Publications – University of Copenhagen

Selected Publications (see all)

Drug discovery trends
Trends in GPCR drug discovery: new agents, targets and indications
Hauser AS, Attwood MM, Rask-Andersen M, Schiöth HB and Gloriam DE
Nature Reviews Drug Discovery. 2017

Personalized medicine / genetic variation
Pharmacogenomics of GPCR drug targets
Hauser AS, Chavali S, Masuho I, Jahn LJ, Martemyanov KA, Gloriam DE and Babu MM
Cell. 2018

GPCR signalling
Selectivity determinants of GPCR-G protein binding
Flock T, Hauser AS, Lund N, Gloriam DE, Balaji S, Babu MM
Nature. 2017

Total synthesis and structure-activity relationship studies of a series of selective G protein inhibitors.
Xiong XF, Zhang H, Underwood CR, Harpsøe K, Gardella TJ, Wöldike MF, Mannstadt M, Gloriam DE, Bräuner-Osborne H, Strømgaard K.
Nature Chemistry. 2016

Computational drug design
Structural Mapping of Adenosine Receptor Mutations: Ligand Binding and Signaling Mechanisms
Jespers W, Schiedel AC, Heitman LH, Cooke RM, Kleene L, van Westen GJP, Gloriam DE, Müller CE, Sotelo E, Gutiérrez-de-Terán H.
Trends in Pharmacological Sciences. 2018

Structural insight to mutation effects uncover a common allosteric site in class C GPCRs.
Harpsøe K, Boesgaard MW, Munk C, Bräuner-Osborne H, Gloriam DE.
Bioinformatics. 2016

GPCRdb web resources

Universal Resource for GPCR Crystallography and Cryo-EM
Munk C, Mutt E, Isberg V, Nikolajsen LF, Bibbe J, Flock T, Hanson MA, Stevens RC, Deupi X and Gloriam DE
Nature Methods, Accepted

GPCRdb in 2018: Adding GPCR structure models and ligands
Pándy-Szekeres G, Munk C, Tsonkov T, Mordalski S, Harpsøe K, Hauser AS, Bojarski AJ and Gloriam DE
Nucleic Acids Research. 2017

Generic GPCR residue numbers - aligning topology maps while minding the gaps.
Isberg V, de Graaf C, Bortolato A, Cherezov V, Katritch V, Marshall FH, Mordalski S, Pin JP, Stevens RC, Vriend G, Gloriam DE.
Trends in Pharmacological Sciences. 2015

Structures of the 5-HT2C Receptor Illuminate the Structural Basis of GPCR Polypharmacology
Yao P, McCorvy JD, Harpsøe K, Yuan S, Popov P, Pu M, Qu L, Che T, Nikolajsen LF, Huang XP, Wu Y, Lansu K, Shen L, Bjørn-Yoshimoto WE, Ding K, Wacker D, Han GW, Cheng J, Katritch V, Jensen AA, Hanson MA, Zhao S, Gloriam DE, Roth BL, Stevens RC, Liu ZJ
Cell. 2018

Orphan receptors
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.
Nøhr AC, Shehata MA, Hauser AS, Isberg V, Mokrosinski J, Andersen KB, Farooqi IS, Pedersen DS, Gloriam DE, Bräuner-Osborne H
Neurochemistry International. 2017