative projects between H. Lundbeck A/S and Hans Bräuner-Osborne, and NeuroSearch A/S and Anders A. Jensen, respectively.


July 1, 2010.
Our group has moved to Symbion Science Park located 2 km from the Department of Medicinal Chemistry building. We have thereby obtained much needed additional laboratory and office space in a state-of-the-art facility.


June 11, 2010.
Bjarke Abrahamsen and Vikram Kjøller Bhatia have each received 3-year post doc grants of approximately 3 million DKK from the Danish Medical Research Council to work on the molecular pharmacology of EAAT glutamate transporters and the GPRC6A receptor, respectively.


March 19, 2010.
Anders Asbjørn Jensen has received a grant of 250,000 DKK from The Augustinus Foundation for running costs for the project "Molecular pharmacology studies of excitatory amino acid transporters and their ligands".



February 9, 2010
Hans Bräuner-Osborne has received a grant of 122,000 DKK from the Danish Medical Research Council to hire Master of Pharmacy student Semsi Kiiic as scholarship student for a project entitled "Development of the first selective ligands for the GPRC6A receptor - a novel human G protein-coupled receptor with unknown physiological functions".


December 22, 2009
Hans Bräuner-Osborne has received a grant of 148,000 DKK from The Augustinus Foundation to obtain a setup to perform electrophysiological recordings in Xenopus oocytes expressing NMDA receptors.


December 21, 2009
Hans Bräuner-Osborne has received a grant of 3,120,000 DKK from the Danish Medical Research Council to hire a post doc for a project entitled "Development of allosteric ß2 adrenergic receptor modulators and delineation of their mechanism of action".


December 14, 2009.
Today Anders A. Jensen received a grant of 300.000 DKK from the Carlsberg Foundation to acquire a FLEXstation3 Plate Reader.


September 30, 2009
Hans Bräuner-Osborne has received a grant of 1,200,000 DKK from the Lundbeck Foundation to hire a PhD student for a project entitled "Identification of allosteric modulators from extended ß2 adrenergic receptor agonist fragments".


September 22, 2009
Hans Bräuner-Osborne has received a grant of 50,000 DKK from the Beckett Foundation to cover running costs for the project entitled "Regulation of phosphate homeostasis by the calcium-sensing receptor"




January 29, 2009
Today Trine Kvist will receive a "EliteForsk" travel prize of 250.000 DKK from the Ministry of Science Technology and Innovation. The prize will be used to travels to our collaborator professor Stephen F. Traynelis at Emory University, USA in order to study NMDA receptors by sophisticated electrophysiological methods.


December 22, 2008
Anders A. Jensen has received a grant of 1,700,000 DKK from the Lundbeck Foundation to hire a PhD student for a project entitled "Molecular pharmacology studies of the 5-HT3 serotonin receptor and other Cys-loop receptors".


December 17, 2008
Today it was announced that the Minstry of Science, Technology and Innovation has awarded 120 million DKK to establish the research center "Food, Fitness & Pharma for Health and Disease" at the University of Copenhagen. Our group participate in the center, which will be led by professor Thue W. Schwartz at the Faculty of Health.


December 14, 2008
Petrine Wellendorph has received a grant of 78,000 DKK from Fonden til Lægevidenskabens Fremme for the project "Cloning and characterization of the GHB receptor". The foundation is part of the A.P. Møller Foundation.


December 10, 2008
Today Anders A. Jensen received a grant of 450.000 DKK from the Carlsberg Foundation to acquire a medium throughput electrophysiological screening system and expand our diverse compound screening library.



December 5, 2008
Today we published a popular scientific article in Danish about our GABA transporter project in the annual magazine Lægemiddelforskning. Download the article here.



 


November 27, 2008
Anders A. Jensen and Hans Bräuner-Osborne have each received a grant of 250,000 DKK from the Novo Nordisk Foundation for the glutamate transporter and GPRC6A receptor projects, respectively.


November 26, 2008
Anders A. Jensen has received a grant of 1,620,000 DKK from the Danish Medical Research Council for the project "Molecular pharmacology studies of nicotinic acetylcholine receptors and GABA receptors".


November 21, 2008
Today Anders A. Jensen received 90,000 DKK from Aase og Ejner Danielsens Fond to expand our diverse screening compound library from 3,000 to 5,000 compounds.


November 4, 2008
Today the union PharmaDanmark published a informercial in the newspaper "Politiken" where ph.d. student Trine Kvist was pictured on the front page and professor Hans Bräuner-Osborne was interviewed about personalized medicine (on page 4). Download the informercial in PDF format here.


September 10, 2008
Today it was announced that Petrine Wellendorph has been awarded a prestigious For Women in Natual Sciences grant of 100,000 DKK sponsored by L'Oréal, UNESCO and The Royal Danish Academy of Science and Letters.


August 16, 2008
Jesper M. Mathiesen has received a grant of 122,000 DKK from the Lundbeck Foundation to cover running costs for the project entitled "Using the ß2 adrenoceptor to understand molecular mechanisms of allosteric modulation of GPCRs".


June 16, 2008
Hans Bräuner-Osborne has received a Alfred Benzon Investigator Fellowship to hire David Gloriam for the project entitled "Identification and elucidation of mechanism-of-action of allosteric ligands for the ß2-adrenergic receptor". Petrine Wellendorph has received a 1-year Alfred Benzon Researcher Stipend for the project entitled "Cloning and characterization of the GHB receptor".


June 15, 2008
Anders A. Jensen has received a grant of 97,000 DKK from Direktør Ib Henriksens Foundation and a grant of 70,000 DKK from The Augustinus Foundation to obtain a setup to perform electrophysiological recordings in Xenopus oocytes expressing ligand-gated ion-channels.


May 15, 2008
Jesper M. Mathiesen has received a 3-year post doc grant from the Danish Medical Research Council for the project entitled "Using the ß2 adrenoceptor to understand molecular mechanisms of allosteric modulation of GPCRs". The project is a collaborative effort with professor Brian Kobilka, Standford University, USA.


May 6, 2008
Hans Bräuner-Osborne has received a grant of 175,000 DKK from Simon Foughner Hartmanns Familiefond to cover equipment and running costs for the project entitled "The physiological function of the GPRC6A receptor".

 


April 16, 2008
Anders A. Jensen has received a grant of 50,000 DKK from Brødrene Hartmanns Fond to cover running costs for the project entitled "Studies of the mechanism-of-action of a novel type of cognitive enhancer".


April 7, 2007
Anders A. Jensen has received a grant of 80,000 DKK from Aase og Ejner Danielsens Fond to cover running costs for the project entitled "Studies of the mechanism-of-action of a novel type of cognitive enhancer".


December 28, 2007
Kasper Bø Hansen has received a grant of 50,000 DKK from Fonden af 17-12-1981 to cover running costs and equipment for the project entitled "Development and characterization of novel NMDA receptor ligands".

 


December 21, 2007
Hans Bräuner-Osborne has received a grant of 233,000 DKK from the Carlsberg Foundation. Together with a previous grant from the Augustinus Foundation and a research prize from the Torkil Holms Foundation the new grant will allow our group to obtain a sophisticated state-of-the electrophysiological set-up which will be able to e.g. measure currents through single ion-channels.


December 19, 2007
Hans Bräuner-Osborne has received a grant of 750,000 DKK from the Villum Kann Rasmussen Foundation to hire a postdoctoral fellow in medicinal chemistry on the GPRC6A receptor project.

December 19, 2007
Kasper Bø Hansen, Anders A. Jensen and Hans Bräuner-Osborne have each received a grant from the Danish Medical Research Council. KBH received a grant of 92,000 DKK to cover travel expenses for his research stay at Emory University whereas AAJ and HBO each received a grant of 81,000 DKK to hire two pharmaceutical master degree students as scholarship students in spring 2008.


December 17, 2007
Hans Bräuner-Osborne has received two grants from the Drug Research Academy: a 3-year ph.d. stipend co-financed by LEO Pharma and a 2-year post doc stipend co-financed by the Danish Medical Research Council. Keep an eye on the "Open positions" webpage where the positions will be posted in 2008.


December 13, 2007
We have just published a popular scientific article in Danish in the faculty publication Lægemiddelforskning. The article explains our data and possible implications in depression that was accepted for publication in Proc. Natl. Acad. Sci. USA two weeks ago. This is your chance to get an explanation of the results in layman's language. Download the article in PDF format here or download the whole issue of Lægemiddelforskning here.


December 10, 2007
Bolette Christiansen has received a grant of 50,000 DKK from Fonden til Lægevidenskabens Fremme for the project "Molecular pharmacology of human GABA transporters". The foundation is part of the A.P. Møller Foundation.


December 3, 2007
Hans Bräuner-Osborne has received a grant of 110,000 DKK from the Novo Nordisk Foundation for the project "Identification and characterization of novel selective NMDA receptor ligands".

November 28, 2007
Our manuscript entitled "A high frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor" has just been accepted for publication in the prestigious high-impact journal Proc. Natl. Acad. Sci. USA. The study has been a collaborative effort between Karen Krzywkowski, Hans Bräuner-Osborne and Anders A. Jensen from our group and Paul A. Davies and Paula L. Feinberg-Zadek from the Massachusetts General Hospital, Boston, USA.


November 27, 2007
Hans Bräuner-Osborne has received a grant of 1,440,000 DKK from the Danish Medical Research Council for the project "Characterization of GPRC6A – a promiscuous L-α-amino acid 7TM receptor with preference for basic amino acids".

 


November 9, 2007
Our department has just been granted a Programme of Excellence worth 24.5 million DKK by the University of Copenhagen. The programme, which focus on structure and pharmacology of ionotropic glutamate receptor, will be led by Dr. Jette Sandhold Kastrup. Our group participate with a sub-project on molecular pharmacology of NMDA receptors and will receive 3,250,000 DKK to conduct the study.


October 23, 2007
Anders A. Jensen og Lennart Bunch have received a grant of 1,500,000 DKK from the Lundbeck Foundation to study glutamate transporters.




October 5, 2007
Anders A. Jensen has received a grant of 1,600,000 DKK from the Lundbeck Foundation to study molecular pharmacological aspects of GABAA receptors.