Darryl S Pickering

Darryl S Pickering

Associate Professor


  1. Published

    Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid : a novel selective inhibitor of human excitatory amino acid transporter subtype 2. / Sagot, Emanuelle; Jensen, Anders A.; Pickering, Darryl S; Pu, Xiaosui; Umberti, Michelle; Stensbøl, Tine B.; Nielsen, Birgitte; Assaf, Zeinab; Aboab, Bétina; Bolte, Jean; Gefflaut, Thierry; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 14, 2008, p. 4085-4092.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotropic glutamate receptor subtypes 5, 6, and 7. / Sagot, Emanuelle; Pickering, Darryl S; Pu, Xiaosui; Umberti, Michelle; Stensbøl, Tine B; Nielsen, Birgitte; Chapelet, Marion; Bolte, Jean; Gefflaut, Thierry; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 14, 2008, p. 4093-103.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. / Assaf, Z.; Larsen, Anja Probst; Venskutonyte, Raminta; Han, Liwei; Abrahamsen, Bjarke; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm; Jensen, Anders A.; Pickering, Darryl S; Frydenvang, Karla ; Gefflaut, T; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 4, 2013, p. 1614-1628.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Cognitive enhancing effects of an AMPA receptor positive modulator on place learning in mice. / Rytter, Hana Malá; Chen, Yuxia; Worm, Vivi Hu; Kure, Julie; Kaae, Birgitte H.; Madsen, Ulf; Badolo, Lassina; Pickering, Darryl S; Mogensen, Jesper.

    In: Behavioural Brain Research, Vol. 226, No. 1, 2012, p. 18-25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Computeren viser vejen til et nyt potentielt lægemiddel. / Harpsøe, Kasper; Kaae, Birgitte Høiriis; Balle, Thomas; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: Lægemiddelforskning, 2008, p. 28-30.

    Research output: Contribution to journalJournal articleCommunication

  6. Published

    Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues. / Vogensen, SB; Clausen, Rasmus Prætorius; Greenwood, JR; Johansen, Tommy Nørskov; Pickering, DS; Nielsen, Birgitte; Ebert, Barke; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 48, No. 9, 05.05.2005, p. 3438-3442.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Correlation between Anticonvulsant Activity and Inhibitory Action on Glial -Aminobutyric Acid Uptake of the Highly Selective Mouse -Aminobutyric Acid Transporter 1 Inhibitor 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and Its N-Alkylated Analogs. / White, Steve; Sarup, Alan; Bolvig, Tina; Petersen, G; Nelson, N; Pickering, Darryl S; Larsson, Orla Miller; Frølund, Bente; Falch, Erik; Krogsgaard-Larsen, Povl; Schousboe, Arne.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 302, 2002, p. 636–644.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. / Kvist, Trine; Steffensen, Thomas Bielefeldt; Greenwood, Jeremy R; Mehrzad Tabrizi, Fatemeh; Hansen, Kasper Bø; Gajhede, Michael; Pickering, Darryl S; Traynelis, Stephen F; Kastrup, Jette Sandholm; Bräuner-Osborne, Hans.

    In: The Journal of Biological Chemistry, Vol. 288, 2013, p. 33124-35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    D-aspartate and NMDA, but not L-aspartate, block AMPA receptors in rat hippocampal neurons. / Gong, Xiang-Qun; Frandsen, Anne; Lu, Wei-Yang; Wan, Yudi; Zabek, Rebecca L; Pickering, Darryl; Bai, Donglin.

    In: British Journal of Pharmacology, Vol. 145, No. 4, 2005, p. 449-59.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Depolarization-induced release of [(3)H]D-aspartate from GABAergic neurons caused by reversal of glutamate transporters. / Jensen, J B; Pickering, D S; Schousboe, A; Pickering, Darryl.

    In: International Journal of Developmental Neuroscience, Vol. 18, No. 2-3, 2000, p. 309-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Design and Synthesis of 2,3-trans-Proline Analogs as Ligands for the Ionotropic Glutamate Receptors and the Excitatory Amino Acid Transporters. / Poulie, Christian Bernard Matthijs; Alcaide Lopez, Anna; Krell-Jørgensen, Mikkel Poul; Larsen, Younes; Astier, Eloi; Bjørn-Yoshimoto, Walden E.; Yi, Feng; Syrenne, Jed T; Storgaard, Morten; Nielsen, Birgitte; Frydenvang, Karla Andrea; Jensen, Anders A.; Hansen, Kasper B; Pickering, Darryl S; Bunch, Lennart.

    In: A C S Chemical Neuroscience, Vol. 10, No. 6, 19.06.2019, p. 2989-3007.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. / Krogsgaard-Larsen, Niels; Delgar, Claudia; Koch, Karina; Brown, Patricia M G E; Møller, Charlotte; Han, Liwei; Huynh, Tri Hien Viet; Hansen, Stinne Wessel; Nielsen, Birgitte; Bowie, Derek; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen; Frydenvang, Karla Andrea; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 60, No. 1, 2017, p. 441-457.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Design and characterization of dimeric ligands cross-linking two identical modulatory AMPA receptor sites. / Kaae, Birgitte H.; Harpsoe, Kasper; Sanz, Alberto Contreras; Pickering, Darryl S.; Sauerberg, Per; Clausen, Rasmus Prætorius; Kastrup, Jette S.; Liljefors, Tommy; Madsen, Ulf.

    In: American Chemical Society. Abstracts of Papers (at the National Meeting), Vol. 234, 19.08.2007.

    Research output: Contribution to journalConference abstract in journalResearch

  14. Published
  15. Published

    Design, synthesis and structure-activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands. / Szymańska, Ewa; Chałupnik, Paulina; Szczepańska, Katarzyna; Moral, Ana Maria Cuñado; Pickering, Darryl S; Nielsen, Birgitte; Johansen, Tommy Nørskov; Kieć-Kononowicz, Kieć-Kononowicz.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 26, No. 22, 2016, p. 5568-5572.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). / Bjerrum, Esben J; Kristensen, Anders S; Pickering, Darryl S; Greenwood, Jeremy R; Nielsen, Birgitte; Liljefors, Tommy; Schousboe, Arne; Bräuner-Osborne, Hans; Madsen, Ulf; Pickering, Darryl.

    In: Journal of Medicinal Chemistry, Vol. 46, No. 11, 2003, p. 2246-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Development of calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in cultured neocortical neurons visualized by cobalt staining. / Jensen, J B; Schousboe, A; Pickering, D S; Pickering, Darryl.

    In: Journal of Neuroscience Research, Vol. 54, No. 2, 1998, p. 273-81.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Differential role of AMPA receptors in mouse tests of antidepressant and anxiolytic action. / Andreasen, Jesper T; Fitzpatrick, Ciaran M; Larsen, Maria; Skovgaard, Lars; Nielsen, Simon D; Clausen, Rasmus P; Troelsen, Karin; Pickering, Darryl S.

    In: Brain Research, Vol. 1601, 19.03.2015, p. 117-26.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Discovery of a New Class of Ionotropic Glutamate Receptor Antagonists by the Rational Design of (2S,3R)-3-(3-Carboxyphenyl)-pyrrolidine-2-carboxylic Acid. / Larsen, Ann Møller; Venskutonyte, Raminta; Valadés, Elena Antón; Nielsen, Birgitte; Pickering, Darryl S; Bunch, Lennart.

    In: ACS Chemical Neuroscience, Vol. 2, No. 2, 04.11.2011, p. 107-114.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests. / Andreasen T., Jesper; Gynther, Mikko Otto Oskari; Rygaard, Allan; Bøgelund, Trine; Nielsen, Simon Dalsgaard; Clausen, Rasmus Prætorius; Mogensen, Jesper; Pickering, Darryl S.

    In: Neuroscience Letters, Vol. 546, 2013, p. 6-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Effect of synthetic and natural phospholipids on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D activity. / Petersen, Gitte; Pedersen, Anders H; Pickering, Darryl S; Begtrup, Mikael; Hansen, Harald S.

    In: Chemistry and Physics of Lipids, Vol. 162, No. 1-2, 2009, p. 53-61.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Effects of dimeric PSD-95 inhibition on excitotoxic cell death and outcome after controlled cortical impact in rats : PSD-95 inhibition in experimental TBI. / Sommer, Jens Bak; Bach, Anders; Rytter, Hana Malá; Gynther, Mikko; Bjerre, Ann-Sofie; Gram, Marie Gajhede; Marschner, Linda; Strømgaard, Kristian; Mogensen, Jesper; Pickering, Darryl S.

    In: Neurochemical Research, Vol. 42, No. 12, 2017, p. 3401-3413.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Effects of sertraline, duloxetine, vortioxetine, and idazoxan in the rat affective bias test. / Refsgaard, Louise Konradsen; Haubro, Kia; Pickering, Darryl S; Stuart, Sarah; Robinson, Emma; Andreasen T., Jesper.

    In: Psychopharmacology, Vol. 233, No. 21, 14.10.2016, p. 3763-3770.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function. / Andreasen, Jesper T; Nasser, Arafat; Caballero-Puntiverio, Maitane; Sahlholt, Maj; Bach, Anders; Gynther, Mikko; Strømgaard, Kristian; Pickering, Darryl S.

    In: European Journal of Pharmacology, Vol. 780, 05.06.2016, p. 166-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats. / Sommer, Jens Bak; Bach, Anders; Malá, Hana ; Strømgaard, Kristian; Mogensen, Jesper; Pickering, Darryl S.

    In: Pharmacology, Biochemistry and Behavior, Vol. 161, 10.2017, p. 62-67.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1299533