We use and develop research tools to help elucidate mechanisms in epigenetics, cancer and Venomics and develop drugs, biomarkers and crystallisation facilitators.
- Need a ligand for your target? EpiDiscoverY is a Contract Research based Organization (CRO) under UCPH. We can deliver novel ligands that are peptide- , nanobody- or full antibody-based. EpiDiscoverY develops customized assays and does phage display screening of costumer targets with our in-house libraries.
- Does Epigenetics shape life while you live? In the EpiDiscoverY group, EpiGenetics is the main focus and here we develop chemical probes for epigenetic protein families. We search for allosteric sites and blocking of interaction partners to reveal secondary epigenetic mechanisms, which ultimately affects life your life while you live.
- Snake antivenom, a luxury for the rich? In the AVV project we are identifying and developing synthetic antivenom (antitoxin), which can neutralize snake venom. Synthetic antitoxin could potentially save millions of lives worldwide in rural countries. Today, due to the price of a treatment, only wealthy people can afford antivenom and so snake antivenom is a luxury for the rich!
- The ultimate tool to develop biopharmaceuticals? Phage display is a powerful tool for selecting peptides, proteins or antibodies with specific binding properties from a very large number of variants (up to billions). The DNA-encoded libraries can be screened on any target to identify selective binders and inhibitors.
Brian Lohse is convenor of the following PhD course:
The course is running every second year, same time. Last course held
12-23 June 2017.
Popular science articles
Genetically modified virus libraries: Producing billions of potential biological drug compounds (Article
Histone tails - a new target for cancer treatment (In Lægemiddelforskning 2010. NB. The article is in Danish)