Darryl S Pickering

Darryl S Pickering

Associate Professor


  1. Published

    Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP. / Nielsen, Bettina B; Pickering, Darryl S; Greenwood, Jeremy R; Brehm, Lotte; Gajhede, Michael; Schousboe, Arne; Kastrup, Jette S.

    In: FEBS Journal, Vol. 272, No. 7, 2005, p. 1639-48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published
  3. Published

    Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine. / Frydenvang, Karla Andrea; Lash, L Leanne; Naur, Peter; Postila, Pekka A; Pickering, Darryl S; Smith, Caleb M; Gajhede, Michael; Sasaki, Makoto; Sakai, Ryuichi; Pentikäinen, Olli T; Swanson, Geoffrey T; Kastrup, Jette Sandholm.

    In: Journal of Biological Chemistry, Vol. 284, No. 21, 2009, p. 14219-14229.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    GABA transporter localization to lipid raft membrane microdomains in neurons and astrocytes. / Madsen, Karsten Kirkegaard; Pickering, Darryl S; Hansen, G.H.; Danielsen, E.M.; Larsson, Orla Miller; Schousboe, Arne.

    In: Journal of Neurochemistry, Vol. 102, No. s1, 2007, p. 46.

    Research output: Contribution to journalConference abstract in journalResearch

  5. Published

    Investigation of antidepressant-like and anxiolytic-like actions and cognitive and motor side effects of four N-methyl-D-aspartate receptor antagonists in mice. / Refsgaard, Louise Konradsen; Pickering, Darryl S; Andreasen T., Jesper.

    In: Behavioural Pharmacology, Vol. 28, No. 1, 01.02.2017, p. 37-47.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Investigation of the presence and antinociceptive function of muscarinic acetylcholine receptors in the African naked mole-rat (Heterocephalus glaber). / Jørgensen, Kristine B.; Krogh-Jensen, Karen; Pickering, Darryl S; Kanui, Titus; Abelson, Klas.

    In: Journal of Comparative Physiology A. Sensory, neural, and behavioral physiology, Vol. 202, No. 1, 01.01.2016, p. 7-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Ionotropic glutamate-like receptor d2 binds D-serine and glycine. / Naur, Peter; Hansen, Kasper Bø; Kristensen, Anders Skov; Dravid, Shashank M.; Pickering, Darryl Scott; Olsen, Lars; Vestergaard, Bente; Egebjerg, Jan; Gajhede, Michael; Traynelis, Stephen F.; Kastrup, Jette Sandholm Jensen.

    In: Proceedings of the National Academy of Science of the United States of America, Vol. 104, No. 35, 2007, p. 14116-14121.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. / Krintel, Christian; Frydenvang, Karla; Ceravalls de Rabassa, Anna; Kaern, Anne Mette; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette S.

    In: F E B S Journal, 27.03.2014, p. 2422–2430.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Lessons from crystal structures of kainate receptors. / Møllerud, Stine; Frydenvang, Karla Andrea; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: Neuropharmacology, Vol. 112, No. Part A, 01.01.2017, p. 16-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Modelling Affective Pain in Mice: Effects of Inflammatory Hypersensitivity on Place Escape/Avoidance Behaviour, Anxiety and Hedonic State. / Refsgaard, Louise Konradsen; Hoffmann-Petersen, Julie; Sahlholt, Maj; Pickering, Darryl S; Andreasen T., Jesper.

    In: Journal of Neuroscience Methods, Vol. 262, 2016, p. 85-92.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Molecular determinants of desensitization and assembly of the chimeric GABA(A) receptor subunits (alpha1/gamma2) and (gamma2/alpha1) in combinations with beta2 and gamma2. / Elster, L; Kristiansen, U; Pickering, D S; Olsen, R W; Schousboe, A.

    In: Neurochemistry International, Vol. 38, No. 7, 2001, p. 581-92.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4 . / Kasper, Christina; Frydenvang, Karla Andrea; Naur, Peter; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: FEBS Letters, Vol. 582, No. 29, 2008, p. 4089-4094.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain. / Venskutonyte, Raminta; Larsen, Anja Probst; Frydenvang, Karla Andrea; Gajhede, Michael; Gefflaut, Thierry; Pickering, Darryl S; Bunch, Lennart; Kastrup, Jette Sandholm Jensen.

    In: ChemMedChem, Vol. 9, No. 10, 2014, p. 2254-2259.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. E-pub ahead of print
  15. Published

    N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships and in vitro Pharmacology. / Pallesen, Jakob Staun; Møllerud, Stine; Frydenvang, Karla Andrea; Pickering, Darryl S; Bornholt, Jan; Nielsen, Birgitte; Pasini, Diletta; Han, Liwei; Marconi, Laura; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov.

    In: A C S Chemical Neuroscience, Vol. 10, 20.03.2019, p. 1841-1853.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Neto2 influences on kainate receptor pharmacology and function. / Han, Liwei; Howe, James; Pickering, Darryl S.

    In: Basic & Clinical Pharmacology & Toxicology, Vol. 119, 2016, p. 141-148.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5 : Structures of the ligand-bining core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid. / Hald, Helle; Naur, Peter; Pickering, Darryl Scott; Sprogøe, Desiree; Madsen, Ulf; Timmermann, Daniel B.; Ahring, Philip K.; Liljefors, Tommy; Schousboe, Arne; Egebjerg, Jan; Gajhede, Michael; Kastrup, Jette Sandholm Jensen.

    In: Journal of Biological Chemistry, Vol. 282, No. 35, 2007, p. 25726-25736.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors. / Juknaite, Lina; Venskutonyte, Raminta; Assaf, Zeinab; Faure, Sophie; Gefflaut, Thierry; Aitken, David J.; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Bunch, Lennart; Frydenvang, Karla; Pickering, Darryl S.

    In: Journal of Structural Biology, Vol. 180, No. 1, 2012, p. 39-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Pharmacological characterisation of biarylisopropylalsulphonamide AMPA-R potentiators. / Pickering, Darryl S; Sanz, Contreraz; Harpsøe, Kasper; Clausen, Rasmus Prætorius; Sauerberg, P.; Liljefors, Tommy; Madsen, Ulf; Kaae, B.H.

    In: Journal of Neurochemistry, Vol. 102 (suppl. 1), No. 41, 2007.

    Research output: Contribution to journalConference abstract in journalResearch

  20. Published

    Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors. / Szymańska, Ewa; Nielsen, Birgitte; Johansen, Tommy Nørskov; Cuñado Moral, Anna Maria; Pickering, Darryl S; Szczepańska, Katarzyna; Mickowska, Anna; Kieć-Kononowicz, Katarzyna.

    In: European Journal of Medicinal Chemistry, Vol. 138, 2017, p. 874-883.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Pharmacological characterization of (4R)-alkyl glutamate analogues at the ionotropic glutamate receptors : focus on subtypes iGlu5-7. / Bunch, Lennart; Gefflaut, Thierry; Alaux, Sebastien; Sagot, Emanuelle; Nielsen, Birgitte; Pickering, Darryl S.

    In: European Journal of Pharmacology, Vol. 609, 2009, p. 1-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Pharmacological properties of homomeric and heteromeric GluR1o and GluR3o receptors. / Nielsen, B S; Banke, T G; Schousboe, A; Pickering, Darryl.

    In: European Journal of Pharmacology, Vol. 360, No. 2-3, 1998, p. 227-38.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Pharmacology and crystal structure of novel 2,3-quinoxalinediones at kainate receptors. / Møllerud, Stine; Pallesen, Jakob Staun; Pasini, Diletta; Marconi, Laura; Han, Liwei; Bornholt, Jan; Johansen, Tommy Nørskov; Kastrup, Jette Sandholm ; Pickering, Darryl S; Frydenvang, Karla Andrea.

    In: Journal of Neurochemistry, Vol. 142, No. S1, MTU07-13, 08.2017, p. 124.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  24. Published

    Positive allosteric modulation of AMPA receptors differentially modulates the behavioural effects of citalopram in mouse models of antidepressant and anxiolytic action. / Fitzpatrick, Ciarán Martin; Larsen, Maria; Madsen, Louise; Pickering, Darryl S; Clausen, Rasmus Prætorius; Andreasen T., Jesper.

    In: Behavioural Pharmacology, Vol. 27, No. 6, 26.06.2016, p. 549-555.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Rational Design, Synthesis and Pharmacological Evaluation of the (2R)- and (2S)-Stereoisomers of 3-(2-Carboxypyrrolidinyl)-2-methyl Acetic Acid as Ligands for the Ionotropic Glutamate Receptors. / Rasmussen, Julie; Storgaard, Morten; Pickering, Darryl S; Bunch, Lennart.

    In: ChemMedChem, Vol. 6, No. 3, 07.03.2011, p. 498-504.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1299533