Darryl S Pickering

Darryl S Pickering

Associate Professor


  1. Published

    Discovery of a New Class of Ionotropic Glutamate Receptor Antagonists by the Rational Design of (2S,3R)-3-(3-Carboxyphenyl)-pyrrolidine-2-carboxylic Acid. / Larsen, Ann Møller; Venskutonyte, Raminta; Valadés, Elena Antón; Nielsen, Birgitte; Pickering, Darryl S; Bunch, Lennart.

    In: ACS Chemical Neuroscience, Vol. 2, No. 2, 04.11.2011, p. 107-114.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. / Kvist, Trine; Steffensen, Thomas Bielefeldt; Greenwood, Jeremy R; Mehrzad Tabrizi, Fatemeh; Hansen, Kasper Bø; Gajhede, Michael; Pickering, Darryl S; Traynelis, Stephen F; Kastrup, Jette Sandholm; Bräuner-Osborne, Hans.

    In: The Journal of Biological Chemistry, Vol. 288, 2013, p. 33124-35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. / Krogsgaard-Larsen, Niels; Delgar, Claudia; Koch, Karina; Brown, Patricia M G E; Møller, Charlotte; Han, Liwei; Huynh, Tri Hien Viet; Hansen, Stinne Wessel; Nielsen, Birgitte; Bowie, Derek; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen; Frydenvang, Karla Andrea; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 60, No. 1, 2017, p. 441-457.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid. / Krogsgaard-Larsen, Niels; Storgaard, Morten; Møller, Charlotte; Demmer, Charles S; Hansen, Jeanette; Han, Liwei; Monrad, Rune N; Nielsen, Birgitte; Tapken, Daniel; Pickering, Darryl S; Kastrup, Jette S; Frydenvang, Karla; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 58, No. 15, 2015, p. 6131-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate. / Kristensen, Ole; Kristensen, Lise Baadsgaard; Møllerud, Stine; Frydenvang, Karla Andrea; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: Structure, Vol. 24, No. 9, 2016, p. 1582-1589.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. / Krintel, Christian; Frydenvang, Karla; Ceravalls de Rabassa, Anna; Kaern, Anne Mette; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette S.

    In: F E B S Journal, 27.03.2014, p. 2422–2430.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2. / Krintel, Christian; Francotte, Pierre; Pickering, Darryl S; Juknaite, Lina; Pøhlsgaaard, Jakob; Olsen, Lars; Frydenvang, Karla Andrea; Goffin, Eric; Pirotte, Bernard; Kastrup, Jette Sandholm Jensen.

    In: Biophysical Journal, Vol. 110, No. 11, 2016, p. 2397-2406.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain. / Krintel, Christian; Harpsøe, Kasper; Zachariassen, Linda G; Peters, Dan; Frydenvang, Karla; Pickering, Darryl S; Gajhede, Michael; Kastrup, Jette S.

    In: Acta crystallographica. Section D, Biological crystallography, Vol. 69, No. Pt 9, 09.2013, p. 1645-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209. / Kasper, Christina; Pickering, Darryl S; Mirza, Osman; Olsen, Lars; Kristensen, Anders S; Greenwood, Jeremy R; Liljefors, Tommy; Schousboe, Arne; Wätjen, Frank; Gajhede, Michael; Sigurskjold, Bent W; Kastrup, Jette S.

    In: Journal of Molecular Biology, Vol. 357, No. 4, 2006, p. 1184-201.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4 . / Kasper, Christina; Frydenvang, Karla Andrea; Naur, Peter; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: FEBS Letters, Vol. 582, No. 29, 2008, p. 4089-4094.

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 1299533