Darryl S Pickering

Darryl S Pickering

Associate Professor


  1. 2010
  2. Published

    Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid. / Frydenvang, Karla Andrea; Pickering, Darryl S; Greenwood, Jeremy R; Krogsgaard-Larsen, Niels; Brehm, Lotte; Nielsen, Birgitte; Vogensen, Stine Byskov; Hald, Helle; Kastrup, Jette Sandholm; Krogsgaard-Larsen, Povl; Clausen, Rasmus Prætorius.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 23, 10.11.2010, p. 8354-8361.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues. / Lolli, Marco L; Giordano, Cecilia; Pickering, Darryl S; Rolando, Barbara; Hansen, Kasper B; Foti, Antonio; Contreras-Sanz, Alberto; Amir, Ahmad; Fruttero, Roberta; Gasco, Alberto; Nielsen, Birgitte; Johansen, Tommy N.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 10, 2010, p. 4110-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2009
  5. Published

    3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands. / Szymanska, Ewa; Pickering, Darryl S; Nielsen, Birgitte; Johansen, Tommy N.

    In: Bioorganic & Medicinal Chemistry, Vol. 17, No. 17, 2009, p. 6390-401.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters. / Bunch, Lennart; Pickering, Darryl S; Gefflaut, Thierry; Vinatier, Virginie; Helaine, Virgil; Amir, Ahmad; Nielsen, Birgitte; Jensen, Anders Asbjørn.

    In: ChemMedChem, Vol. 4, No. 11, 2009, p. 1925-1929.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Effect of synthetic and natural phospholipids on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D activity. / Petersen, Gitte; Pedersen, Anders H; Pickering, Darryl S; Begtrup, Mikael; Hansen, Harald S.

    In: Chemistry and Physics of Lipids, Vol. 162, No. 1-2, 2009, p. 53-61.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine. / Frydenvang, Karla Andrea; Lash, L Leanne; Naur, Peter; Postila, Pekka A; Pickering, Darryl S; Smith, Caleb M; Gajhede, Michael; Sasaki, Makoto; Sakai, Ryuichi; Pentikäinen, Olli T; Swanson, Geoffrey T; Kastrup, Jette Sandholm.

    In: Journal of Biological Chemistry, Vol. 284, No. 21, 2009, p. 14219-14229.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Pharmacological characterization of (4R)-alkyl glutamate analogues at the ionotropic glutamate receptors : focus on subtypes iGlu5-7. / Bunch, Lennart; Gefflaut, Thierry; Alaux, Sebastien; Sagot, Emanuelle; Nielsen, Birgitte; Pickering, Darryl S.

    In: European Journal of Pharmacology, Vol. 609, 2009, p. 1-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue : synthesis, molecular pharmacology, and biostructural characterization. / Clausen, Rasmus Prætorius; Naur, Peter; Kristensen, Anders Skov; Greenwood, Jeremy R; Strange, Mette; Bräuner-Osborne, Hans; Jensen, Anders Asbjørn; Nielsen, Anne Sophie T; Geneser, Ulla; Ringgaard, Lone M; Nielsen, Birgitte; Pickering, Darryl S; Brehm, Lotte; Gajhede, Michael; Krogsgaard-Larsen, Povl; Kastrup, Jette Sandholm.

    In: Journal of Medicinal Chemistry, Vol. 52, No. 15, 2009, p. 4911-4922.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2008
  12. Published

    1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators. / Butini, Stefania; Pickering, Darryl S; Morelli, Elena; Coccone, Salvatore Sanna; Trotta, Francesco; De Angelis, Meri; Guarino, Egeria; Fiorini, Isabella; Campiani, Giuseppe; Novellino, Ettore; Schousboe, Arne; Christensen, Jeppe K; Gemma, Sandra.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 20, 2008, p. 6614-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid : a novel selective inhibitor of human excitatory amino acid transporter subtype 2. / Sagot, Emanuelle; Jensen, Anders A.; Pickering, Darryl S; Pu, Xiaosui; Umberti, Michelle; Stensbøl, Tine B.; Nielsen, Birgitte; Assaf, Zeinab; Aboab, Bétina; Bolte, Jean; Gefflaut, Thierry; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 14, 2008, p. 4085-4092.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1299533