Darryl S Pickering
Darryl S Pickering

Associate Professor


  1. 2006
  2. Published

    3-hydroxypyridazine 1-oxides as carboxylate bioisosteres: a new series of subtype-selective AMPA receptor agonists

    Greenwood, J. R., Mewett, K. N., Allan, R. D., Martín, B. O. & Pickering, Darryl S, Jul 2006, In : Neuropharmacology. 51, 1, p. 52-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209

    Kasper, C., Pickering, Darryl S, Mirza, Osman Asghar, Olsen, L., Kristensen, Anders Skov, Greenwood, J. R., Liljefors, T., Schousboe, Arne, Wätjen, F., Gajhede, Michael, Sigurskjold, B. W. & Kastrup, Jette Sandholm Jensen, 2006, In : Journal of Molecular Biology. 357, 4, p. 1184-201 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2005
  5. Published

    Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues

    Vogensen, S., Clausen, Rasmus Prætorius, Greenwood, J., Johansen, Tommy Nørskov, Pickering, Darryl S, Nielsen, Birgitte, Ebert, B. & Krogsgaard-Larsen, Povl, 5 May 2005, In : Journal of Medicinal Chemistry. 48, 9, p. 3438-3442

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published
  7. Published

    D-aspartate and NMDA, but not L-aspartate, block AMPA receptors in rat hippocampal neurons

    Gong, X., Frandsen, A., Lu, W., Wan, Y., Zabek, R. L., Pickering, Darryl S & Bai, D., 2005, In : British Journal of Pharmacology. 145, 4, p. 449-59 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP

    Nielsen, B. B., Pickering, Darryl S, Greenwood, J. R., Brehm, L., Gajhede, Michael, Schousboe, Arne & Kastrup, Jette Sandholm Jensen, 2005, In : FEBS Journal. 272, 7, p. 1639-48 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2

    Frandsen, A., Pickering, Darryl S, Vestergaard, Bente, Kasper, C., Nielsen, B. B., Greenwood, J. R., Campiani, G., Fattorusso, C., Gajhede, Michael, Schousboe, Arne & Kastrup, Jette Sandholm Jensen, 2005, In : Molecular Pharmacology. 67, 3, p. 703-13 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2004
  11. Published

    A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors

    Vogensen, S., Greenwood, J., Varming, A. R., Brehm, L., Pickering, Darryl S, Nielsen, Birgitte, Liljefors, T., Clausen, Rasmus Prætorius, Johansen, Tommy Nørskov & Krogsgaard-Larsen, Povl, 2004, In : Organic & Biomolecular Chemistry. 2, 2, p. 206-213

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. 2003
  13. Published

    Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO)

    Bjerrum, E. J., Kristensen, Anders Skov, Pickering, D. S., Greenwood, J. R., Nielsen, Birgitte, Liljefors, T., Schousboe, Arne, Bräuner-Osborne, Hans, Madsen, Ulf & Pickering, Darryl S, 2003, In : Journal of Medicinal Chemistry. 46, 11, p. 2246-9 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues

    Valgeirsson, J., Christensen, J. K., Kristensen, Anders Skov, Pickering, Darryl S, Nielsen, Birgitte, Fischer, C., Bräuner-Osborne, Hans, Nielsen, E. Ø., Krogsgaard-Larsen, Povl & Madsen, U., 2003, In : Bioorganic & Medicinal Chemistry. 11, 20, p. 4341-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2002
  16. Published

    Correlation between Anticonvulsant Activity and Inhibitory Action on Glial -Aminobutyric Acid Uptake of the Highly Selective Mouse -Aminobutyric Acid Transporter 1 Inhibitor 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and Its N-Alkylated Analogs

    White, S., Sarup, A., Bolvig, T., Petersen, G., Nelson, N., Pickering, Darryl S, Larsson, O. M., Frølund, Bente, Falch, E., Krogsgaard-Larsen, Povl & Schousboe, Arne, 2002, In : Journal of Pharmacology and Experimental Therapeutics. 302, p. 636–644

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2001
  18. Published

    Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties

    Campiani, G., Morelli, E., Nacci, V., Fattorusso, C., Ramunno, A., Novellino, E., Greenwood, J., Liljefors, T., Griffiths, R., Sinclair, C., Reavy, H., Kristensen, A. S., Pickering, Darryl S, Schousboe, Arne, Cagnotto, A., Fumagalli, E., Mennini, T. & Pickering, Darryl S, 2001, In : Journal of Medicinal Chemistry. 44, 26, p. 4501-4 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Molecular determinants of desensitization and assembly of the chimeric GABA(A) receptor subunits (alpha1/gamma2) and (gamma2/alpha1) in combinations with beta2 and gamma2

    Elster, L., Kristiansen, Uffe, Pickering, Darryl S, Olsen, R. W. & Schousboe, Arne, 2001, In : Neurochemistry International. 38, 7, p. 581-92 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Role of GluR2 expression in AMPA-induced toxicity in cultured murine cerebral cortical neurons

    Jensen, J. B., Lund, Trine Meldgaard, Timmermann, D. B., Schousboe, Arne & Pickering, Darryl S, 2001, In : Journal of Neuroscience Research. 65, 3, p. 267-277 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. 2000
  22. Published

    Agonist discrimination between AMPA receptor subtypes

    Coquelle, T., Christensen, J. K., Banke, T. G., Madsen, U., Schousboe, Arne & Pickering, Darryl S, 2000, In : NeuroReport. 11, 12, p. 2643-8 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Depolarization-induced release of [(3)H]D-aspartate from GABAergic neurons caused by reversal of glutamate transporters

    Jensen, J. B., Pickering, Darryl S, Schousboe, Arne & Pickering, Darryl S, 2000, In : International Journal of Developmental Neuroscience. 18, 2-3, p. 309-15 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 1999
  25. Published

    Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity

    Bolvig, T., Larsson, O. M., Pickering, Darryl S, Nelson, N., Falch, E., Krogsgaard-Larsen, Povl, Schousboe, Arne & Pickering, Darryl S, 1999, In : European Journal of Pharmacology. 375, 1-3, p. 367-74 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Role of desensitization and subunit expression for kainate receptor-mediated neurotoxicity in murine neocortical cultures

    Jensen, J. B., Schousboe, Arne, Pickering, Darryl S & Pickering, Darryl S, 1999, In : Journal of Neuroscience Research. 55, 2, p. 208-17 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1299533