Darryl S Pickering
Darryl S Pickering

Associate Professor


  1. Published
  2. Published

    Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

    Szymanska, E., Frydenvang, Karla Andrea, Pickering, Darryl S, Krintel, C., Nielsen, Birgitte, Kooshki, A., Dorvil, Linda Grønborg, Olsen, L., Kastrup, Jette Sandholm Jensen & Johansen, Tommy Nørskov, 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 448-461 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization

    Juknaite, L., Sugamata, Y., Tokiwa, K., Ishikawa, Y., Takamizawa, S., Eng, A., Sakai, R., Pickering, Darryl S, Frydenvang, Karla Andrea, Swanson, G. T., Kastrup, Jette Sandholm Jensen & Oikawa, M., 2013, In : Journal of Medicinal Chemistry. 56, 6, p. 2283-2293

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Synthesis and Pharmacological Characterization of the Selective GluK1 Radioligand (S)-2-Amino-3-(6-[3H]-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)propanoic acid ([3H]-NF608)

    Alcaide, A., Marconi, L., Marek, A., Haym, I., Nielsen, Birgitte, Møllerud, Stine, Jensen, M., Conti, P., Pickering, Darryl S & Bunch, Lennart, 2016, In : MedChemComm. 7, p. 2136-2144 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs

    Gynther, M., Pickering, Darryl S, Spicer, J., Denny, W. & Huttunen, K., 2016, In : Molecular Pharmaceutics. 13, 7, p. 2484-2491 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Targeting specific sub-domains of the GluA4 ionotropic glutamate receptor by murine Fab fragments

    Mohr, A. Ø., Riise, E. S., Pickering, Darryl S, Jensen, A. A., Madden, D., Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius & Skottrup, P. D., 16 Jun 2011.

    Research output: Contribution to conferencePosterResearchpeer-review

  7. Published

    The Presence of Calcitonin Gene-Related Peptide and Its Receptors in Rat, Pig and Human Brain: Species Differences in Calcitonin Gene-Related Peptide Pharmacology

    Warfvinge, K., Edvinsson, Lars, Pickering, Darryl S & Sheykhzade, Majid, 1 Dec 2019, In : Pharmacology. 104, p. 332-341 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    The antagonistic effect of antipsychotic drugs on a HEK293 cell line stably expressing human alpha(1A1)-adrenoceptors

    Nourian, Z., Mulvany, M. J., Nielsen, K. B., Pickering, Darryl S & Kristensen, T., 2008, In : European Journal of Pharmacology. 596, 1-3, p. 32-40

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization

    Clausen, Rasmus Prætorius, Naur, P., Kristensen, Anders Skov, Greenwood, J. R., Strange, M., Bräuner-Osborne, Hans, Jensen, Anders A., Nielsen, A. S. T., Geneser, U., Ringgaard, L. M., Nielsen, Birgitte, Pickering, Darryl S, Brehm, L., Gajhede, Michael, Krogsgaard-Larsen, Povl & Kastrup, Jette Sandholm Jensen, 2009, In : Journal of Medicinal Chemistry. 52, 15, p. 4911-4922

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209

    Kasper, C., Pickering, Darryl S, Mirza, Osman Asghar, Olsen, L., Kristensen, Anders Skov, Greenwood, J. R., Liljefors, T., Schousboe, Arne, Wätjen, F., Gajhede, Michael, Sigurskjold, B. W. & Kastrup, Jette Sandholm Jensen, 2006, In : Journal of Molecular Biology. 357, 4, p. 1184-201 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Tweaking subtype-selectivity and agonist efficacy at (S)-2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) receptors in a small series of BnTetAMPA analogues

    Wang, S., Larsen, Y., Navarrete, C. V., Jensen, Anders A., Nielsen, Birgitte, Al-Musaed, A., Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen, Pickering, Darryl S & Clausen, Rasmus Prætorius, 2016, In : Journal of Medicinal Chemistry. 59, 5, p. 2244-2254 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2

    Frandsen, A., Pickering, Darryl S, Vestergaard, Bente, Kasper, C., Nielsen, B. B., Greenwood, J. R., Campiani, G., Fattorusso, C., Gajhede, Michael, Schousboe, Arne & Kastrup, Jette Sandholm Jensen, 2005, In : Molecular Pharmacology. 67, 3, p. 703-13 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: Comparison with the NMDA receptor antagonist MK-801

    Andreasen T., Jesper, Bach, Anders, Gynther, M., Nasser, A., Mogensen, Jesper, Strømgaard, Kristian & Pickering, Darryl S, Apr 2013, In : Neuropharmacology. 67, p. 193-200 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Use of the 4-Hydroxy-Triazole Moiety as a Bioisosteric Tool for the Development of Ionotropic Glutamate Receptor Ligands

    Sainas, S., Temperini, P., Farnsworth, J. C., Yi, F., Møllerud, Stine, Jensen, Anders A., Nielsen, Birgitte, Kastrup, Jette Sandholm Jensen, Hansen, K. B., Boschi, D., Pickering, Darryl S, Clausen, Rasmus Prætorius & Lolli, M., 9 May 2019, In : Journal of Medicinal Chemistry. 62, p. 4467-4482 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Vascular and molecular pharmacology of the metabolically stable CGRP analogue, SAX

    Sheykhzade, Majid, Abdolalizadeh, B., Koole, C., Pickering, Darryl S, Dreisig, K., Johansson, S. E., Abboud, B. K., Dreier, R., Berg, J. O., Jeppesen, Jørgen, Sexton, P., Edvinsson, Lars, Wootten, D. & Sams, A., 2018, In : European Journal of Pharmacology. 829, p. 85-92

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of ionotropic glutamate receptor binding pocket

    Tamborini, L., Nicosia, V., Conti, P., Dall'Oglio, F., De Micheli, C., Nielsen, Birgitte, Jensen, Anders A., Pickering, Darryl S & Pinto, A., 1 Dec 2016, In : Tetrahedron. 72, 51, p. 8586-8492 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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