Darryl S Pickering

Darryl S Pickering

Associate Professor


  1. Published

    Role of GluR2 expression in AMPA-induced toxicity in cultured murine cerebral cortical neurons. / Jensen, Jette Bisgaard; Lund, Trine Meldgaard; Timmermann, Daniel B.; Schousboe, Arne; Pickering, Darryl S.

    In: Journal of Neuroscience Research, Vol. 65, No. 3, 2001, p. 267-277.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Role of desensitization and subunit expression for kainate receptor-mediated neurotoxicity in murine neocortical cultures. / Jensen, J B; Schousboe, A; Pickering, D S; Pickering, Darryl.

    In: Journal of Neuroscience Research, Vol. 55, No. 2, 1999, p. 208-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Selective kainate receptor (GluK1) ligands structurally based upon1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. / Venskutonyte, Raminta; Butini, Stefania; Coccone, Salvatore Sanna; Gemma, Sandra; Brindisi, Margherita; Kumar, Vinod; Guarino, Ergeria; Maramai, Samuele; Valenti, Salvatore; Amir, Ahmad; Valades, Elena Anton; Frydenvang, Karla Andrea; Kastrup, Jette Sandholm Jensen; Novellino, Ettore; Campiani, Giuseppe; Pickering, Darryl S.

    In: Journal of Medicinal Chemistry, Vol. 54, No. 13, 14.07.2011, p. 4793-4805.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Simple cellemodeller for kommunikation i hjernen. / Schousboe, Arne; Madsen, Karsten Kirkegaard; Pickering, Darryl S.

    Bioteknologi - en temabog. ed. / Peder Gasbjerg; Gunnar Jensen; Annette Sørensen. Aarhus Danmark : Systime Academic, 2011. p. 98-107.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  5. Published

    Solid-Phase Peptide Synthesis of Human alfa-Calcitonin Gene-Related Peptide and Two Fluorescent Analogs. / Fuente-Moreno, Marina; Oddo, Alberto; Sheykhzade, Majid; Pickering, Darryl S; Hansen, Paul Robert.

    Proceedings of the 24th American Peptide Symposium . 2015.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  6. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain. / Krintel, Christian; Harpsøe, Kasper; Zachariassen, Linda G; Peters, Dan; Frydenvang, Karla; Pickering, Darryl S; Gajhede, Michael; Kastrup, Jette S.

    In: Acta crystallographica. Section D, Biological crystallography, Vol. 69, No. Pt 9, 09.2013, p. 1645-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors. / Venskutonyte, Raminta; Frydenvang, Karla; Valadés, Elena Antón; Szymanska, Ewa Monika; Johansen, Tommy N; Kastrup, Jette S; Pickering, Darryl S.

    In: ChemMedChem, Vol. 7, No. 10, 10.2012, p. 1793-1798.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites. / Kaae, Birgitte Høiriis; Harpsøe, Kasper; Kastrup, Jette Sandholm Jensen; Sanz, Alberto Contreras; Pickering, Darryl Scott; Metzler, Bjørn; Clausen, Rasmus Prætorius; Gajhede, Michael; Sauerberg, Per; Liljefors, Tommy; Madsen, Ulf.

    In: Chemistry & Biology, Vol. 14, No. 11, 2007, p. 1294-303.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Structural rearrangement of the intracellular domains during AMPA receptor activation. / Zachariassen, Linda Grønborg; Katchan, Ljudmila; Jensen, Anna Guldvang; Pickering, Darryl S; Plested, Andrew; Kristensen, Anders Skov.

    In: Proceedings of the National Academy of Sciences USA (PNAS), Vol. 113, No. 27, 2016, p. E3950-E3959.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Structure and affinity of two bicyclic glutamate analogues at AMPA and kainate receptors. / Møllerud, Stine; Pinto, Andrea; Marconi, Laura; Frydenvang, Karla Andrea; Thorsen, Thor Seneca; Laulumaa, Saara Kaisa; Venskutonyte, Raminta; Winther, Nikolaj; Cunado Moral, Ana Maria; Tamborini, Lucia; Conti, Paola; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: A C S Chemical Neuroscience, Vol. 8, No. 9, 2017, p. 2056-2064.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate. / Kristensen, Ole; Kristensen, Lise Baadsgaard; Møllerud, Stine; Frydenvang, Karla Andrea; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: Structure, Vol. 24, No. 9, 2016, p. 1582-1589.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid. / Krogsgaard-Larsen, Niels; Storgaard, Morten; Møller, Charlotte; Demmer, Charles S; Hansen, Jeanette; Han, Liwei; Monrad, Rune N; Nielsen, Birgitte; Tapken, Daniel; Pickering, Darryl S; Kastrup, Jette S; Frydenvang, Karla; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 58, No. 15, 2015, p. 6131-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency. / Beich-Frandsen, Mads; Pickering, Darryl S; Mirza, Osman; Johansen, Tommy N; Greenwood, Jeremy; Vestergaard, Bente; Schousboe, Arne; Gajhede, Michael; Liljefors, Tommy; Kastrup, Jette S.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 5, 2008, p. 1459-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors. / Szymanska, Ewa; Frydenvang, Karla Andrea; Pickering, Darryl S; Krintel, Christian; Nielsen, Birgitte; Kooshki, Ayesheh; Zachariassen, Linda Grønborg; Olsen, Lars; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov.

    In: Journal of Medicinal Chemistry, Vol. 59, No. 1, 2016, p. 448-461.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159 : asymmetric synthesis, neuroactivity, and structural characterization. / Juknaite, Lina; Sugamata, Yutaro; Tokiwa, Kazuya; Ishikawa, Yuichi; Takamizawa, Satoshi; Eng, Andrew; Sakai, Ryuichi; Pickering, Darryl S; Frydenvang, Karla; Swanson, Geoffrey T; Kastrup, Jette Sandholm Jensen; Oikawa, Masato.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 6, 2013, p. 2283-2293.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Synthesis and Pharmacological Characterization of the Selective GluK1 Radioligand (S)-2-Amino-3-(6-[3H]-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)propanoic acid ([3H]-NF608). / Alcaide, Anna; Marconi, Laura; Marek, Ales; Haym, Isabell; Nielsen, Birgitte; Møllerud, Stine; Jensen, Mikael; Conti, Paola; Pickering, Darryl S; Bunch, Lennart.

    In: MedChemComm, Vol. 7, 2016, p. 2136-2144.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues. / Valgeirsson, Jon; Christensen, Jeppe K; Kristensen, Anders S; Pickering, Darryl S; Nielsen, Birgitte; Fischer, Christina; Bräuner-Osborne, Hans; Nielsen, Elsebet Ø; Krogsgaard-Larsen, Povl; Madsen, Ulf.

    In: Bioorganic & Medicinal Chemistry, Vol. 11, No. 20, 2003, p. 4341-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs. / Gynther, Mikko; Pickering, Darryl S; Spicer, Julie; Denny, William; Huttunen, Kristiina.

    In: Molecular Pharmaceutics, Vol. 13, No. 7, 2016, p. 2484-2491.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Targeting specific sub-domains of the GluA4 ionotropic glutamate receptor by murine Fab fragments. / Mohr, Andreas Ørgaard; Riise, Erik Skjold; Pickering, Darryl S; Jensen, Anders A.; Madden, Dean; Kastrup, Jette Sandholm Jensen; Clausen, Rasmus Prætorius; Skottrup, Peter Durand.

    2011. Poster session presented at Affinity2011, Tavira, Portugal.

    Research output: Contribution to conferencePosterResearchpeer-review

  20. E-pub ahead of print

    The Presence of Calcitonin Gene-Related Peptide and Its Receptors in Rat, Pig and Human Brain : Species Differences in Calcitonin Gene-Related Peptide Pharmacology. / Warfvinge, Karin; Edvinsson, Lars; Pickering, Darryl S; Sheykhzade, Majid.

    In: Pharmacology, 04.09.2019, p. 1-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    The antagonistic effect of antipsychotic drugs on a HEK293 cell line stably expressing human alpha(1A1)-adrenoceptors. / Nourian, Zahra; Mulvany, Michael J; Nielsen, Karsten Bork; Pickering, Darryl S; Kristensen, Torsten.

    In: European Journal of Pharmacology, Vol. 596, No. 1-3, 2008, p. 32-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue : synthesis, molecular pharmacology, and biostructural characterization. / Clausen, Rasmus Prætorius; Naur, Peter; Kristensen, Anders Skov; Greenwood, Jeremy R; Strange, Mette; Bräuner-Osborne, Hans; Jensen, Anders Asbjørn; Nielsen, Anne Sophie T; Geneser, Ulla; Ringgaard, Lone M; Nielsen, Birgitte; Pickering, Darryl S; Brehm, Lotte; Gajhede, Michael; Krogsgaard-Larsen, Povl; Kastrup, Jette Sandholm.

    In: Journal of Medicinal Chemistry, Vol. 52, No. 15, 2009, p. 4911-4922.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209. / Kasper, Christina; Pickering, Darryl S; Mirza, Osman; Olsen, Lars; Kristensen, Anders S; Greenwood, Jeremy R; Liljefors, Tommy; Schousboe, Arne; Wätjen, Frank; Gajhede, Michael; Sigurskjold, Bent W; Kastrup, Jette S.

    In: Journal of Molecular Biology, Vol. 357, No. 4, 2006, p. 1184-201.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Tweaking subtype-selectivity and agonist efficacy at (S)-2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) receptors in a small series of BnTetAMPA analogues. / Wang, Shuang-Yan; Larsen, Younes; Navarrete, Cristina V.; Jensen, Anders A.; Nielsen, Birgitte; Al-Musaed, Ali; Frydenvang, Karla; Kastrup, Jette Sandholm; Pickering, Darryl S; Clausen, Rasmus Prætorius.

    In: Journal of Medicinal Chemistry, Vol. 59, No. 5, 2016, p. 2244-2254.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2. / Frandsen, Anne; Pickering, Darryl S.; Vestergaard, Bente; Kasper, Christina; Nielsen, Bettina Bryde; Greenwood, Jeremy R; Campiani, Giuseppe; Fattorusso, Caterina; Gajhede, Michael; Schousboe, Arne; Kastrup, Jette Sandholm.

    In: Molecular Pharmacology, Vol. 67, No. 3, 2005, p. 703-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1299533