Alexander Sebastian Hauser

Alexander Sebastian Hauser

Postdoc


  1. Published

    A new crystal structure fragment-based pharmacophore method for G protein-coupled receptors

    Fidom, K., Isberg, V., Hauser, Alexander Sebastian, Mordalski, S., Lehto, T., Bojarski, A. J. & Gloriam, David E., Jan 2015, In : Methods. 71, p. 104-112 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Selectivity determinants of GPCR-G-protein binding

    Flock, T., Hauser, Alexander Sebastian, Lund, N., Gloriam, David E., Balaji, S. & Babu, M. M., 18 May 2017, In : Nature. 545, 7654, p. 317-322 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors

    Foster, S. R., Hauser, Alexander Sebastian, Vedel, L., Strachan, R. T., Huang, X., Gavin, A. C., Shah, S. D., Nayak, A. P., Haugaard-Kedström, L. M., Penn, R. B., Roth, B. L., Bräuner-Osborne, Hans & Gloriam, David E., 31 Oct 2019, In : Cell. 179, 4, p. 895-908

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method

    Frandsen, I. O., Boesgaard, M. W., Fidom, K., Hauser, Alexander Sebastian, Isberg, V., Bräuner-Osborne, Hans, Wellendorph, Petrine & Gloriam, David E., 6 Jul 2017, In : Scientific Reports. 7, 1, 10 p., 4829.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Novel approaches leading towards peptide GPCR de-orphanisation

    Hauser, Alexander Sebastian, Gloriam, David E., Bräuner-Osborne, Hans & Foster, S. R., 1 Mar 2020, In : British Journal of Pharmacology. 177, 5, p. 961-968 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  6. E-pub ahead of print

    Utilizing drug-target-event relationships to unveil safety patterns in pharmacovigilance

    Hauser, Alexander Sebastian, Kooistra, Albert Jelke, Sverrisdóttir, Eva & Sessa, Maurizio, 8 Jun 2020, In : Expert Opinion on Drug Safety.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Investigations and design of pyridine-2-carboxylic acid thiazol-2-ylamide analogs as methionine aminopeptidase inhibitors using 3D-QSAR and molecular docking

    Hauser, Alexander Sebastian, 1 Aug 2014, In : Medicinal Chemistry Research. 23, 8, p. 3861 3875 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. LEADS-PEP: A Benchmark Data Set for Assessment of Peptide Docking Performance

    Hauser, Alexander Sebastian & Windshügel, B., 11 Jan 2016, In : Journal of Chemical Information and Modeling. 56, 1, p. 188-200 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Pharmacogenomics of GPCR Drug Targets

    Hauser, Alexander Sebastian, Chavali, S., Masuho, I., Jahn, L., Martemyanov, K., Gloriam, David E. & Babu, M., Jan 2018, In : Cell. 172, p. 41–54

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Trends in GPCR drug discovery: new agents, targets and indications

    Hauser, Alexander Sebastian, Gloriam, David E., Attwood, M. M., Rask-Andersen, M. & Schiöth, H. B., 27 Oct 2017, In : Nature Reviews. Drug Discovery. 16, p. 829-842 14 p., 178.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    GPCRdb: an information system for G protein-coupled receptors

    Isberg, V., Mordalski, S., Munk, Christian, Rataj, K., Harpsøe, Kasper, Hauser, Alexander Sebastian, Vroling, B., Bojarski, A. J., Vriend, G. & Gloriam, David E., 4 Jan 2016, In : Nucleic Acids Research. 44, D1, p. D356-64

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW

    Jensen, A. C. N., Shehata, Mohamed A., Hauser, Alexander Sebastian, Isberg, V., Mokrosinski, J., Farooqi, I. S., Pedersen, D. S., Gloriam, David E. & Bräuner-Osborne, Hans, 1 Jan 2017, In : Neurochemistry International. 102, p. 105-113

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Accepted/In press

    Primary Care Prescription Drug Use and Related Actionable Drug-Gene Interactions in the Danish Population

    Lunenburg, C. A. T. C., Hauser, Alexander Sebastian, Ishtiak-Ahmed, K. & Gasse, C., 2020, (Accepted/In press) In : Clinical and Translational Science.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Receptor selectivity between the G proteins Gα 12 and Gα 13 is defined by a single leucine-to-isoleucine variation

    Mackenzie, A. E., Quon, T., Lin, L. C., Hauser, Alexander Sebastian, Jenkins, L., Inoue, A., Tobin, A. B., Gloriam, David E., Hudson, B. D. & Milligan, G., 1 Apr 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 4, p. 5005-5017 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    GPCRdb: The G protein-coupled receptor database - an introduction

    Munk, Christian, Isberg, V., Mordalski, S., Harpsøe, Kasper, Rataj, K., Hauser, Alexander Sebastian, Kolb, P., Bojarski, A. J., Vriend, G. & Gloriam, David E., Jul 2016, In : British Journal of Pharmacology. 173, 14, p. 2195-207 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Integrating structural and mutagenesis data to elucidate GPCR ligand binding

    Munk, Christian, Harpsøe, Kasper, Hauser, Alexander Sebastian, Isberg, V. & Gloriam, David E., Oct 2016, In : Current Opinion in Pharmacology. 30, p. 51-58 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Trade-off between GPCR folding and functional versatility

    Prado, D. E., Flock, T., Hauser, Alexander Sebastian, Hegde, R. S. & Babu, M. M., Dec 2017, In : Protein Science. 26, p. 135-136

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  18. Published

    GPCRdb in 2018: adding GPCR structure models and ligands

    Pándy-Szekeres, G., Munk, Christian, Tsonkov, T. M., Mordalski, Stefan Mateusz, Harpsøe, Kasper, Hauser, Alexander Sebastian, Bojarski, A. J. & Gloriam, David E., 2018, In : Nucleic Acids Research. 46, D1, 7 p., gkx1109.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 143688078