Computational Receptor Biology – Gloriam Group

David Gloriam’s group identifies mechanisms, structures and ligands of G protein-coupled receptors (GPCRs) – the main mediators of human signalling and drug responses – and develop the field’s main online database, GPCRdb (see video and






































































































GPCR activation mechanisms across classes and macro/microscales
Nature Structural & Molecular Biology. Accepted

GPCRdb in 2021: Integrating GPCR sequence, structure and function
Nucleic Acids Research. 2021

Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors.
Cell. 2019

An online resource for GPCR structure determination and analysis.
Nature Methods. 2019

Trends in GPCR drug discovery: new agents, targets and indications
Nature Reviews Drug Discovery. 2017 [Citations: 1,065]

From collaborations
Structural insights into the lipid and ligand regulation of serotonin receptors
Nature. 2021

Structure of the class D GPCR Ste2 dimer coupled to two G proteins.
Nature. 2020

Combinatorial expression of functionally distinct GPCR isoforms can diversify receptor signalling
Nature. 2020

Pharmacogenomics of GPCR drug targets
Cell. 2018 [Citations: 329]

Selectivity determinants of GPCR–G-protein binding
T Flock, AS Hauser, N Lund, DE Gloriam, S Balaji, MM Babu
Nature. 2017 [Citations: 217]







































GPCRdb accelerates data-driven receptor research

2021 01 18
GPCRdb accelerates data-driven receptor research

Discovery of new hormone-receptor signalling systems

Press release and video

Ultra-large virtual screening for drugs

News & views article and podcast

Press release: GPCR structure determination resource

Online tools to determine GPCR 3D structures.
The first web-based tool to determine GPCR 3D structures (Nature Methods) - Eng

Press release: 5-HT2C structure

Shedding insight on GPCR-ligand polypharmacology.
Polypharmacology and 3D structure of the serotonin 5-HT2C receptor (Cell) - Eng 

Video on GPCR pharmacogenomics

From the Cell article on pharmacogenomics of GPCR drug targets. … »

Press release: GPCR pharmacogenomics

Genetic variation in GPCR drug targets.
Pharmacogenomics of GPCR drug targets (Cell) - Eng1Eng2 & Dan 

Press release: GPCR drug discovery

Trends for drugs, clinical trials and indications.
Trends in GPCR drug discovery (Nat Rev Drug Discov) - Eng & Dan 

Press release: G protein selectivity

Determinants of GPCR-G protein coupling.
Receptor signalling: GPCR - G protein selectivity (Nature) - Eng & Dan 

Intro to the GPCRdb database

Popular scientific article about the GPCRdb database.  

Video on orphan receptor ligand identification

Video made in relation to the award of the Lundbeck Foundation Fellowship to David Gloriam. English: … »


































































































































Group leader

Group Leader

David Gloriam

Phone +45 3533 6162

Group members

Name Title Image
Breinholt, Christian Sigvald Research Assistant Billede af Breinholt, Christian Sigvald
Caroli, Jimmy Postdoc Billede af Caroli, Jimmy
Ghosh, Eshan Postdoc Billede af Ghosh, Eshan
Harpsøe, Kasper Special Consultant Billede af Harpsøe, Kasper
Hauser, Alexander Sebastian Postdoc Billede af Hauser, Alexander Sebastian
Kastrup, Jette Sandholm Jensen Professor Billede af Kastrup, Jette Sandholm Jensen
Kooistra, Albert Jelke Assistant Professor Billede af Kooistra, Albert Jelke
Nygaard, Mads Mørup PhD Student Billede af Nygaard, Mads Mørup
Pándy-Szekeres, Gáspár Academic Research Staff Billede af Pándy-Szekeres, Gáspár

Navn Titel E-mail
Alibek Mamyrbekov PhD stud E-mail