Darryl S Pickering
Darryl S Pickering

Associate Professor


  1. Published

    Lessons from crystal structures of kainate receptors

    Møllerud, Stine, Frydenvang, Karla Andrea, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 1 Jan 2017, In : Neuropharmacology. 112, Part A, p. 16-28 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Modelling Affective Pain in Mice: Effects of Inflammatory Hypersensitivity on Place Escape/Avoidance Behaviour, Anxiety and Hedonic State

    Refsgaard, L. K., Hoffmann-Petersen, J., Sahlholt, M., Pickering, Darryl S & Andreasen T., Jesper, 2016, In : Journal of Neuroscience Methods. 262, p. 85-92 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4

    Kasper, C., Frydenvang, Karla Andrea, Naur, P., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2008, In : FEBS Letters. 582, 29, p. 4089-4094

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain

    Venskutonyte, R., Larsen, A. P., Frydenvang, Karla Andrea, Gajhede, Michael, Gefflaut, T., Pickering, Darryl S, Bunch, Lennart & Kastrup, Jette Sandholm Jensen, 2014, In : ChemMedChem. 9, 10, p. 2254-2259 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships and in vitro Pharmacology

    Pallesen, J. S., Møllerud, Stine, Frydenvang, Karla Andrea, Pickering, Darryl S, Bornholt, J., Nielsen, Birgitte, Pasini, D., Han, L., Marconi, L., Kastrup, Jette Sandholm Jensen & Johansen, Tommy Nørskov, 20 Mar 2019, In : A C S Chemical Neuroscience. 10, p. 1841-1853 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Neto2 influences on kainate receptor pharmacology and function

    Han, L., Howe, J. & Pickering, Darryl S, 2016, In : Basic & Clinical Pharmacology & Toxicology. 119, p. 141-148 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: Structures of the ligand-bining core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid

    Hald, H., Naur, P., Pickering, Darryl S, Sprogøe, D., Madsen, Ulf, Timmermann, D. B., Ahring, P. K., Liljefors, T., Schousboe, Arne, Egebjerg, J., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2007, In : Journal of Biological Chemistry. 282, 35, p. 25726-25736

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

    Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Bunch, Lennart, Frydenvang, Karla Andrea & Pickering, Darryl S, 2012, In : Journal of Structural Biology. 180, 1, p. 39-46

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Pharmacological characterisation of biarylisopropylalsulphonamide AMPA-R potentiators

    Pickering, Darryl S, Sanz, C., Harpsøe, Kasper, Clausen, Rasmus Prætorius, Sauerberg, P., Liljefors, T., Madsen, Ulf & Kaae, B. H., 2007, In : Journal of Neurochemistry. 102 (suppl. 1), 41

    Research output: Contribution to journalConference abstract in journalResearch

  10. Published

    Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors

    Szymańska, E., Nielsen, Birgitte, Johansen, Tommy Nørskov, Cuñado Moral, A. M., Pickering, Darryl S, Szczepańska, K., Mickowska, A. & Kieć-Kononowicz, K., 2017, In : European Journal of Medicinal Chemistry. 138, p. 874-883 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Pharmacological characterization of (4R)-alkyl glutamate analogues at the ionotropic glutamate receptors: focus on subtypes iGlu5-7

    Bunch, Lennart, Gefflaut, T., Alaux, S., Sagot, E., Nielsen, Birgitte & Pickering, Darryl S, 2009, In : European Journal of Pharmacology. 609, p. 1-4

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Pharmacology and crystal structure of novel 2,3-quinoxalinediones at kainate receptors

    Møllerud, Stine, Pallesen, J. S., Pasini, D., Marconi, L., Han, L., Bornholt, J., Johansen, Tommy Nørskov, Kastrup, Jette Sandholm Jensen, Pickering, Darryl S & Frydenvang, Karla Andrea, Aug 2017, In : Journal of Neurochemistry. 142, S1, p. 124 1 p., MTU07-13.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  13. Published

    Positive allosteric modulation of AMPA receptors differentially modulates the behavioural effects of citalopram in mouse models of antidepressant and anxiolytic action

    Fitzpatrick, C. M., Larsen, M., Madsen, L., Pickering, Darryl S, Clausen, Rasmus Prætorius & Andreasen T., Jesper, 26 Jun 2016, In : Behavioural Pharmacology. 27, 6, p. 549-555 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Rational Design, Synthesis and Pharmacological Evaluation of the (2R)- and (2S)-Stereoisomers of 3-(2-Carboxypyrrolidinyl)-2-methyl Acetic Acid as Ligands for the Ionotropic Glutamate Receptors.

    Rasmussen, J., Storgaard, M., Pickering, Darryl S & Bunch, Lennart, 7 Mar 2011, In : ChemMedChem. 6, 3, p. 498-504 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Revisiting the Quinoxalinedione scaffold in the Construction of New Ligands for the Ionotropic Glutamate Receptors.

    Demmer, C. S., Rombach, D., Liu, N., Nielsen, Birgitte, Pickering, Darryl S & Bunch, Lennart, 1 Dec 2017, In : A C S Chemical Neuroscience. 8, 11, p. 2477-2495 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Selective kainate receptor (GluK1) ligands structurally based upon1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization

    Venskutonyte, R., Butini, S., Coccone, S. S., Gemma, S., Brindisi, M., Kumar, V., Guarino, E., Maramai, S., Valenti, S., Amir, A., Valades, E. A., Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen, Novellino, E., Campiani, G. & Pickering, Darryl S, 14 Jul 2011, In : Journal of Medicinal Chemistry. 54, 13, p. 4793-4805

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Simple cellemodeller for kommunikation i hjernen

    Schousboe, Arne, Madsen, K. K. & Pickering, Darryl S, 2011, Bioteknologi - en temabog. Gasbjerg, P., Jensen, G. & Sørensen, A. (eds.). Aarhus Danmark: Systime Academic, p. 98-107 10 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  18. Published

    Solid-Phase Peptide Synthesis of Human alfa-Calcitonin Gene-Related Peptide and Two Fluorescent Analogs.

    Fuente-Moreno, M., Oddo, A., Sheykhzade, Majid, Pickering, Darryl S & Hansen, Paul Robert, 2015, Proceedings of the 24th American Peptide Symposium . 2 p.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  19. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

    Krintel, C., Harpsøe, Kasper, Dorvil, Linda Grønborg, Peters, D., Frydenvang, Karla Andrea, Pickering, Darryl S, Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2013, In : Acta Crystallographica Section D: Structural Biology. 69, Pt 9, p. 1645-1652 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors

    Venskutonyte, R., Frydenvang, Karla Andrea, Valadés, E. A., Szymanska, E. M., Johansen, Tommy Nørskov, Kastrup, Jette Sandholm Jensen & Pickering, Darryl S, Oct 2012, In : ChemMedChem. 7, 10, p. 1793-1798 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites

    Kaae, B. H., Harpsøe, Kasper, Kastrup, Jette Sandholm Jensen, Sanz, A. C., Pickering, Darryl S, Metzler, B., Clausen, Rasmus Prætorius, Gajhede, Michael, Sauerberg, P., Liljefors, T. & Madsen, Ulf, 2007, In : Chemistry & Biology. 14, 11, p. 1294-303 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Structural rearrangement of the intracellular domains during AMPA receptor activation

    Dorvil, Linda Grønborg, Katchan, L., Jensen, A. G., Pickering, Darryl S, Plested, A. & Kristensen, Anders Skov, 2016, In : Proceedings of the National Academy of Sciences USA (PNAS). 113, 27, p. E3950-E3959 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Structure and affinity of two bicyclic glutamate analogues at AMPA and kainate receptors

    Møllerud, Stine, Pinto, A., Marconi, L., Frydenvang, Karla Andrea, Thorsen, Thor Seneca, Laulumaa, S. K., Venskutonyte, R., Winther, Nikolaj Sebastian, Cunado Moral, A. M., Tamborini, L., Conti, P., Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2017, In : A C S Chemical Neuroscience. 8, 9, p. 2056-2064 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate

    Kristensen, O., Kristensen, L. B., Møllerud, Stine, Frydenvang, Karla Andrea, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2016, In : Structure. 24, 9, p. 1582-1589 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid

    Krogsgaard-Larsen, N., Storgaard, M., Møller, C., Demmer, C. S., Hansen, J., Han, L., Monrad, R. N., Nielsen, Birgitte, Tapken, D., Pickering, Darryl S, Kastrup, Jette Sandholm Jensen, Frydenvang, Karla Andrea & Bunch, Lennart, 2015, In : Journal of Medicinal Chemistry. 58, 15, p. 6131-50 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1299533