Albert Jelke Kooistra
Albert Jelke Kooistra

Assistant professor


  1. 2019
  2. Published

    Aminergic GPCR-Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data

    Vass, M., Podlewska, S., De Esch, I. J. P., Bojarski, A. J., Leurs, R., Kooistra, Albert Jelke & De Graaf, C., 2019, In : Journal of Medicinal Chemistry. 62, 8, p. 3784-3839 56 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2018
  4. Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells

    Stoddart, L. A., Vernall, A. J., Bouzo-Lorenzo, M., Bosma, R., Kooistra, Albert Jelke, De Graaf, C., Vischer, H. F., Leurs, R., Briddon, S. J., Kellam, B. & Hill, S. J., 1 Dec 2018, In : Scientific Reports. 8, 1, 1572.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Structural insights into serotonin receptor ligands polypharmacology

    Podlewska, S., Kafel, R., Lacivita, E., Satała, G., Kooistra, Albert Jelke, Vass, M., de Graaf, C., Leopoldo, M., Bojarski, A. J. & Mordalski, Stefan Mateusz, 10 May 2018, In : European Journal of Medicinal Chemistry. 151, p. 797-814 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Chemical Diversity in the G Protein-Coupled Receptor Superfamily

    Vass, M., Kooistra, Albert Jelke, Yang, D., Stevens, R. C., Wang, M. W. & de Graaf, C., 1 May 2018, In : Trends in Pharmacological Sciences. 39, 5, p. 494-512 19 p.

    Research output: Contribution to journalReviewResearchpeer-review

  7. Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology

    Hauwert, N. J., Mocking, T. A. M., Da Costa Pereira, D., Kooistra, Albert Jelke, Wijnen, L. M., Vreeker, G. C. M., Verweij, E. W. E., De Boer, A. H., Smit, M. J., De Graaf, C., Vischer, H. F., De Esch, I. J. P., Wijtmans, M. & Leurs, R., 28 Mar 2018, In : Journal of the American Chemical Society. 140, 12, p. 4232-4243 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 3D-e-Chem: Structural Cheminformatics Workflows for Computer-Aided Drug Discovery

    Kooistra, Albert Jelke, Vass, M., McGuire, R., Leurs, R., de Esch, I. J. P., Vriend, G., Verhoeven, S. & de Graaf, C., 20 Mar 2018, In : ChemMedChem. 13, 6, p. 614-626 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    A Structural Framework for GPCR Chemogenomics: What’s In a Residue Number?

    Vass, M., Kooistra, Albert Jelke, Verhoeven, S., Gloriam, David E., de Esch, I. J. P. & de Graaf, C., 1 Jan 2018, Methods in Molecular Biology. Humana Press, p. 73-113 41 p. (Methods in Molecular Biology, Vol. 1705).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  10. 2017
  11. Structural Chemogenomics Databases to Navigate Protein-Ligand Interaction Space

    Kanev, G. K., Kooistra, Albert Jelke, de Esch, I. J. P. & de Graaf, C., 3 Jun 2017, The Future of Drug Discovery. Elsevier Science Inc., Vol. 1-8. p. 444-471 28 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  12. 3D-e-Chem-VM: Structural Cheminformatics Research Infrastructure in a Freely Available Virtual Machine

    McGuire, R., Verhoeven, S., Vass, M., Vriend, G., De Esch, I. J. P., Lusher, S. J., Leurs, R., Ridder, L., Kooistra, Albert Jelke, Ritschel, T. & De Graaf, C., 27 Feb 2017, In : Journal of Chemical Information and Modeling. 57, 2, p. 115-121 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Kinase-Centric Computational Drug Development

    Kooistra, Albert Jelke & Volkamer, A., 1 Jan 2017, Annual Reports in Medicinal Chemistry. Academic Press, p. 263-299 37 p. (Annual Reports in Medicinal Chemistry, Vol. 50).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  14. 2016
  15. Identification of Ligand Binding Hot Spots of the Histamine H1 Receptor following Structure-Based Fragment Optimization

    Kuhne, S., Kooistra, Albert Jelke, Bosma, R., Bortolato, A., Wijtmans, M., Vischer, H. F., Mason, J. S., De Graaf, C., De Esch, I. J. P. & Leurs, R., 13 Oct 2016, In : Journal of Medicinal Chemistry. 59, 19, p. 9047-9061 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Molecular interaction fingerprint approaches for GPCR drug discovery

    Vass, M., Kooistra, Albert Jelke, Ritschel, T., Leurs, R., de Esch, I. J. & de Graaf, C., 1 Oct 2016, In : Current Opinion in Pharmacology. 30, p. 59-68 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  17. PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design

    Jansen, C., Kooistra, Albert Jelke, Kanev, G. K., Leurs, R., De Esch, I. J. P. & De Graaf, C., 11 Aug 2016, In : Journal of Medicinal Chemistry. 59, 15, p. 7029-7065 37 p.

    Research output: Contribution to journalReviewResearchpeer-review

  18. Function-specific virtual screening for GPCR ligands using a combined scoring method

    Kooistra, Albert Jelke, Vischer, H. F., McNaught-Flores, D., Leurs, R., De Esch, I. J. P. & De Graaf, C., 24 Jun 2016, In : Scientific Reports. 6, 28288.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. KLIFS: A structural kinase-ligand interaction database

    Kooistra, Albert Jelke, Kanev, G. K., Van Linden, O. P. J., Leurs, R., De Esch, I. J. P. & De Graaf, C., 1 Jan 2016, In : Nucleic Acids Research. 44, D1, p. D365-D371

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 2015
  21. Structure-based virtual screening for fragment-like ligands of the G protein-coupled histamine H4 receptor

    Istyastono, E. P., Istyastono, E. P., Kooistra, Albert Jelke, Vischer, H. F., Kuijer, M., Roumen, L., Nijmeijer, S., Smits, R. A., De Esch, I. J. P., Leurs, R. & De Graaf, C., 1 Jun 2015, In : MedChemComm. 6, 6, p. 1003-1017 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Combinatorial consensus scoring for ligand-based virtual fragment screening: A comparative case study for serotonin 5-HT3A, histamine H1, and Histamine H4 receptors

    Schultes, S., Kooistra, Albert Jelke, Vischer, H. F., Nijmeijer, S., Haaksma, E. E. J., Leurs, R., De Esch, I. J. P. & De Graaf, C., 26 May 2015, In : Journal of Chemical Information and Modeling. 55, 5, p. 1030-1034 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Structure-based prediction of g-protein-coupled receptor ligand function: A β-adrenoceptor case study

    Kooistra, Albert Jelke, Leurs, R., De Esch, I. J. P. & De Graaf, C., 26 May 2015, In : Journal of Chemical Information and Modeling. 55, 5, p. 1045-1061 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. The viral G protein-coupled receptor ORF74 hijacks β-arrestins for endocytic trafficking in response to human chemokines

    De Munnik, S. M., Kooistra, Albert Jelke, Van Offenbeek, J., Nijmeijer, S., De Graaf, C., Smit, M. J., Leurs, R. & Vischer, H. F., 20 Apr 2015, In : PLOS ONE. 10, 4, e0124486.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Analyzing multitarget activity landscapes using protein-ligand interaction fingerprints: Interaction cliffs

    Méndez-Lucio, O., Kooistra, Albert Jelke, Graaf, C. D., Bender, A. & Medina-Franco, J. L., 23 Feb 2015, In : Journal of Chemical Information and Modeling. 55, 2, p. 251-262 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. 2014
  27. KLIFS: A knowledge-based structural database to navigate kinase-ligand interaction space

    Van Linden, O. P. J., Kooistra, Albert Jelke, Leurs, R., De Esch, I. J. P. & De Graaf, C., 23 Jan 2014, In : Journal of Medicinal Chemistry. 57, 2, p. 249-277 29 p.

    Research output: Contribution to journalReviewResearchpeer-review

  28. From three-dimensional GPCR structure to rational ligand discovery

    Kooistra, Albert Jelke, Leurs, R., De Esch, I. J. P. & Graaf, C. D., 1 Jan 2014, G Protein-Coupled Receptors - Modeling and Simulation. Springer New York LLC, p. 129-157 29 p. (Advances in Experimental Medicine and Biology, Vol. 796).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  29. The Receptor Concept in 3D: From Hypothesis and Metaphor to GPCR–Ligand Structures

    Kooistra, Albert Jelke, de Graaf, C. & Timmerman, H., 1 Jan 2014, In : Neurochemical Research. 39, 10, p. 1850-1861 12 p.

    Research output: Contribution to journalReviewResearchpeer-review

  30. 2013
  31. A structural chemogenomics analysis of aminergic GPCRs: Lessons for histamine receptor ligand design

    Kooistra, Albert Jelke, Kuhne, S., De Esch, I. J. P., Leurs, R. & De Graaf, C., 1 Sep 2013, In : British Journal of Pharmacology. 170, 1, p. 101-126 26 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Small and colorful stones make beautiful mosaics: Fragment-based chemogenomics

    De Graaf, C., Vischer, H. F., De Kloe, G. E., Kooistra, Albert Jelke, Nijmeijer, S., Kuijer, M., Verheij, M. H. P., England, P. J., Van Muijlwijk-Koezen, J. E., Leurs, R. & De Esch, I. J. P., 1 Apr 2013, In : Drug Discovery Today. 18, 7-8, p. 323-330 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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