Darryl S Pickering

Darryl S Pickering

Associate Professor


  1. 2019
  2. Published
  3. Published

    N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships and in vitro Pharmacology. / Pallesen, Jakob Staun; Møllerud, Stine; Frydenvang, Karla Andrea; Pickering, Darryl S; Bornholt, Jan; Nielsen, Birgitte; Pasini, Diletta; Han, Liwei; Marconi, Laura; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov.

    In: A C S Chemical Neuroscience, Vol. 10, 20.03.2019, p. 1841-1853.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Design and Synthesis of 2,3-trans-Proline Analogs as Ligands for the Ionotropic Glutamate Receptors and the Excitatory Amino Acid Transporters. / Poulie, Christian Bernard Matthijs; Alcaide Lopez, Anna; Krell-Jørgensen, Mikkel Poul; Larsen, Younes; Astier, Eloi; Bjørn-Yoshimoto, Walden E.; Yi, Feng; Syrenne, Jed T; Storgaard, Morten; Nielsen, Birgitte; Frydenvang, Karla Andrea; Jensen, Anders A.; Hansen, Kasper B; Pickering, Darryl S; Bunch, Lennart.

    In: A C S Chemical Neuroscience, Vol. 10, No. 6, 19.06.2019, p. 2989-3007.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Use of the 4-Hydroxy-Triazole Moiety as a Bioisosteric Tool for the Development of Ionotropic Glutamate Receptor Ligands. / Sainas, Stefano; Temperini, Piero; Farnsworth, Jill C; Yi, Feng; Møllerud, Stine; Jensen, Anders A.; Nielsen, Birgitte; Kastrup, Jette Sandholm Jensen; Hansen, Kasper B; Boschi, Donatella; Pickering, Darryl S; Clausen, Rasmus Prætorius; Lolli, Marco.

    In: Journal of Medicinal Chemistry, Vol. 62, 09.05.2019, p. 4467-4482.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The Presence of Calcitonin Gene-Related Peptide and Its Receptors in Rat, Pig and Human Brain : Species Differences in Calcitonin Gene-Related Peptide Pharmacology. / Warfvinge, Karin; Edvinsson, Lars; Pickering, Darryl S; Sheykhzade, Majid.

    In: Pharmacology, Vol. 104, 01.12.2019, p. 332-341.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2018
  8. Published

    (S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements, Structural and Biological Investigation. / Brogi, Simone; Brindisi, Marghertia; Butini, Stefania; Kshirsagar, Giridhar; Maramai, Samuele; Chemi, Giulia; Gemma, Sandra; Campiani, Giuseppe; Novellino, Ettore; Fiorenzani, Paolo; Pinassi, Jessica; Aloisi, Anna Maria; Gynther, Mikko; Venskutonyte, Raminta; Han, Liwei; Frydenvang, Karla Andrea; Kastrup, Jette Sandholm Jensen; Pickering, Darryl S.

    In: Journal of Medicinal Chemistry, Vol. 61, No. 5, 08.03.2018, p. 2124-2130.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Vascular and molecular pharmacology of the metabolically stable CGRP analogue, SAX. / Sheykhzade, Majid; Abdolalizadeh, Bahareh; Koole, Cassandra; Pickering, Darryl S; Dreisig, Karin; Johansson, Sara Ellinor; Abboud, Balsam Kadri; Dreier, Rasmus; Berg, Jais Oliver; Jeppesen, Jørgen Lykke; Sexton, Patrick; Edvinsson, Lars; Wootten, Denise; Sams, Anette.

    In: European Journal of Pharmacology, Vol. 829, 2018, p. 85-92.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2017
  11. Published

    Revisiting the Quinoxalinedione scaffold in the Construction of New Ligands for the Ionotropic Glutamate Receptors. / Demmer, Charles Sylvain; Rombach, David; Liu, Na; Nielsen, Birgitte; Pickering, Darryl S; Bunch, Lennart.

    In: A C S Chemical Neuroscience, Vol. 8, No. 11, 01.12.2017, p. 2477-2495.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist. / Gynther, Mikko; Proietti Silvestri, Ilaria; Hansen, Jacob C; Hansen, Kasper B; Malm, Tarja; Ishchenko, Yevheniia; Larsen, Younes; Han, Liwei; Kayser, Silke; Auriola, Seppo; Petsalo, Aleksanteri; Nielsen, Birgitte; Pickering, Darryl S; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 60, No. 23, 14.12.2017, p. 9885-9904.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. / Krogsgaard-Larsen, Niels; Delgar, Claudia; Koch, Karina; Brown, Patricia M G E; Møller, Charlotte; Han, Liwei; Huynh, Tri Hien Viet; Hansen, Stinne Wessel; Nielsen, Birgitte; Bowie, Derek; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen; Frydenvang, Karla Andrea; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 60, No. 1, 2017, p. 441-457.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Lessons from crystal structures of kainate receptors. / Møllerud, Stine; Frydenvang, Karla Andrea; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: Neuropharmacology, Vol. 112, No. Part A, 01.01.2017, p. 16-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Pharmacology and crystal structure of novel 2,3-quinoxalinediones at kainate receptors. / Møllerud, Stine; Pallesen, Jakob Staun; Pasini, Diletta; Marconi, Laura; Han, Liwei; Bornholt, Jan; Johansen, Tommy Nørskov; Kastrup, Jette Sandholm ; Pickering, Darryl S; Frydenvang, Karla Andrea.

    In: Journal of Neurochemistry, Vol. 142, No. S1, MTU07-13, 08.2017, p. 124.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  16. Published

    Structure and affinity of two bicyclic glutamate analogues at AMPA and kainate receptors. / Møllerud, Stine; Pinto, Andrea; Marconi, Laura; Frydenvang, Karla Andrea; Thorsen, Thor Seneca; Laulumaa, Saara Kaisa; Venskutonyte, Raminta; Winther, Nikolaj; Cunado Moral, Ana Maria; Tamborini, Lucia; Conti, Paola; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: A C S Chemical Neuroscience, Vol. 8, No. 9, 2017, p. 2056-2064.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Investigation of antidepressant-like and anxiolytic-like actions and cognitive and motor side effects of four N-methyl-D-aspartate receptor antagonists in mice. / Refsgaard, Louise Konradsen; Pickering, Darryl S; Andreasen T., Jesper.

    In: Behavioural Pharmacology, Vol. 28, No. 1, 01.02.2017, p. 37-47.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Binding and functional pharmacological characteristics of gepant-type antagonists in rat brain and mesenteric arteries. / Sheykhzade, Majid; Amandi, Nilofar; Pla, Monica Vidal; Abdolalizadeh, Bahareh; Sams, Anette; Warfvinge, Karin; Edvinsson, Lars; Pickering, Darryl S.

    In: Vascular Pharmacology, Vol. 90, 10.02.2017, p. 36-43.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    In vitro and in vivo effects of a novel dimeric inhibitor of PSD‐95 on excitotoxicity and functional recovery after experimental traumatic brain injury. / Sommer, Jens Bak; Bach, Anders; Rytter, Hana Malá; Strømgaard, Kristian; Mogensen, Jesper; Pickering, Darryl S.

    In: European Journal of Neuroscience, Vol. 45, No. 2, 20.01.2017, p. 238-248.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Effects of dimeric PSD-95 inhibition on excitotoxic cell death and outcome after controlled cortical impact in rats : PSD-95 inhibition in experimental TBI. / Sommer, Jens Bak; Bach, Anders; Rytter, Hana Malá; Gynther, Mikko; Bjerre, Ann-Sofie; Gram, Marie Gajhede; Marschner, Linda; Strømgaard, Kristian; Mogensen, Jesper; Pickering, Darryl S.

    In: Neurochemical Research, Vol. 42, No. 12, 2017, p. 3401-3413.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats. / Sommer, Jens Bak; Bach, Anders; Malá, Hana ; Strømgaard, Kristian; Mogensen, Jesper; Pickering, Darryl S.

    In: Pharmacology, Biochemistry and Behavior, Vol. 161, 10.2017, p. 62-67.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Aryl- and heteroaryl-substituted phenylalanines as AMPA receptor ligands. / Szymańska, Ewa; Chałupnik, Paulina; Johansen, Tommy Nørskov; Nielsen, Birgitte; Cuñado Moral, Ana Maria; Pickering, Darryl S; Kieć-Kononowicz, Katarzyna.

    In: Chemical Biology & Drug Design, Vol. 90, 01.12.2017, p. 1271-1281.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors. / Szymańska, Ewa; Nielsen, Birgitte; Johansen, Tommy Nørskov; Cuñado Moral, Anna Maria; Pickering, Darryl S; Szczepańska, Katarzyna; Mickowska, Anna; Kieć-Kononowicz, Katarzyna.

    In: European Journal of Medicinal Chemistry, Vol. 138, 2017, p. 874-883.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2016
  25. Published

    Synthesis and Pharmacological Characterization of the Selective GluK1 Radioligand (S)-2-Amino-3-(6-[3H]-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)propanoic acid ([3H]-NF608). / Alcaide, Anna; Marconi, Laura; Marek, Ales; Haym, Isabell; Nielsen, Birgitte; Møllerud, Stine; Jensen, Mikael; Conti, Paola; Pickering, Darryl S; Bunch, Lennart.

    In: MedChemComm, Vol. 7, 2016, p. 2136-2144.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function. / Andreasen, Jesper T; Nasser, Arafat; Caballero-Puntiverio, Maitane; Sahlholt, Maj; Bach, Anders; Gynther, Mikko; Strømgaard, Kristian; Pickering, Darryl S.

    In: European Journal of Pharmacology, Vol. 780, 05.06.2016, p. 166-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Positive allosteric modulation of AMPA receptors differentially modulates the behavioural effects of citalopram in mouse models of antidepressant and anxiolytic action. / Fitzpatrick, Ciarán Martin; Larsen, Maria; Madsen, Louise; Pickering, Darryl S; Clausen, Rasmus Prætorius; Andreasen T., Jesper.

    In: Behavioural Pharmacology, Vol. 27, No. 6, 26.06.2016, p. 549-555.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs. / Gynther, Mikko; Pickering, Darryl S; Spicer, Julie; Denny, William; Huttunen, Kristiina.

    In: Molecular Pharmaceutics, Vol. 13, No. 7, 2016, p. 2484-2491.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Neto2 influences on kainate receptor pharmacology and function. / Han, Liwei; Howe, James; Pickering, Darryl S.

    In: Basic & Clinical Pharmacology & Toxicology, Vol. 119, 2016, p. 141-148.

    Research output: Contribution to journalJournal articleResearchpeer-review

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