Albert Jelke Kooistra

Albert Jelke Kooistra

Assistant professor

Member of:


    1. 2010
    2. Electron density fingerprints (EDprints) : Virtual screening using assembled information of electron density. / Kooistra, Albert J.; Binsl, Thomas W.; Van Beek, Johannes H.G.M.; De Graaf, Chris; Heringa, Jaap.

      In: Journal of Chemical Information and Modeling, Vol. 50, No. 10, 25.10.2010, p. 1772-1780.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. 2011
    4. Crystal structure-based virtual screening for fragment-like ligands of the human histamine H 1 receptor. / De Graaf, Chris; Kooistra, Albert J.; Vischer, Henry F.; Katritch, Vsevolod; Kuijer, Martien; Shiroishi, Mitsunori; Iwata, So; Shimamura, Tatsuro; Stevens, Raymond C.; De Esch, Iwan J P; Leurs, Rob.

      In: Journal of Medicinal Chemistry, Vol. 54, No. 23, 08.12.2011, p. 8195-8206.

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Molecular determinants of ligand binding modes in the histamine H 4 receptor : Linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies. / Istyastono, Enade P.; Nijmeijer, Saskia; Lim, Herman D.; Van De Stolpe, Andrea; Roumen, Luc; Kooistra, Albert J.; Vischer, Henry F.; De Esch, Iwan J.P.; Leurs, Rob; De Graaf, Chris.

      In: Journal of Medicinal Chemistry, Vol. 54, No. 23, 08.12.2011, p. 8136-8147.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. 2012
    7. Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain. / Akdemir, Atilla; Edink, Ewald; Thompson, Andrew J.; Lummis, Sarah C.R.; Kooistra, Albert J.; De Graaf, Chris; De Esch, Iwan J.P.

      In: Bioorganic and Medicinal Chemistry, Vol. 20, No. 19, 01.10.2012, p. 5992-6002.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Virtual fragment screening : Discovery of histamine H3 receptor ligands using ligand-based and protein-based molecular fingerprints. / Sirci, Francesco; Istyastono, Enade P.; Istyastono, Enade P.; Vischer, Henry F.; Kooistra, Albert J.; Nijmeijer, Saskia; Kuijer, Martien; Wijtmans, Maikel; Mannhold, Raimund; Leurs, Rob; De Esch, Iwan J.P.; De Graaf, Chris.

      In: Journal of Chemical Information and Modeling, Vol. 52, No. 12, 21.12.2012, p. 3308-3324.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. 2013
    10. Mapping histamine H4 receptor-ligand binding modes. / Schultes, Sabine; Nijmeijer, Saskia; Engelhardt, Harald; Kooistra, Albert J.; Vischer, Henry F.; De Esch, Iwan J P; Haaksma, Eric E J; Leurs, Rob; De Graaf, Chris.

      In: MedChemComm, Vol. 4, No. 1, 01.01.2013, p. 193-204.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. From heptahelical bundle to hits from the haystack : Structure-based virtual screening for GPCR ligands. / Kooistra, Albert J.; Roumen, Luc; Leurs, Rob; De Esch, Iwan J.P.; De Graaf, Chris.

      G Protein Coupled ReceptorsModeling, Activation, Interactions and Virtual Screening. 2013. p. 279-336 (Methods in Enzymology, Vol. 522).

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    12. Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure. / Jansen, Chimed; Wang, Huanchen; Kooistra, Albert J.; De Graaf, Chris; Orrling, Kristina M.; Tenor, Hermann; Seebeck, Thomas; Bailey, David; De Esch, Iwan J.P.; Ke, Hengming; Leurs, Rob.

      In: Journal of Medicinal Chemistry, Vol. 56, No. 5, 14.03.2013, p. 2087-2096.

      Research output: Contribution to journalJournal articleResearchpeer-review

    13. Small and colorful stones make beautiful mosaics : Fragment-based chemogenomics. / De Graaf, Chris; Vischer, Henry F.; De Kloe, Gerdien E.; Kooistra, Albert J.; Nijmeijer, Saskia; Kuijer, Martien; Verheij, Mark H.P.; England, Paul J.; Van Muijlwijk-Koezen, Jacqueline E.; Leurs, Rob; De Esch, Iwan J.P.

      In: Drug Discovery Today, Vol. 18, No. 7-8, 01.04.2013, p. 323-330.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. A structural chemogenomics analysis of aminergic GPCRs : Lessons for histamine receptor ligand design. / Kooistra, A. J.; Kuhne, S.; De Esch, I. J.P.; Leurs, R.; De Graaf, C.

      In: British Journal of Pharmacology, Vol. 170, No. 1, 01.09.2013, p. 101-126.

      Research output: Contribution to journalJournal articleResearchpeer-review

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