Darryl S Pickering

Darryl S Pickering

Associate Professor


  1. Published

    Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). / Bjerrum, Esben J; Kristensen, Anders S; Pickering, Darryl S; Greenwood, Jeremy R; Nielsen, Birgitte; Liljefors, Tommy; Schousboe, Arne; Bräuner-Osborne, Hans; Madsen, Ulf; Pickering, Darryl.

    In: Journal of Medicinal Chemistry, Vol. 46, No. 11, 2003, p. 2246-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties. / Campiani, G; Morelli, E; Nacci, V; Fattorusso, C; Ramunno, A; Novellino, E; Greenwood, J; Liljefors, T; Griffiths, R; Sinclair, C; Reavy, H; Kristensen, A S; Pickering, D S; Schousboe, A; Cagnotto, A; Fumagalli, E; Mennini, T; Pickering, Darryl.

    In: Journal of Medicinal Chemistry, Vol. 44, No. 26, 2001, p. 4501-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Molecular determinants of desensitization and assembly of the chimeric GABA(A) receptor subunits (alpha1/gamma2) and (gamma2/alpha1) in combinations with beta2 and gamma2. / Elster, L; Kristiansen, U; Pickering, D S; Olsen, R W; Schousboe, A.

    In: Neurochemistry International, Vol. 38, No. 7, 2001, p. 581-92.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2. / Frandsen, Anne; Pickering, Darryl S.; Vestergaard, Bente; Kasper, Christina; Nielsen, Bettina Bryde; Greenwood, Jeremy R; Campiani, Giuseppe; Fattorusso, Caterina; Gajhede, Michael; Schousboe, Arne; Kastrup, Jette Sandholm.

    In: Molecular Pharmacology, Vol. 67, No. 3, 2005, p. 703-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    D-aspartate and NMDA, but not L-aspartate, block AMPA receptors in rat hippocampal neurons. / Gong, Xiang-Qun; Frandsen, Anne; Lu, Wei-Yang; Wan, Yudi; Zabek, Rebecca L; Pickering, Darryl; Bai, Donglin.

    In: British Journal of Pharmacology, Vol. 145, No. 4, 2005, p. 449-59.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    3-hydroxypyridazine 1-oxides as carboxylate bioisosteres : a new series of subtype-selective AMPA receptor agonists. / Greenwood, Jeremy R; Mewett, Ken N; Allan, Robin D; Martín, Belén Ortiz; Pickering, Darryl.

    In: Neuropharmacology, Vol. 51, No. 1, 07.2006, p. 52-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Role of GluR2 expression in AMPA-induced toxicity in cultured murine cerebral cortical neurons. / Jensen, Jette Bisgaard; Lund, Trine Meldgaard; Timmermann, Daniel B.; Schousboe, Arne; Pickering, Darryl S.

    In: Journal of Neuroscience Research, Vol. 65, No. 3, 2001, p. 267-277.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209. / Kasper, Christina; Pickering, Darryl S; Mirza, Osman; Olsen, Lars; Kristensen, Anders S; Greenwood, Jeremy R; Liljefors, Tommy; Schousboe, Arne; Wätjen, Frank; Gajhede, Michael; Sigurskjold, Bent W; Kastrup, Jette S.

    In: Journal of Molecular Biology, Vol. 357, No. 4, 2006, p. 1184-201.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published
  10. Published

    Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP. / Nielsen, Bettina B; Pickering, Darryl S; Greenwood, Jeremy R; Brehm, Lotte; Gajhede, Michael; Schousboe, Arne; Kastrup, Jette S.

    In: FEBS Journal, Vol. 272, No. 7, 2005, p. 1639-48.

    Research output: Contribution to journalJournal articleResearchpeer-review

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