Darryl S Pickering

Darryl S Pickering

Associate Professor


  1. 2013
  2. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain. / Krintel, Christian; Harpsøe, Kasper; Zachariassen, Linda G; Peters, Dan; Frydenvang, Karla; Pickering, Darryl S; Gajhede, Michael; Kastrup, Jette S.

    In: Acta crystallographica. Section D, Biological crystallography, Vol. 69, No. Pt 9, 09.2013, p. 1645-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. / Kvist, Trine; Steffensen, Thomas Bielefeldt; Greenwood, Jeremy R; Mehrzad Tabrizi, Fatemeh; Hansen, Kasper Bø; Gajhede, Michael; Pickering, Darryl S; Traynelis, Stephen F; Kastrup, Jette Sandholm; Bräuner-Osborne, Hans.

    In: The Journal of Biological Chemistry, Vol. 288, 2013, p. 33124-35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2012
  5. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors. / Juknaite, Lina; Venskutonyte, Raminta; Assaf, Zeinab; Faure, Sophie; Gefflaut, Thierry; Aitken, David J.; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Bunch, Lennart; Frydenvang, Karla; Pickering, Darryl S.

    In: Journal of Structural Biology, Vol. 180, No. 1, 2012, p. 39-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Cognitive enhancing effects of an AMPA receptor positive modulator on place learning in mice. / Rytter, Hana Malá; Chen, Yuxia; Worm, Vivi Hu; Kure, Julie; Kaae, Birgitte H.; Madsen, Ulf; Badolo, Lassina; Pickering, Darryl S; Mogensen, Jesper.

    In: Behavioural Brain Research, Vol. 226, No. 1, 2012, p. 18-25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors. / Venskutonyte, Raminta; Frydenvang, Karla; Valadés, Elena Antón; Szymanska, Ewa Monika; Johansen, Tommy N; Kastrup, Jette S; Pickering, Darryl S.

    In: ChemMedChem, Vol. 7, No. 10, 10.2012, p. 1793-1798.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2011
  9. Published

    Discovery of a New Class of Ionotropic Glutamate Receptor Antagonists by the Rational Design of (2S,3R)-3-(3-Carboxyphenyl)-pyrrolidine-2-carboxylic Acid. / Larsen, Ann Møller; Venskutonyte, Raminta; Valadés, Elena Antón; Nielsen, Birgitte; Pickering, Darryl S; Bunch, Lennart.

    In: ACS Chemical Neuroscience, Vol. 2, No. 2, 04.11.2011, p. 107-114.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Targeting specific sub-domains of the GluA4 ionotropic glutamate receptor by murine Fab fragments. / Mohr, Andreas Ørgaard; Riise, Erik Skjold; Pickering, Darryl S; Jensen, Anders A.; Madden, Dean; Kastrup, Jette Sandholm Jensen; Clausen, Rasmus Prætorius; Skottrup, Peter Durand.

    2011. Poster session presented at Affinity2011, Tavira, Portugal.

    Research output: Contribution to conferencePosterResearchpeer-review

  11. Published

    Rational Design, Synthesis and Pharmacological Evaluation of the (2R)- and (2S)-Stereoisomers of 3-(2-Carboxypyrrolidinyl)-2-methyl Acetic Acid as Ligands for the Ionotropic Glutamate Receptors. / Rasmussen, Julie; Storgaard, Morten; Pickering, Darryl S; Bunch, Lennart.

    In: ChemMedChem, Vol. 6, No. 3, 07.03.2011, p. 498-504.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure : Synthesis, resolution, pharmacology, and crystal structure. / Szymanska, Ewa; Frydenvang, Karla; Contreras-Sanz, Alberto; Pickering, Darryl S; Frola, Elena; Serafimoska, Zorica; Nielsen, Birgitte; Kastrup, Jette Sandholm; Johansen, Tommy Nørskov.

    In: Journal of Medicinal Chemistry, Vol. 54, No. 20, 04.10.2011, p. 7289-7298.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. / Venskutonyte, Raminta; Frydenvang, Karla; Gajhede, Michael; Bunch, Lennart; Pickering, Darryl S; Kastrup, Jette Sandholm.

    In: Journal of Structural Biology, Vol. 176, No. 3, 12.2011, p. 307-314.

    Research output: Contribution to journalJournal articleResearchpeer-review

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