Darryl S Pickering
Darryl S Pickering

Associate Professor


  1. 2012
  2. Published

    Cognitive enhancing effects of an AMPA receptor positive modulator on place learning in mice

    Rytter, Hana Malá, Chen, Y., Worm, V. H., Kure, J., Kaae, B. H., Madsen, Ulf, Badolo, L., Pickering, Darryl S & Mogensen, Jesper, 2012, In : Behavioural Brain Research. 226, 1, p. 18-25

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

    Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Bunch, Lennart, Frydenvang, Karla Andrea & Pickering, Darryl S, 2012, In : Journal of Structural Biology. 180, 1, p. 39-46

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors

    Venskutonyte, R., Frydenvang, Karla Andrea, Valadés, E. A., Szymanska, E. M., Johansen, Tommy Nørskov, Kastrup, Jette Sandholm Jensen & Pickering, Darryl S, Oct 2012, In : ChemMedChem. 7, 10, p. 1793-1798 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2013
  6. Published

    Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

    Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Jensen, Anders A., Pickering, Darryl S, Frydenvang, Karla Andrea, Gefflaut, T. & Bunch, Lennart, 2013, In : Journal of Medicinal Chemistry. 56, 4, p. 1614-1628

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site

    Kvist, T., Steffensen, T. B., Greenwood, J. R., Mehrzad Tabrizi, F., Hansen, K. B., Gajhede, Michael, Pickering, Darryl S, Traynelis, S. F., Kastrup, Jette Sandholm Jensen & Bräuner-Osborne, Hans, 2013, In : The Journal of Biological Chemistry. 288, p. 33124-35 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests

    Andreasen T., Jesper, Gynther, M. O. O., Rygaard, A., Bøgelund, T., Nielsen, S. D., Clausen, Rasmus Prætorius, Mogensen, Jesper & Pickering, Darryl S, 2013, In : Neuroscience Letters. 546, p. 6-10 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

    Krintel, C., Harpsøe, Kasper, Dorvil, Linda Grønborg, Peters, D., Frydenvang, Karla Andrea, Pickering, Darryl S, Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2013, In : Acta Crystallographica Section D: Structural Biology. 69, Pt 9, p. 1645-1652 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization

    Juknaite, L., Sugamata, Y., Tokiwa, K., Ishikawa, Y., Takamizawa, S., Eng, A., Sakai, R., Pickering, Darryl S, Frydenvang, Karla Andrea, Swanson, G. T., Kastrup, Jette Sandholm Jensen & Oikawa, M., 2013, In : Journal of Medicinal Chemistry. 56, 6, p. 2283-2293

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: Comparison with the NMDA receptor antagonist MK-801

    Andreasen T., Jesper, Bach, Anders, Gynther, M., Nasser, A., Mogensen, Jesper, Strømgaard, Kristian & Pickering, Darryl S, Apr 2013, In : Neuropharmacology. 67, p. 193-200 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. 2014
  13. Published
  14. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain

    Venskutonyte, R., Larsen, A. P., Frydenvang, Karla Andrea, Gajhede, Michael, Gefflaut, T., Pickering, Darryl S, Bunch, Lennart & Kastrup, Jette Sandholm Jensen, 2014, In : ChemMedChem. 9, 10, p. 2254-2259 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published
  16. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

    Krintel, C., Frydenvang, Karla Andrea, Ceravalls de Rabassa, A., Kaern, A. M., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 27 Mar 2014, In : F E B S Journal. p. 2422–2430 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published
  18. 2015
  19. Published

    Solid-Phase Peptide Synthesis of Human alfa-Calcitonin Gene-Related Peptide and Two Fluorescent Analogs.

    Fuente-Moreno, M., Oddo, A., Sheykhzade, Majid, Pickering, Darryl S & Hansen, Paul Robert, 2015, Proceedings of the 24th American Peptide Symposium . 2 p.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  20. Published

    Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid

    Krogsgaard-Larsen, N., Storgaard, M., Møller, C., Demmer, C. S., Hansen, J., Han, L., Monrad, R. N., Nielsen, Birgitte, Tapken, D., Pickering, Darryl S, Kastrup, Jette Sandholm Jensen, Frydenvang, Karla Andrea & Bunch, Lennart, 2015, In : Journal of Medicinal Chemistry. 58, 15, p. 6131-50 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Blood-brain barrier permeability and brain uptake mechanism of kainic Acid and dihydrokainic Acid

    Gynther, M., Petsalo, A., Hansen, S. H., Bunch, Lennart & Pickering, Darryl S, Mar 2015, In : Neurochemical Research. 40, 3, p. 542-549 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Differential role of AMPA receptors in mouse tests of antidepressant and anxiolytic action

    Andreasen T., Jesper, Fitzpatrick, C. M., Larsen, M., Skovgaard, L., Nielsen, S. D., Clausen, Rasmus Prætorius, Troelsen, K. & Pickering, Darryl S, 19 Mar 2015, In : Brain Research. 1601, p. 117-26 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1

    Demmer, C. S., Møller, C., Brown, P. M. G. E., Han, L., Pickering, Darryl S, Nielsen, Birgitte, Bowie, D., Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen & Bunch, Lennart, 9 Apr 2015, In : A C S Chemical Neuroscience. 6, p. 845-854 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2016
  25. Published

    A pharmacological profile of the high-affinity GluK5 kainate receptor

    Møllerud, Stine, Kastrup, Jette Sandholm Jensen & Pickering, Darryl S, 2016, In : European Journal of Pharmacology. 788, p. 315-320 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Design, synthesis and structure-activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands

    Szymańska, E., Chałupnik, P., Szczepańska, K., Moral, A. M. C., Pickering, Darryl S, Nielsen, Birgitte, Johansen, Tommy Nørskov & Kieć-Kononowicz, K., 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 22, p. 5568-5572 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2

    Krintel, C., Francotte, P., Pickering, Darryl S, Juknaite, L., Pøhlsgaaard, J., Olsen, L., Frydenvang, Karla Andrea, Goffin, E., Pirotte, B. & Kastrup, Jette Sandholm Jensen, 2016, In : Biophysical Journal. 110, 11, p. 2397-2406 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Modelling Affective Pain in Mice: Effects of Inflammatory Hypersensitivity on Place Escape/Avoidance Behaviour, Anxiety and Hedonic State

    Refsgaard, L. K., Hoffmann-Petersen, J., Sahlholt, M., Pickering, Darryl S & Andreasen T., Jesper, 2016, In : Journal of Neuroscience Methods. 262, p. 85-92 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Neto2 influences on kainate receptor pharmacology and function

    Han, L., Howe, J. & Pickering, Darryl S, 2016, In : Basic & Clinical Pharmacology & Toxicology. 119, p. 141-148 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Structural rearrangement of the intracellular domains during AMPA receptor activation

    Dorvil, Linda Grønborg, Katchan, L., Jensen, A. G., Pickering, Darryl S, Plested, A. & Kristensen, Anders Skov, 2016, In : Proceedings of the National Academy of Sciences USA (PNAS). 113, 27, p. E3950-E3959 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1299533