Darryl S Pickering

Darryl S Pickering

Associate Professor


  1. Published

    Synthesis and Pharmacological Characterization of the Selective GluK1 Radioligand (S)-2-Amino-3-(6-[3H]-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)propanoic acid ([3H]-NF608). / Alcaide, Anna; Marconi, Laura; Marek, Ales; Haym, Isabell; Nielsen, Birgitte; Møllerud, Stine; Jensen, Mikael; Conti, Paola; Pickering, Darryl S; Bunch, Lennart.

    In: MedChemComm, Vol. 7, 2016, p. 2136-2144.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Differential role of AMPA receptors in mouse tests of antidepressant and anxiolytic action. / Andreasen, Jesper T; Fitzpatrick, Ciaran M; Larsen, Maria; Skovgaard, Lars; Nielsen, Simon D; Clausen, Rasmus P; Troelsen, Karin; Pickering, Darryl S.

    In: Brain Research, Vol. 1601, 19.03.2015, p. 117-26.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function. / Andreasen, Jesper T; Nasser, Arafat; Caballero-Puntiverio, Maitane; Sahlholt, Maj; Bach, Anders; Gynther, Mikko; Strømgaard, Kristian; Pickering, Darryl S.

    In: European Journal of Pharmacology, Vol. 780, 05.06.2016, p. 166-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published
  5. Published

    Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests. / Andreasen T., Jesper; Gynther, Mikko Otto Oskari; Rygaard, Allan; Bøgelund, Trine; Nielsen, Simon Dalsgaard; Clausen, Rasmus Prætorius; Mogensen, Jesper; Pickering, Darryl S.

    In: Neuroscience Letters, Vol. 546, 2013, p. 6-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. / Assaf, Z.; Larsen, Anja Probst; Venskutonyte, Raminta; Han, Liwei; Abrahamsen, Bjarke; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm; Jensen, Anders A.; Pickering, Darryl S; Frydenvang, Karla ; Gefflaut, T; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 4, 2013, p. 1614-1628.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency. / Beich-Frandsen, Mads; Pickering, Darryl S; Mirza, Osman; Johansen, Tommy N; Greenwood, Jeremy; Vestergaard, Bente; Schousboe, Arne; Gajhede, Michael; Liljefors, Tommy; Kastrup, Jette S.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 5, 2008, p. 1459-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). / Bjerrum, Esben J; Kristensen, Anders S; Pickering, Darryl S; Greenwood, Jeremy R; Nielsen, Birgitte; Liljefors, Tommy; Schousboe, Arne; Bräuner-Osborne, Hans; Madsen, Ulf; Pickering, Darryl.

    In: Journal of Medicinal Chemistry, Vol. 46, No. 11, 2003, p. 2246-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity. / Bolvig, T; Larsson, O M; Pickering, D S; Nelson, N; Falch, E; Krogsgaard-Larsen, P; Schousboe, A; Pickering, Darryl.

    In: European Journal of Pharmacology, Vol. 375, No. 1-3, 1999, p. 367-74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    (S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements, Structural and Biological Investigation. / Brogi, Simone; Brindisi, Marghertia; Butini, Stefania; Kshirsagar, Giridhar; Maramai, Samuele; Chemi, Giulia; Gemma, Sandra; Campiani, Giuseppe; Novellino, Ettore; Fiorenzani, Paolo; Pinassi, Jessica; Aloisi, Anna Maria; Gynther, Mikko; Venskutonyte, Raminta; Han, Liwei; Frydenvang, Karla Andrea; Kastrup, Jette Sandholm Jensen; Pickering, Darryl S.

    In: Journal of Medicinal Chemistry, Vol. 61, No. 5, 08.03.2018, p. 2124-2130.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Pharmacological characterization of (4R)-alkyl glutamate analogues at the ionotropic glutamate receptors : focus on subtypes iGlu5-7. / Bunch, Lennart; Gefflaut, Thierry; Alaux, Sebastien; Sagot, Emanuelle; Nielsen, Birgitte; Pickering, Darryl S.

    In: European Journal of Pharmacology, Vol. 609, 2009, p. 1-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters. / Bunch, Lennart; Pickering, Darryl S; Gefflaut, Thierry; Vinatier, Virginie; Helaine, Virgil; Amir, Ahmad; Nielsen, Birgitte; Jensen, Anders Asbjørn.

    In: ChemMedChem, Vol. 4, No. 11, 2009, p. 1925-1929.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators. / Butini, Stefania; Pickering, Darryl S; Morelli, Elena; Coccone, Salvatore Sanna; Trotta, Francesco; De Angelis, Meri; Guarino, Egeria; Fiorini, Isabella; Campiani, Giuseppe; Novellino, Ettore; Schousboe, Arne; Christensen, Jeppe K; Gemma, Sandra.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 20, 2008, p. 6614-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties. / Campiani, G; Morelli, E; Nacci, V; Fattorusso, C; Ramunno, A; Novellino, E; Greenwood, J; Liljefors, T; Griffiths, R; Sinclair, C; Reavy, H; Kristensen, A S; Pickering, D S; Schousboe, A; Cagnotto, A; Fumagalli, E; Mennini, T; Pickering, Darryl.

    In: Journal of Medicinal Chemistry, Vol. 44, No. 26, 2001, p. 4501-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue : synthesis, molecular pharmacology, and biostructural characterization. / Clausen, Rasmus Prætorius; Naur, Peter; Kristensen, Anders Skov; Greenwood, Jeremy R; Strange, Mette; Bräuner-Osborne, Hans; Jensen, Anders Asbjørn; Nielsen, Anne Sophie T; Geneser, Ulla; Ringgaard, Lone M; Nielsen, Birgitte; Pickering, Darryl S; Brehm, Lotte; Gajhede, Michael; Krogsgaard-Larsen, Povl; Kastrup, Jette Sandholm.

    In: Journal of Medicinal Chemistry, Vol. 52, No. 15, 2009, p. 4911-4922.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Agonist discrimination between AMPA receptor subtypes. / Coquelle, T; Christensen, J K; Banke, T G; Madsen, U; Schousboe, A; Pickering, Darryl.

    In: NeuroReport, Vol. 11, No. 12, 2000, p. 2643-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1. / Demmer, Charles S; Møller, Charlotte; Brown, Patricia M G E; Han, Liwei; Pickering, Darryl S; Nielsen, Birgitte; Bowie, Derek; Frydenvang, Karla; Kastrup, Jette S; Bunch, Lennart.

    In: A C S Chemical Neuroscience, Vol. 6, 09.04.2015, p. 845-854.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Revisiting the Quinoxalinedione scaffold in the Construction of New Ligands for the Ionotropic Glutamate Receptors. / Demmer, Charles Sylvain; Rombach, David; Liu, Na; Nielsen, Birgitte; Pickering, Darryl S; Bunch, Lennart.

    In: A C S Chemical Neuroscience, Vol. 8, No. 11, 01.12.2017, p. 2477-2495.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Molecular determinants of desensitization and assembly of the chimeric GABA(A) receptor subunits (alpha1/gamma2) and (gamma2/alpha1) in combinations with beta2 and gamma2. / Elster, L; Kristiansen, U; Pickering, D S; Olsen, R W; Schousboe, A.

    In: Neurochemistry International, Vol. 38, No. 7, 2001, p. 581-92.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Positive allosteric modulation of AMPA receptors differentially modulates the behavioural effects of citalopram in mouse models of antidepressant and anxiolytic action. / Fitzpatrick, Ciarán Martin; Larsen, Maria; Madsen, Louise; Pickering, Darryl S; Clausen, Rasmus Prætorius; Andreasen T., Jesper.

    In: Behavioural Pharmacology, Vol. 27, No. 6, 26.06.2016, p. 549-555.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2. / Frandsen, Anne; Pickering, Darryl S.; Vestergaard, Bente; Kasper, Christina; Nielsen, Bettina Bryde; Greenwood, Jeremy R; Campiani, Giuseppe; Fattorusso, Caterina; Gajhede, Michael; Schousboe, Arne; Kastrup, Jette Sandholm.

    In: Molecular Pharmacology, Vol. 67, No. 3, 2005, p. 703-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine. / Frydenvang, Karla Andrea; Lash, L Leanne; Naur, Peter; Postila, Pekka A; Pickering, Darryl S; Smith, Caleb M; Gajhede, Michael; Sasaki, Makoto; Sakai, Ryuichi; Pentikäinen, Olli T; Swanson, Geoffrey T; Kastrup, Jette Sandholm.

    In: Journal of Biological Chemistry, Vol. 284, No. 21, 2009, p. 14219-14229.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid. / Frydenvang, Karla Andrea; Pickering, Darryl S; Greenwood, Jeremy R; Krogsgaard-Larsen, Niels; Brehm, Lotte; Nielsen, Birgitte; Vogensen, Stine Byskov; Hald, Helle; Kastrup, Jette Sandholm; Krogsgaard-Larsen, Povl; Clausen, Rasmus Prætorius.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 23, 10.11.2010, p. 8354-8361.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Solid-Phase Peptide Synthesis of Human alfa-Calcitonin Gene-Related Peptide and Two Fluorescent Analogs. / Fuente-Moreno, Marina; Oddo, Alberto; Sheykhzade, Majid; Pickering, Darryl S; Hansen, Paul Robert.

    Proceedings of the 24th American Peptide Symposium . 2015.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  25. Published

    D-aspartate and NMDA, but not L-aspartate, block AMPA receptors in rat hippocampal neurons. / Gong, Xiang-Qun; Frandsen, Anne; Lu, Wei-Yang; Wan, Yudi; Zabek, Rebecca L; Pickering, Darryl; Bai, Donglin.

    In: British Journal of Pharmacology, Vol. 145, No. 4, 2005, p. 449-59.

    Research output: Contribution to journalJournal articleResearchpeer-review

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