Albert Jelke Kooistra

Albert Jelke Kooistra

Assistant professor

Member of:


    1. Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain. / Akdemir, Atilla; Edink, Ewald; Thompson, Andrew J.; Lummis, Sarah C.R.; Kooistra, Albert J.; De Graaf, Chris; De Esch, Iwan J.P.

      In: Bioorganic and Medicinal Chemistry, Vol. 20, No. 19, 01.10.2012, p. 5992-6002.

      Research output: Contribution to journalJournal articleResearchpeer-review

    2. Crystal structure-based virtual screening for fragment-like ligands of the human histamine H 1 receptor. / De Graaf, Chris; Kooistra, Albert J.; Vischer, Henry F.; Katritch, Vsevolod; Kuijer, Martien; Shiroishi, Mitsunori; Iwata, So; Shimamura, Tatsuro; Stevens, Raymond C.; De Esch, Iwan J P; Leurs, Rob.

      In: Journal of Medicinal Chemistry, Vol. 54, No. 23, 08.12.2011, p. 8195-8206.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Small and colorful stones make beautiful mosaics : Fragment-based chemogenomics. / De Graaf, Chris; Vischer, Henry F.; De Kloe, Gerdien E.; Kooistra, Albert J.; Nijmeijer, Saskia; Kuijer, Martien; Verheij, Mark H.P.; England, Paul J.; Van Muijlwijk-Koezen, Jacqueline E.; Leurs, Rob; De Esch, Iwan J.P.

      In: Drug Discovery Today, Vol. 18, No. 7-8, 01.04.2013, p. 323-330.

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. The viral G protein-coupled receptor ORF74 hijacks β-arrestins for endocytic trafficking in response to human chemokines. / De Munnik, Sabrina M.; Kooistra, Albert J.; Van Offenbeek, Jody; Nijmeijer, Saskia; De Graaf, Chris; Smit, Martine J.; Leurs, Rob; Vischer, Henry F.

      In: PLOS ONE, Vol. 10, No. 4, e0124486, 20.04.2015.

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology. / Hauwert, Niels J.; Mocking, Tamara A.M.; Da Costa Pereira, Daniel; Kooistra, Albert J.; Wijnen, Lisa M.; Vreeker, Gerda C.M.; Verweij, Eléonore W.E.; De Boer, Albertus H.; Smit, Martine J.; De Graaf, Chris; Vischer, Henry F.; De Esch, Iwan J.P.; Wijtmans, Maikel; Leurs, Rob.

      In: Journal of the American Chemical Society, Vol. 140, No. 12, 28.03.2018, p. 4232-4243.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Structure-based virtual screening for fragment-like ligands of the G protein-coupled histamine H4 receptor. / Istyastono, Enade P.; Istyastono, Enade P.; Kooistra, Albert J.; Vischer, Henry F.; Kuijer, Martien; Roumen, Luc; Nijmeijer, Saskia; Smits, Rogier A.; De Esch, Iwan J.P.; Leurs, Rob; De Graaf, Chris.

      In: MedChemComm, Vol. 6, No. 6, 01.06.2015, p. 1003-1017.

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Molecular determinants of ligand binding modes in the histamine H 4 receptor : Linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies. / Istyastono, Enade P.; Nijmeijer, Saskia; Lim, Herman D.; Van De Stolpe, Andrea; Roumen, Luc; Kooistra, Albert J.; Vischer, Henry F.; De Esch, Iwan J.P.; Leurs, Rob; De Graaf, Chris.

      In: Journal of Medicinal Chemistry, Vol. 54, No. 23, 08.12.2011, p. 8136-8147.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. PDEStrIAn : A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design. / Jansen, Chimed; Kooistra, Albert J.; Kanev, Georgi K.; Leurs, Rob; De Esch, Iwan J.P.; De Graaf, Chris.

      In: Journal of Medicinal Chemistry, Vol. 59, No. 15, 11.08.2016, p. 7029-7065.

      Research output: Contribution to journalReviewResearchpeer-review

    9. Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure. / Jansen, Chimed; Wang, Huanchen; Kooistra, Albert J.; De Graaf, Chris; Orrling, Kristina M.; Tenor, Hermann; Seebeck, Thomas; Bailey, David; De Esch, Iwan J.P.; Ke, Hengming; Leurs, Rob.

      In: Journal of Medicinal Chemistry, Vol. 56, No. 5, 14.03.2013, p. 2087-2096.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Structural Chemogenomics Databases to Navigate Protein-Ligand Interaction Space. / Kanev, G. K.; Kooistra, A. J.; de Esch, I. J.P.; de Graaf, C.

      The Future of Drug Discovery. Vol. 1-8 Elsevier Science Inc., 2017. p. 444-471.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

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