Darryl S Pickering

Darryl S Pickering

Associate Professor


  1. Published

    1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators. / Butini, Stefania; Pickering, Darryl S; Morelli, Elena; Coccone, Salvatore Sanna; Trotta, Francesco; De Angelis, Meri; Guarino, Egeria; Fiorini, Isabella; Campiani, Giuseppe; Novellino, Ettore; Schousboe, Arne; Christensen, Jeppe K; Gemma, Sandra.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 20, 2008, p. 6614-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands. / Szymanska, Ewa; Pickering, Darryl S; Nielsen, Birgitte; Johansen, Tommy N.

    In: Bioorganic & Medicinal Chemistry, Vol. 17, No. 17, 2009, p. 6390-401.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    3-hydroxypyridazine 1-oxides as carboxylate bioisosteres : a new series of subtype-selective AMPA receptor agonists. / Greenwood, Jeremy R; Mewett, Ken N; Allan, Robin D; Martín, Belén Ortiz; Pickering, Darryl.

    In: Neuropharmacology, Vol. 51, No. 1, 07.2006, p. 52-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters. / Bunch, Lennart; Pickering, Darryl S; Gefflaut, Thierry; Vinatier, Virginie; Helaine, Virgil; Amir, Ahmad; Nielsen, Birgitte; Jensen, Anders Asbjørn.

    In: ChemMedChem, Vol. 4, No. 11, 2009, p. 1925-1929.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published
  6. Published

    4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues. / Lolli, Marco L; Giordano, Cecilia; Pickering, Darryl S; Rolando, Barbara; Hansen, Kasper B; Foti, Antonio; Contreras-Sanz, Alberto; Amir, Ahmad; Fruttero, Roberta; Gasco, Alberto; Nielsen, Birgitte; Johansen, Tommy N.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 10, 2010, p. 4110-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure : Synthesis, resolution, pharmacology, and crystal structure. / Szymanska, Ewa; Frydenvang, Karla; Contreras-Sanz, Alberto; Pickering, Darryl S; Frola, Elena; Serafimoska, Zorica; Nielsen, Birgitte; Kastrup, Jette Sandholm; Johansen, Tommy Nørskov.

    In: Journal of Medicinal Chemistry, Vol. 54, No. 20, 04.10.2011, p. 7289-7298.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors. / Vogensen, SB; Greenwood, JR; Varming, Annemarie R.; Brehm, L; Pickering, DS; Nielsen, Birgitte; Liljefors, T; Clausen, Rasmus Prætorius; Johansen, Tommy Nørskov; Krogsgaard-Larsen, P.

    In: Organic & Biomolecular Chemistry, Vol. 2, No. 2, 2004, p. 206-213.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    A tetrazolyl-substituted subtype-selective AMPA receptor agonist. / Vogensen, Stine Byskov; Frydenvang, Karla Andrea; Greenwood, Jeremy R.; Postorino, Giovanna; Nielsen, Birgitte; Pickering, Darryl Scott; Ebert, Bjarke; Bølcho, Ulrik; Egebjerg, Jan; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov; Clausen, Rasmus Prætorius; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 50, No. 10, 2007, p. 2408-2414.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Agonist discrimination between AMPA receptor subtypes. / Coquelle, T; Christensen, J K; Banke, T G; Madsen, U; Schousboe, A; Pickering, Darryl.

    In: NeuroReport, Vol. 11, No. 12, 2000, p. 2643-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. / Venskutonyte, Raminta; Frydenvang, Karla; Gajhede, Michael; Bunch, Lennart; Pickering, Darryl S; Kastrup, Jette Sandholm.

    In: Journal of Structural Biology, Vol. 176, No. 3, 12.2011, p. 307-314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid. / Frydenvang, Karla Andrea; Pickering, Darryl S; Greenwood, Jeremy R; Krogsgaard-Larsen, Niels; Brehm, Lotte; Nielsen, Birgitte; Vogensen, Stine Byskov; Hald, Helle; Kastrup, Jette Sandholm; Krogsgaard-Larsen, Povl; Clausen, Rasmus Prætorius.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 23, 10.11.2010, p. 8354-8361.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties. / Campiani, G; Morelli, E; Nacci, V; Fattorusso, C; Ramunno, A; Novellino, E; Greenwood, J; Liljefors, T; Griffiths, R; Sinclair, C; Reavy, H; Kristensen, A S; Pickering, D S; Schousboe, A; Cagnotto, A; Fumagalli, E; Mennini, T; Pickering, Darryl.

    In: Journal of Medicinal Chemistry, Vol. 44, No. 26, 2001, p. 4501-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid : a novel selective inhibitor of human excitatory amino acid transporter subtype 2. / Sagot, Emanuelle; Jensen, Anders A.; Pickering, Darryl S; Pu, Xiaosui; Umberti, Michelle; Stensbøl, Tine B.; Nielsen, Birgitte; Assaf, Zeinab; Aboab, Bétina; Bolte, Jean; Gefflaut, Thierry; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 14, 2008, p. 4085-4092.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotropic glutamate receptor subtypes 5, 6, and 7. / Sagot, Emanuelle; Pickering, Darryl S; Pu, Xiaosui; Umberti, Michelle; Stensbøl, Tine B; Nielsen, Birgitte; Chapelet, Marion; Bolte, Jean; Gefflaut, Thierry; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 14, 2008, p. 4093-103.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. / Assaf, Z.; Larsen, Anja Probst; Venskutonyte, Raminta; Han, Liwei; Abrahamsen, Bjarke; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm; Jensen, Anders A.; Pickering, Darryl S; Frydenvang, Karla ; Gefflaut, T; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 4, 2013, p. 1614-1628.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Cognitive enhancing effects of an AMPA receptor positive modulator on place learning in mice. / Rytter, Hana Malá; Chen, Yuxia; Worm, Vivi Hu; Kure, Julie; Kaae, Birgitte H.; Madsen, Ulf; Badolo, Lassina; Pickering, Darryl S; Mogensen, Jesper.

    In: Behavioural Brain Research, Vol. 226, No. 1, 2012, p. 18-25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Computeren viser vejen til et nyt potentielt lægemiddel. / Harpsøe, Kasper; Kaae, Birgitte Høiriis; Balle, Thomas; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: Lægemiddelforskning, 2008, p. 28-30.

    Research output: Contribution to journalJournal articleCommunication

  19. Published

    Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues. / Vogensen, SB; Clausen, Rasmus Prætorius; Greenwood, JR; Johansen, Tommy Nørskov; Pickering, DS; Nielsen, Birgitte; Ebert, Barke; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 48, No. 9, 05.05.2005, p. 3438-3442.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Correlation between Anticonvulsant Activity and Inhibitory Action on Glial -Aminobutyric Acid Uptake of the Highly Selective Mouse -Aminobutyric Acid Transporter 1 Inhibitor 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and Its N-Alkylated Analogs. / White, Steve; Sarup, Alan; Bolvig, Tina; Petersen, G; Nelson, N; Pickering, Darryl S; Larsson, Orla Miller; Frølund, Bente; Falch, Erik; Krogsgaard-Larsen, Povl; Schousboe, Arne.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 302, 2002, p. 636–644.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. / Kvist, Trine; Steffensen, Thomas Bielefeldt; Greenwood, Jeremy R; Mehrzad Tabrizi, Fatemeh; Hansen, Kasper Bø; Gajhede, Michael; Pickering, Darryl S; Traynelis, Stephen F; Kastrup, Jette Sandholm; Bräuner-Osborne, Hans.

    In: The Journal of Biological Chemistry, Vol. 288, 2013, p. 33124-35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    D-aspartate and NMDA, but not L-aspartate, block AMPA receptors in rat hippocampal neurons. / Gong, Xiang-Qun; Frandsen, Anne; Lu, Wei-Yang; Wan, Yudi; Zabek, Rebecca L; Pickering, Darryl; Bai, Donglin.

    In: British Journal of Pharmacology, Vol. 145, No. 4, 2005, p. 449-59.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Depolarization-induced release of [(3)H]D-aspartate from GABAergic neurons caused by reversal of glutamate transporters. / Jensen, J B; Pickering, D S; Schousboe, A; Pickering, Darryl.

    In: International Journal of Developmental Neuroscience, Vol. 18, No. 2-3, 2000, p. 309-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Design and characterization of dimeric ligands cross-linking two identical modulatory AMPA receptor sites. / Kaae, Birgitte H.; Harpsoe, Kasper; Sanz, Alberto Contreras; Pickering, Darryl S.; Sauerberg, Per; Clausen, Rasmus Prætorius; Kastrup, Jette S.; Liljefors, Tommy; Madsen, Ulf.

    In: American Chemical Society. Abstracts of Papers (at the National Meeting), Vol. 234, 19.08.2007.

    Research output: Contribution to journalConference abstract in journalResearch

  25. Published

    Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). / Bjerrum, Esben J; Kristensen, Anders S; Pickering, Darryl S; Greenwood, Jeremy R; Nielsen, Birgitte; Liljefors, Tommy; Schousboe, Arne; Bräuner-Osborne, Hans; Madsen, Ulf; Pickering, Darryl.

    In: Journal of Medicinal Chemistry, Vol. 46, No. 11, 2003, p. 2246-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

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