Darryl S Pickering

Darryl S Pickering

Associate Professor


  1. Published

    Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotropic glutamate receptor subtypes 5, 6, and 7. / Sagot, Emanuelle; Pickering, Darryl S; Pu, Xiaosui; Umberti, Michelle; Stensbøl, Tine B; Nielsen, Birgitte; Chapelet, Marion; Bolte, Jean; Gefflaut, Thierry; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 14, 2008, p. 4093-103.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid : a novel selective inhibitor of human excitatory amino acid transporter subtype 2. / Sagot, Emanuelle; Jensen, Anders A.; Pickering, Darryl S; Pu, Xiaosui; Umberti, Michelle; Stensbøl, Tine B.; Nielsen, Birgitte; Assaf, Zeinab; Aboab, Bétina; Bolte, Jean; Gefflaut, Thierry; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 14, 2008, p. 4085-4092.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Use of the 4-Hydroxy-Triazole Moiety as a Bioisosteric Tool for the Development of Ionotropic Glutamate Receptor Ligands. / Sainas, Stefano; Temperini, Piero; Farnsworth, Jill C; Yi, Feng; Møllerud, Stine; Jensen, Anders A.; Nielsen, Birgitte; Kastrup, Jette Sandholm Jensen; Hansen, Kasper B; Boschi, Donatella; Pickering, Darryl S; Clausen, Rasmus Prætorius; Lolli, Marco.

    In: Journal of Medicinal Chemistry, Vol. 62, 09.05.2019, p. 4467-4482.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Simple cellemodeller for kommunikation i hjernen. / Schousboe, Arne; Madsen, Karsten Kirkegaard; Pickering, Darryl S.

    Bioteknologi - en temabog. ed. / Peder Gasbjerg; Gunnar Jensen; Annette Sørensen. Aarhus Danmark : Systime Academic, 2011. p. 98-107.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  5. Published

    Vascular and molecular pharmacology of the metabolically stable CGRP analogue, SAX. / Sheykhzade, Majid; Abdolalizadeh, Bahareh; Koole, Cassandra; Pickering, Darryl S; Dreisig, Karin; Johansson, Sara Ellinor; Abboud, Balsam Kadri; Dreier, Rasmus; Berg, Jais Oliver; Jeppesen, Jørgen Lykke; Sexton, Patrick; Edvinsson, Lars; Wootten, Denise; Sams, Anette.

    In: European Journal of Pharmacology, Vol. 829, 2018, p. 85-92.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Binding and functional pharmacological characteristics of gepant-type antagonists in rat brain and mesenteric arteries. / Sheykhzade, Majid; Amandi, Nilofar; Pla, Monica Vidal; Abdolalizadeh, Bahareh; Sams, Anette; Warfvinge, Karin; Edvinsson, Lars; Pickering, Darryl S.

    In: Vascular Pharmacology, Vol. 90, 10.02.2017, p. 36-43.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published
  8. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats. / Sommer, Jens Bak; Bach, Anders; Malá, Hana ; Strømgaard, Kristian; Mogensen, Jesper; Pickering, Darryl S.

    In: Pharmacology, Biochemistry and Behavior, Vol. 161, 10.2017, p. 62-67.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    In vitro and in vivo effects of a novel dimeric inhibitor of PSD‐95 on excitotoxicity and functional recovery after experimental traumatic brain injury. / Sommer, Jens Bak; Bach, Anders; Rytter, Hana Malá; Strømgaard, Kristian; Mogensen, Jesper; Pickering, Darryl S.

    In: European Journal of Neuroscience, Vol. 45, No. 2, 20.01.2017, p. 238-248.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Effects of dimeric PSD-95 inhibition on excitotoxic cell death and outcome after controlled cortical impact in rats : PSD-95 inhibition in experimental TBI. / Sommer, Jens Bak; Bach, Anders; Rytter, Hana Malá; Gynther, Mikko; Bjerre, Ann-Sofie; Gram, Marie Gajhede; Marschner, Linda; Strømgaard, Kristian; Mogensen, Jesper; Pickering, Darryl S.

    In: Neurochemical Research, Vol. 42, No. 12, 2017, p. 3401-3413.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors. / Szymanska, Ewa; Frydenvang, Karla Andrea; Pickering, Darryl S; Krintel, Christian; Nielsen, Birgitte; Kooshki, Ayesheh; Zachariassen, Linda Grønborg; Olsen, Lars; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov.

    In: Journal of Medicinal Chemistry, Vol. 59, No. 1, 2016, p. 448-461.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands. / Szymanska, Ewa; Pickering, Darryl S; Nielsen, Birgitte; Johansen, Tommy N.

    In: Bioorganic & Medicinal Chemistry, Vol. 17, No. 17, 2009, p. 6390-401.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure : Synthesis, resolution, pharmacology, and crystal structure. / Szymanska, Ewa; Frydenvang, Karla; Contreras-Sanz, Alberto; Pickering, Darryl S; Frola, Elena; Serafimoska, Zorica; Nielsen, Birgitte; Kastrup, Jette Sandholm; Johansen, Tommy Nørskov.

    In: Journal of Medicinal Chemistry, Vol. 54, No. 20, 04.10.2011, p. 7289-7298.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Design, synthesis and structure-activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands. / Szymańska, Ewa; Chałupnik, Paulina; Szczepańska, Katarzyna; Moral, Ana Maria Cuñado; Pickering, Darryl S; Nielsen, Birgitte; Johansen, Tommy Nørskov; Kieć-Kononowicz, Kieć-Kononowicz.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 26, No. 22, 2016, p. 5568-5572.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Aryl- and heteroaryl-substituted phenylalanines as AMPA receptor ligands. / Szymańska, Ewa; Chałupnik, Paulina; Johansen, Tommy Nørskov; Nielsen, Birgitte; Cuñado Moral, Ana Maria; Pickering, Darryl S; Kieć-Kononowicz, Katarzyna.

    In: Chemical Biology & Drug Design, Vol. 90, 01.12.2017, p. 1271-1281.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors. / Szymańska, Ewa; Nielsen, Birgitte; Johansen, Tommy Nørskov; Cuñado Moral, Anna Maria; Pickering, Darryl S; Szczepańska, Katarzyna; Mickowska, Anna; Kieć-Kononowicz, Katarzyna.

    In: European Journal of Medicinal Chemistry, Vol. 138, 2017, p. 874-883.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of ionotropic glutamate receptor binding pocket. / Tamborini, Lucia; Nicosia, Veronica; Conti, Paola; Dall'Oglio, Federica; De Micheli, Carlo; Nielsen, Birgitte; Jensen, Anders A.; Pickering, Darryl S; Pinto, Andrea.

    In: Tetrahedron, Vol. 72, No. 51, 01.12.2016, p. 8586-8492.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues. / Valgeirsson, Jon; Christensen, Jeppe K; Kristensen, Anders S; Pickering, Darryl S; Nielsen, Birgitte; Fischer, Christina; Bräuner-Osborne, Hans; Nielsen, Elsebet Ø; Krogsgaard-Larsen, Povl; Madsen, Ulf.

    In: Bioorganic & Medicinal Chemistry, Vol. 11, No. 20, 2003, p. 4341-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. / Venskutonyte, Raminta; Frydenvang, Karla; Gajhede, Michael; Bunch, Lennart; Pickering, Darryl S; Kastrup, Jette Sandholm.

    In: Journal of Structural Biology, Vol. 176, No. 3, 12.2011, p. 307-314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Selective kainate receptor (GluK1) ligands structurally based upon1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. / Venskutonyte, Raminta; Butini, Stefania; Coccone, Salvatore Sanna; Gemma, Sandra; Brindisi, Margherita; Kumar, Vinod; Guarino, Ergeria; Maramai, Samuele; Valenti, Salvatore; Amir, Ahmad; Valades, Elena Anton; Frydenvang, Karla Andrea; Kastrup, Jette Sandholm Jensen; Novellino, Ettore; Campiani, Giuseppe; Pickering, Darryl S.

    In: Journal of Medicinal Chemistry, Vol. 54, No. 13, 14.07.2011, p. 4793-4805.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain. / Venskutonyte, Raminta; Larsen, Anja Probst; Frydenvang, Karla Andrea; Gajhede, Michael; Gefflaut, Thierry; Pickering, Darryl S; Bunch, Lennart; Kastrup, Jette Sandholm Jensen.

    In: ChemMedChem, Vol. 9, No. 10, 2014, p. 2254-2259.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors. / Venskutonyte, Raminta; Frydenvang, Karla; Valadés, Elena Antón; Szymanska, Ewa Monika; Johansen, Tommy N; Kastrup, Jette S; Pickering, Darryl S.

    In: ChemMedChem, Vol. 7, No. 10, 10.2012, p. 1793-1798.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors. / Vogensen, SB; Greenwood, JR; Varming, Annemarie R.; Brehm, L; Pickering, DS; Nielsen, Birgitte; Liljefors, T; Clausen, Rasmus Prætorius; Johansen, Tommy Nørskov; Krogsgaard-Larsen, P.

    In: Organic & Biomolecular Chemistry, Vol. 2, No. 2, 2004, p. 206-213.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues. / Vogensen, SB; Clausen, Rasmus Prætorius; Greenwood, JR; Johansen, Tommy Nørskov; Pickering, DS; Nielsen, Birgitte; Ebert, Barke; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 48, No. 9, 05.05.2005, p. 3438-3442.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    A tetrazolyl-substituted subtype-selective AMPA receptor agonist. / Vogensen, Stine Byskov; Frydenvang, Karla Andrea; Greenwood, Jeremy R.; Postorino, Giovanna; Nielsen, Birgitte; Pickering, Darryl Scott; Ebert, Bjarke; Bølcho, Ulrik; Egebjerg, Jan; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov; Clausen, Rasmus Prætorius; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 50, No. 10, 2007, p. 2408-2414.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1299533