Darryl S Pickering
Associate Professor
Molecular and Cellular Pharmacology
Jagtvej 160, 2100 København Ø, 22, Building: C213
- 2013
- Published
Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain. / Krintel, Christian; Harpsøe, Kasper; Zachariassen, Linda G; Peters, Dan; Frydenvang, Karla; Pickering, Darryl S; Gajhede, Michael; Kastrup, Jette S.
In: Acta crystallographica. Section D, Biological crystallography, Vol. 69, No. Pt 9, 09.2013, p. 1645-52.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: Comparison with the NMDA receptor antagonist MK-801. / Andreasen, Jesper T.; Bach, Anders; Gynther, Mikko; Nasser, Arafat; Mogensen, Jesper; Strømgaard, Kristian; Pickering, Darryl S.
In: Neuropharmacology, Vol. 67, 04.2013, p. 193-200.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. / Assaf, Z.; Larsen, Anja Probst; Venskutonyte, Raminta; Han, Liwei; Abrahamsen, Bjarke; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm; Jensen, Anders A.; Pickering, Darryl S; Frydenvang, Karla ; Gefflaut, T; Bunch, Lennart.
In: Journal of Medicinal Chemistry, Vol. 56, No. 4, 2013, p. 1614-1628.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. / Kvist, Trine; Steffensen, Thomas Bielefeldt; Greenwood, Jeremy R; Mehrzad Tabrizi, Fatemeh; Hansen, Kasper Bø; Gajhede, Michael; Pickering, Darryl S; Traynelis, Stephen F; Kastrup, Jette Sandholm; Bräuner-Osborne, Hans.
In: The Journal of Biological Chemistry, Vol. 288, 2013, p. 33124-35.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests. / Andreasen T., Jesper; Gynther, Mikko Otto Oskari; Rygaard, Allan; Bøgelund, Trine; Nielsen, Simon Dalsgaard; Clausen, Rasmus Prætorius; Mogensen, Jesper; Pickering, Darryl S.
In: Neuroscience Letters, Vol. 546, 2013, p. 6-10.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159 : asymmetric synthesis, neuroactivity, and structural characterization. / Juknaite, Lina; Sugamata, Yutaro; Tokiwa, Kazuya; Ishikawa, Yuichi; Takamizawa, Satoshi; Eng, Andrew; Sakai, Ryuichi; Pickering, Darryl S; Frydenvang, Karla; Swanson, Geoffrey T; Kastrup, Jette Sandholm Jensen; Oikawa, Masato.
In: Journal of Medicinal Chemistry, Vol. 56, No. 6, 2013, p. 2283-2293.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors. / Venskutonyte, Raminta; Frydenvang, Karla; Valadés, Elena Antón; Szymanska, Ewa Monika; Johansen, Tommy N; Kastrup, Jette S; Pickering, Darryl S.
In: ChemMedChem, Vol. 7, No. 10, 10.2012, p. 1793-1798.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cognitive enhancing effects of an AMPA receptor positive modulator on place learning in mice. / Rytter, Hana Malá; Chen, Yuxia; Worm, Vivi Hu; Kure, Julie; Kaae, Birgitte H.; Madsen, Ulf; Badolo, Lassina; Pickering, Darryl S; Mogensen, Jesper.
In: Behavioural Brain Research, Vol. 226, No. 1, 2012, p. 18-25.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors. / Juknaite, Lina; Venskutonyte, Raminta; Assaf, Zeinab; Faure, Sophie; Gefflaut, Thierry; Aitken, David J.; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Bunch, Lennart; Frydenvang, Karla; Pickering, Darryl S.
In: Journal of Structural Biology, Vol. 180, No. 1, 2012, p. 39-46.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. / Venskutonyte, Raminta; Frydenvang, Karla; Gajhede, Michael; Bunch, Lennart; Pickering, Darryl S; Kastrup, Jette Sandholm.
In: Journal of Structural Biology, Vol. 176, No. 3, 12.2011, p. 307-314.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1299533
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Investigation of the presence and antinociceptive function of muscarinic acetylcholine receptors in the African naked mole-rat (Heterocephalus glaber)
Research output: Contribution to journal › Journal article › Research › peer-review
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