Employees – University of Copenhagen

Bente Frølund

Bente Frølund

Associate Professor


  1. 2013
  2. Published

    The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors. / Hoestgaard-Jensen, K; O'Connor, R M; Dalby, Nils Ole; Simonsen, C; Finger, B C; Golubeva, A; Hammer, H; Bergmann, M L; Kristiansen, U; Krogsgaard-Larsen, P; Bräuner-Osborne, H; Ebert, B; Frølund, B; Cryan, J F; Jensen, A A.

    In: British journal of pharmacology, Vol. 170, No. 4, 10.2013, p. 919-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues : novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties. / Jensen, Anders A; Plath, Niels; Pedersen, Martin H. F.; Isberg, Vignir; Krall, Jacob; Wellendorph, Petrine; Stensbøl, Tine B.; Gloriam, David E.; Krogsgaard-Larsen, Povl; Frølund, Bente.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 3, 14.02.2013, p. 1211-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Exploring the orthosteric binding site of the γ-aminobutyric acid type A receptor using 4-(piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-imidazolyl substituted : design, synthesis, and pharmacological evaluation. / Krall, Jacob; Jensen, Claus Hatt; Sørensen, Troels Ersted; Nielsen, Birgitte; Jensen, Anders A.; Sander, Tommy; Balle, Thomas; Frølund, Bente.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 16, 15.07.2013, p. 6536−6540.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Probing the orthosteric binding site of GABAA receptors with heterocyclic GABA carboxylic acid bioisosteres. / Petersen, Jette G; Bergmann, Rikke; Krogsgaard-Larsen, Povl; Balle, Thomas; Frølund, Bente.

    In: Neurochemical research, Vol. 39, 21.12.2013, p. 1005-1015.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as ¿-aminobutyric acidA receptor agonists. / Petersen, Jette Gellert; Bergmann, Rikke; Møller, Henriette A.; Jørgensen, Charlotte Grube; Nielsen, Birgitte; Kehler, Jan; Frydenvang, Karla ; Kristensen, Jesper; Balle, Thomas; Jensen, Anders A.; Kristiansen, Uffe; Frølund, Bente.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 3, 2013, p. 993-1006.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Synthesis, pharmacology and biostructural characterization of novel a4ß2 nicotinic acetylcholine receptor agonists. / Ussing, Christine A.; Hansen, Camilla Petrycer; Petersen, Jette Gellert; Jensen, Anders A.; Rohde, Line A.H. ; Ahring, Philip K.; Nielsen, Elisabeth Ø. ; Kastrup, Jette Sandholm; Gajhede, Michael; Frølund, Bente; Balle, Thomas.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 3, 2013, p. 940-951.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites. / Vogensen, Stine Byskov; Marek, A; Bay, Tina; Wellendorph, Petrine; Kehler, J; Bundgaard, C; Frølund, Bente; Pedersen, M.H.F.; Clausen, Rasmus Prætorius.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 20, 2013, p. 8201–8205.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2012
  10. Published

    α4βδ GABA receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). / Absalom, N.; Karim, N.; Eghorn, L.F.; Villumsen, I.S.; Bay, T.; Bräuner-Osborne, H.; Frølund, B.; Clausen, R.P.; Olsen, J.V.; Knudsen, G.M.; Chebib, M.; Wellendorph, P.

    In: Proceedings of the National Academy of Sciences USA (PNAS), Vol. 109, No. 33, 14.08.2012, p. 13404-13409.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    5-(Piperidine-4-yl)-3-hydroxypyrazole: a novel scaffold forprobing the orthosteric GABAA receptor binding site. / Krall, Jacob; Johansen, Kenneth; Balle, Thomas; Nielsen, Birgitte; Jensen, Anders A.; Frølund, Bente.

    2012. Poster session presented at EFMC-ISMC 2012 - 22nd International Symposium on Medicinal Chemistry, Berlin, Germany.

    Research output: Contribution to conferencePosterResearch

  12. 2011
  13. Published

    Discovery of benzamide analogues as a novel class of 5-HT3 receptor agonists. / Jørgensen, Charlotte Grube; Frølund, Bente Flensborg; Kehler, Jan; Jensen, Anders Asbjørn.

    In: ChemMedChem, Vol. 6, No. 4, 04.04.2011, p. 725-736.

    Research output: Contribution to journalJournal articleResearchpeer-review

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